2,905
Views
5
CrossRef citations to date
0
Altmetric
Research Article

Gastric protective effect of Alpinia officinarum flavonoids: mediating TLR4/NF-κB and TRPV1 signalling pathways and gastric mucosal healing

ORCID Icon, , , , , ORCID Icon, & show all
Pages 50-60 | Received 20 Jul 2022, Accepted 19 Nov 2022, Published online: 21 Dec 2022

References

  • Abubakar IB, Malami I, Yahaya Y, Sule SM. 2018. A review on the ethnomedicinal uses, phytochemistry and pharmacology of Alpinia officinarum Hance. J Ethnopharmacol. 224:45–62.
  • Ardalani H, Hadipanah A, Sahebkar A. 2020. Medicinal plants in the treatment of peptic ulcer disease: A review. Mini Rev Med Chem. 20(8):662–702.
  • Asali AM, Alghamdi MA, Fallatah SA, Alholaily WA, Aldandan RG, Alnosair AH, AlKhars AA, Alreheli MF, Almohaini MO, Alharbi RA. 2018. Risk factors leading to peptic ulcer disease: systematic review in literature. Int J Community Med Public Health. 5(10):4617–4624.
  • Barker PA, Mantyh P, Arendt-Nielsen L, Viktrup L, Tive L. 2020. Nerve growth factor signaling and its contribution to pain. J Pain Res. 13:1223–1241.
  • Ersahin T, Tuncbag N, Cetin-Atalay R. 2015. The PI3K/AKT/mTOR interactive pathway. Mol Biosyst. 11(7):1946–1954.
  • Fitzgerald KA, Kagan JC. 2020. Toll-like receptors and the control of immunity. Cell. 180(6):1044–1066.
  • Guzel T, Mirowska-Guzel D. 2022. The role of serotonin neurotransmission in gastrointestinal tract and pharmacotherapy. Molecules. 27(5):1680.
  • Hrdlickova R, Toloue M, Tian B. 2017. RNA-Seq methods for transcriptome analysis. Wiley Interdiscip Rev RNA. 8.
  • Hu YH, Wang Y, Wang F, Dong YM, Jiang WL, Wang YP, Zhong X, Ma LX. 2021. SPOP negatively regulates toll-like receptor-induced inflammation by disrupting myD88 self-association. Cell Mol Immunol. 18(7):1708–1717.
  • Lin KW, Wang Y, Gong JW, Tan YF, Deng T, Wei N. 2020. Protective effects of total flavonoids from Alpinia officinarum rhizoma against ethanol-induced gastric ulcer in vivo and in vitro. Pharm Biol. 58(1):854–862.
  • Malin SA, Davis BM, Koerber HR, Reynolds IJ, Albers KM, Molliver DC. 2008. Thermal nociception and TRPV1 function are attenuated in mice lacking the nucleotide receptor P2Y2. Pain. 138(3):484–496.
  • Okabe S, Roth JLA, Pfeiffer CJ. 1971. A method for experimental, penetrating gastric and duodenal ulcers in rats. Am J Dig Dis. 16(3):277–284.
  • Oncel S, Basson MD. 2022. Gut homeostasis, injury, and healing: new therapeutic targets. World J Gastroenterol. 28(17):1725–1750.
  • Pereira M, Durso DF, Bryant CE, Kurt-Jones EA, Silverman N, Golenbock DT, Gazzinelli RT. 2022. The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways. Cell Rep. 40(7):111225.
  • Quartu M, Serra MP, Boi M, Poddighe L, Picci C, Demontis R, Del FM. 2016. TRPV1 receptor in the human trigeminal ganglion and spinal nucleus: immunohistochemical localization and comparison with the neuropeptides CGRP and SP. J Anat. 229(6):755–767.
  • Robilotto GL, Mohapatra DP, Shepherd AJ, Mickle AD. 2022. Role of Src kinase in regulating protein kinase C mediated phosphorylation of TRPV1. Eur J Pain. 26(9):1967–1978.
  • Ruzza P, Biondi B, Calderan A. 2009. Therapeutic prospect of Syk inhibitors. Expert Opin Ther Pat. 19(10):1361–1376.
  • Shuba YM. 2020. Beyond neuronal heat sensing: diversity of TRPV1 heat-capsaicin receptor-channel functions. Front Cell Neurosci. 14:612480.
  • Su YS, Chiu YY, Lin SY, Chen CC, Sun WH. 2016. Serotonin receptor 2B mediates mechanical hyperalgesia by regulating transient receptor potential vanilloid 1. J Mol Neurosci. 59(1):113–125.
  • Tarnawski AS, Ahluwalia A. 2012. Molecular mechanisms of epithelial regeneration and neovascularization during healing of gastric and esophageal ulcers. Curr Med Chem. 19(1):16–27.
  • Tarnawski AS, Ahluwalia A. 2021. The critical role of growth factors in gastric ulcer healing: the cellular and molecular mechanisms and potential clinical implications. Cells. 10(8):1964.
  • Tarnawski AS, Ahluwalia A, Jones MK. 2012. The mechanisms of gastric mucosal injury: focus on microvascular endothelium as a key target. Curr Med Chem. 19(1):4–15.
  • Wise BL, Seidel MF, Lane NE. 2021. The evolution of nerve growth factor inhibition in clinical medicine. Nat Rev Rheumatol. 17(1):34–46.
  • Yang X, Kui L, Tang M, Li D, Wei KH, Chen W, Miao JH, Dong Y. 2020. High-Throughput Transcriptome Profiling in Drug and Biomarker Discovery. Front Genet. 5:11–19.
  • Yu L-Y, Sun L-N, Zhang X-H, Li Y-Q, Yu L, Yuan Z-Q-Y, Meng L, Zhang H-W, Wang Y-Q. 2017. A review of the novel application and potential adverse effects of proton pump inhibitors. Adv Ther. 34(5):1070–1086.