3,412
Views
7
CrossRef citations to date
0
Altmetric
Research Article

Baicalein attenuates bleomycin-induced lung fibroblast senescence and lung fibrosis through restoration of Sirt3 expression

, , , , , & show all
Pages 288-297 | Received 08 Feb 2022, Accepted 15 Dec 2022, Published online: 23 Feb 2023

References

  • Alvarez D, Cardenes N, Sellares J, Bueno M, Corey C, Hanumanthu VS, Peng Y, D'Cunha H, Sembrat J, Nouraie M, et al. 2017. IPF lung fibroblasts have a senescent phenotype. Am J Physiol Lung Cell Mol Physiol. 313(6):L1164–L1173.
  • Blokland KEC, Habibie H, Borghuis T, Teitsma GJ, Schuliga M, Melgert BN, Knight DA, Brandsma CA, Pouwels SD, Burgess JK. 2021. Regulation of cellular senescence is independent from profibrotic fibroblast-deposited ECM. Cells. 10(7):1628.
  • Cao X, Li Y, Shi J, Tang H. 2021. The potentially therapeutic role of EPAC in curbing the process of idiopathic pulmonary fibrosis via differential cellular pathways. J Inflamm Res. 14:611–619.
  • Chale-Dzul J, Perez-Cabeza de Vaca R, Quintal-Novelo C, Olivera-Castillo L, Moo-Puc R. 2020. Hepatoprotective effect of a fucoidan extract from Sargassum fluitans Borgesen against CCl4-induced toxicity in rats. Int J Biol Macromol. 145:500–509.
  • Chen T, Guo Y, Wang J, Ai L, Ma L, He W, Li Z, Yu X, Li J, Fan X, et al. 2021. LncRNA CTD-2528L19.6 prevents the progression of IPF by alleviating fibroblast activation. Cell Death Dis. 12(6):600.
  • Chen Y, Zhao Z, Li Y, Yang Y, Li L, Jiang Y, Lin C, Cao Y, Zhou P, Tian Y, et al. 2021. Baicalein alleviates hyperuricemia by promoting uric acid excretion and inhibiting xanthine oxidase. Phytomedicine. 80:153374.
  • Cheresh P, Kim S-J, Jablonski R, Watanabe S, Lu Z, Chi M, Helmin KA, Gius D, Budinger GRS, Kamp DW. 2021. SIRT3 overexpression ameliorates asbestos-induced pulmonary fibrosis, mt-DNA damage, and lung fibrogenic monocyte recruitment. Int J Mol Sci. 22(13):6856.
  • Cui X, Sun X, Lu F, Jiang X. 2018. Baicalein represses TGF-beta1-induced fibroblast differentiation through the inhibition of miR-21. Toxicol Appl Pharmacol. 358:35–42.
  • D'Amico R, Fusco R, Gugliandolo E, Cordaro M, Siracusa R, Impellizzeri D, Peritore AF, Crupi R, Cuzzocrea S, Di Paola R. 2019. Effects of a new compound containing palmitoylethanolamide and baicalein in myocardial ischaemia/reperfusion injury in vivo. Phytomedicine. 54:27–42.
  • D’Amico R, Genovese T, Cordaro M, Siracusa R, Gugliandolo E, Peritore AF, Interdonato L, Crupi R, Cuzzocrea S, Di Paola R, et al. 2021. Palmitoylethanolamide/baicalein regulates the androgen receptor signaling and NF-kappaB/Nrf2 pathways in benign prostatic hyperplasia. Antioxidants. 10(7):1014.
  • Demaria M, Ohtani N, Youssef SA, Rodier F, Toussaint W, Mitchell JR, Laberge RM, Vijg J, Van Steeg H, Dolle ME, et al. 2014. An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. Dev Cell. 31(6):722–733.
  • Du JK, Cong BH, Yu Q, Wang H, Wang L, Wang CN, Tang XL, Lu JQ, Zhu XY, Ni X. 2016. Upregulation of microRNA-22 contributes to myocardial ischemia–reperfusion injury by interfering with the mitochondrial function. Free Radic Biol Med. 96:406–417.
  • Du J-K, Yu Q, Liu Y-J, Du S-F, Huang L-Y, Xu D-H, Ni X, Zhu X-Y. 2021. A novel role of kallikrein-related peptidase 8 in the pathogenesis of diabetic cardiac fibrosis. Theranostics. 11(9):4207–4231.
  • Du S-F, Wang X-L, Ye C-L, He Z-J, Li D-X, Du B-R, Liu Y-J, Zhu X-Y. 2019. Exercise training ameliorates bleomycin-induced epithelial mesenchymal transition and lung fibrosis through restoration of H2S synthesis. Acta Physiol. 225(2):e13177.
  • Gao Y, Lu J, Zhang Y, Chen Y, Gu Z, Jiang X. 2013. Baicalein attenuates bleomycin-induced pulmonary fibrosis in rats through inhibition of miR-21. Pulm Pharmacol Ther. 26(6):649–654.
  • Hecker L, Logsdon NJ, Kurundkar D, Kurundkar A, Bernard K, Hock T, Meldrum E, Sanders YY, Thannickal VJ. 2014. Reversal of persistent fibrosis in aging by targeting Nox4–Nrf2 redox imbalance. Sci Transl Med. 6:231–247.
  • Hohmann MS, Habiel DM, Coelho AL, Verri WA Jr, Hogaboam CM. 2019. Quercetin enhances ligand-induced apoptosis in senescent idiopathic pulmonary fibrosis fibroblasts and reduces lung fibrosis in vivo. Am J Respir Cell Mol Biol. 60(1):28–40.
  • Hu Q, Gao L, Peng B, Liu X. 2017. Baicalin and baicalein attenuate renal fibrosis in vitro via inhibition of the TGF-β1 signaling pathway. Exp Ther Med. 14(4):3074–3080.
  • Hung KC, Huang HJ, Wang YT, Lin AM. 2016. Baicalein attenuates α-synuclein aggregation, inflammasome activation and autophagy in the MPP+-treated nigrostriatal dopaminergic system in vivo. J Ethnopharmacol. 194:522–529.
  • Hussein KH, Park KM, Yu L, Kwak HH, Woo HM. 2020. Decellularized hepatic extracellular matrix hydrogel attenuates hepatic stellate cell activation and liver fibrosis. Mater Sci Eng C Mater Biol Appl. 116:111160.
  • Im J, Hergert P, Nho RS. 2015. Reduced FoxO3a expression causes low autophagy in idiopathic pulmonary fibrosis fibroblasts on collagen matrices. Am J Physiol Lung Cell Mol Physiol. 309(6):L552–L561.
  • Jacobs KM, Pennington JD, Bisht KS, Aykin-Burns N, Kim H-S, Mishra M, Sun L, Nguyen P, Ahn B-H, Leclerc J, et al. 2008. SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression. Int J Biol Sci. 4(5):291–299.
  • Kong EKC, Huang Y, Sanderson JE, Chan K-B, Yu S, Yu C-M. 2010. Baicalein and wogonin inhibit collagen deposition in SHR and WKY cardiac fibroblast cultures. BMB Rep. 43(4):297–303.
  • Lehmann M, Korfei M, Mutze K, Klee S, Skronska-Wasek W, Alsafadi HN, Ota C, Costa R, Schiller HB, Lindner M, et al. 2017. Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo. Eur Respir J. 50(2):1602367.
  • Li J, Tian C, Xia Y, Mutanda I, Wang K, Wang Y. 2019. Production of plant-specific flavones baicalein and scutellarein in an engineered E. coli from available phenylalanine and tyrosine. Metab Eng. 52:124–133.
  • Li X-F, Zhang S-H, Liu G-F, Yu S-N. 2020. miR-363 alleviates detrusor fibrosis via the TGF-beta1/Smad signaling pathway by targeting Col1a2 in rat models of STZ-induced T2DM. Mol Ther Nucleic Acids. 22:1142–1153.
  • Li X-x, He G-r, Mu X, Xu B, Tian S, Yu X, Meng F-r, Xuan Z-h, Du G-h 2012. Protective effects of baicalein against rotenone-induced neurotoxicity in PC12 cells and isolated rat brain mitochondria. Eur J Pharmacol. 674(2–3):227–233.
  • Li Y, Zhao J, Holscher C. 2017. Therapeutic potential of baicalein in Alzheimer’s disease and Parkinson’s disease. CNS Drugs. 31(8):639–652.
  • Lin M, Li L, Li L, Pokhrel G, Qi G, Rong R, Zhu T. 2014. The protective effect of baicalin against renal ischemia–reperfusion injury through inhibition of inflammation and apoptosis. BMC Complement Altern Med. 14:19.
  • Liu A, Wang W, Fang H, Yang Y, Jiang X, Liu S, Hu J, Hu Q, Dahmen U, Dirsch O. 2015. Baicalein protects against polymicrobial sepsis-induced liver injury via inhibition of inflammation and apoptosis in mice. Eur J Pharmacol. 748:45–53.
  • Liu C, Wu J, Xu K, Cai F, Gu J, Ma L, Chen J. 2010. Neuroprotection by baicalein in ischemic brain injury involves PTEN/AKT pathway. J Neurochem. 112(6):1500–1512.
  • Ma H, Liu S, Li S, Xia Y. 2022. Targeting growth factor and cytokine pathways to treat idiopathic pulmonary fibrosis. Front Pharmacol. 13:918771.
  • Parimon T, Hohmann MS, Yao C. 2021. Cellular senescence: pathogenic mechanisms in lung fibrosis. Int J Mol Sci. 22(12):6214.
  • Raghu G, Remy-Jardin M, Richeldi L, Thomson CC, Inoue Y, Johkoh T, Kreuter M, Lynch DA, Maher TM, Martinez FJ, et al. 2022. Idiopathic pulmonary fibrosis (an update) and progressive pulmonary fibrosis in adults: an Official ATS/ERS/JRS/ALAT Clinical Practice Guideline. Am J Respir Crit Care Med. 205(9):e18–e47.
  • Röhrich M, Leitz D, Glatting FM, Wefers AK, Weinheimer O, Flechsig P, Kahn N, Mall MA, Giesel FL, Kratochwil C, et al. 2022. Fibroblast activation protein-specific PET/CT imaging in fibrotic interstitial lung diseases and lung cancer: a translational exploratory study. J Nucl Med. 63(1):127–133.
  • Rui W, Li S, Xiao H, Xiao M, Shi J. 2020. Baicalein attenuates neuroinflammation by inhibiting NLRP3/caspase-1/GSDMD pathway in MPTP induced mice model of Parkinson’s disease. Int J Neuropsychopharmacol. 23(11):762–773.
  • Schafer MJ, White TA, Iijima K, Haak AJ, Ligresti G, Atkinson EJ, Oberg AL, Birch J, Salmonowicz H, Zhu Y, et al. 2017. Cellular senescence mediates fibrotic pulmonary disease. Nat Commun. 8:14532.
  • Shi R, Zhu D, Wei Z, Fu N, Wang C, Liu L, Zhang H, Liang Y, Xing J, Wang X, et al. 2018. Baicalein attenuates monocrotaline-induced pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition. Life Sci. 207:442–450.
  • Sosulski ML, Gongora R, Feghali-Bostwick C, Lasky JA, Sanchez CG. 2017. Sirtuin 3 deregulation promotes pulmonary fibrosis. J Gerontol A Biol Sci Med Sci. 72(5):595–602.
  • Srivastava SP, Li J, Kitada M, Fujita H, Yamada Y, Goodwin JE, Kanasaki K, Koya D. 2018. SIRT3 deficiency leads to induction of abnormal glycolysis in diabetic kidney with fibrosis. Cell Death Dis. 9(10):997.
  • Sun H, Che QM, Zhao X, Pu XP. 2010. Antifibrotic effects of chronic baicalein administration in a CCl4 liver fibrosis model in rats. Eur J Pharmacol. 631(1–3):53–60.
  • Sun X, Chen E, Dong R, Chen W, Hu Y. 2015. Nuclear factor (NF)-kappaB p65 regulates differentiation of human and mouse lung fibroblasts mediated by TGF-β. Life Sci. 122:8–14.
  • Sun X, Cui X, Chen X, Jiang X. 2020. Baicalein alleviated TGF β1-induced type I collagen production in lung fibroblasts via downregulation of connective tissue growth factor. Biomed Pharmacother. 131:110744.
  • Sundaresan NR, Bindu S, Pillai VB, Samant S, Pan Y, Huang J-Y, Gupta M, Nagalingam RS, Wolfgeher D, Verdin E, et al. 2015. SIRT3 blocks aging-associated tissue fibrosis in mice by deacetylating and activating glycogen synthase kinase 3β. Mol Cell Biol. 36(5):678–692.
  • Takehara K, Koga Y, Hachisu Y, Utsugi M, Sawada Y, Saito Y, Yoshimi S, Yatomi M, Shin Y, Wakamatsu I, et al. 2022. Differential discontinuation profiles between pirfenidone and nintedanib in patients with idiopathic pulmonary fibrosis. Cells. 11(1):143.
  • Tang LX, Wang B, Wu ZK. 2018. Aerobic exercise training alleviates renal injury by interfering with mitochondrial function in type-1 diabetic mice. Med Sci Monit. 24:9081–9089.
  • Teng C, Lin C, Huang F, Xing X, Chen S, Ye L, Azevedo HS, Xu C, Wu Z, Chen Z, et al. 2020. Intracellular codelivery of anti-inflammatory drug and anti-miR 155 to treat inflammatory disease. Acta Pharm Sin B. 10(8):1521–1533.
  • Tran BH, Yu Y, Chang L, Tan B, Jia W, Xiong Y, Dai T, Zhong R, Zhang W, Le VM, et al. 2019. A novel liposomal S-propargyl-cysteine: a sustained release of hydrogen sulfide reducing myocardial fibrosis via TGF-β1/Smad pathway. Int J Nanomedicine. 14:10061–10077.
  • Tseliou E, Reich H, de Couto G, Terrovitis J, Sun B, Liu W, Marban E. 2014. Cardiospheres reverse adverse remodeling in chronic rat myocardial infarction: roles of soluble endoglin and Tgf-β signaling. Bas Res Cardiol. 109:443.
  • Wang M, Dong Y, Wu J, Li H, Zhang Y, Fan S, Li D. 2020. Baicalein ameliorates ionizing radiation-induced injuries by rebalancing gut microbiota and inhibiting apoptosis. Life Sci. 261:118463.
  • Wang Q, Liu J, Hu Y, Pan T, Xu Y, Yu J, Xiong W, Zhou Q, Wang Y. 2021. Local administration of liposomal-based Srpx2 gene therapy reverses pulmonary fibrosis by blockading fibroblast-to-myofibroblast transition. Theranostics. 11(14):7110–7125.
  • Wolters PJ, Collard HR, Jones KD. 2014. Pathogenesis of idiopathic pulmonary fibrosis. Annu Rev Pathol. 9:157–179.
  • Wu W-H, Bonnet S, Shimauchi T, Toro V, Grobs Y, Romanet C, Bourgeois A, Vitry G, Omura J, Tremblay E, et al. 2022. Potential for inhibition of checkpoint kinases 1/2 in pulmonary fibrosis and secondary pulmonary hypertension. Thorax. 77(3):247–258.
  • Yang S, Wang H, Yang Y, Wang R, Wang Y, Wu C, Du G. 2019. Baicalein administered in the subacute phase ameliorates ischemia–reperfusion-induced brain injury by reducing neuroinflammation and neuronal damage. Biomed Pharmacother. 117:109102.
  • Yao Y, Chen R, Wang G, Zhang Y, Liu F. 2019. Exosomes derived from mesenchymal stem cells reverse EMT via TGF-β1/Smad pathway and promote repair of damaged endometrium. Stem Cell Res Ther. 10(1):225.
  • Zhang JX, Huang PJ, Wang DP, Yang WY, Lu J, Zhu Y, Meng XX, Wu X, Lin QH, Lv H, et al. 2021. m6A modification regulates lung fibroblast-to-myofibroblast transition through modulating KCNH6 mRNA translation. Mol Ther. 29(12):3436–3448.