PI3K/AKT/SERBP-1 pathway regulates Alisma orientalis beverage treatment of atherosclerosis in APOE^−/− high-fat diet mice

References

• Aljabban J, Rohr M, Syed S, Khorfan K, Borkowski V, Aljabban H, Segal M, Mukhtar M, Mohammed M, Panahiazar M, et al. 2022. Transcriptome changes in stages of non-alcoholic fatty liver disease. World J Hepatol. 14(7):1382–1397.
   PubMed Web of Science ®Google Scholar
• Aryal A, Harmon AC, Dugas TR. 2021. Particulate matter air pollutants and cardiovascular disease: strategies for intervention. Pharmacol Ther. 223:107890.
   PubMed Web of Science ®Google Scholar
• Barboza LN, Lívero FA, Prando TB, Ribeiro Rde C, Lourenço EL, Budel JM, de Souza LM, Acco A, Dalsenter PR, Gasparotto AJ. 2016. Atheroprotective effects of Cuphea carthagenensis (Jacq.) J. F. Macbr. in New Zealand rabbits fed with cholesterol-rich diet. J Ethnopharmacol. 187:134–145.
   PubMed Web of Science ®Google Scholar
• Chen Y, Yang W, Guo L, Wu X, Zhang T, Liu J, Zhang J. 2017. Atractylodes lactone compounds inhibit platelet activation. Platelets. 28(2):194–202.
   PubMed Web of Science ®Google Scholar
• Francis GA. 2010. The complexity of HDL. Biochim Biophys Acta. 1801(12):1286–1293.
   PubMed Web of Science ®Google Scholar
• Ge L, Liu D, Mao X, Liu S, Guo J, Hou L, Chen X, Huang K. 2022. Low dose of deoxynivalenol aggravates intestinal inflammation and barrier dysfunction induced by enterotoxigenic Escherichia coli infection through activating macroautophagy/NLRP3 inflammasomes. J Agric Food Chem. 70(9):3009–3022.
   PubMed Web of Science ®Google Scholar
• Geovanini GR, Libby P. 2018. Atherosclerosis and inflammation: overview and updates. Clin Sci. 132(12):1243–1252.
   PubMed Web of Science ®Google Scholar
• Hamosh A, Scott AF, Amberger JS, Bocchini CA, McKusick VA. 2005. Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders. Nucleic Acids Res. 33(Database issue):D514–517.
   PubMed Web of Science ®Google Scholar
• Hopkins AL. 2008. Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol. 4(11):682–690.
   PubMed Web of Science ®Google Scholar
• Huang H, He Y, Li Y, Gu M, Wu M, Ji L. 2022. Eriodictyol suppresses the malignant progression of colorectal cancer by downregulating tissue specific transplantation antigen P35B (TSTA3) expression to restrain fucosylation. Bioengineered. 13(3):5551–5563.
   PubMed Web of Science ®Google Scholar
• Jaquish CE, Mahaney MC, Blangero J, Haffner SM, Stern MP, MacCluer JW. 1996. Genetic correlations between lipoprotein phenotypes and indicators of sex hormone levels in Mexican Americans. Atherosclerosis. 122(1):117–125.
   PubMed Web of Science ®Google Scholar
• Jeon TI, Osborne TF. 2012. SREBPs: metabolic integrators in physiology and metabolism. Trends Endocrinol Metab. 23(2):65–72.
   PubMed Web of Science ®Google Scholar
• Jia CY, Li JY, Hao GF, Yang GF. 2020. A drug-likeness toolbox facilitates ADMET study in drug discovery. Drug Discov Today. 25(1):248–258.
   PubMed Web of Science ®Google Scholar
• Jin HG, Jin Q, Ryun Kim A, Choi H, Lee JH, Kim YS, Lee DG, Woo ER. 2012. A new triterpenoid from Alisma orientale and their antibacterial effect. Arch Pharm Res. 35(11):1919–1926.
   PubMed Web of Science ®Google Scholar
• Karasawa T, Takahashi A, Saito R, Sekiya M, Igarashi M, Iwasaki H, Miyahara S, Koyasu S, Nakagawa Y, Ishii K, et al. 2011. Sterol regulatory element-binding protein-1 determines plasma remnant lipoproteins and accelerates atherosclerosis in low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol. 31(8):1788–1795.
   PubMed Web of Science ®Google Scholar
• Keir HR, Chalmers JD. 2022. Neutrophil extracellular traps in chronic lung disease: implications for pathogenesis and therapy. Eur Respir Rev. 31:210241.
   PubMed Web of Science ®Google Scholar
• Kimura I, Kagawa S, Tsuneki H, Tanaka K, Nagashima F. 2022. Multitasking bamboo leaf-derived compounds in prevention of infectious, inflammatory, atherosclerotic, metabolic, and neuropsychiatric diseases. Pharmacol Ther. 235:108159.
   PubMed Web of Science ®Google Scholar
• Kobiyama K, Ley K. 2018. Atherosclerosis. Circ Res. 123(10):1118–1120.
   PubMed Web of Science ®Google Scholar
• Koeth RA, Lam-Galvez BR, Kirsop J, Wang Z, Levison BS, Gu X, Copeland MF, Bartlett D, Cody DB, Dai HJ, et al. 2019. l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans. J Clin Invest. 129(1):373–387.
   PubMed Web of Science ®Google Scholar
• Li W, Zhi W, Liu F, Zhao J, Yao Q, Niu X. 2018. Paeoniflorin inhibits VSMCs proliferation and migration by arresting cell cycle and activating HO-1 through MAPKs and NF-κB pathway. Int Immunopharmacol. 54:103–111.
   PubMed Web of Science ®Google Scholar
• Lin YP, Fu SN, Li XP, Wang MM, Fang QL, Qiao X, Yan Q, Hua Y. 2022. Two novel flavonoids with lipid-lowering activity from Yi medicine Shekaqi. Chem Biodivers. 19:e202200363.
   PubMed Web of Science ®Google Scholar
• Liu J, Zhang W, Li Y, Li X, Li Y, Guo F. 2022. Flavonoids extract from the seeds of Psoralea corylifolia L. (PFE) alleviates atherosclerosis in high-fat diet-induced LDLR(−/−) mice. Phytomedicine. 98:153983.
   PubMed Web of Science ®Google Scholar
• Mahtta D, Lee MT, Ramsey DJ, Akeroyd JM, Krittanawong C, Khan SU, Sinh P, Alam M, Garratt KN, Schofield RS, et al. 2022. Significant facility-level variation in utilization of and adherence with secondary prevention therapies among patients with premature atherosclerotic cardiovascular disease: insights from the VITAL (Veterans wIth premaTure AtheroscLerosis) Registry7. Cardiovasc Drugs Ther. 36(1):93–102.
   PubMed Web of Science ®Google Scholar
• Moslehi A, Hamidi-Zad Z. 2018. Role of SREBPs in liver diseases: a mini-review. J Clin Transl Hepatol. 6(3):332–338.
   PubMed Web of Science ®Google Scholar
• Pan X, Wan R, Wang Y, Liu S, He Y, Deng B, Luo S, Chen Y, Wen L, Hong T, et al. 2022. Salvianolic acid B inhibiting chemically and mechanically activated Piezo1 channels as a mechanism for ameliorating atherosclerosis. Br J Pharmacol. 179(14):3778–3814.
   PubMed Web of Science ®Google Scholar
• Pérez-Belmonte LM, Moreno-Santos I, Cabrera-Bueno F, Sánchez-Espín G, Castellano D, Such M, Crespo-Leiro MG, Carrasco-Chinchilla F, Alonso-Pulpón L, López-Garrido M, et al. 2017. Expression of sterol regulatory element-binding proteins in epicardial adipose tissue in patients with coronary artery disease and diabetes mellitus: preliminary study. Int J Med Sci. 14(3):268–274.
   PubMed Web of Science ®Google Scholar
• Rebhan M, Chalifa-Caspi V, Prilusky J, Lancet D. 1997. GeneCards: integrating information about genes, proteins and diseases. Trends Genet. 13(4):163.
   PubMed Web of Science ®Google Scholar
• Roth GA, Mensah GA, Johnson CO, Addolorato G, Ammirati E, Baddour LM, Barengo NC, Beaton AZ, Benjamin EJ, Benziger CP, et al. 2020. Global burden of cardiovascular diseases and risk factors, 1990–2019: update from the GBD 2019 study. J Am Coll Cardiol. 76(25):2982–3021.
   PubMed Web of Science ®Google Scholar
• Ru J, Li P, Wang J, Zhou W, Li B, Huang C, Li P, Guo Z, Tao W, Yang Y, et al. 2014. TCMSP: a database of systems pharmacology for drug discovery from herbal medicines. J Cheminform. 6(1):13.
   PubMed Web of Science ®Google Scholar
• Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B, Ideker T. 2003. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 13(11):2498–2504.
   PubMed Web of Science ®Google Scholar
• Solanki A, Bhatt LK, Johnston TP. 2018. Evolving targets for the treatment of atherosclerosis. Pharmacol Ther. 187:1–12.
   PubMed Web of Science ®Google Scholar
• Soppert J, Lehrke M, Marx N, Jankowski J, Noels H. 2020. Lipoproteins and lipids in cardiovascular disease: from mechanistic insights to therapeutic targeting. Adv Drug Deliv Rev. 159:4–33.
   PubMed Web of Science ®Google Scholar
• Szklarczyk D, Morris JH, Cook H, Kuhn M, Wyder S, Simonovic M, Santos A, Doncheva NT, Roth A, Bork P, et al. 2017. The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible. Nucleic Acids Res. 45(D1):D362–D368.
   PubMed Web of Science ®Google Scholar
• Xu X, Zhang W, Huang C, Li Y, Yu H, Wang Y, Duan J, Ling Y. 2012. A novel chemometric method for the prediction of human oral bioavailability. Int J Mol Sci. 13(6):6964–6982.
   PubMed Web of Science ®Google Scholar
• Xu YH, Zhao LJ, Li Y. 2009. Alisol B acetate induces apoptosis of SGC7901 cells via mitochondrial and phosphatidylinositol 3-kinases/Akt signaling pathways. World J Gastroenterol. 15(23):2870–2877.
   PubMed Web of Science ®Google Scholar
• Zeng Q, Li L, Siu W, Jin Y, Cao M, Li W, Chen J, Cong W, Ma M, Chen K, et al. 2019. A combined molecular biology and network pharmacology approach to investigate the multi-target mechanisms of Chaihu Shugan San on Alzheimer’s disease. Biomed Pharmacother. 120:109370.
   PubMed Web of Science ®Google Scholar
• Zhang R, Zhu X, Bai H, Ning K. 2019. Network pharmacology databases for traditional Chinese medicine: review and assessment. Front Pharmacol. 10:123.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C, Chanda SK. 2019. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun. 10(1):1523.
   PubMed Web of Science ®Google Scholar
• Zhu C, Cai T, Jin Y, Chen J, Liu G, Xu N, Shen R, Chen Y, Han L, Wang S, et al. 2020. Artificial intelligence and network pharmacology based investigation of pharmacological mechanism and substance basis of Xiaokewan in treating diabetes. Pharmacol Res. 159:104935.
   PubMed Web of Science ®Google Scholar
• Zhu B, Zhai Y, Ji M, Wei Y, Wu J, Xue W, Tao WW, Wu H. 2020. Alisma orientalis beverage treats atherosclerosis by regulating gut microbiota in ApoE−/− mice. Front Pharmacol. 11:570555.
   PubMed Web of Science ®Google Scholar