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Research Article

Stigmasterol alleviates allergic airway inflammation and airway hyperresponsiveness in asthma mice through inhibiting substance-P receptor

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Pages 449-458 | Received 12 Jul 2022, Accepted 20 Jan 2023, Published online: 14 Feb 2023

References

  • Antwi AO, Obiri DD, Osafo N. 2017. Stigmasterol modulates allergic airway inflammation in Guinea pig model of ovalbumin-induced asthma. Mediators Inflamm. 2017:2953930.
  • Bradford PG, Awad AB. 2007. Phytosterols as anticancer compounds. Mol Nutr Food Res. 51(2):161–170.
  • Bright FM, Byard RW, Vink R, Paterson DS. 2018. Normative distribution of substance P and its tachykinin neurokinin-1 receptor in the medullary serotonergic network of the human infant during postnatal development. Brain Res Bull. 137:319–328.
  • Carpagnano GE, Scioscia G, Lacedonia D, Soccio P, Quarato CMI, Cotugno G, Palumbo MG, Foschino Barbaro MP. 2021. Searching for inflammatory and oxidative stress markers capable of clustering severe asthma. Arch Bronconeumol . 57(5):338–344.
  • Chen WP, Yu C, Hu PF, Bao JP, Tang JL, Wu LD. 2012. Stigmasterol blocks cartilage degradation in rabbit model of osteoarthritis. Acta Biochim Pol. 59(4):537–541.
  • Chu HW, Kraft M, Krause JE, Rex MD, Martin RJ. 2000. Substance P and its receptor neurokinin 1 expression in asthmatic airways. J Allergy Clin Immunol. 106(4):713–722.
  • Dinh QT, Klapp BF, Fischer A. 2006. Airway sensory nerve and tachykinins in asthma and COPD. Pneumologie. 60(2):80–85.
  • Dumolt JH, Rideout TC. 2017. The lipid-lowering effects and associated mechanisms of dietary phytosterol supplementation. Curr Pharm Des. 23(34):5077–5085.
  • Ebrahimi S, Alalikhan A, Aghaee-Bakhtiari SH, Hashemy SI. 2022. The redox modulatory effects of SP/NK1R system: implications for oxidative stress-associated disorders. Life Sci. 296:120448.
  • Farah CS, Salome CM. 2012. Asthma and obesity: a known association but unknown mechanism. Respirology. 17(3):412–421.
  • Feng S, Dai Z, Liu A, Wang H, Chen J, Luo Z, Yang CS. 2017. β-Sitosterol and stigmasterol ameliorate dextran sulfate sodium-induced colitis in mice fed a high fat Western-style diet. Food Funct. 8(11):4179–4186.
  • Gabay O, Sanchez C, Salvat C, Chevy F, Breton M, Nourissat G, Wolf C, Jacques C, Berenbaum F. 2010. Stigmasterol: a phytosterol with potential anti-osteoarthritic properties. Osteoarthritis Cartilage. 18(1):106–116.
  • Hens G, Raap U, Vanoirbeek J, Meyts I, Callebaut I, Verbinnen B, Vanaudenaerde BM, Cadot P, Nemery B, Bullens DM, et al. 2011. Selective nasal allergen provocation induces substance P-mediated bronchial hyperresponsiveness. Am J Respir Cell Mol Biol. 44(4):517–523.
  • Joos GF, De Swert KO, Pauwels RA. 2001. Airway inflammation and tachykinins: prospects for the development of tachykinin receptor antagonists. Eur J Pharmacol. 429(1-3):239–250.
  • Liang Q, Yang J, He J, Chen X, Zhang H, Jia M, Liu K, Jia C, Pan Y, Wei J. 2020. Stigmasterol alleviates cerebral ischemia/reperfusion injury by attenuating inflammation and improving antioxidant defenses in rats. Biosci Rep. 40
  • Maggi CA. 2000. The troubled story of tachykinins and neurokinins. Trends Pharmacol Sci. 21(5):173–175.
  • Makhmudova U, Schulze PC, Lütjohann D, Weingärtner O. 2021. Phytosterols and cardiovascular disease. Curr Atheroscler Rep. 23(11):68.
  • Mantyh PW. 2002. Neurobiology of substance P and the NK1 receptor. J Clin Psychiatry. 63(Suppl 11):6–10.
  • Moreau RA, Whitaker BD, Hicks KB. 2002. Phytosterols, phytostanols, and their conjugates in foods: structural diversity, quantitative analysis, and health-promoting uses. Prog Lipid Res. 41(6):457–500.
  • Morgan LV, Petry F, Scatolin M, de Oliveira PV, Alves BO, Zilli GAL, Volfe CRB, Oltramari AR, de Oliveira D, Scapinello J, et al. 2021. Investigation of the anti-inflammatory effects of stigmasterol in mice: insight into its mechanism of action. Behav Pharmacol. 32(8):640–651.
  • Nieber K, Baumgarten CR, Rathsack R, Furkert J, Oehme P, Kunkel G. 1992. Substance P and beta-endorphin-like immunoreactivity in lavage fluids of subjects with and without allergic asthma. J Allergy Clin Immunol. 90(4 Pt 1):646–652.
  • Pratiwi R, Nantasenamat C, Ruankham W, Suwanjang W, Prachayasittikul V, Prachayasittikul S, Phopin K. 2021. Mechanisms and neuroprotective activities of stigmasterol against oxidative stress-induced neuronal cell death via Sirtuin family. Front Nutr. 8:648995.
  • Rocha VZ, Ras RT, Gagliardi AC, Mangili LC, Trautwein EA, Santos RD. 2016. Effects of phytosterols on markers of inflammation: a systematic review and meta-analysis. Atherosclerosis. 248:76–83.
  • Ryan E, Galvin K, O'Connor TP, Maguire AR, O'Brien NM. 2007. Phytosterol, squalene, tocopherol content and fatty acid profile of selected seeds, grains, and legumes. Plant Foods Hum Nutr. 62(3):85–91.
  • Sampath SJP, Kotikalapudi N, Venkatesan V. 2021a. A novel therapeutic combination of mesenchymal stem cells and stigmasterol to attenuate osteoarthritis in rodent model system-a proof of concept study. Stem Cell Investig. 8:5.
  • Sampath SJP, Rath SN, Kotikalapudi N, Venkatesan V. 2021b. Beneficial effects of secretome derived from mesenchymal stem cells with stigmasterol to negate IL-1β-induced inflammation in-vitro using rat chondrocytes-OA management. Inflammopharmacology. 29:1701–1717.
  • Shahzad N, Khan W, Md S, Ali A, Saluja SS, Sharma S, Al-Allaf FA, Abduljaleel Z, Ibrahim IAA, Abdel-Wahab AF, et al. 2017. Phytosterols as a natural anticancer agent: current status and future perspective. Biomed Pharmacother. 88:786–794.
  • Sun J, Li X, Liu J, Pan X, Zhao Q. 2019. Stigmasterol exerts meuro-protective effect against ischemic/reperfusion injury through reduction of oxidative stress and inactivation of autophagy. Neuropsychiatr Dis Treat. 15:2991–3001.
  • Tomaki M, Ichinose M, Miura M, Hirayama Y, Yamauchi H, Nakajima N, Shirato K. 1995. Elevated substance P content in induced sputum from patients with asthma and patients with chronic bronchitis. Am J Respir Crit Care Med. 151(3 Pt 1):613–617.
  • Vilahur G, Ben-Aicha S, Diaz-Riera E, Badimon L, Padró T. 2019. Phytosterols and inflammation. Curr Med Chem. 26(37):6724–6734.
  • Wang J, Li FS, Pang NN, Tian G, Jiang M, Zhang HP, Ding JB. 2016. Inhibition of asthma in OVA sensitized mice model by a traditional Uygur herb Nepeta bracteata Benth. Evid Based Complement Alternat Med. 2016:5769897.
  • Ward C, Reid DW, Orsida BE, Feltis B, Ryan VA, Johns DP, Walters EH. 2005. Inter-relationships between airway inflammation, reticular basement membrane thickening and bronchial hyper-reactivity to methacholine in asthma; a systematic bronchoalveolar lavage and airway biopsy analysis. Clin Exp Allergy. 35(12):1565–1571.
  • Wei B, Sun M, Shang Y, Zhang C, Jiao X. 2018. Neurokinin 1 receptor promotes rat airway smooth muscle cell migration in asthmatic airway remodelling by enhancing tubulin expression. J Thorac Dis. 10(8):4849–4857.
  • Zhang D, Qiao XR, Cui WJ, Zhang JT, Pan Y, Liu XF, Dong L. 2021. Syndecan-1 amplifies ovalbumin-induced airway remodeling by strengthening TGFβ1/Smad3 action. Front Immunol. 12:744477.
  • Zheng GQ. 1994. Cytotoxic terpenoids and flavonoids from Artemisia annua. Planta Med. 60(1):54–57.