Morroniside ameliorates glucocorticoid-induced osteoporosis and promotes osteoblastogenesis by interacting with sodium-glucose cotransporter 2

References

• An Y, Zhang H, Wang C, Jiao F, Xu H, Wang X, Luan W, Ma F, Ni L, Tang X, et al. 2019. Activation of ROS/MAPKs/NF-κB/NLRP3 and inhibition of efferocytosis in osteoclast-mediated diabetic osteoporosis. FASEB J. 33(11):12515–12527.
   PubMed Web of Science ®Google Scholar
• Bellavia D, Caradonna F, Dimarco E, Costa V, Carina V, De Luca A, Raimondi L, Gentile C, Alessandro R, Fini M, et al. 2021. Terpenoid treatment in osteoporosis: this is where we have come in research. Trends Endocrinol Metab. 32(11):846–861.
   PubMed Web of Science ®Google Scholar
• Busse B, Galloway JL, Gray RS, Harris MP, Kwon RY. 2020. Zebrafish: an emerging model for orthopedic research. J Orthop Res. 38(5):925–936.
   PubMed Web of Science ®Google Scholar
• Cipriani C, Colangelo L, Santori R, Renella M, Mastrantonio M, Minisola S, Pepe J. 2020. The interplay between bone and glucose metabolism. Front Endocrinol. 11:122.
   PubMed Web of Science ®Google Scholar
• Compston J. 2018. Glucocorticoid-induced osteoporosis: an update. Endocrine. 61(1):7–16.
   PubMed Web of Science ®Google Scholar
• Compston JE, McClung MR, Leslie WD. 2019. Osteoporosis. Lancet. 393(10169):364–376.
   PubMed Web of Science ®Google Scholar
• Daina A, Michielin O, Zoete V. 2019. SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules. Nucleic Acids Res. 47(W1):W357–W364.
   PubMed Web of Science ®Google Scholar
• Esen E, Long F. 2014. Aerobic glycolysis in osteoblasts. Curr Osteoporos Rep. 12(4):433–438.
   PubMed Web of Science ®Google Scholar
• Giangregorio LM, McGill S, Wark JD, Laprade J, Heinonen A, Ashe MC, MacIntyre NJ, Cheung AM, Shipp K, Keller H, et al. 2015. Too fit to fracture: outcomes of a Delphi consensus process on physical activity and exercise recommendations for adults with osteoporosis with or without vertebral fractures. Osteoporos Int. 26(3):891–910.
   PubMed Web of Science ®Google Scholar
• Gregorio F, Cristallini S, Santeusanio F, Filipponi P, Fumelli P. 1994. Osteopenia associated with non-insulin-dependent diabetes mellitus: what are the causes? Diabetes Res Clin Pract. 23(1):43–54.
   PubMed Web of Science ®Google Scholar
• Gupta G, Aronow WS. 2007. Treatment of postmenopausal osteoporosis. Compr Ther. 33(3):114–119.
   PubMedGoogle Scholar
• He LH. 2011. Comparative study on α-glucosidase inhibitory effects of total iridoid glycosides in the crude products and the wine-processed products from Cornus officinalis. Yakugaku Zasshi. 131(12):1801–1805.
   PubMed Web of Science ®Google Scholar
• Hsu JH, Wu YC, Liu IM, Cheng JT. 2006. Release of acetylcholine to raise insulin secretion in Wistar rats by oleanolic acid, one of the active principles contained in Cornus officinalis. Neurosci Lett. 404(1–2):112–116.
   PubMed Web of Science ®Google Scholar
• Jilka RL, O'Brien CA, Roberson PK, Bonewald LF, Weinstein RS, Manolagas SC. 2014. Dysapoptosis of osteoblasts and osteocytes increases cancellous bone formation but exaggerates cortical porosity with age. J Bone Miner Res. 29(1):103–117.
   PubMed Web of Science ®Google Scholar
• Karner CM, Esen E, Chen J, Hsu FF, Turk J, Long F. 2016. Wnt protein signaling reduces nuclear acetyl-CoA levels to suppress gene expression during osteoblast differentiation. J Biol Chem. 291(25):13028–13039.
   PubMed Web of Science ®Google Scholar
• Keiser MJ, Roth BL, Armbruster BN, Ernsberger P, Irwin JJ, Shoichet BK. 2007. Relating protein pharmacology by ligand chemistry. Nat Biotechnol. 25(2):197–206.
   PubMed Web of Science ®Google Scholar
• Komori T. 2019. Regulation of proliferation, differentiation and functions of osteoblasts by Runx2. Int J Mol Sci. 20(7):1694.
   PubMed Web of Science ®Google Scholar
• Lee WC, Guntur AR, Long F, Rosen CJ. 2017. Energy metabolism of the osteoblast: implications for osteoporosis. Endocr Rev. 38(3):255–266.
   PubMed Web of Science ®Google Scholar
• Lee CG, Kim J, Yun SH, Hwang S, Jeon H, Park E, Jeong SY. 2021. Anti-osteoporotic effect of morroniside on osteoblast and osteoclast differentiation in vitro and ovariectomized mice in vivo. Int J Mol Sci. 22(19):10642.
   PubMed Web of Science ®Google Scholar
• Lee NH, Seo CS, Lee HY, Jung DY, Lee JK, Lee JA, Song KY, Shin HK, Lee MY, Seo YB, et al. 2012. Hepatoprotective and antioxidative activities of Cornus officinalis against acetaminophen-induced hepatotoxicity in mice. Evid Based Complement Alternat Med. 2012:804924.
   PubMed Web of Science ®Google Scholar
• Liu H, Li X, Lin J, Lin M. 2021. Morroniside promotes the osteogenesis by activating PI3K/Akt/mTOR signaling. Biosci Biotechnol Biochem. 85(2):332–339.
   PubMed Web of Science ®Google Scholar
• Liu T, Sun F, Cui J, Zheng S, Li Z, Guo D, Tian X, Zhu Z, Zheng W, Wang Y, et al. 2020. Morroniside enhances angiogenesis and improves cardiac function following acute myocardial infarction in rats. Eur J Pharmacol. 872:172954.
   PubMed Web of Science ®Google Scholar
• Liu T, Xiang B, Guo D, Sun F, Wei R, Zhang G, Ai H, Tian X, Zhu Z, Zheng W, et al. 2016. Morroniside promotes angiogenesis and further improves microvascular circulation after focal cerebral ischemia/reperfusion. Brain Res Bull. 127:111–118.
   PubMed Web of Science ®Google Scholar
• Pi WX, Feng XP, Ye LH, Cai BC. 2017. Combination of morroniside and diosgenin prevents high glucose-induced cardiomyocytes apoptosis. Molecules. 22(1):163.
   PubMed Web of Science ®Google Scholar
• Sakai T, Honzawa S, Kaga M, Iwasaki Y, Masuyama T. 2020. Osteoporosis pathology in people with severe motor and intellectual disability. Brain Dev. 42(3):256–263.
   PubMed Web of Science ®Google Scholar
• Shoback D, Rosen CJ, Black DM, Cheung AM, Murad MH, Eastell R. 2020. Pharmacological management of osteoporosis in postmenopausal women: an endocrine society guideline update. J Clin Endocrinol Metab. 105:048.
   Web of Science ®Google Scholar
• Sun H, Li L, Zhang A, Zhang N, Lv H, Sun W, Wang X. 2013. Protective effects of sweroside on human MG-63 cells and rat osteoblasts. Fitoterapia. 84:174–179.
   PubMed Web of Science ®Google Scholar
• Sun Y, Zhu Y, Liu X, Chai Y, Xu J. 2020. Morroniside attenuates high glucose-induced BMSC dysfunction by regulating the Glo1/AGE/RAGE axis. Cell Prolif. 53(8):e12866.
   PubMed Web of Science ®Google Scholar
• Tang X, Wu H, Mao X, Li X, Wang Y. 2020. The GLP-1 receptor herbal agonist morroniside attenuates neuropathic pain via spinal microglial expression of IL-10 and β-endorphin. Biochem Biophys Res Commun. 530(3):494–499.
   PubMed Web of Science ®Google Scholar
• Wang H, Feng T, Guo D, Zhang M, Chen L, Zhou Y. 2018. Sanggenon C stimulates osteoblastic proliferation and differentiation, inhibits osteoclastic resorption, and ameliorates prednisone-induced osteoporosis in zebrafish model. Molecules. 23(9):2343.
   PubMed Web of Science ®Google Scholar
• Wang Y, Zhao H, Li X, Wang Q, Yan M, Zhang H, Zhao T, Zhang N, Zhang P, Peng L, et al. 2019. Formononetin alleviates hepatic steatosis by facilitating TFEB-mediated lysosome biogenesis and lipophagy. J Nutr Biochem. 73:108214.
   PubMed Web of Science ®Google Scholar
• Wei J, Shimazu J, Makinistoglu MP, Maurizi A, Kajimura D, Zong H, Takarada T, Lezaki T, Pessin JE, Hinoi E, et al. 2015. Glucose uptake and runx2 synergize to orchestrate osteoblast differentiation and bone formation. Cell. 161(7):1576–1591.
   PubMed Web of Science ®Google Scholar
• Xia C, Zou Z, Fang L, Ge Q, Zhang P, Xu H, Xu R, Shi Z, Lin H, Ding X, et al. 2020. Bushenhuoxue formula promotes osteogenic differentiation of growth plate chondrocytes through β-catenin-dependent manner during osteoporosis. Biomed Pharmacother. 127:110170.
   PubMed Web of Science ®Google Scholar
• Xiao Z, Wang J, Chen S, Feng Y. 2020. Autophagy promotion enhances the protective effect of morroniside on human OA chondrocyte. Biosci Biotechnol Biochem. 84(5):989–996.
   PubMed Web of Science ®Google Scholar
• Xu HQ, Hao HP. 2004. Effects of iridoid total glycoside from Cornus officinalis on prevention of glomerular overexpression of transforming growth factor beta 1 and matrixes in an experimental diabetes model. Biol Pharm Bull. 27(7):1014–1018.
   PubMed Web of Science ®Google Scholar
• Xu HQ, Hao HP, Zhang X, Pan Y. 2004. Morroniside protects cultured human umbilical vein endothelial cells from damage by high ambient glucose. Acta Pharmacol Sin. 25(4):412–415.
   PubMed Web of Science ®Google Scholar
• Yamabe N, Kang KS, Goto E, Tanaka T, Yokozawa T. 2007. Beneficial effect of Corni Fructus, a constituent of Hachimi-jio-gan, on advanced glycation end-product-mediated renal injury in streptozotocin-treated diabetic rats. Biol Pharm Bull. 30(3):520–526.
   PubMed Web of Science ®Google Scholar
• Yao ZJ, Dong J, Che YJ, Zhu MF, Wen M, Wang NN, Wang S, Lu AP, Cao DS. 2016. TargetNet: a web service for predicting potential drug–target interaction profiling via multi-target SAR models. J Comput Aided Mol Des. 30(5):413–424.
   PubMed Web of Science ®Google Scholar
• Ye J, Zhang X, Dai W, Yan S, Huang H, Liang X, Li Y, Zhang W. 2009. Chemical fingerprinting of Liuwei Dihuang Pill and simultaneous determination of its major bioactive constituents by HPLC coupled with multiple detections of DAD, ELSD and ESI-MS. J Pharm Biomed Anal. 49(3):638–645.
   PubMed Web of Science ®Google Scholar
• Yokozawa T, Kang KS, Park CH, Noh JS, Yamabe N, Shibahara N, Tanaka T. 2010. Bioactive constituents of Corni Fructus: the therapeutic use of morroniside, loganin, and 7-O-galloyl-d-sedoheptulose as renoprotective agents in type 2 diabetes. Drug Discov Ther. 4(4):223–234.
   PubMedGoogle Scholar
• Yu H, Yao S, Zhou C, Fu F, Luo H, Du W, Jin H, Tong P, Chen D, Wu C, et al. 2021. Morroniside attenuates apoptosis and pyroptosis of chondrocytes and ameliorates osteoarthritic development by inhibiting NF-κB signaling. J Ethnopharmacol. 266:113447.
   PubMed Web of Science ®Google Scholar
• Zeng G, Ding W, Li Y, Sun M, Deng L. 2018. Morroniside protects against cerebral ischemia/reperfusion injury by inhibiting neuron apoptosis and MMP2/9 expression. Exp Ther Med. 16:2229–2234.
   PubMed Web of Science ®Google Scholar
• Zhang P, Xu H, Wang P, Dong R, Xia C, Shi Z, Xu R, Fang L, Zou Z, Ge Q, et al. 2019. Yougui pills exert osteoprotective effects on rabbit steroid-related osteonecrosis of the femoral head by activating β-catenin. Biomed Pharmacother. 120:109520.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Zhang H, Xiao Z, Yuan G, Yang G. 2022. IPO7 promotes odontoblastic differentiation and inhibits osteoblastic differentiation through regulation of RUNX2 expression and translocation. Stem Cells. 40(11):1020–1030.
   PubMed Web of Science ®Google Scholar