Sanziguben polysaccharides improve diabetic nephropathy in mice by regulating gut microbiota to inhibit the TLR4/NF-κB/NLRP3 signalling pathway

References

• Andrade-Oliveira V, Foresto-Neto O, Watanabe I, Zatz R, Câmara N. 2019. Inflammation in renal diseases: new and old players. Front Pharmacol. 10:1192.
   PubMed Web of Science ®Google Scholar
• Ayodele OE, Alebiosu CO, Salako BL. 2004. Diabetic nephropathy – a review of the natural history, burden, risk factors and treatment. J Natl Med Assoc. 96(11):1445–1454.
   PubMed Web of Science ®Google Scholar
• Barlow GM, Yu A, Mathur R. 2015. Role of the gut microbiome in obesity and diabetes mellitus. Nutr Clin Pract. 30(6):787–797.
   PubMed Web of Science ®Google Scholar
• Cai TT, Ye XL, Li RR, Chen H, Wang YY, Yong HJ, Pan ML, Lu W, Tang Y, Miao H, et al. 2020. Resveratrol modulates the gut microbiota and inflammation to protect against diabetic nephropathy in mice. Front Pharmacol. 11:1249.
   PubMed Web of Science ®Google Scholar
• Chi M, Ma K, Wang J, Ding Z, Li Y, Zhu S, Liang X, Zhang Q, Song L, Liu C. 2021. The immunomodulatory effect of the gut microbiota in kidney disease. J Immunol Res. 2021:5516035.
   PubMed Web of Science ®Google Scholar
• Cho JH, Lee SS, Han KD, Joo YH. 2018. Insulin resistance is associated with chronic laryngitis in Korean women. J Nutr Health Aging. 22(4):471–475.
   PubMed Web of Science ®Google Scholar
• Dedhia N, Marathe SJ, Singhal RS. 2022. Food polysaccharides: a review on emerging microbial sources, bioactivities, nanoformulations and safety considerations. Carbohydr Polym. 287:119355.
   PubMed Web of Science ®Google Scholar
• Ding T, Wang S, Zhang X, Zai W, Fan J, Chen W, Bian Q, Luan J, Shen Y, Zhang Y, et al. 2018. Kidney protection effects of dihydroquercetin on diabetic nephropathy through suppressing ROS and NLRP3 inflammasome. Phytomedicine. 41:45–53.
   PubMed Web of Science ®Google Scholar
• Ekblad LL, Rinne JO, Puukka PJ, Laine HK, Ahtiluoto SE, Sulkava RO, Viitanen MH, Jula AM. 2015. Insulin resistance is associated with poorer verbal fluency performance in women. Diabetologia. 58(11):2545–2553.
   PubMed Web of Science ®Google Scholar
• Fritsche KL. 2015. The science of fatty acids and inflammation. Adv Nutr. 6(3):293S–301S.
   PubMed Web of Science ®Google Scholar
• Ge Y, Ahmed S, Yao W, You L, Zheng J, Hileuskaya K. 2021. Regulation effects of indigestible dietary polysaccharides on intestinal microflora: an overview. J Food Biochem. 45:13564.
   Web of Science ®Google Scholar
• Gryaznova M, Dvoretskaya Y, Burakova I, Syromyatnikov M, Popov E, Kokina A, Mikhaylov E, Popov V. 2022. Dynamics of changes in the gut microbiota of healthy mice fed with lactic acid bacteria and Bifidobacteria. Microorganisms. 10:1020.
   PubMed Web of Science ®Google Scholar
• Guo Y, Ran Z, Zhang Y, Song Z, Wang L, Yao L, Zhang M, Xin J, Mao X. 2020. Marein ameliorates diabetic nephropathy by inhibiting renal sodium glucose transporter 2 and activating the AMPK signaling pathway in db/db mice and high glucose-treated HK-2 cells. Biomed Pharmacother. 131:110684.
   PubMed Web of Science ®Google Scholar
• Guthrie RA, Guthrie DW. 2004. Pathophysiology of diabetes mellitus. Crit Care Nurs Q. 27(2):113–125.
   PubMedGoogle Scholar
• Haenen D, Zhang J, Souza da Silva C, Bosch G, van der Meer IM, van Arkel J, van den Borne JJ, Pérez Gutiérrez O, Smidt H, Kemp B, et al. 2013. A diet high in resistant starch modulates microbiota composition, SCFA concentrations, and gene expression in pig intestine. J Nutr. 143(3):274–283.
   PubMed Web of Science ®Google Scholar
• Herman-Edelstein M, Scherzer P, Tobar A, Levi M, Gafter U. 2014. Altered renal lipid metabolism and renal lipid accumulation in human diabetic nephropathy. J Lipid Res. 55(3):561–572.
   PubMed Web of Science ®Google Scholar
• Ho Do M, Seo YS, Park HY. 2021. Polysaccharides: bowel health and gut microbiota. Crit Rev Food Sci Nutr. 61(7):1212–1224.
   PubMed Web of Science ®Google Scholar
• Hu X, Ouyang S, Xie Y, Gong Z, Du J. 2020. Characterizing the gut microbiota in patients with chronic kidney disease. Postgrad Med. 132(6):495–505.
   PubMed Web of Science ®Google Scholar
• Hua Q, Han Y, Zhao H, Zhang H, Yan B, Pei S, He X, Li Y, Meng X, Chen L, et al. 2022. Punicalagin alleviates renal injury via the gut–kidney axis in high-fat diet-induced diabetic mice. Food Funct. 13(2):867–879.
   PubMed Web of Science ®Google Scholar
• Lee JH, Sarker MK, Choi H, Shin D, Kim D, Jun HS. 2019. Lysophosphatidic acid receptor 1 inhibitor, AM095, attenuates diabetic nephropathy in mice by downregulation of TLR4/NF-κB signaling and NADPH oxidase. Biochim Biophys Acta Mol Basis Dis. 1865(6):1332–1340.
   PubMed Web of Science ®Google Scholar
• Linh HT, Iwata Y, Senda Y, Sakai-Takemori Y, Nakade Y, Oshima M, Nakagawa-Yoneda S, Ogura H, Sato K, Minami T, et al. 2022. Intestinal bacterial translocation contributes to diabetic kidney disease. J Am Soc Nephrol. 33(6):1105–1119.
   PubMed Web of Science ®Google Scholar
• Ma Q, Li Y, Li P, Wang M, Wang J, Tang Z, Wang T, Luo L, Wang C, Wang T, et al. 2019. Research progress in the relationship between type 2 diabetes mellitus and intestinal flora. Biomed Pharmacother. 117:109138.
   PubMed Web of Science ®Google Scholar
• Mukherjee S, Jana S, Khawas S, Kicuntod J, Marschall M, Ray B, Ray S. 2022. Synthesis, molecular features and biological activities of modified plant polysaccharides. Carbohydr Polym. 289:119299.
   PubMed Web of Science ®Google Scholar
• Niu X, Song H, Xiao X, Yu J, Yu J, Yang Y, Huang Q, Zang L, Han T, Zhang D, et al. 2022. Tectoridin alleviates lipopolysaccharide-induced inflammation via inhibiting TLR4-NF-κB/NLRP3 signaling in vivo and in vitro. Immunopharmacol Immunotoxicol. 44(5):641–655.
   PubMed Web of Science ®Google Scholar
• Nørgaard SA, Briand F, Sand FW, Galsgaard ED, Søndergaard H, Sørensen DB, Sulpice T. 2019. Nephropathy in diabetic db/db mice is accelerated by high protein diet and improved by the SGLT2 inhibitor dapagliflozin. Eur J Pharmacol. 860:172537.
   PubMed Web of Science ®Google Scholar
• Ram C, Jha AK, Ghosh A, Gairola S, Syed AM, Murty US, Naidu V, Sahu BD. 2020. Targeting NLRP3 inflammasome as a promising approach for treatment of diabetic nephropathy: preclinical evidences with therapeutic approaches. Eur J Pharmacol. 885:173503.
   PubMed Web of Science ®Google Scholar
• Sabatino A, Regolisti G, Cosola C, Gesualdo L, Fiaccadori E. 2017. Intestinal microbiota in type 2 diabetes and chronic kidney disease. Curr Diab Rep. 17(3):16.
   PubMed Web of Science ®Google Scholar
• Samsu N. 2021. Diabetic nephropathy: challenges in pathogenesis, diagnosis, and treatment. Biomed Res Int. 2021:1497449.
   PubMed Web of Science ®Google Scholar
• Schmidt AM. 2018. Highlighting diabetes mellitus: the epidemic continues. Arterioscler Thromb Vasc Biol. 38(1):e1–e8.
   PubMed Web of Science ®Google Scholar
• Stephens M, von der Weid PY. 2020. Lipopolysaccharides modulate intestinal epithelial permeability and inflammation in a species-specific manner. Gut Microbes. 11(3):421–432.
   PubMed Web of Science ®Google Scholar
• Svensson M, Eriksson JW. 2006. Insulin resistance in diabetic nephropathy – cause or consequence. Diabetes Metab Res Rev. 22(5):401–410.
   PubMed Web of Science ®Google Scholar
• Tang G, Li S, Zhang C, Chen H, Wang N, Feng Y. 2021. Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management. Acta Pharm Sin B. 11(9):2749–2767.
   PubMed Web of Science ®Google Scholar
• Tervaert TW, Mooyaart AL, Amann K, Cohen AH, Cook HT, Drachenberg CB, Ferrario F, Fogo AB, Haas M, de Heer E, et al. 2010. Pathologic classification of diabetic nephropathy. J Am Soc Nephrol. 21(4):556–563.
   PubMed Web of Science ®Google Scholar
• Thingholm LB, Rühlemann MC, Koch M, Fuqua B, Laucke G, Boehm R, Bang C, Franzosa EA, Hübenthal M, Rahnavard A, et al. 2019. Obese individuals with and without type 2 diabetes show different gut microbial functional capacity and composition. Cell Host Microbe. 26(2):252–264.e10.
   PubMed Web of Science ®Google Scholar
• Wada J, Makino H. 2013. Inflammation and the pathogenesis of diabetic nephropathy. Clin Sci. 124(3):139–152.
   PubMed Web of Science ®Google Scholar
• Warren AM, Knudsen ST, Cooper ME. 2019. Diabetic nephropathy: an insight into molecular mechanisms and emerging therapies. Expert Opin Ther Targets. 23(7):579–591.
   PubMed Web of Science ®Google Scholar
• Xiong Y, Zhou L. 2019. The signaling of cellular senescence in diabetic nephropathy. Oxid Med Cell Longev. 2019:7495629.
   PubMed Web of Science ®Google Scholar
• Yang G, Wei J, Liu P, Zhang Q, Tian Y, Hou G, Meng L, Xin Y, Jiang X. 2021. Role of the gut microbiota in type 2 diabetes and related diseases. Metabolism. 117:154712.
   PubMed Web of Science ®Google Scholar
• Yang M, Wang X, Han Y, Li C, Wei L, Yang J, Chen W, Zhu X, Sun L. 2021. Targeting the NLRP3 inflammasome in diabetic nephropathy. Curr Med Chem. 28(42):8810–8824.
   PubMed Web of Science ®Google Scholar
• Yang R, Li Y, Mehmood S, Yan C, Huang Y, Cai J, Ji J, Pan W, Zhang W, Chen Y. 2020. Polysaccharides from Armillariella tabescens mycelia ameliorate renal damage in type 2 diabetic mice. Int J Biol Macromol. 162:1682–1691.
   PubMed Web of Science ®Google Scholar
• Zeng P, Li J, Chen Y, Zhang L. 2019. The structures and biological functions of polysaccharides from traditional Chinese herbs. Prog Mol Biol Transl Sci. 163:423–444.
   PubMed Web of Science ®Google Scholar
• Zhang T, Yang Y, Liang Y, Jiao X, Zhao C. 2018. Beneficial effect of intestinal fermentation of natural polysaccharides. Nutrients. 10:1055.
   PubMed Web of Science ®Google Scholar
• Zhang XX, Kong J, Yun K. 2020. Prevalence of diabetic nephropathy among patients with type 2 diabetes mellitus in China: a meta-analysis of observational studies. J Diabetes Res. 2020:2315607.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Chen L, Hu M, Kim JJ, Lin R, Xu J, Fan L, Qi Y, Wang L, Liu W, et al. 2020. Dietary type 2 resistant starch improves systemic inflammation and intestinal permeability by modulating microbiota and metabolites in aged mice on high-fat diet. Aging. 12(10):9173–9187.
   PubMedGoogle Scholar
• Zhou K, Zhang J, Liu C, Ou L, Wang F, Yu Y, Wang Y, Bai S. 2021. Sanziguben polysaccharides inhibit diabetic nephropathy through NF-κB-mediated anti-inflammation. Nutr Metab. 18(1):81.
   Google Scholar