Schisandrin B promotes senescence of activated hepatic stellate cell via NCOA4-mediated ferritinophagy

References

• Ameziane-El-Hassani R, Dupuy C. 2017. Detection of reactive oxygen species in cells undergoing oncogene-induced senescence. Methods Mol Biol. 1534:139–145.
   PubMedGoogle Scholar
• Azarm K, Bhardwaj A, Kim E, Smith S. 2020. Persistent telomere cohesion protects aged cells from premature senescence. Nat Commun. 11(1):3321.
   PubMed Web of Science ®Google Scholar
• Bataller R, Brenner DA. 2005. Liver fibrosis. J Clin Invest. 115(2):209–218.
   PubMed Web of Science ®Google Scholar
• Bernadotte A, Mikhelson VM, Spivak IM. 2016. Markers of cellular senescence. Telomere shortening as a marker of cellular senescence. Aging. 8(1):3–11.
   PubMedGoogle Scholar
• Bogdan AR, Miyazawa M, Hashimoto K, Tsuji Y. 2016. Regulators of iron homeostasis: new players in metabolism, cell death, and disease. Trends Biochem Sci. 41(3):274–286.
   PubMed Web of Science ®Google Scholar
• Chen Q, Bao L, Lv L, Xie F, Zhou X, Zhang H, Zhang G. 2021. Schisandrin B regulates macrophage polarization and alleviates liver fibrosis via activation of PPARgamma. Ann Transl Med. 9(19):1500.
   PubMed Web of Science ®Google Scholar
• Chen Q, Zhang H, Cao Y, Li Y, Sun S, Zhang J, Zhang G. 2017. Schisandrin B attenuates CCl4-induced liver fibrosis in rats by regulation of Nrf2-ARE and TGF-beta/Smad signaling pathways. Drug Des Devel Ther. 11:2179–2191.
   PubMed Web of Science ®Google Scholar
• Chen WJ, Kung GP, Gnana-Prakasam JP. 2022. Role of iron in aging related diseases. Antioxidants 11(5):865.
   Web of Science ®Google Scholar
• Coluzzi E, Leone S, Sgura A. 2019. Oxidative stress induces telomere dysfunction and senescence by replication fork arrest. Cells. 8(1):19.
   PubMed Web of Science ®Google Scholar
• Cuiqiong W, Chao X, Xinling F, Yinyan J. 2020. Schisandrin B suppresses liver fibrosis in rats by targeting miR-101-5p through the TGF-beta signaling pathway. Artif Cells Nanomed Biotechnol. 48(1):473–478.
   PubMed Web of Science ®Google Scholar
• Dang Y, An Y, He J, Huang B, Zhu J, Gao M, Zhang S, Wang X, Yang B, Xie Z. 2020. Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression. Aging Cell. 19(1):e13060.
   PubMed Web of Science ®Google Scholar
• Di Micco R, Krizhanovsky V, Baker D, d‘Adda di Fagagna F. 2021. Cellular senescence in ageing: from mechanisms to therapeutic opportunities. Nat Rev Mol Cell Biol. 22(2):75–95.
   PubMed Web of Science ®Google Scholar
• Dixon SJ, Stockwell BR. 2014. The role of iron and reactive oxygen species in cell death. Nat Chem Biol. 10(1):9–17.
   PubMed Web of Science ®Google Scholar
• Dowdle WE, Nyfeler B, Nagel J, Elling RA, Liu S, Triantafellow E, Menon S, Wang Z, Honda A, Pardee G, et al. 2014. Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nat Cell Biol. 16(11):1069–1079.
   PubMed Web of Science ®Google Scholar
• El Mai M, Janho Dit Hreich S, Gaggioli C, Roisin A, Wagner N, Ye J, Jalinot P, Cherfils-Vicini J, Gilson E. 2021. A novel screen for expression regulators of the telomeric protein TRF2 identified small molecules that impair TRF2 dependent immunosuppression and tumor growth. Cancers13(12):2998.
   PubMed Web of Science ®Google Scholar
• Fernandez-Real JM, Manco M. 2014. Effects of iron overload on chronic metabolic diseases. Lancet Diabetes Endocrinol. 2(6):513–526.
   PubMed Web of Science ®Google Scholar
• Forouzanfar MH, Afshin A, Alexander LT, Anderson HR, Bhutta ZA, Biryukov S, Brauer M, Burnett R, Cercy K, Charlson FJ, et al. 2016. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the global burden of disease Study 2015. The Lancet. 388(10053):1659–1724.
   PubMed Web of Science ®Google Scholar
• Haase M, Bellomo R, Haase-Fielitz A. 2010. Novel biomarkers, oxidative stress, and the role of labile iron toxicity in cardiopulmonary bypass-associated acute kidney injury. J Am Coll Cardiol. 55(19):2024–2033.
   PubMed Web of Science ®Google Scholar
• Halcrow PW, Lynch ML, Geiger JD, Ohm JE. 2021. Role of endolysosome function in iron metabolism and brain carcinogenesis. Semin Cancer Biol. 76:74–85.
   PubMed Web of Science ®Google Scholar
• Herranz N, Gil J. 2018. Mechanisms and functions of cellular senescence. J Clin Invest. 128(4):1238–1246.
   PubMed Web of Science ®Google Scholar
• Jin H, Jia Y, Yao Z, Huang J, Hao M, Yao S, Lian N, Zhang F, Zhang C, Chen X, et al. 2017. Hepatic stellate cell interferes with NK cell regulation of fibrogenesis via curcumin induced senescence of hepatic stellate cell. Cell Signal. 33:79–85.
   PubMed Web of Science ®Google Scholar
• Jin H, Lian N, Zhang F, Chen L, Chen Q, Lu C, Bian M, Shao J, Wu L, Zheng S. 2016. Activation of PPARgamma/P53 signaling is required for curcumin to induce hepatic stellate cell senescence. Cell Death Dis. 7(4):e2189.
   PubMedGoogle Scholar
• Kong Z, Liu R, Cheng Y. 2019. Artesunate alleviates liver fibrosis by regulating ferroptosis signaling pathway. Biomed Pharmacother. 109:2043–2053.
   PubMed Web of Science ®Google Scholar
• Krizhanovsky V, Yon M, Dickins RA, Hearn S, Simon J, Miething C, Yee H, Zender L, Lowe SW. 2008. Senescence of activated stellate cells limits liver fibrosis. Cell. 134(4):657–667.
   PubMed Web of Science ®Google Scholar
• Leong PK, Ko KM. 2016. Schisandrin B: a double-edged sword in nonalcoholic fatty liver disease. Oxid Med Cell Longev. 2016:6171658.
   PubMed Web of Science ®Google Scholar
• Li N, Wang W, Zhou H, Wu Q, Duan M, Liu C, Wu H, Deng W, Shen D, Tang Q. 2020. Ferritinophagy-mediated ferroptosis is involved in sepsis-induced cardiac injury. Free Radic Biol Med. 160:303–318.
   PubMed Web of Science ®Google Scholar
• Mancias JD, Pontano Vaites L, Nissim S, Biancur DE, Kim AJ, Wang X, Liu Y, Goessling W, Kimmelman AC, Harper JW. 2015. Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis. Elife. 4:e10308.
   PubMed Web of Science ®Google Scholar
• Mangan D. 2021. Iron: an underrated factor in aging. Aging (Albany NY). 13(19):23407–23415.
   PubMedGoogle Scholar
• Munoz-Espin D, Serrano M. 2014. Cellular senescence: from physiology to pathology. Nat Rev Mol Cell Biol. 15(7):482–496.
   PubMed Web of Science ®Google Scholar
• Nakamura T, Naguro I, Ichijo H. 2019. Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases. Biochim Biophys Acta Gen Subj. 1863(9):1398–1409.
   PubMed Web of Science ®Google Scholar
• Nault JC, Ningarhari M, Rebouissou S, Zucman-Rossi J. 2019. The role of telomeres and telomerase in cirrhosis and liver cancer. Nat Rev Gastroenterol Hepatol. 16(9):544–558.
   PubMed Web of Science ®Google Scholar
• Oyama K, El-Nachef D, Fang C, Kajimoto H, Brown JP, Singh PB, MacLellan WR. 2018. Deletion of HP1gamma in cardiac myocytes affects H4K20me3 levels but does not impact cardiac growth. Epigenetics Chromatin. 11(1):18.
   PubMedGoogle Scholar
• Pellicoro A, Ramachandran P, Iredale JP, Fallowfield JA. 2014. Liver fibrosis and repair: immune regulation of wound healing in a solid organ. Nat Rev Immunol. 14(3):181–194.
   PubMed Web of Science ®Google Scholar
• Qi X, Song A, Ma M, Wang P, Zhang X, Lu C, Zhang J, Zheng S, Jin H. 2021. Curcumol inhibits ferritinophagy to restrain hepatocyte senescence through YAP/NCOA4 in non-alcoholic fatty liver disease. Cell Prolif. 54(9):e13107.
   PubMed Web of Science ®Google Scholar
• Roy N, Bagchi S, Raychaudhuri P. 2012. Damaged DNA binding protein 2 in reactive oxygen species (ROS) regulation and premature senescence. Int J Mol Sci. 13(9):11012–11026.
   PubMed Web of Science ®Google Scholar
• Santana-Codina N, Mancias JD. 2018. The role of NCOA4-mediated ferritinophagy in health and disease. Pharmaceuticals (Basel). 11(4):114.
   PubMedGoogle Scholar
• Schuppan D, Kim YO. 2013. Evolving therapies for liver fibrosis. J Clin Invest. 123(5):1887–1901.
   PubMed Web of Science ®Google Scholar
• Shmulevich R, Krizhanovsky V. 2021. Cell Senescence, DNA damage, and metabolism. Antioxid Redox Signal. 34(4):324–334.
   PubMed Web of Science ®Google Scholar
• Tsuchida T, Friedman SL. 2017. Mechanisms of hepatic stellate cell activation. Nat Rev Gastroenterol Hepatol. 14(7):397–411.
   PubMed Web of Science ®Google Scholar
• Wang L, Lankhorst L, Bernards R. 2022. Exploiting senescence for the treatment of cancer. Nat Rev Cancer. 22(6):340–355.
   PubMed Web of Science ®Google Scholar
• Xiu Z, Zhu Y, Han J, Li Y, Yang X, Yang G, Song G, Li S, Li Y, Cheng C, et al. 2022. Caryophyllene oxide induces ferritinophagy by regulating the NCOA4/FTH1/LC3 pathway in hepatocellular carcinoma. Front Pharmacol. 13:930958.
   PubMed Web of Science ®Google Scholar
• Yang F, Yang L, Li Y, Yan G, Feng C, Liu T, Gong R, Yuan Y, Wang N, Idiiatullina E, et al. 2017. Melatonin protects bone marrow mesenchymal stem cells against iron overload-induced aberrant differentiation and senescence. J Pineal Res. 63(3):e12422.
   Web of Science ®Google Scholar
• Yang K, Qiu J, Huang Z, Yu Z, Wang W, Hu H, You Y. 2022. A comprehensive review of ethnopharmacology, phytochemistry, pharmacology, and pharmacokinetics of Schisandra chinensis (Turcz). Baill. and Schisandra Sphenanthera Rehd. et Wils. J Ethnopharmacol. 284:114759.
   PubMed Web of Science ®Google Scholar
• Yuan P, Qi X, Song A, Ma M, Zhang X, Lu C, Bian M, Lian N, He J, Zheng S, et al. 2021. LncRNA MAYA promotes iron overload and hepatocyte senescence through inhibition of YAP in non-alcoholic fatty liver disease. J Cell Mol Med. 25(15):7354–7366.
   PubMed Web of Science ®Google Scholar
• Zhang H, Chen Q, Dahan A, Xue J, Wei L, Tan W, Zhang G. 2019. Transcriptomic analyses reveal the molecular mechanisms of schisandrin B alleviates CCl4-induced liver fibrosis in rats by RNA-sequencing. Chem Biol Interact. 309:108675.
   PubMed Web of Science ®Google Scholar
• Zhang M, Serna-Salas S, Damba T, Borghesan M, Demaria M, Moshage H. 2021. Hepatic stellate cell senescence in liver fibrosis: characteristics, mechanisms and perspectives. Mech Ageing Dev. 199:111572.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Zhang QQ, Guo XH, Zhang HY, Liu LX. 2014. IGFBPrP1 induces liver fibrosis by inducing hepatic stellate cell activation and hepatocyte apoptosis via Smad2/3 signaling. WJG. 20(21):6523–6533.
   PubMed Web of Science ®Google Scholar