Wen-Shen-Tong-Luo-Zhi-Tong Decoction regulates bone–fat balance in osteoporosis by adipocyte-derived exosomes

References

• Barnsley J, Buckland G, Chan PE, Ong A, Ramos AS, Baxter M, Laskou F, Dennison EM, Cooper C, Patel HP. 2021. Pathophysiology and treatment of osteoporosis: challenges for clinical practice in older people. Aging Clin Exp Res. 33(4):759–773.
   PubMed Web of Science ®Google Scholar
• Cornish J, Wang T, Lin JM. 2018. Role of marrow adipocytes in regulation of energy metabolism and bone homeostasis. Curr Osteoporos Rep. 16(2):116–122.
   PubMed Web of Science ®Google Scholar
• Delort L, Cholet J, Decombat C, Vermerie M, Dumontet C, Castelli FA, Fenaille F, Auxenfans C, Rossary A, Caldefie-Chezet F. 2020. The adipose microenvironment dysregulates the mammary myoepithelial cells and could participate to the progression of breast cancer. Front Cell Dev Biol. 8:571948.
   PubMed Web of Science ®Google Scholar
• Deng S, Zeng Y, Xiang J, Lin S, Shen J. 2022. Icariin protects bone marrow mesenchymal stem cells in aplastic anemia by targeting MAPK pathway. Mol Biol Rep. 49(9):8317–8324.
   PubMed Web of Science ®Google Scholar
• Fassio A, Idolazzi L, Rossini M, Gatti D, Adami G, Giollo A, Viapiana O. 2018. The obesity paradox and osteoporosis. Eat Weight Disord. 23(3):293–302.
   PubMed Web of Science ®Google Scholar
• Fazeli PK, Horowitz MC, Macdougald OA, Scheller EL, Rodeheffer MS, Rosen CJ, Klibanski A. 2013. Marrow fat and bone – new perspectives. J Clin Endocrinol Metab. 98(3):935–945.
   PubMed Web of Science ®Google Scholar
• Gao XR, Ge J, Li WY, Zhou WC, Xu L, Geng DQ. 2021. miR-34a carried by adipocyte exosomes inhibits the polarization of M1 macrophages in mouse osteolysis model. J Biomed Mater Res. 109(6):994–1003.
   Web of Science ®Google Scholar
• Jiang M, Ma W, Gao Y, Jia K, Zhang Y, Liu H, Sun Q. 2017. IL-22-induced miR-122-5p promotes keratinocyte proliferation by targeting Sprouty2. Exp Dermatol. 26(4):368–374.
   PubMed Web of Science ®Google Scholar
• Jiang Y, Xin N, Xiong Y, Guo Y, Yuan Y, Zhang Q, Gong P. 2022. AlphaCGRP regulates osteogenic differentiation of bone marrow mesenchymal stem cells through ERK1/2 and p38 MAPK signaling pathways. Cell Transplant. 31:9636897221107636.
   Web of Science ®Google Scholar
• Kalluri R, Lebleu VS. 2020. The biology, function, and biomedical applications of exosomes. Science. 367(6478):u6977.
   Web of Science ®Google Scholar
• Kim EK, Choi EJ. 2010. Pathological roles of MAPK signaling pathways in human diseases. Biochim Biophys Acta. 1802(4):396–405.
   PubMed Web of Science ®Google Scholar
• Liao W, Ning Y, Xu H-J, Zou W-Z, Hu J, Liu X-Z, Yang Y, Li Z-H. 2019. BMSC-derived exosomes carrying microRNA-122-5p promote proliferation of osteoblasts in osteonecrosis of the femoral head. Clin Sci. 133(18):1955–1975.
   PubMed Web of Science ®Google Scholar
• Liu H-F, He H-C, Yang L, Yang Z-Y, Yao K, Wu Y-C, Yang X-B, He C-Q. 2015. Pulsed electromagnetic fields for postmenopausal osteoporosis and concomitant lumbar osteoarthritis in southwest China using proximal femur bone mineral density as the primary endpoint: study protocol for a randomized controlled trial. Trials. 16(1):265.
   PubMedGoogle Scholar
• Liu S, Liu D, Chen C, Hamamura K, Moshaverinia A, Yang R, Liu Y, Jin Y, Shi S. 2015. MSC transplantation improves osteopenia via epigenetic regulation of notch signaling in lupus. Cell Metab. 22(4):606–618.
   PubMed Web of Science ®Google Scholar
• Ma Y, Wang L, Zheng S, Xu J, Pan Y, Tu P, Sun J, Guo Y. 2019. Osthole inhibits osteoclasts formation and bone resorption by regulating NF-kappaB signaling and NFATc1 activations stimulated by RANKL. J Cell Biochem. 120(9):16052–16061.
   PubMed Web of Science ®Google Scholar
• McCubrey JA, Lahair MM, Franklin RA. 2006. Reactive oxygen species-induced activation of the MAP kinase signaling pathways. Antioxid Redox Signal. 8(9–10):1775–1789.
   PubMed Web of Science ®Google Scholar
• Meldolesi J. 2018. Exosomes and ectosomes in intercellular communication. Curr Biol. 28(8):R435–R444.
   PubMed Web of Science ®Google Scholar
• Rachner TD, Khosla S, Hofbauer LC. 2011. Osteoporosis: now and the future. Lancet. 377(9773):1276–1287.
   PubMed Web of Science ®Google Scholar
• Rendina-Ruedy E, Rosen CJ. 2017. Bone–fat interaction. Endocrinol Metab Clin North Am. 46(1):41–50.
   PubMed Web of Science ®Google Scholar
• Sano S, Izumi Y, Yamaguchi T, Yamazaki T, Tanaka M, Shiota M, Osada-Oka M, Nakamura Y, Wei M, Wanibuchi H, et al. 2014. Lipid synthesis is promoted by hypoxic adipocyte-derived exosomes in 3T3-L1 cells. Biochem Biophys Res Commun. 445(2):327–333.
   PubMed Web of Science ®Google Scholar
• Sartori E, Magro-Filho O, Mendonça D, Li X, Fu J, Mendonça G. 2018. Modulation of microRNA expression and osteoblast differentiation by nanotopography. Int J Oral Maxillofac Implants. 33(2):269–280.
   PubMed Web of Science ®Google Scholar
• Scheller EL, Doucette CR, Learman BS, Cawthorn WP, Khandaker S, Schell B, Wu B, Ding S-Y, Bredella MA, Fazeli PK, et al. 2015. Region-specific variation in the properties of skeletal adipocytes reveals regulated and constitutive marrow adipose tissues. Nat Commun. 6:7808.
   PubMed Web of Science ®Google Scholar
• Scheller EL, Rosen CJ. 2014. What’s the matter with MAT? Marrow adipose tissue, metabolism, and skeletal health. Ann N Y Acad Sci. 1311(1):14–30.
   PubMedGoogle Scholar
• Si L, Winzenberg TM, Jiang Q, Chen M, Palmer AJ. 2015. Projection of osteoporosis-related fractures and costs in China: 2010–2050. Osteoporos Int. 26(7):1929–1937.
   PubMed Web of Science ®Google Scholar
• Sun W, Zhao C, Li Y, Wang L, Nie G, Peng J, Wang A, Zhang P, Tian W, Li Q, et al. 2016. Osteoclast-derived microRNA-containing exosomes selectively inhibit osteoblast activity. Cell Discov. 2(1):16015.
   PubMedGoogle Scholar
• Taketomi T, Onimura T, Yoshiga D, Muratsu D, Sanui T, Fukuda T, Kusukawa J, Nakamura S. 2018. Sprouty2 is involved in the control of osteoblast proliferation and differentiation through the FGF and BMP signaling pathways. Cell Biol Int. 42(9):1106–1114.
   PubMed Web of Science ®Google Scholar
• Torii S, Yamamoto T, Tsuchiya Y, Nishida E. 2006. ERK MAP kinase in G cell cycle progression and cancer. Cancer Sci. 97(8):697–702.
   PubMed Web of Science ®Google Scholar
• Wang L, Zheng S, Huang G, Sun J, Pan Y, Si Y, Tu P, Xu G, Ma Y, Guo Y. 2020. Osthole-loaded N-octyl-O-sulfonyl chitosan micelles (NSC-OST) inhibits RANKL-induced osteoclastogenesis and prevents ovariectomy-induced bone loss in rats. J Cell Mol Med. 24(7):4105–4117.
   PubMed Web of Science ®Google Scholar
• Wu P, Jiao F, Huang H, Liu D, Tang W, Liang J, Chen W. 2022. Morinda officinalis polysaccharide enable suppression of osteoclastic differentiation by exosomes derived from rat mesenchymal stem cells. Pharm Biol. 60(1):1303–1316.
   PubMed Web of Science ®Google Scholar
• Xu R, Shen X, Si Y, Fu Y, Zhu W, Xiao T, Fu Z, Zhang P, Cheng J, Jiang H. 2018. MicroRNA-31a-5p from aging BMSCs links bone formation and resorption in the aged bone marrow microenvironment. Aging Cell. 17(4):e12794.
   PubMed Web of Science ®Google Scholar
• Yang J, Gao F, Zhang Y, Liu Y, Zhang D. 2015. Buyang Huanwu Decoction (BYHWD) enhances angiogenic effect of mesenchymal stem cell by upregulating VEGF expression after focal cerebral ischemia. J Mol Neurosci. 56(4):898–906.
   PubMed Web of Science ®Google Scholar
• Yu B, Huo L, Liu Y, Deng P, Szymanski J, Li J, Luo X, Hong C, Lin J, Wang C-Y. 2018. PGC-1α controls skeletal stem cell fate and bone–fat balance in osteoporosis and skeletal aging by inducing TAZ. Cell Stem Cell. 23(2):193–209.e5.
   PubMed Web of Science ®Google Scholar
• Zheng S, Ma Y, Guo Y, Wang L, Pan Y. 2018. Osthole promote differentiation and inhibit proliferation of osteoblast by activating Wnt signaling and endoplasmic reticulum stress. Pharmacogn Mag. 14:641–646.
   Web of Science ®Google Scholar
• Zheng S, Ma Y, Guo Y, Dong W, Fan J, Huang G. 2016. Treating primary osteoporosis with Wen-Shen-Tong-Luo-Zhi-Tong Decoction. Liaoning J Tradit Chin Med. 43:2098–2100.
   Google Scholar