Angelica sinensis polysaccharides alleviate the oxidative burden on hematopoietic cells by restoring 5-fluorouracil-induced oxidative damage in perivascular mesenchymal progenitor cells

References

• Ahmadzadeh A, Norozi F, Shahrabi S, Shahjahani M, Saki N. 2016. Wnt/β-catenin signaling in bone marrow niche. Cell Tissue Res. 363(2):321–335.
   PubMed Web of Science ®Google Scholar
• Ai S, Fan X, Fan L, Sun Q, Liu Y, Tao X, Dai K. 2013. Extraction and chemical characterization of Angelica sinensis polysaccharides and its antioxidant activity. Carbohydr Polym. 94(2):731–736.
   PubMed Web of Science ®Google Scholar
• Ambrosi TH, Scialdone A, Graja A, Gohlke S, Jank AM, Bocian C, Woelk L, Fan H, Logan DW, Schürmann A, et al. 2017. Adipocyte accumulation in the bone marrow during obesity and aging impairs stem cell-based hematopoietic and bone regeneration. Cell Stem Cell. 20(6):771–784.e6.
   PubMed Web of Science ®Google Scholar
• Arai F, Hirao A, Ohmura M, Sato H, Matsuoka S, Takubo K, Ito K, Koh GY, Suda T. 2004. Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell. 118(2):149–161.
   PubMed Web of Science ®Google Scholar
• Atkins S, He F. 2019. Chemotherapy and beyond: infections in the era of old and new treatments for hematologic malignancies. Infect Dis Clin North Am. 33(2):289–309.
   PubMed Web of Science ®Google Scholar
• Bigas A, Espinosa L. 2012. Hematopoietic stem cells: to be or notch to be. Blood. The J Am Soc Hematol. 119(14):3226–3235.
   Google Scholar
• Brack AS, Conboy MJ, Roy S, Lee M, Kuo CJ, Keller C, Rando TA. 2007. Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science. 317(5839):807–810.
   PubMed Web of Science ®Google Scholar
• Chen L, Zhao Q, Wang XL, You R, Zhang YH, Ji H, Lai YS. 2011. ZLJ-6, a novel COX/5-LOX inhibitor, attenuates TNF-α-induced endothelial E-selectin, ICAM-1 and VCAM-1 expression and monocyte-endothelial interactions via a COX/5-LOX-independent mechanism. Vascul Pharmacol. 55(5–6):135–142.
   PubMed Web of Science ®Google Scholar
• Chen Z, Cheng L, Zhang J, Cui X. 2020. Angelica sinensis polysaccharide prevents mitochondrial apoptosis by regulating the Treg/Th17 ratio in aplastic anemia. BMC Complement Med Ther. 20(1):192.
   PubMedGoogle Scholar
• Cheng X, Yao H, Xiang Y, Chen L, Xiao M, Wang Z, Xiao H, Wang L, Wang S, Wang Y. 2019. Effect of Angelica polysaccharide on brain senescence of Nestin-GFP mice induced by d-galactose. Neurochem Int. 122:149–156.
   PubMed Web of Science ®Google Scholar
• Ding L, Morrison SJ. 2013. Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches. Nature. 495(7440):231–235.
   PubMed Web of Science ®Google Scholar
• Ding L, Saunders TL, Enikolopov G, Morrison SJ. 2012. Endothelial and perivascular cells maintain haematopoietic stem cells. Nature. 481(7382):457–462.
   PubMed Web of Science ®Google Scholar
• Fox N, Priestley G, Papayannopoulou T, Kaushansky K. 2002. Thrombopoietin expands hematopoietic stem cells after transplantation. J Clin Invest. 110(3):389–394.
   PubMed Web of Science ®Google Scholar
• Kiel MJ, Yilmaz OH, Iwashita T, Yilmaz OH, Terhorst C, Morrison SJ. 2005. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell. 121(7):1109–1121.
   PubMed Web of Science ®Google Scholar
• Kim W, Kim M, Jho EH. 2013. Wnt/β-catenin signalling: from plasma membrane to nucleus. Biochem J. 450(1):9–21.
   PubMedGoogle Scholar
• Komori T. 2019. Regulation of proliferation, differentiation and functions of osteoblasts by Runx2. IJMS. 20(7):1694.
   Google Scholar
• Liu PJ, Hsieh WT, Huang SH, Liao HF, Chiang BH. 2010. Hematopoietic effect of water-soluble polysaccharides from Angelica sinensis on mice with acute blood loss. Exp Hematol. 38(6):437–445.
   PubMed Web of Science ®Google Scholar
• Méndez-Ferrer S, Michurina TV, Ferraro F, Mazloom AR, Macarthur BD, Lira SA, Scadden DT, Ma’ayan A, Enikolopov GN, Frenette PS. 2010. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature. 466(7308):829–834.
   PubMed Web of Science ®Google Scholar
• Mu X, Zhang Y, Li J, Xia J, Chen X, Jing P, Song X, Wang L, Wang Y. 2017. 2017: 1687-966X. Angelica sinensis polysaccharide prevents hematopoietic stem cells senescence in d-galactose-induced aging mouse model. Stem Cells Int. 2017:3508907.
   PubMed Web of Science ®Google Scholar
• Naveiras O, Nardi V, Wenzel PL, Hauschka PV, Fahey F, Daley GQ. 2009. Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment. Nature. 460(7252):259–263.
   PubMed Web of Science ®Google Scholar
• Nemeth MJ, Bodine DM. 2007. Regulation of hematopoiesis and the hematopoietic stem cell niche by Wnt signaling pathways. Cell Res. 17(9):746–758.
   PubMed Web of Science ®Google Scholar
• Parchment RE, Gordon M, Grieshaber CK, Sessa C, Volpe D, Ghielmini M. 1998. Predicting hematological toxicity (myelosuppression) of cytotoxic drug therapy from in vitro tests. Ann Oncol. 9(4):357–364.
   PubMed Web of Science ®Google Scholar
• Pillozzi S, Becchetti A. 2012. Ion channels in hematopoietic and mesenchymal stem cells. Stem Cells Int. 2012:1–9.
   Web of Science ®Google Scholar
• Pinho S, Frenette PS. 2019. Haematopoietic stem cell activity and interactions with the niche. Nat Rev Mol Cell Biol. 20(5):303–320.
   PubMed Web of Science ®Google Scholar
• Pinho S, Lacombe J, Hanoun M, Mizoguchi T, Bruns I, Kunisaki Y, Frenette PS. 2013. PDGFRα and CD51 mark human nestin + sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion. J Exp Med. 210(7):1351–1367.
   PubMed Web of Science ®Google Scholar
• Pittman K, Perren T, Ward U, Primrose J, Slevin M, Patel N, Selby P. 1993. Pharmacokinetics of 5-fluorouracil in colorectal cancer patients receiving interferon. Ann Oncol. 4(6):515–516.
   PubMed Web of Science ®Google Scholar
• Ponomaryov T, Peled A, Petit I, Taichman RS, Habler L, Sandbank J, Arenzana-Seisdedos F, Magerus A, Caruz A, Fujii N, et al. 2000. Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function. J Clin Invest. 106(11):1331–1339.
   PubMed Web of Science ®Google Scholar
• Qian H, Buza-Vidas N, Hyland CD, Jensen CT, Antonchuk J, Månsson R, Thoren LA, Ekblom M, Alexander WS, Jacobsen SEW. 2007. Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells. Cell Stem Cell. 1(6):671–684.
   PubMed Web of Science ®Google Scholar
• Ren F, Li J, Wang Y, Wang Y, Feng S, Yuan Z, Qian X. 2018. The effects of Angelica sinensis polysaccharide on tumor growth and iron metabolism by regulating hepcidin in tumor-bearing mice. Cell Physiol Biochem. 47(3):1084–1094.
   PubMedGoogle Scholar
• Richter R, Forssmann W, Henschler R. 2017. Current developments in mobilization of hematopoietic stem and progenitor cells and their interaction with niches in bone marrow. Transfus Med Hemother. 44(3):151–164.
   PubMed Web of Science ®Google Scholar
• Rodeheffer MS, Horowitz MC. 2016. Fat decisions: leptin regulates bone versus fat in the marrow. Cell Stem Cell. 18(6):684–686.
   PubMed Web of Science ®Google Scholar
• Rosen ED, Sarraf P, Troy AE, Bradwin G, Moore K, Milstone DS, Spiegelman BM, Mortensen RM. 1999. PPARγ is required for the differentiation of adipose tissue in vivo and in vitro. Mol Cell. 4(4):611–617.
   PubMed Web of Science ®Google Scholar
• Sahin AO, Buitenhuis M. 2012. Molecular mechanisms underlying adhesion and migration of hematopoietic stem cells. Cell Adh Migr. 6(1):39–48.
   PubMed Web of Science ®Google Scholar
• Schepers K, Campbell TB, Passegué E. 2015. Normal and leukemic stem cell niches: insights and therapeutic opportunities. Cell Stem Cell. 16(3):254–267.
   PubMed Web of Science ®Google Scholar
• Staal FJT, Chhatta A, Mikkers H. 2016. Caught in a Wnt storm: complexities of Wnt signaling in hematopoiesis. Exp Hematol. 44(6):451–457.
   PubMed Web of Science ®Google Scholar
• Stier S, Cheng T, Dombkowski D, Carlesso N, Scadden DT. 2002. Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome. Blood. 99(7):2369–2378.
   PubMed Web of Science ®Google Scholar
• Stier S, Ko Y, Forkert R, Lutz C, Neuhaus T, Grünewald E, Cheng T, Dombkowski D, Calvi LM, Rittling SR, et al. 2005. Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size. J Exp Med. 201(11):1781–1791.
   PubMed Web of Science ®Google Scholar
• Sugimura R, Jha DK, Han A, Soria-Valles C, Da Rocha EL, Lu YF, Goettel JA, Serrao E, Rowe RG, Malleshaiah M, et al. 2017. Haematopoietic stem and progenitor cells from human pluripotent stem cells. Nature. 545(7655):432–438.
   PubMed Web of Science ®Google Scholar
• Tikhonova AN, Dolgalev I, Hu H, Sivaraj KK, Hoxha E, Cuesta-Domínguez Á, Pinho S, Akhmetzyanova I, Gao J, Witkowski M, et al. 2019. The bone marrow microenvironment at single-cell resolution. Nature. 569(7755):222–228.
   PubMed Web of Science ®Google Scholar
• Tzeng YS, Li H, Kang YL, Chen WC, Cheng WC, Lai DM. 2011. Loss of CXCL12/Sdf-1 in adult mice decreases the quiescent state of hematopoietic stem/progenitor cells and alters the pattern of hematopoietic regeneration after myelosuppression. Blood. 117(2):429–439.
   PubMed Web of Science ®Google Scholar
• Van Laere AS, Nguyen M, Braunschweig M, Nezer C, Collette C, Moreau L, Archibald AL, Haley CS, Buys N, Tally M, et al. 2003. A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig. Nature. 425(6960):832–836.
   PubMed Web of Science ®Google Scholar
• Vodenkova S, Buchler T, Cervena K, Veskrnova V, Vodicka P, Vymetalkova V. 2020. 5-Fluorouracil and other fluoropyrimidines in colorectal cancer: past, present and future. Pharmacol Ther. 206:107447.
   PubMed Web of Science ®Google Scholar
• Wang S, Zheng G, Tian S, Zhang Y, Shen L, Pak Y, Shen Y, Qian J. 2015. Echinacoside improves hematopoietic function in 5-FU-induced myelosuppression mice. Life Sci. 123:86–92.
   PubMed Web of Science ®Google Scholar
• Waskow C, Paul S, Haller C, Gassmann M, Rodewald HR. 2002. Viable c-Kit(W/W) mutants reveal pivotal role for c-kit in the maintenance of lymphopoiesis. Immunity. 17(3):277–288.
   PubMed Web of Science ®Google Scholar
• Wei WL, Zeng R, Gu CM, Qu Y, Huang LF. 2016. Angelica sinensis in China-A review of botanical profile, ethnopharmacology, phytochemistry and chemical analysis. J Ethnopharmacol. 190:116–141.
   PubMed Web of Science ®Google Scholar
• Xiao H, Xiong L, Song X, Jin P, Chen L, Chen X, Yao H, Wang Y, Wang L. 2017. Angelica sinensis polysaccharides ameliorate stress-induced premature senescence of hematopoietic cell via protecting bone marrow stromal cells from oxidative injuries caused by 5-fluorouracil. IJMS. 18(11):2265.
   Google Scholar
• Yamashita M, Dellorusso PV, Olson OC, Passegué E. 2020. Dysregulated haematopoietic stem cell behaviour in myeloid leukaemogenesis. Nat Rev Cancer. 20(7):365–382.
   PubMed Web of Science ®Google Scholar
• Yoshihara H, Arai F, Hosokawa K, Hagiwara T, Takubo K, Nakamura Y, Gomei Y, Iwasaki H, Matsuoka S, Miyamoto K, et al. 2007. Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche. Cell Stem Cell. 1(6):685–697.
   PubMed Web of Science ®Google Scholar
• Zeng D, Wang Y, Chen Y, Li D, Li G, Xiao H, Hou J, Wang Z, Hu L, Wang L, et al. 2021. Angelica polysaccharide antagonizes 5-FU-induced oxidative stress injury to reduce apoptosis in the liver through Nrf2 pathway. Front Oncol. 11:720620.
   PubMed Web of Science ®Google Scholar
• Zhang DY, Pan Y, Zhang C, Yan BX, Yu SS, Wu DL, Shi MM, Shi K, Cai XX, Zhou SS, et al. 2013. Wnt/β-catenin signaling induces the aging of mesenchymal stem cells through promoting the ROS production. Mol Cell Biochem. 374(1-2):13–20.
   PubMed Web of Science ®Google Scholar
• Zhang J, Niu C, Ye L, Huang H, He X, Tong WG, Ross J, Haug J, Johnson T, Feng JQ, et al. 2003. Identification of the haematopoietic stem cell niche and control of the niche size. Nature. 425(6960):836–841.
   PubMed Web of Science ®Google Scholar
• Zhao L, Wang Y, Shen HL, Shen XD, Nie Y, Wang Y, Han T, Yin M, Zhang QY. 2012. Structural characterization and radioprotection of bone marrow hematopoiesis of two novel polysaccharides from the root of Angelica sinensis (Oliv.) Diels. Fitoterapia. 83(8):1712–1720.
   PubMed Web of Science ®Google Scholar
• Zhou BO, Yue R, Murphy MM, Peyer JG, Morrison SJ. 2014. Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow. Cell Stem Cell. 15(2):154–168.
   PubMed Web of Science ®Google Scholar