Acacetin-loaded microemulsion for transdermal delivery: preparation, optimization and evaluation

References

• Alexander A, Dwivedi S, Giri TK, Saraf S, Saraf S, Tripathi, DK, Ajazuddin . 2012. Approaches for breaking the barriers of drug permeation through transdermal drug delivery. J Control Release. 164(1):26–40.
   PubMed Web of Science ®Google Scholar
• Carballo-Villalobos AI, Gonzalez-Trujano ME, Lopez-Munoz FJ. 2014. Evidence of mechanism of action of anti-inflammatory/antinociceptive activities of acacetin. Eur J Pain. 18(3):396–405.
   PubMed Web of Science ®Google Scholar
• Csizmazia E, Berko S, Maroda M, Szabone RP, Csanyi E. 2012. Modelling of pecutaneous drug permeation and investigation of penetration enhancer effect. Acta Pharm Hung. 82(1):15–22.
   PubMedGoogle Scholar
• Diblíková D, Kopečná M, Školová B, Krečmerová M, Roh J, Hrabálek A, Vávrová K. 2014. Transdermal delivery and cutaneous targeting of antivirals using a penetration enhancer and lysolipid prodrugs. Pharm Res. 31(4):1071–1081.
   PubMed Web of Science ®Google Scholar
• Farooqui RK, Kaurav M, Kumar M, Sudheesh MS, Pandey RS. 2022. Permeation enhancer nanovesicles mediated topical delivery of curcumin for the treatment of hyperpigmentation. J Liposome Res. 32(4):332–339.
   PubMed Web of Science ®Google Scholar
• Fouad SA, Basalious EB, El-Nabarawi MA, Tayel SA. 2013. Microemulsion and poloxamer microemulsion-based gel for sustained transdermal delivery of diclofenac epolamine using in-skin drug depot: in vitro/in vivo evaluation. Int J Pharm. 453(2):569–578.
   PubMed Web of Science ®Google Scholar
• Hathout RM, Elshafeey AH. 2012. Development and characterization of colloidal soft nano-carriers for transdermal delivery and bioavailability enhancement of an angiotensin II receptor blocker. Eur J Pharm Biopharm. 82(2):230–240.
   PubMed Web of Science ®Google Scholar
• Hathout RM, Woodman TJ, Mansour S, Mortada ND, Geneidi AS, Guy RH. 2010. Microemulsion formulations for the transdermal delivery of testosterone. Eur J Pharm Sci. 40(3):188–196.
   PubMed Web of Science ®Google Scholar
• Huang WC, Liou CJ. 2012. Dietary acacetin reduces airway hyperresponsiveness and eosinophil infiltration by modulating eotaxin-1 and th2 cytokines in a mouse model of asthma. Evid Based Complement Alternat Med. 2012:910520.
   PubMed Web of Science ®Google Scholar
• Jampilek J, Brychtova K. 2012. Azone analogues: classification, design, and transdermal penetration principles. Med Res Rev. 32(5):907–947.
   PubMed Web of Science ®Google Scholar
• Jung SK, Kim JE, Lee S-Y, Lee MH, Byun S, Kim YA, Lim TG, Reddy K, Huang Z, Bode AM, et al. 2014. The P110 subunit of PI3-K is a therapeutic target of acacetin in skin cancer. Carcinogenesis. 35(1):123–130.
   PubMed Web of Science ®Google Scholar
• Kim HG, Ju MS, Ha SK, Lee H, Lee H, Kim SY, Oh MS. 2012. Acacetin protects dopaminergic cells against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neuroinflammation in vitro and in vivo. Biol Pharm Bull. 35(8):1287–1294.
   PubMed Web of Science ®Google Scholar
• Kim HR, Park CG, Jung JY. 2014. Acacetin (5,7-dihydroxy-4'-methoxyflavone) exhibits in vitro and in vivo anticancer activity through the suppression of NF-kappaB/Akt signaling in prostate cancer cells. Int J Mol Med. 33(2):317–324.
   PubMed Web of Science ®Google Scholar
• Kogan A, Garti N. 2006. Microemulsions as transdermal drug delivery vehicles. Adv Colloid Interface Sci. 123-126:369–385.
   PubMed Web of Science ®Google Scholar
• Li GR, Wang HB, Qin GW, Jin MW, Tang Q, Sun HY, Du XL, Deng XL, Zhang XH, Chen JB, et al. 2008. Acacetin, a natural flavone, selectively inhibits human atrial repolarization potassium currents and prevents atrial fibrillation in dogs. Circulation. 117(19):2449–2457.
   PubMed Web of Science ®Google Scholar
• Liuzzi R, Carciati A, Guido S, Caserta S. 2016. Transport efficiency in transdermal drug delivery: what is the role of fluid microstructure? Colloids Surf B Biointerfaces. 139:294–305.
   PubMed Web of Science ®Google Scholar
• Lopes LB. 2014. Overcoming the cutaneous barrier with microemulsions. Pharmaceutics. 6(1):52–77.
   PubMedGoogle Scholar
• Marren K. 2011. Dimethyl sulfoxide: an effective penetration enhancer for topical administration of NSAIDs. Phys Sportsmed. 39(3):75–82.
   PubMed Web of Science ®Google Scholar
• Marwah H, Garg T, Goyal AK, Rath G. 2016. Permeation enhancer strategies in transdermal drug delivery. Drug Deliv. 23(2):564–578.
   PubMed Web of Science ®Google Scholar
• Omar MM, Hasan OA, El Sisi AM. 2019. Preparation and optimization of lidocaine transferosomal gel containing permeation enhancers: a promising approach for enhancement of skin permeation. Int J Nanomedicine. 14:1551–1562.
   PubMed Web of Science ®Google Scholar
• Ravens U, Christ T. 2010. Atrial-selective drugs for treatment of atrial fibrillation. Herzschrittmacherther Elektrophysiol. 21(4):217–221.
   PubMedGoogle Scholar
• Rosiello AP, Essignmann JM, Wogan GN. 1977. Rapid and accurate determination of the median lethal dose (LD50) and its error with a small computer. J Toxicol Environ Health. 3(5-6):797–809.
   PubMed Web of Science ®Google Scholar
• Santos P, Watkinson AC, Hadgraft J, Lane ME. 2008. Application of microemulsions in dermal and transdermal drug delivery. Skin Pharmacol Physiol. 21(5):246–259.
   PubMed Web of Science ®Google Scholar
• Simoes RL, Mendes T, Eleutério CV, Pinto P, Ascenso A. 2016. Development and characterization of a novel vesicular system for topical delivery: an opportunity for dimethylsulfoxide. Med Chem. 06(04):1–7.
   Google Scholar
• Singh G, Pai RS. 2015. Trans-resveratrol self-nano-emulsifying drug delivery system (SNEDDS) with enhanced bioavailability potential: optimization, pharmacokinetics and in situ single pass intestinal perfusion (SPIP) studies. Drug Deliv. 22(4):522–530.
   PubMed Web of Science ®Google Scholar
• Sintov AC. 2015. Transdermal delivery of curcumin via microemulsion. Int J Pharm. 481(1–2):97–103.
   PubMedGoogle Scholar
• Sintov AC, Botner S. 2006. Transdermal drug delivery using microemulsion and aqueous systems: influence of skin storage conditions on the in vitro permeability of diclofenac from aqueous vehicle systems. Int J Pharm. 311(1-2):55–62.
   PubMed Web of Science ®Google Scholar
• Tiwari G, Tiwari R. 2010. Bioanalytical method validation: an updated review. Pharm Methods. 1(1):25–38.
   PubMedGoogle Scholar
• Todosijević MN, Savić MM, Batinić BB, Marković BD, Gašperlin M, Ranđelović DV, Lukić MŽ, Savić SD. 2015. Biocompatible microemulsions of a model NSAID for skin delivery: a decisive role of surfactants in skin penetration/irritation profiles and pharmacokinetic performance. Int J Pharmaceut. 496(2):931–941.
   PubMed Web of Science ®Google Scholar
• Ustundag Okur N, Apaydin S, Karabay Yavasoglu NU, Yavasoglu A, Karasulu HY. 2011. Evaluation of skin permeation and anti-inflammatory and analgesic effects of new naproxen microemulsion formulations. Int J Pharmaceut. 416(1):136–144.
   PubMed Web of Science ®Google Scholar
• Vitorino C, Almeida J, Goncalves LM, Almeida AJ, Sousa JJ, Pais AA. 2013. Co-encapsulating nanostructured lipid carriers for transdermal application: from experimental design to the molecular detail. J Control Release. 167(3):301–314.
   PubMed Web of Science ®Google Scholar
• Wiedersberg S, Guy RH. 2014. Transdermal drug delivery: 30+ years of war and still fighting!. J Control Release. 190:150–156.
   PubMed Web of Science ®Google Scholar
• Wu HJ, Sun HY, Wu W, Zhang YH, Qin GW, Li GR. 2013. Properties and molecular determinants of the natural flavone acacetin for blocking hKv4.3 channels. PLOS One. 8(3):e57864.
   PubMed Web of Science ®Google Scholar
• Wu H-J, Wu W, Sun H-Y, Qin G-W, Wang H-B, Wang P, Yalamanchili HK, Wang J, Tse H-F, Lau C-P, et al. 2011. Acacetin causes a frequency- and use-dependent blockade of hKv1.5 channels by binding to the S6 domain. J Mol Cell Cardiol. 51(6):966–973.
   PubMed Web of Science ®Google Scholar
• Yuan Y, Li SM, Mo FK, Zhong DF. 2006. Investigation of microemulsion system for transdermal delivery of meloxicam. Int J Pharm. 321(1–2):117–123.
   PubMed Web of Science ®Google Scholar
• Zhao L, Wang Y, Zhai Y, Wang Z, Liu J, Zhai G. 2014. Ropivacaine loaded microemulsion and microemulsion-based gel for transdermal delivery: preparation, optimization, and evaluation. Int J Pharm. 477(1-2):47–56.
   PubMed Web of Science ®Google Scholar
• Zhao X, Liu JP, Zhang X, Li Y. 2006. Enhancement of transdermal delivery of theophylline using microemulsion vehicle. Int J Pharm. 327(1-2):58–64.
   PubMedGoogle Scholar
• Zhu W, Guo C, Yu A, Gao Y, Cao F, Zhai G. 2009. Microemulsion-based hydrogel formulation of penciclovir for topical delivery. Int J Pharm. 378(1-2):152–158.
   PubMedGoogle Scholar
• Zhu W, Yu A, Wang W, Dong R, Wu J, Zhai G. 2008. Formulation design of microemulsion for dermal delivery of penciclovir. Int J Pharm. 360(1-2):184–190.
   PubMedGoogle Scholar