Baicalin suppress the development of polycystic ovary syndrome via regulating the miR-874-3p/FOXO3 and miR-144/FOXO1 axis

References

• Abid MR, Yano K, Guo S, Patel VI, Shrikhande G, Spokes KC, Ferran C, Aird WC. 2005. Forkhead transcription factors inhibit vascular smooth muscle cell proliferation and neointimal hyperplasia. J Biol Chem. 280(33):29864–29873.
   PubMed Web of Science ®Google Scholar
• Armanini D, Boscaro M, Bordin L, Sabbadin C. 2022. Controversies in the pathogenesis, diagnosis and treatment of PCOS: focus on insulin resistance, inflammation, and hyperandrogenism. IJMS. 23(8):4110.
   Google Scholar
• Azziz R. 2018. Polycystic ovary syndrome. Obstet Gynecol. 132(2):321–336.
   PubMed Web of Science ®Google Scholar
• Begum Y. 2022. Regulatory role of microRNAs (miRNAs) in the recent development of abiotic stress tolerance of plants. Gene. 821:146283.
   PubMed Web of Science ®Google Scholar
• Beretta GL, Corno C, Zaffaroni N, Perego P. 2019. Role of FoxO proteins in cellular response to antitumor agents. Cancers (Basel). 11(1):90.
   PubMed Web of Science ®Google Scholar
• Chen B, Xu P, Wang J, Zhang C. 2019. The role of miRNA in polycystic ovary syndrome (PCOS). Gene. 706:91–96.
   PubMed Web of Science ®Google Scholar
• Chen J, Li Z, Chen AY, Ye X, Luo H, Rankin GO, Chen YC. 2013. Inhibitory effect of baicalin and baicalein on ovarian cancer cells. Int J Mol Sci. 14(3):6012–6025.
   PubMed Web of Science ®Google Scholar
• Deb B, Uddin A, Chakraborty S. 2018. miRNAs and ovarian cancer: an overview. J Cell Physiol. 233(5):3846–3854.
   PubMed Web of Science ®Google Scholar
• Fan H, He J, Bai Y, He Q, Zhang T, Zhang J, Yang G, Xu Z, Hu J, Yao G. 2022. Baicalin improves the functions of granulosa cells and the ovary in aged mice through the mTOR signaling pathway. J Ovarian Res. 15(1):34.
   PubMed Web of Science ®Google Scholar
• Ji R, Jia FY, Chen X, Wang ZH, Jin WY, Yang J. 2022. Salidroside alleviates oxidative stress and apoptosis via AMPK/Nrf2 pathway in DHT-induced human granulosa cell line KGN. Arch Biochem Biophys. 715:109094.
   PubMed Web of Science ®Google Scholar
• Jin P, Xie Y. 2018. Treatment strategies for women with polycystic ovary syndrome. Gynecol Endocrinol. 34(4):272–277.
   PubMed Web of Science ®Google Scholar
• Joham AE, Norman RJ, Stener-Victorin E, Legro RS, Franks S, Moran LJ, Boyle J, Teede HJ. 2022. Polycystic ovary syndrome. Lancet Diabetes Endocrinol. 10(9):668–680.
   PubMed Web of Science ®Google Scholar
• Khmil M, Khmil Doswald A, Halnykina S, Khmil S. 2022. Hormonal profile in women with infertility against the background of polycystic ovary syndrome depending on the type of pre-pregnancy pre-treatment. Pol Merkur Lekarski. 50(300):333–336.
   PubMedGoogle Scholar
• Kuscu N, Celik-Ozenci C. 2015. FOXO1, FOXO3, AND FOXO4 are differently expressed during mouse oocyte maturation and preimplantation embryo development. Gene Expr Patterns. 18(1-2):16–20.
   PubMed Web of Science ®Google Scholar
• Li Y, Yao N, Gao Y, Wang Y, Bai L, Xu J, Wang H. 2021. MiR-1224-5p attenuates polycystic ovary syndrome through inhibiting NOD-like receptor protein 3 inflammasome activation via targeting Forkhead box O 1. Bioengineered. 12(1):8555–8569.
   PubMed Web of Science ®Google Scholar
• Liao H, Ye J, Gao L, Liu Y. 2021. The main bioactive compounds of Scutellaria baicalensis Georgi. for alleviation of inflammatory cytokines: a comprehensive review. Biomed Pharmacother. 133:110917.
   PubMed Web of Science ®Google Scholar
• Lin X, Yang F, Qi X, Li Q, Wang D, Yi T, Yin R, Zhao X, Zhong X, Bian C. 2019. LncRNA DANCR promotes tumor growth and angiogenesis in ovarian cancer through direct targeting of miR-145. Mol Carcinog. 58(12):2286–2296.
   PubMed Web of Science ®Google Scholar
• Liu J, Zhao Y, Chen L, Li R, Ning Y, Zhu X. 2022. Role of metformin in functional endometrial hyperplasia and polycystic ovary syndrome involves the regulation of MEG3/miR‑223/GLUT4 and SNHG20/miR‑4486/GLUT4 signaling. Mol Med Rep. 26(1):218.
   PubMed Web of Science ®Google Scholar
• Martins R, Lithgow GJ, Link W. 2016. Long live FOXO: unraveling the role of FOXO proteins in aging and longevity. Aging Cell. 15(2):196–207.
   PubMed Web of Science ®Google Scholar
• McAllister JM, Han AX, Modi BP, Teves ME, Mavodza GR, Anderson ZL, Shen T, Christenson LK, Archer KJ, Strauss JF. 2019. miRNA profiling reveals miRNA-130b-3p mediates DENND1A variant 2 expression and androgen biosynthesis. Endocrinology. 160(8):1964–1981.
   PubMed Web of Science ®Google Scholar
• Mendoza N, Losa F, Palacios S. 2022. Strategy to improve the female fertility in the general gynecologist’s office: use of a nutritional supplement based on myo-inositol/d-chiro-inositol and antioxidants. Gynecol Endocrinol. 38(4):275–278.
   PubMed Web of Science ®Google Scholar
• Morris BJ, Willcox DC, Donlon TA, Willcox BJ. 2015. FOXO3: a major gene for human longevity–a mini-review. Gerontology. 61(6):515–525.
   PubMed Web of Science ®Google Scholar
• Murtaza G, Khan AK, Rashid R, Muneer S, Hasan SMF, Chen J. 2017. FOXO transcriptional factors and long-term living. Oxid Med Cell Longev. 2017:3494289.
   PubMed Web of Science ®Google Scholar
• Naderpoor N, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ. 2015. Obesity and polycystic ovary syndrome. Minerva Endocrinol. 40(1):37–51.
   PubMed Web of Science ®Google Scholar
• Patel S. 2018. Polycystic ovary syndrome (PCOS), an inflammatory, systemic, lifestyle endocrinopathy. J Steroid Biochem Mol Biol. 182:27–36.
   PubMed Web of Science ®Google Scholar
• Pervaz S, Ullah A, Adu-Gyamfi EA, Lamptey J, Sah SK, Wang MJ, Wang YX. 2023. Role of CPXM1 in impaired glucose metabolism and ovarian dysfunction in polycystic ovary syndrome. Reprod Sci. 30(2):526–543.
   PubMed Web of Science ®Google Scholar
• Qiu Z, Dong J, Xue C, Li X, Liu K, Liu B, Cheng J, Huang F. 2020. Liuwei Dihuang Pills alleviate the polycystic ovary syndrome with improved insulin sensitivity through PI3K/Akt signaling pathway. J Ethnopharmacol. 250:111965.
   PubMed Web of Science ®Google Scholar
• Shafienia H, Montazeri F, Heydari L, Khalili MA, Mazloomzadeh S, Sheikhha MH, Biglari A. 2022. Target gene repression mediated by miR-144 and miR-224 in cumulus cells is related to the success of oocyte in vitro maturation and fertilization in patients with polycystic ovary syndrome (PCOS). Reprod Fertil Dev. 34(17):1089–1098.
   PubMed Web of Science ®Google Scholar
• Tsuzuki M, Watanabe Y. 2017. Profiling new small RNA sequences. Methods Mol Biol. 1456:177–188.
   PubMedGoogle Scholar
• Wang S, Wang C, Liu O, Hu Y, Li X, Lin B. 2022. miRNA-651-3p regulates EMT in ovarian cancer cells by targeting ZNF703 and via the MEK/ERK pathway. Biochem Biophys Res Commun. 619:76–83.
   PubMed Web of Science ®Google Scholar
• Wang W, Zheng J, Cui N, Jiang L, Zhou H, Zhang D, Hao G. 2019. Baicalin ameliorates polycystic ovary syndrome through AMP-activated protein kinase. J Ovarian Res. 12(1):109.
   PubMed Web of Science ®Google Scholar
• Wei Q, Hao X, Lau BW, Wang S, Li Y. 2022. Baicalin regulates stem cells as a creative point in the treatment of climacteric syndrome. Front Pharmacol. 13:986436.
   PubMed Web of Science ®Google Scholar
• Wei Y, Wang Z, Wei L, Li S, Qiu X, Liu C. 2021. MicroRNA-874-3p promotes testosterone-induced granulosa cell apoptosis by suppressing HDAC1-mediated p53 deacetylation. Exp Ther Med. 21(4):359.
   PubMed Web of Science ®Google Scholar
• Xia B, Lin M, Dong W, Chen H, Li B, Zhang X, Hou Y, Lou G. 2018. Upregulation of miR-874-3p and miR-874-5p inhibits epithelial ovarian cancer malignancy via SIK2. J Biochem Mol Toxicol. 32(8):e22168.
   PubMed Web of Science ®Google Scholar
• Xu Y, Tang J, Guo Q, Xu Y, Yan K, Wu L, Xie K, Zhu A, Rong X, Ye D, et al. 2021. Traditional Chinese medicine formula FTZ protects against polycystic ovary syndrome through modulating adiponectin-mediated fat-ovary crosstalk in mice. J Ethnopharmacol. 268:113587.
   PubMed Web of Science ®Google Scholar
• Yi W, Li X, Chen K, Li J, Chen K, Pan A. 2020. Effect of rNA interference on Oatp3a1 gene expression on biological characteristics and immune factors of ovarian granulosa cells in rats with PCOS. Am J Transl Res. 12:4659–4668.
   PubMed Web of Science ®Google Scholar
• Yu J, Liu Y, Zhang D, Zhai D, Song L, Cai Z, Yu C. 2019. Baicalin inhibits recruitment of GATA1 to the HSD3B2 promoter and reverses hyperandrogenism of PCOS. J Endocrinol. 240(3):497–507.
   Web of Science ®Google Scholar
• Yu Y, Li G, He X, Lin Y, Chen Z, Lin X, Xu H. 2021. MicroRNA-21 regulate the cell apoptosis and cell proliferation of polycystic ovary syndrome (PCOS) granulosa cells through target toll like receptor TLR8. Bioengineered. 12(1):5789–5796.
   PubMed Web of Science ®Google Scholar
• Zhang J, Bao Y, Zhou X, Zheng L. 2019. Polycystic ovary syndrome and mitochondrial dysfunction. Reprod Biol Endocrinol. 17(1):67.
   PubMed Web of Science ®Google Scholar
• Zhang J, Xu Y, Liu H, Pan Z. 2019. MicroRNAs in ovarian follicular atresia and granulosa cell apoptosis. Reprod Biol Endocrinol. 17(1):9.
   PubMedGoogle Scholar
• Zhao H, Zhou D, Chen Y, Liu D, Chu S, Zhang S. 2017. Beneficial effects of Heqi san on rat model of polycystic ovary syndrome through the PI3K/AKT pathway. Daru. 25(1):21.
   PubMedGoogle Scholar
• Zong ZH, Du YP, Guan X, Chen S, Zhao Y. 2019. CircWHSC1 promotes ovarian cancer progression by regulating MUC1 and hTERT through sponging miR-145 and miR-1182. J Exp Clin Cancer Res. 38(1):437.
   PubMed Web of Science ®Google Scholar