Liver protective effect of chloroform extract of Bauhinia purpurea leaves is attributed partly to its antioxidant action and the presence of flavonoids

References

• Ahmed OM, Fahim HI, Ahmed HY, Al-Muzafar HM, Ahmed RR, Amin KA, El-Nahass ES, Abdelazeem WH. 2019. The preventive effects and the mechanisms of action of navel orange peel hydroethanolic extract, naringin, and naringenin in N-acetyl-p-aminophenol-induced liver injury in Wistar rats. Oxid Med Cell Longev. 2019:2745352. doi:10.1155/2019/2745352.
   PubMed Web of Science ®Google Scholar
• Aldini G, Altomare A, Baron G, Vistoli G, Carini M, Borsani L, Sergio F. 2018. N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why. Free Radic Res. 52(7):751–762. doi:10.1080/10715762.2018.1468564.
   PubMed Web of Science ®Google Scholar
• Ananth KV, Asad M, Prem Kumar N, Asdaq SM, Rao GS. 2010. Evaluation of wound healing potential of Bauhinia purpurea leaf extracts in rats. Indian J Pharm Sci. 72(1):122–127. doi:10.4103/0250-474X.62250.
   PubMed Web of Science ®Google Scholar
• Aryal S, Baniya MK, Danekhu K, Kunwar P, Gurung R, Koirala N. 2019. Total phenolic content, flavonoid content and antioxidant potential of wild vegetables from western Nepal. Plants. 8(4):96. doi:10.3390/plants8040096.
   Web of Science ®Google Scholar
• Babbar N, Oberoi HS, Sandhu SK. 2015. Therapeutic and nutraceutical potential of bioactive compounds extracted from fruit residues. Crit Rev Food Sci Nutr. 55(3):319–337. doi:10.1080/10408398.2011.653734.
   PubMed Web of Science ®Google Scholar
• Barraza-Garza G, Pérez-León JA, Castillo-Michel H, de la Rosa LA, Martinez-Martinez A, Cotte M, Alvarez-Parrilla E. 2020. Antioxidant effect of phenolic compounds (PC) at different concentrations in IEC-6 cells: a spectroscopic analysis. Spectrochim Acta A Mol Biomol Spectrosc. 227:117570. doi:10.1016/j.saa.2019.117570.
   PubMed Web of Science ®Google Scholar
• Blois MS. 1958. Antioxidant determinations by the use of a stable free radical. Nature. 181(4617):1199–1200. doi:10.1038/1811199a0.
   Web of Science ®Google Scholar
• Boonphong S, Puangsombat P, Baramee A, Mahidol C, Ruchirawat S, Kittakoop P. 2007. Bioactive compounds from Bauhinia purpurea possessing antimalarial, antimycobacterial, antifungal, anti-inflammatory, and cytotoxic activities. J Nat Prod. 70(5):795–801. doi:10.1021/np070010e.
   PubMed Web of Science ®Google Scholar
• Caparrotta TM, Antoine DJ, Dear JW. 2018. Are some people at increased risk of paracetamol-induced liver injury? A critical review of the literature. Eur J Clin Pharmacol. 74(2):147–160. doi:10.1007/s00228-017-2356-6.
   PubMed Web of Science ®Google Scholar
• Chang WS, Lin CC, Chuang SC, Chiang HC. 1996. Superoxide anion scavenging effect of coumarins. Am J Chin Med. 24(1):11–17. doi:10.1142/S0192415X96000037.
   PubMed Web of Science ®Google Scholar
• El-Beshbishy HA, Mohamadin AM, Nagy AA, Abdel-Naim AB. 2010. Amelioration of tamoxifen-induced liver injury in rats by grape seed extract, black seed extract and curcumin. Indian J Exp Biol. 48(3):280–288.
   PubMed Web of Science ®Google Scholar
• Gan RY, Chan CL, Yang QQ, Li HB, Zhang D, Ge YY, Gunaratne A, Ge J, Corke H. 2019. Bioactive compounds and beneficial functions of sprouted grains. In: Feng H, Nemzer B, DeVries JW, editors. Sprouted Grains: nutritional value, production and application, 1st ed. Duxford, UK: Woodhead Publishing; p. 191–246.
   Google Scholar
• Garcia-Cortes M, Robles-Diaz M, Stephens C, Ortega-Alonso A, Lucena MI, Andrade RJ. 2020. Drug induced liver injury: an update. Arch Toxicol. 94(10):3381–3407. doi:10.1007/s00204-020-02885-1.
   PubMed Web of Science ®Google Scholar
• Guo H, Sun J, Li D, Hu Y, Yu X, Hua H, Jing X, Chen F, Jia Z, Xu J. 2019. Shikonin attenuates acetaminophen-induced acute liver injury via inhibition of oxidative stress and inflammation. Biomed Pharmacother. 112:108704. doi:10.1016/j.biopha.2019.108704.
   PubMed Web of Science ®Google Scholar
• Hidalgo M, Sánchez-Moreno C, Pascual-Teresa S. 2010. Flavonoid–flavonoid interaction and its effect on their antioxidant activity. Food Chem. 121(3):691–696. doi:10.1016/j.foodchem.2009.12.097.
   Web of Science ®Google Scholar
• Huang D, Ou B, Hampsch-Woodill M, Flanagan JA, Prior RL. 2002. High-throughput assay of oxygen radical absorbance capacity (ORAC) using a multichannel liquid handling system coupled with a microplate fluorescence reader in 96-well format. J Agric Food Chem. 50(16):4437–4444. doi:10.1021/jf0201529.
   PubMed Web of Science ®Google Scholar
• Hukkinen M, Mutanen A, Nissinen M, Merras-Salmio L, Gylling H, Pakarinen MP. 2017. Parenteral plant sterols accumulate in the liver reflecting their increased serum levels and portal inflammation in children with intestinal failure. JPEN J Parenter Enteral Nutr. 41(6):1014–1022. doi:10.1177/0148607116637855.
   PubMed Web of Science ®Google Scholar
• Ismail Suhaimy NW, Noor Azmi AK, Mohtarrudin N, Omar MH, Tohid SF, Cheema MS, Teh LK, Salleh MZ, Zakaria ZA. 2017. Semipurified ethyl acetate partition of methanolic extract of Melastoma malabathricum leaves exerts gastroprotective activity partly via its antioxidant-antisecretory-anti-inflammatory action and synergistic action of several flavonoid-based compounds. Oxid Med Cell Longev. 2017:6542631. doi:10.1155/2017/6542631.
   PubMed Web of Science ®Google Scholar
• Kaurinovic B, Vastag D. 2019. Flavonoids and phenolic acids as potential natural antioxidants. In: Shalaby E, editor. Antioxidants, 1st ed. London, UK: IntechOpen; p. 127–146.
   Google Scholar
• Kullak-Ublick GA, Andrade RJ, Merz M, End P, Benesic A, Gerbes AL, Aithal G. 2017. Drug-induced liver injury: recent advances in diagnosis and risk assessment. Gut. 66(6):1154–1164. doi:10.1136/gutjnl-2016-313369.
   PubMed Web of Science ®Google Scholar
• Kumar S, Kumar R, Gupta YK, Singh S. 2019. In vivo anti-arthritic activity of Bauhinia purpurea Linn. bark extract. Indian J Pharmacol. 51(1):25–30. doi:10.4103/ijp.IJP_107_16.
   PubMed Web of Science ®Google Scholar
• Lakshmi BV, Neelima N, Kasthuri N, Umarani V, Sudhakar M. 2009. Protective effect of Bauhinia purpurea on gentamicin-induced nephrotoxicity in rats. Indian J Pharm Sci. 71(5):551–554. doi:10.4103/0250-474X.58196.
   PubMed Web of Science ®Google Scholar
• Lawal B, Shittu OK, Oibiokpa FI, Berinyuy EB, Mohammed H. 2017. African natural products with potential antioxidant and hepatoprotective properties: a review. Clin Phytosci. 2(1):1–66. doi:10.1186/s40816-016-0037-0.
   Google Scholar
• Mondal M, Hossain MM, Hasan MR, Tarun MTI, Islam MAF, Choudhuri MSK, Islam MT, Mubarak MS. 2020. Hepatoprotective and antioxidant capacity of Mallotus repandus ethyl acetate stem extract against d-galactosamine-induced hepatotoxicity in rats. ACS Omega. 5(12):6523–6531. doi:10.1021/acsomega.9b04189.
   PubMed Web of Science ®Google Scholar
• Nafees S, Ali N, Rashid S, Hasan SK, Sultana S. 2013. Chemopreventive effect of Bauhinia purpurea against chemically induced hepatocarcinogenesis via amelioration of oxidative damage, cell proliferation and induction of apoptosis in Wistar rats. Toxicol Int. 20(2):117–125. doi:10.4103/0971-6580.117252.
   PubMedGoogle Scholar
• Negi BS, Dave BP, Agarwal YK. 2012. Evaluation of antimicrobial activity of Bauhinia purpurea leaves under in vitro conditions. Indian J Microbiol. 52(3):360–365. doi:10.1007/s12088-012-0264-0.
   PubMed Web of Science ®Google Scholar
• Nowland MH, Hugunin KM, Rogers KL. 2011. Effects of short-term fasting in male Sprague-Dawley rats. Comp Med. 61(2):138–144.
   PubMed Web of Science ®Google Scholar
• Omachi F, Kaneko M, Iijima R, Watanabe M, Itagaki F. 2019. Relationship between the effects of food on the pharmacokinetics of oral antineoplastic drugs and their physicochemical properties. J Pharm Health Care Sci. 5:26. doi:10.1186/s40780-019-0155-1.
   PubMed Web of Science ®Google Scholar
• Ouyang X, Li X, Lu W, Zhao X, Chen D. 2018. A null B-ring improves the antioxidant levels of flavonol: a comparative study between galangin and 3,5,7-trihydroxychromone. Molecules. 23:3083. doi:10.3390/molecules23123083.
   PubMed Web of Science ®Google Scholar
• Platzer M, Kiese S, Tybussek T, Herfellner T, Schneider F, Schweiggert-Weisz U, Eisner P. 2022. Radical scavenging mechanisms of phenolic compounds: a quantitative structure-property relationship (QSPR) study. Front Nutr. 9:882458. doi:10.3389/fnut.2022.882458.
   PubMed Web of Science ®Google Scholar
• Pettit GR, Numata A, Iwamoto C, Usami Y, Yamada T, Ohishi H, Cragg GM. 2006. Antineoplastic agents. 551. Isolation and structures of bauhiniastatins 1-4 from Bauhinia purpurea. J Nat Prod. 69(3):323–327. doi:10.1021/np058075+.
   PubMed Web of Science ®Google Scholar
• Rakib A, Ahmed S, Islam MA, Haye A, Uddin SMN, Uddin MMN, Hossain MK, Paul A, Emran TB. 2020. Antipyretic and hepatoprotective potential of Tinospora crispa and investigation of possible lead compounds through in silico approaches. Food Sci Nutr. 8(1):547–556. doi:10.1002/fsn3.1339.
   PubMed Web of Science ®Google Scholar
• Rana MA, Khan RA, Nasiruddin M, Khan AA. 2016. Amelioration of cisplatin-induced nephrotoxicity by ethanolic extract of Bauhinia purpurea: an in vivo study in rats. Saudi J Kidney Dis Transpl. 27(1):41–48. doi:10.4103/1319-2442.174068.
   PubMed Web of Science ®Google Scholar
• Rashmi R, Bojan Magesh S, Mohanram Ramkumar K, Suryanarayanan S, Venkata SubbaRao M. 2018. Antioxidant potential of naringenin helps to protect liver tissue from streptozotocin-induced damage. Rep Biochem Mol Biol. 7(1):76–84.
   PubMed Web of Science ®Google Scholar
• Šalamon Š, Kramar B, Marolt TP, Poljšak B, Milisav I. 2019. Medical and dietary uses of N-acetylcysteine. Antioxidants. 8:pii: E111. doi:10.3390/antiox8050111.
   Web of Science ®Google Scholar
• Schmeda-Hirschmann G, Yesilada E. 2005. Traditional medicine and gastroprotective crude drugs. J Ethnopharmacol. 100(1–2):61–66. doi:10.1016/j.jep.2005.06.002.
   PubMed Web of Science ®Google Scholar
• Singleton VL, Rossi JA. Jr. 1965. Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am J Enol Vitic. 16(3):144–158. doi:10.5344/ajev.1965.16.3.144.
   Google Scholar
• Tsai MS, Chien CC, Lin TH, Liu CC, Liu RH, Su HL, Chiu YT, Wang SH. 2015. Galangin prevents acute hepatorenal toxicity in novel propacetamol-induced acetaminophen-overdosed mice. J Med Food. 18(11):1187–1197. doi:10.1089/jmf.2014.3328.
   PubMed Web of Science ®Google Scholar
• Ugwu CE, Suru SM. 2021. Medicinal plants with hepatoprotective potentials against carbon tetrachloride-induced toxicity: a review. Egypt Liver J. 11:88.
   Google Scholar
• Wahyuni W, Malaka MH, Yanti NA, Hartati R, Sukrasno S, Sahidin I. 2018. Radical scavenging and antibacterial activity of phenolic compounds from Anacardium occidentale L. stem barks from South East Sulawesi-Indonesia. Indian J Pharm Sci. 80(1):143–149.
   Web of Science ®Google Scholar
• Xu GB, Xiao YH, Zhang QY, Zhou M, Liao SG. 2018. Hepatoprotective natural triterpenoids. Eur J Med Chem. 145(1):691–716. doi:10.1016/j.ejmech.2018.01.011.
   PubMedGoogle Scholar
• Yahya F, Mamat SS, Kamarolzaman MFF, Seyedan AA, Jakius KF, Mahmood ND, Shahril MS, Suhaili Z, Mohtarrudin N, Susanti D, et al. 2013. Hepatoprotective activity of methanolic extract of Bauhinia purpurea leaves against paracetamol-induced hepatic damage in rats. Evid Based Complement Alternat Med. 2013:636580.,. doi:10.1155/2013/636580.
   PubMed Web of Science ®Google Scholar
• Yan M, Huo Y, Yin S, Hu H. 2018. Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions. Redox Biol. 17:274–283. doi:10.1016/j.redox.2018.04.019.
   PubMed Web of Science ®Google Scholar
• Yang Y, Gong XB, Huang LG, Wang ZX, Wan RZ, Zhang P, Zhang QY, Chen Z, Zhang BS. 2017. Diosmetin exerts anti-oxidative, anti-inflammatory and anti-apoptotic effects to protect against endotoxin-induced acute hepatic failure in mice. Oncotarget. 8(19):30723–30733. doi:10.18632/oncotarget.15413.
   PubMedGoogle Scholar
• Yin Y, Zhang Y, Li H, Zhao Y, Cai E, Zhu H, Li P, Liu J. 2019. Triterpenoids from fruits of Sorbus pohuashanensis inhibit acetaminophen-induced acute liver injury in mice. Biomed Pharmacother. 109(1):493–502. doi:10.1016/j.biopha.2018.10.160.
   PubMedGoogle Scholar
• Zakaria ZA, Abdul Hisam EE, Rofiee MS, Norhafizah M, Somchit MN, Teh LK, Salleh MZ. 2011. In vivo antiulcer activity of the aqueous extract of Bauhinia purpurea leaf. J Ethnopharmacol. 137(2):1047–1054. doi:10.1016/j.jep.2011.07.038.
   PubMed Web of Science ®Google Scholar
• Zhang Q, Ju Y, Ma Y, Wang T. 2018. N-Acetylcysteine improves oxidative stress and inflammatory response in patients with community acquired pneumonia: a randomized controlled trial. Medicine. 97(45):e13087. doi:10.1097/MD.0000000000013087.
   PubMed Web of Science ®Google Scholar
• Zuo AR, Dong HH, Yu YY, Shu QL, Zheng LX, Yu XY, Cao SW. 2018. The antityrosinase and antioxidant activities of flavonoids dominated by the number and location of phenolic hydroxyl groups. Chin Med. 13(1):51. doi:10.1186/s13020-018-0206-9.
   PubMedGoogle Scholar