Xiaojianzhong decoction attenuates aspirin-induced gastric mucosal injury via the PI3K/AKT/mTOR/ULK1 and AMPK/ULK1 pathways

References

• Bendriem RM, Singh S, Aleem AA, Antonetti DA, Ross ME. 2019. Tight junction protein occludin regulates progenitor self-renewal and survival in developing cortex. eLife. 8:e49376. DOI: 10.7554/eLife.49376.
   PubMed Web of Science ®Google Scholar
• Cao L, Zhang D, Chen J, Qin YY, Sheng R, Feng X, Chen Z, Ding Y, Li M, Qin ZH. 2017. G6PD plays a neuroprotective role in brain ischemia through promoting pentose phosphate pathway. Free Radic Biol Med. 112:433–444. DOI: 10.1016/j.freeradbiomed.2017.08.011.
   PubMed Web of Science ®Google Scholar
• Chen J, Wang L, Liu WH, Shi J, Zhong Y, Liu SJ, Liu SM. 2020. Aspirin protects human coronary artery endothelial cells by inducing autophagy. Physiol Int. 107(2):294–305. DOI: 10.1556/2060.2020.00029.
   PubMed Web of Science ®Google Scholar
• Chen X, Luo Y, Wang M, Sun L, Huang K, Li Y, Chen Y, Ding Y, Zhang X, Jiao L, et al. 2019. Wuhu decoction regulates dendritic cell autophagy in the treatment of respiratory syncytial virus (RSV)-induced mouse asthma by AMPK/ULK1 signaling pathway. Med Sci Monit. 25:5389–5400. DOI: 10.12659/MSM.917692.
   PubMed Web of Science ®Google Scholar
• Cheng YT, Lu CC, Yen GC. 2017. Phytochemicals enhance antioxidant enzyme expression to protect against NSAID-induced oxidative damage of the gastrointestinal mucosa. Mol Nutr Food Res. 61:10–1002. DOI: 10.1002/mnfr.201600659.
   Web of Science ®Google Scholar
• Condello M, Pellegrini E, Caraglia M, Meschini S. 2019. Targeting autophagy to overcome human diseases. Int J Mol Sci. 20:725. DOI: 10.3390/ijms20030725.
   PubMed Web of Science ®Google Scholar
• Din FV, Valanciute A, Houde VP, Zibrova D, Green KA, Sakamoto K, Alessi DR, Dunlop MG. 2012. Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells. Gastroenterology. 142(7):1504–1515.e3. DOI: 10.1053/j.gastro.2012.02.050.
   PubMed Web of Science ®Google Scholar
• Dorri M, Hashemitabar S, Hosseinzadeh H. 2018. Cinnamon (Cinnamomum zeylanicum) as an antidote or a protective agent against natural or chemical toxicities: a review. Drug Chem Toxicol. 41(3):338–351. DOI: 10.1080/01480545.2017.1417995.
   PubMed Web of Science ®Google Scholar
• Eccleston C, Cooper TE, Fisher E, Anderson B, Wilkinson NM. 2017. Non-steroidal anti-inflammatory drugs (NSAIDs) for chronic non-cancer pain in children and adolescents. Cochrane Database Syst Rev. 8(8):CD012537. DOI: 10.1002/14651858.CD012537.pub2.
   PubMedGoogle Scholar
• Edlich F. 2018. BCL-2 proteins and apoptosis: recent insights and unknowns. Biochem Biophys Res Commun. 500(1):26–34. DOI: 10.1016/j.bbrc.2017.06.190.
   PubMed Web of Science ®Google Scholar
• Fiala C, Pasic MD. 2020. Aspirin: bitter pill or miracle drug? Clin Biochem. 85:1–4. DOI: 10.1016/j.clinbiochem.2020.07.003.
   PubMed Web of Science ®Google Scholar
• Gao J, Chen X, Shan C, Wang Y, Li P, Shao K. 2021. Autophagy in cardiovascular diseases: role of noncoding RNAs. Mol Ther Nucleic Acids. 23:101–118. DOI: 10.1016/j.omtn.2020.10.039.
   PubMedGoogle Scholar
• Grilo AL, Mantalaris A. 2019. Apoptosis: a mammalian cell bioprocessing perspective. Biotechnol Adv. 37(3):459–475. DOI: 10.1016/j.biotechadv.2019.02.012.
   PubMed Web of Science ®Google Scholar
• Gu Q, Wang JD, Xia HH, Lin MC, He H, Zou B, Tu SP, Yang Y, Liu XG, Lam SK, et al. 2005. Activation of the caspase-8/Bid and Bax pathways in aspirin-induced apoptosis in gastric cancer. Carcinogenesis. 26(3):541–546. DOI: 10.1093/carcin/bgh345.
   PubMed Web of Science ®Google Scholar
• Guth PH, Aures D, Paulsen G. 1979. Topical aspirin plus HCl gastric lesions in the rat. Cytoprotective effect of prostaglandin, cimetidine, and probanthine. Gastroenterology. 76(1):88–93. DOI: 10.1016/S0016-5085(79)80133-X.
   PubMed Web of Science ®Google Scholar
• Haniadka R, Saldanha E, Sunita V, Palatty PL, Fayad R, Baliga MS. 2013. A review of the gastroprotective effects of ginger (Zingiber officinale Roscoe). Food Funct. 4(6):845–855. DOI: 10.1039/c3fo30337c.
   PubMed Web of Science ®Google Scholar
• Hernández C, Barrachina MD, Vallecillo-Hernández J, Álvarez Á, Ortiz-Masiá D, Cosín-Roger J, Esplugues JV, Calatayud S. 2016. Aspirin-induced gastrointestinal damage is associated with an inhibition of epithelial cell autophagy. J Gastroenterol. 51(7):691–701. DOI: 10.1007/s00535-015-1137-1.
   PubMed Web of Science ®Google Scholar
• Holczer M, Hajdú B, Lőrincz T, Szarka A, Bánhegyi G, Kapuy O. 2020. Fine-tuning of AMPK-ULK1-mTORC1 regulatory triangle is crucial for autophagy oscillation. Sci Rep. 10(1):17803. DOI: 10.1038/s41598-020-75030-8.
   PubMed Web of Science ®Google Scholar
• Huang CY, Deng JS, Huang WC, Jiang WP, Huang GJ. 2020. Attenuation of lipopolysaccharide-induced acute lung injury by hispolon in mice, through regulating the TLR4/PI3K/Akt/mTOR and Keap1/Nrf2/HO-1 pathways, and suppressing oxidative stress-mediated ER stress-induced apoptosis and autophagy. Nutrients. 12:1742. DOI: 10.3390/nu12061742.
   PubMed Web of Science ®Google Scholar
• Joshi SR, Kitagawa A, Jacob C, Hashimoto R, Dhagia V, Ramesh A, Zheng C, Zhang H, Jordan A, Waddell I, et al. 2020. Hypoxic activation of glucose-6-phosphate dehydrogenase controls the expression of genes involved in the pathogenesis of pulmonary hypertension through the regulation of DNA methylation. Am J Physiol Lung Cell Mol Physiol. 318(4):L773–L786. DOI: 10.1152/ajplung.00001.2020.
   PubMed Web of Science ®Google Scholar
• Kim KA, Kim D, Kim JH, Shin YJ, Kim ES, Akram M, Kim EH, Majid A, Baek SH, Bae ON. 2020. Autophagy-mediated occludin degradation contributes to blood–brain barrier disruption during ischemia in bEnd.3 brain endothelial cells and rat ischemic stroke models. Fluids Barriers CNS. 17(1):21. DOI: 10.1186/s12987-020-00182-8.
   PubMed Web of Science ®Google Scholar
• Kuo WT, Zuo L, Odenwald MA, Madha S, Singh G, Gurniak CB, Abraham C, Turner JR. 2021. The tight junction protein ZO-1 is dispensable for barrier function but critical for effective mucosal repair. Gastroenterology. 161(6):1924–1939. DOI: 10.1053/j.gastro.2021.08.047.
   PubMed Web of Science ®Google Scholar
• Kusuhara H, Matsuyuki H, Matsuura M, Imayoshi T, Okumoto T, Matsui H. 1998. Induction of apoptotic DNA fragmentation by nonsteroidal anti-inflammatory drugs in cultured rat gastric mucosal cells. Eur J Pharmacol. 360(2–3):273–280. DOI: 10.1016/s0014-2999(98)00679-7.
   PubMed Web of Science ®Google Scholar
• Kwon DA, Kim YS, Baek SH, Kim SK, Kim HK, Jo SK, Jung U, Park HR, Lee HS. 2019. Protective effects of a standardized extract (HemoHIM) using indomethacin-and ethanol/HCl-induced gastric mucosal injury models. Pharm Biol. 57(1):543–549. DOI: 10.1080/13880209.2019.1651875.
   PubMed Web of Science ®Google Scholar
• Lei Q, Huang X, Zheng L, Zheng F, Dong J, Chen F, Zeng W. 2022. Biosensors for caspase-3: from chemical methodologies to biomedical applications. Talanta. 240:123198. DOI: 10.1016/j.talanta.2021.123198.
   PubMed Web of Science ®Google Scholar
• Levine B, Kroemer G. 2008. Autophagy in the pathogenesis of disease. Cell. 132(1):27–42. DOI: 10.1016/j.cell.2007.12.018.
   PubMed Web of Science ®Google Scholar
• Li M, Lv R, Xu X, Ge Q, Lin S. 2021. Tricholoma matsutake-derived peptides show gastroprotective effects against ethanol-induced acute gastric injury. J Agric Food Chem. 69(49):14985–14994. DOI: 10.1021/acs.jafc.1c07050.
   PubMed Web of Science ®Google Scholar
• Mahmoud YI, Abd El-Ghffar EA. 2019. Spirulina ameliorates aspirin-induced gastric ulcer in albino mice by alleviating oxidative stress and inflammation. Biomed Pharmacother. 109:314–321. DOI: 10.1016/j.biopha.2018.10.118.
   PubMed Web of Science ®Google Scholar
• McIlwain DR, Berger T, Mak TW. 2015. Caspase functions in cell death and disease. Cold Spring Harb Perspect Biol. 7:a026716. DOI: 10.1101/cshperspect.a026716.
   PubMed Web of Science ®Google Scholar
• Mizushima N, Levine B. 2020. Autophagy in human diseases. N Engl J Med. 383(16):1564–1576. DOI: 10.1056/NEJMra2022774.
   PubMed Web of Science ®Google Scholar
• Mohamed DZ, El-Sisi AEE, Sokar SS, Shebl AM, Abu-Risha SE. 2021. Targeting autophagy to modulate hepatic ischemia/reperfusion injury: a comparative study between octreotide and melatonin as autophagy modulators through AMPK/PI3K/AKT/mTOR/ULK1 and Keap1/Nrf2 signaling pathways in rats. Eur J Pharmacol. 897:173920. DOI: 10.1016/j.ejphar.2021.173920.
   PubMed Web of Science ®Google Scholar
• Müller SL, Portwich M, Schmidt A, Utepbergenov DI, Huber O, Blasig IE, Krause G. 2005. The tight junction protein occludin and the adherens junction protein alpha-catenin share a common interaction mechanism with ZO-1. J Biol Chem. 280(5):3747–3756. DOI: 10.1074/jbc.M411365200.
   PubMed Web of Science ®Google Scholar
• Oncel S, Gupta R, Wang Q, Basson MD. 2021. ZINC40099027 promotes gastric mucosal repair in ongoing aspirin-associated gastric injury by activating focal adhesion kinase. Cells. 10:908. DOI: 10.3390/cells10040908.
   PubMed Web of Science ®Google Scholar
• Osanai M, Murata M, Nishikiori N, Chiba H, Kojima T, Sawada N. 2007. Occludin-mediated premature senescence is a fail-safe mechanism against tumorigenesis in breast carcinoma cells. Cancer Sci. 98(7):1027–1034. DOI: 10.1111/j.1349-7006.2007.00494.x.
   PubMed Web of Science ®Google Scholar
• Oshima T, Miwa H. 2016. Gastrointestinal mucosal barrier function and diseases. J Gastroenterol. 51(8):768–778. DOI: 10.1007/s00535-016-1207-z.
   PubMed Web of Science ®Google Scholar
• Park MY, Ha SE, Vetrivel P, Kim HH, Bhosale PB, Abusaliya A, Kim GS. 2021. Differences of key proteins between apoptosis and necroptosis. Biomed Res Int. 2021:3420168. DOI: 10.1155/2021/3420168.
   PubMed Web of Science ®Google Scholar
• Qiu Y, Lin X, Chen Z, Li B, Zhang Y. 2022. 5-Hydroxymethylfurfural exerts negative effects on gastric mucosal epithelial cells by inducing oxidative stress, apoptosis, and tight junction disruption. J Agric Food Chem. 70(12):3852–3861. DOI: 10.1021/acs.jafc.2c00269.
   PubMed Web of Science ®Google Scholar
• Ren S, Wei Y, Wang R, Wei S, Wen J, Yang T, Chen X, Wu S, Jing M, Li H, et al. 2020. Rutaecarpine ameliorates ethanol-induced gastric mucosal injury in mice by modulating genes related to inflammation, oxidative stress and apoptosis. Front Pharmacol. 11:600295. DOI: 10.3389/fphar.2020.600295.
   PubMed Web of Science ®Google Scholar
• Salah Khalil M. 2015. The postulated mechanism of the protective effect of ginger on the aspirin induced gastric ulcer: histological and immunohistochemical studies. Histol Histopathol. 30:855–864.
   PubMed Web of Science ®Google Scholar
• Scherz-Shouval R, Elazar Z. 2011. Regulation of autophagy by ROS: physiology and pathology. Trends Biochem Sci. 36(1):30–38. DOI: 10.1016/j.tibs.2010.07.007.
   PubMed Web of Science ®Google Scholar
• Stanton RC. 2012. Glucose-6-phosphate dehydrogenase, NADPH, and cell survival. IUBMB Life. 64(5):362–369. DOI: 10.1002/iub.1017.
   PubMed Web of Science ®Google Scholar
• Teng JF, Qin DL, Mei QB, Qiu WQ, Pan R, Xiong R, Zhao Y, Law BY, Wong VK, Tang Y, et al. 2019. Polyphyllin VI, a saponin from Trillium tschonoskii Maxim. induces apoptotic and autophagic cell death via the ROS triggered mTOR signaling pathway in non-small cell lung cancer. Pharmacol Res. 147:104396. DOI: 10.1016/j.phrs.2019.104396.
   PubMed Web of Science ®Google Scholar
• Tseng ZF, Hsu PI, Peng NJ, Kao SS, Tsay FW, Cheng JS, Chen WC, Tsai KF, Tang SY, Chuah SK, et al. 2021. Omeprazole vs famotidine for the prevention of gastroduodenal injury in high-risk users of low-dose aspirin: a randomized controlled trial. J Chin Med Assoc. 84(1):19–24. DOI: 10.1097/JCMA.0000000000000465.
   PubMed Web of Science ®Google Scholar
• Wang K. 2015. Autophagy and apoptosis in liver injury. Cell Cycle. 14(11):1631–1642. DOI: 10.1080/15384101.2015.1038685.
   PubMed Web of Science ®Google Scholar
• Yang L, Meng H, Yang M. 2016. Autophagy protects osteoblasts from advanced glycation end products-induced apoptosis through intracellular reactive oxygen species. J Mol Endocrinol. 56(4):291–300. DOI: 10.1530/JME-15-0267.
   PubMed Web of Science ®Google Scholar
• Yang Y, Wang S, Bao YR, Li TJ, Yang GL, Chang X, Meng XS. 2017. Anti-ulcer effect and potential mechanism of licoflavone by regulating inflammation mediators and amino acid metabolism. J Ethnopharmacol. 199:175–182. DOI: 10.1016/j.jep.2017.01.053.
   PubMed Web of Science ®Google Scholar
• Yu Y, Shiou SR, Guo Y, Lu L, Westerhoff M, Sun J, Petrof EO, Claud EC. 2013. Erythropoietin protects epithelial cells from excessive autophagy and apoptosis in experimental neonatal necrotizing enterocolitis. PLOS One. 8(7):e69620. DOI: 10.1371/journal.pone.0069620.
   PubMed Web of Science ®Google Scholar
• Zhang MH, Feng L, Zhu MM, Gu JF, Wu C, Jia XB. 2013. Antioxidative and anti-inflammatory activities of paeoniflorin and oxypaeoniflora on AGEs-induced mesangial cell damage. Planta Med. 79(14):1319–1323. DOI: 10.1055/s-0033-1350649.
   PubMed Web of Science ®Google Scholar
• Zhu J, Chen Y, Ji Y, Yu Y, Jin Y, Zhang X, Zhou J. 2018. Gemcitabine induces apoptosis and autophagy via the AMPK/mTOR signaling pathway in pancreatic cancer cells. Biotechnol Appl Biochem. 65(5):665–671. DOI: 10.1002/bab.1657.
   PubMed Web of Science ®Google Scholar