Nardostachys jatamansi and levodopa combination alleviates Parkinson’s disease symptoms in rats through activation of Nrf2 and inhibition of NLRP3 signaling pathways

References

• Arab HH, Safar MM, Shahin NN. 2021. Targeting ROS-dependent AKT/GSK-3β/NF-κB and DJ-1/Nrf2 pathways by dapagliflozin attenuates neuronal injury and motor dysfunction in rotenone-induced Parkinson’s disease rat model. ACS Chem Neurosci. 12(4):689–703. doi:10.1021/acschemneuro.0c00722.
   PubMed Web of Science ®Google Scholar
• Astradsson A, Jenkins BG, Choi JK, Hallett PJ, Levesque MA, McDowell JS, Brownell AL, Spealman RD, Isacson O. 2009. The blood-brain barrier is intact after levodopa-induced dyskinesias in Parkinsonian primates–evidence from in vivo neuroimaging studies. Neurobiol Dis. 35(3):348–351. doi:10.1016/j.nbd.2009.05.018.
   PubMed Web of Science ®Google Scholar
• Bezard E. 2013. Experimental reappraisal of continuous dopaminergic stimulation against L-dopa-induced dyskinesia. Mov Disord. 28(8):1021–1022. doi:10.1002/mds.25251.
   PubMed Web of Science ®Google Scholar
• Bhakkiyalakshmi E, Dineshkumar K, Karthik S, Sireesh D, Hopper W, Paulmurugan R, Ramkumar KM. 2016. Pterostilbene-mediated Nrf2 activation: mechanistic insights on Keap1: nrf2 interface. Bioorg Med Chem. 24(16):3378–3386. doi:10.1016/j.bmc.2016.05.011.
   PubMed Web of Science ®Google Scholar
• Bian H, Wang G, Huang J, Liang L, Zheng Y, Wei Y, Wang H, Xiao L, Wang H. 2020. Dihydrolipoic acid protects against lipopolysaccharide-induced behavioral deficits and neuroinflammation via regulation of Nrf2/HO-1/NLRP3 signaling in rat. J Neuroinflammation. 17(1):166–178. doi:10.1186/s12974-020-01836-y.
   PubMed Web of Science ®Google Scholar
• Bian LH, Yao ZW, Wang ZY, Wang XM, Li QY, Yang X, Li JY, Wei XJ, Wan GH, Wang YQ, et al. 2022. Nardosinone regulates the slc38a2 gene to alleviate Parkinson’s symptoms in rats through the GABAergic synaptic and cAMP pathways. Biomed Pharmacother. 153:113269. doi:10.1016/j.biopha.2022.113269.
   PubMed Web of Science ®Google Scholar
• Bian LH, Yao ZW, Zhao CB, Li QY, Shi JL, Guo JY. 2021. Nardosinone alleviates Parkinson’s disease symptoms in mice by regulating dopamine D2 receptor. Evid Based Complement Alternat Med. 2021:6686965. doi:10.1155/2021/6686965.
   PubMed Web of Science ®Google Scholar
• Bu XL, Wang X, Xiang Y, Shen LL, Wang QH, Liu YH, Jiao SS, Wang YR, Cao HY, Yi X, et al. 2015. The association between infectious burden and Parkinson’s disease: a case-control study. Parkinsonism Relat Disord. 21(8):877–881. doi:10.1016/j.parkreldis.2015.05.015.
   PubMed Web of Science ®Google Scholar
• Cuevas C, Huenchuguala S, Muñoz P, Villa M, Paris I, Mannervik B, Segura-Aguilar J. 2015. Glutathione transferase-M2-2 secreted from glioblastoma cell protects SH-SY5Y cells from aminochrome neurotoxicity. Neurotox Res. 27(3):217–228. doi:10.1007/s12640-014-9500-1.
   PubMed Web of Science ®Google Scholar
• de Araújo DP, Nogueira PCN, Santos ADC, Costa RO, de Lucena JD, Jataí Gadelha-Filho CV, Lima FAV, Neves KRT, Leal L, Silveira ER, et al. 2018. Aspidosperma pyrifolium Mart: neuroprotective, antioxidant and anti-inflammatory effects in a Parkinson’s disease model in rats. J Pharm Pharmacol. 70(6):787–796. doi:10.1111/jphp.12866.
   PubMed Web of Science ®Google Scholar
• de Farias CC, Maes M, Bonifácio KL, Bortolasci CC, de Souza Nogueira A, Brinholi FF, Matsumoto AK, do Nascimento MA, de Melo LB, Nixdorf SL, et al. 2016. Highly specific changes in antioxidant levels and lipid peroxidation in Parkinson’s disease and its progression: disease and staging biomarkers and new drug targets. Neurosci Lett. 617:66–71. doi:10.1016/j.neulet.2016.02.011.
   PubMed Web of Science ®Google Scholar
• Fan Z, Liang Z, Yang H, Pan Y, Zheng Y, Wang X. 2017. Tenuigenin protects dopaminergic neurons from inflammation via suppressing NLRP3 inflammasome activation in microglia. J Neuroinflammation. 14(1):256–267. doi:10.1186/s12974-017-1036-x.
   PubMedGoogle Scholar
• Huang L, Deng M, Zhang S, Lu S, Gui X, Fang Y. 2017. β-Asarone and levodopa coadministration increases striatal levels of dopamine and levodopa and improves behavioral competence in Parkinson’s rat by enhancing dopa decarboxylase activity. Biomed Pharmacother. 94:666–678. doi:10.1016/j.biopha.2017.07.125.
   PubMed Web of Science ®Google Scholar
• Klein A, Gidyk DC, Shriner AM, Colwell KL, Tatton NA, Tatton WG, Metz GA. 2011. Dose-dependent loss of motor function after unilateral medial forebrain bundle rotenone lesion in rats: a cautionary note. Behav Brain Res. 222(1):33–42. doi:10.1016/j.bbr.2011.03.018.
   PubMed Web of Science ®Google Scholar
• Kobayashi M, Yamamoto M. 2006. Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species. Adv Enzyme Regul. 46:113–140. doi:10.1016/j.advenzreg.2006.01.007.
   PubMedGoogle Scholar
• Kwon DK, Kwatra M, Wang J, Ko HS. 2022. Levodopa-induced dyskinesia in Parkinson’s disease: pathogenesis and emerging treatment strategies. Cells. 11:3736. doi:10.3390/cells11233736.
   PubMed Web of Science ®Google Scholar
• Li ZH, Li W, Shi JL, Tang MK. 2014. Nardosinone improves the proliferation, migration and selective differentiation of mouse embryonic neural stem cells. PLoS One. 9(3):e91260. doi:10.1371/journal.pone.0091260.
   PubMed Web of Science ®Google Scholar
• Lin ZH, Liu Y, Xue NJ, Zheng R, Yan YQ, Wang ZX, Li YL, Ying CZ, Song Z, Tian J, et al. 2022. Quercetin protects against MPP+/MPTP-induced dopaminergic neuron death in Parkinson’s disease by inhibiting ferroptosis. Oxid Med Cell Longev. 2022:7769355.
   PubMed Web of Science ®Google Scholar
• Liu X, Wei F, Liu H, Zhao S, Du G, Qin X. 2021. Integrating hippocampal metabolomics and network pharmacology deciphers the antidepressant mechanisms of Xiaoyaosan. J Ethnopharmacol. 268:113549. doi:10.1016/j.jep.2020.113549.
   PubMed Web of Science ®Google Scholar
• Li JY, Wei XJ, Wan GH, Yang X, Yu JH, Liu JF, Jin ZX, Wang YQ, Lyu Y, Shi JL. 2022. [Mechanism of Nardostachys jatamansi on levodopa-induced dyskinesia in rats based on Nrf2/D1R-ERK signaling pathway]. Chinese Trad Herbal Drugs. 53:134–142.
   Google Scholar
• Lyle N, Gomes A, Sur T, Munshi S, Paul S, Chatterjee S, Bhattacharyya D. 2009. The role of antioxidant properties of Nardostachys jatamansi in alleviation of the symptoms of the chronic fatigue syndrome. Behav Brain Res. 202(2):285–290. doi:10.1016/j.bbr.2009.04.005.
   PubMed Web of Science ®Google Scholar
• Ma Q. 2013. Role of nrf2 in oxidative stress and toxicity. Annu Rev Pharmacol Toxicol. 53:401–426. doi:10.1146/annurev-pharmtox-011112-140320.
   PubMed Web of Science ®Google Scholar
• Martinez EM, Young AL, Patankar YR, Berwin BL, Wang L, von Herrmann KM, Weier JM, Havrda MC. 2017. Editor’s highlight: nlrp3 is required for inflammatory changes and nigral cell loss resulting from chronic intragastric rotenone exposure in mice. Toxicol Sci. 159(1):64–75. doi:10.1093/toxsci/kfx117.
   PubMed Web of Science ®Google Scholar
• Maturana MG, Pinheiro AS, de Souza TL, Follmer C. 2015. Unveiling the role of the pesticides paraquat and rotenone on α-synuclein fibrillation in vitro. Neurotoxicology. 46:35–43. doi:10.1016/j.neuro.2014.11.006.
   PubMed Web of Science ®Google Scholar
• McCoy MK, Martinez TN, Ruhn KA, Szymkowski DE, Smith CG, Botterman BR, Tansey KE, Tansey MG. 2006. Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson’s disease. J Neurosci. 26(37):9365–9375. doi:10.1523/JNEUROSCI.1504-06.2006.
   PubMed Web of Science ®Google Scholar
• Nam HY, Nam JH, Yoon G, Lee JY, Nam Y, Kang HJ, Cho HJ, Kim J, Hoe HS. 2018. Ibrutinib suppresses LPS-induced neuroinflammatory responses in BV2 microglial cells and wild-type mice. J Neuroinflammation. 15(1):271. doi:10.1186/s12974-018-1308-0.
   PubMed Web of Science ®Google Scholar
• Nevalainen N, Lundblad M, Gerhardt GA, Strömberg I. 2013. Striatal glutamate release in L-DOPA-induced dyskinetic animals. PLoS One. 8(2):e55706. doi:10.1371/journal.pone.0055706.
   PubMed Web of Science ®Google Scholar
• Nuvolone M, Sorce S, Schwarz P, Aguzzi A. 2015. Prion pathogenesis in the absence of NLRP3/ASC inflammasomes. PLoS One. 10(2):e0117208. doi:10.1371/journal.pone.0117208.
   PubMed Web of Science ®Google Scholar
• Olanow CW. 2015. Levodopa: effect on cell death and the natural history of Parkinson’s disease. Mov Disord. 30(1):37–44. doi:10.1002/mds.26119.
   PubMed Web of Science ®Google Scholar
• Sayed AS, El Sayed NS, Budzyńska B, Skalicka-Woźniak K, Ahmed MK, Kandil EA. 2022. Xanthotoxin modulates oxidative stress, inflammation, and MAPK signaling in a rotenone-induced Parkinson’s disease model. Life Sci. 310:121129. doi:10.1016/j.lfs.2022.121129.
   PubMed Web of Science ®Google Scholar
• Shin JY, Bae GS, Choi SB, Jo IJ, Kim DG, Lee DS, An RB, Oh H, Kim YC, Shin YK, et al. 2015. Anti-inflammatory effect of desoxo-narchinol-A isolated from Nardostachys jatamansi against lipopolysaccharide. Int Immunopharmacol. 29(2):730–738. doi:10.1016/j.intimp.2015.09.002.
   PubMed Web of Science ®Google Scholar
• Stansley BJ, Yamamoto BK. 2013. L-DOPA-induced dopamine synthesis and oxidative stress in serotonergic cells. Neuropharmacology. 67:243–251. doi:10.1016/j.neuropharm.2012.11.010.
   PubMed Web of Science ®Google Scholar
• Todorovic M, Wood SA, Mellick GD. 2016. Nrf2: a modulator of Parkinson’s disease? J Neural Transm (Vienna). 123(6):611–619. doi:10.1007/s00702-016-1563-0.
   PubMed Web of Science ®Google Scholar
• Toulouse A, Sullivan AM. 2008. Progress in Parkinson’s disease-where do we stand? Prog Neurobiol. 85(4):376–392. doi:10.1016/j.pneurobio.2008.05.003.
   PubMed Web of Science ®Google Scholar
• Wan GH, Wei XJ, Li JY, Yang X, Yu JH, Liu JF, Wang YQ, Lyu Y, Jin ZX, Shi JL. 2022. Effects of Nardostachys jatamansi on gut microbiota of rats with Parkinson’s disease. China J Chinese Materia Med. 47:499–510.
   Google Scholar
• Wijeyekoon RS, Moore SF, Farrell K, Breen DP, Barker RA, Williams-Gray CH. 2020. Cerebrospinal fluid cytokines and neurodegeneration-associated proteins in Parkinson’s disease. Mov Disord. 35(6):1062–1066. doi:10.1002/mds.28015.
   PubMed Web of Science ®Google Scholar
• Yan J, Li J, Zhang L, Sun Y, Jiang J, Huang Y, Xu H, Jiang H, Hu R. 2018. Nrf2 protects against acute lung injury and inflammation by modulating TLR4 and Akt signaling. Free Radic Biol Med. 121:78–85. doi:10.1016/j.freeradbiomed.2018.04.557.
   PubMed Web of Science ®Google Scholar
• Ye J, Jiang Z, Chen X, Liu M, Li J, Liu N. 2016. Electron transport chain inhibitors induce microglia activation through enhancing mitochondrial reactive oxygen species production. Exp Cell Res. 340(2):315–326. doi:10.1016/j.yexcr.2015.10.026.
   PubMed Web of Science ®Google Scholar
• Zhang X, Liu Y, Deng G, Huang B, Kai G, Chen K, Li J. 2021. A purified biflavonoid extract from Selaginella moellendorffii alleviates gout arthritis via NLRP3/ASC/Caspase-1 axis suppression. Front Pharmacol. 12:676297. doi:10.3389/fphar.2021.676297.
   PubMed Web of Science ®Google Scholar
• Zhang W, Tao WW, Zhou J, Wu CY, Long F, Shen H, Zhu H, Mao Q, Xu J, Li SL, et al. 2021. Structural analogues in herbal medicine ginseng hit a shared target to achieve cumulative bioactivity. Commun Biol. 4(1):549–562. doi:10.1038/s42003-021-02084-3.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Wu Q, Zhang L, Wang Q, Yang Z, Liu J, Feng L. 2019. Caffeic acid reduces A53T α-synuclein by activating JNK/Bcl-2-mediated autophagy in vitro and improves behaviour and protects dopaminergic neurons in a mouse model of Parkinson’s disease. Pharmacol Res. 150:104538. doi:10.1016/j.phrs.2019.104538.
   PubMed Web of Science ®Google Scholar