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Research Article

Saponins from Panax japonicus improve neuronal mitochondrial injury of aging rats

, , , , , , , & ORCID Icon show all
Pages 1401-1412 | Received 19 Jan 2023, Accepted 31 Jul 2023, Published online: 04 Sep 2023

References

  • Al-Baqami NM, Hamza RZ. 2021. Synergistic antioxidant capacities of vanillin and chitosan nanoparticles against reactive oxygen species, hepatotoxicity, and genotoxicity induced by aging in male Wistar rats. Hum Exp Toxicol. 40(1):183–202. doi: 10.1177/0960327120943267.
  • Ali T, Kim MO. 2015. Melatonin ameliorates amyloid beta-induced memory deficits, tau hyperphosphorylation and neurodegeneration via PI3/Akt/GSk3β pathway in the mouse hippocampus. J Pineal Res. 59(1):47–59. doi: 10.1111/jpi.12238.
  • Balog J, Mehta SL, Vemuganti R. 2016. Mitochondrial fission and fusion in secondary brain damage after CNS insults. J Cereb Blood Flow Metab. 36(12):2022–2033. doi: 10.1177/0271678X16671528.
  • Banji OJF, Banji D, Ch K. 2014. Curcumin and hesperidin improve cognition by suppressing mitochondrial dysfunction and apoptosis induced by d-galactose in rat brain. Food Chem Toxicol. 74:51–59. doi: 10.1016/j.fct.2014.08.020.
  • Chen Q, Wang Y, Jiao F, Shi C, Pei M, Wang L, Gong Z. 2020. Histone deacetylase 6 inhibitor ACY1215 ameliorates mitochondrial dynamic and function injury in hepatocytes by activating AMPK signaling pathway in acute liver failure mice. Histol Histopathol. 35:1047–1058.
  • Delmotte P, Marin Mathieu N, Sieck GC. 2021. TNFα induces mitochondrial fragmentation and biogenesis in human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 320(1):L137–L151. doi: 10.1152/ajplung.00305.2020.
  • Deng LL, Wan JZ, Yuan D, Zhang CC, Li G, Wang T. 2015. Protective effects of total saponins from Panax japonicus on H2O2 induced injury via mitochondria pathway in SH-SY5Y cells. Zhong Yao Cai. 38(8):1690–1693.
  • Deng LL, Yuan D, Zhou ZY, Wan JZ, Zhang CC, Liu CQ, Dun YY, Zhao HX, Zhao B, Yang YJ, et al. 2017. Saponins from Panax japonicus attenuate age-related neuroinflammation via regulation of the mitogen-activated protein kinase and nuclear factor kappa B signaling pathways. Neural Regen Res. 12(11):1877–1884. doi: 10.4103/1673-5374.219047.
  • Du F, Yu Q, Yan SJ, Hu G, Lue LF, Walker DG, Wu L, Yan SF, Tieu K, Yan SS. 2017. PINK1 signalling rescues amyloid pathology and mitochondrial dysfunction in Alzheimer’s disease. Brain. 140(12):3233–3251. doi: 10.1093/brain/awx258.
  • Durand MJ, Ait-Aissa K, Levchenko V, Staruschenko A, Gutterman DD, Beyer AM. 2019. Visualization and quantification of mitochondrial structure in the endothelium of intact arteries. Cardiovasc Res. 115(10):1546–1556. doi: 10.1093/cvr/cvy294.
  • Esencan E, Jiang Z, Wang T, Zhang M, Soylemez-Imamoglu G, Seli E. 2020. Impaired mitochondrial stress response due to CLPP deletion is associated with altered mitochondrial dynamics and increased apoptosis in cumulus cells. Reprod Sci. 27(2):621–630. doi: 10.1007/s43032-019-00063-y.
  • Friedland-Leuner K, Stockburger C, Denzer I, Eckert GP, Muller WE. 2014. Mitochondrial dysfunction: cause and consequence of Alzheimer’s disease. Prog Mol Biol Transl Sci. 127:183–210. doi: 10.1016/B978-0-12-394625-6.00007-6.
  • Giacomello M, Pyakurel A, Glytsou C, Scorrano L. 2020. The cell biology of mitochondrial membrane dynamics. Nat Rev Mol Cell Biol. 21(4):204–224. doi: 10.1038/s41580-020-0210-7.
  • He C, Yu Z, He Y, Xu C, Chang C, Yuan D. 2017. Purification of macroporous adsorption resin and decolorization of ion exchange resin of total saponins of Panax japonicus. Chia Tradit Herbal Drugs. 48:1146–1152.
  • Hou YJ, Dan XL, Babbar M, Wei Y, Hasselbalch SG, Croteau DL, Bohr VA. 2019. Ageing as a risk factor for neurodegenerative disease. Nat Rev Neurol. 15(10):565–581. doi: 10.1038/s41582-019-0244-7.
  • Juan SMA, Adlard PA. 2019. Ageing and Cognition. Subcell Biochem. 91:107–122. doi: 10.1007/978-981-13-3681-2_5.
  • Kou X, Li J, Liu X, Chang J, Zhao Q, Jia S, Fan J, Chen N. 2017. Swimming attenuated-galactose-induced brain aging via suppressing miR-34a-mediated autophagy impairment and abnormal mitochondrial dynamics. J Appl Physiol. 122(6):1462–1469. doi: 10.1152/japplphysiol.00018.2017.
  • Li R, Robinson M, Ding X, Geetha T, Al-Nakkash L, Broderick TL, Babu JR. 2022. Genistein: a focus on several neurodegenerative diseases. J Food Biochem. 46(7):e14155. doi: 10.1111/jfbc.14155.
  • Liu X, Cai Y, Cao X, Wei R, Li H, Zhou X, Zhang K, Wu S, Qian Q, Cheng B, et al. 2012. A new oncolytic adenoviral vector carrying dual tumour suppressor genes shows potent anti-tumour effect. J Cell Mol Med. 16(6):1298–1309. doi: 10.1111/j.1582-4934.2011.01396.x.
  • Maharajan N, Cho GW. 2021. Camphorquinone promotes the antisenescence effect via activating AMPK/SIRT1 in stem cells and d-galactose-induced aging mice. Antioxidants. 10:1916. doi: 10.3390/antiox10121916.
  • Manczak M, Calkins MJ, Hemachandra RP. 2011. Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer’s disease: implications for neuronal damage. Hum Mol Genet. 20(13):2495–2509. doi: 10.1093/hmg/ddr139.
  • Marcos-Rabal P, González-Fuentes J, Castro-Vázquez L, Lozano MV, Rodríguez-Robledo V, Santander-Ortega MJ, Selva-Clemente J, Villaseca-González N, Del Mar Arroyo-Jiménez M. 2021. Neurodegenerative diseases: a multidisciplinary approach. Curr Pharm Des. 27(30):3305–3336. doi: 10.2174/1381612827666210608152745.
  • Mattson MP, Arumugam TV. 2018. Hallmarks of brain aging: adaptive and pathological modification by metabolic states. Cell Metab. 27(6):1176–1199. doi: 10.1016/j.cmet.2018.05.011.
  • Meng X, Wang M, Wang X, Sun G, Ye J, Xu H, Sun X. 2014. Suppression of NADPH oxidase- and mitochondrion-derived superoxide by notoginsenoside R1 protects against cerebral ischemia-reperfusion injury through estrogen receptor-dependent activation of Akt/Nrf2 pathways. Free Radic Res. 48(7):823–838. doi: 10.3109/10715762.2014.911853.
  • OuYang LN, Xiang DW, Wu X, Xiang DX. 2010. Research progress on chemical constituents and pharmacological activities of Panax japonicus. Chinese Trad Herbal Drugs. 41:1023–1027.
  • Panchal K, Tiwari AK. 2019. Mitochondrial dynamics, a key executioner in neurodegenerative diseases. Mitochondrion. 47:151–173. doi: 10.1016/j.mito.2018.11.002.
  • Rana A, Oliveira MP, Khamoui AV, Aparicio R, Rera M, Rossiter HB, Walker DW. 2017. Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster. Nat Commun. 8(1):448. doi: 10.1038/s41467-017-00525-4.
  • Rappold PM, Cui M, Grima JC, Fan RZ, de Mesy-Bentley KL, Chen L, Zhuang X, Bowers WJ, Tieu K. 2014. Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo. Nat Commun. 5(1):5244. doi: 10.1038/ncomms6244.
  • Reddy PH, Reddy TP. 2011. Mitochondria as a therapeutic target for aging and neurodegenerative diseases. Curr Alzheimer Res. 8(4):393–409. doi: 10.2174/156720511795745401.
  • Sebastian D, Palacin M, Zorzano A. 2017. Mitochondrial dynamics: coupling mitochondrial fitness with healthy aging. Trends Mol Med. 23(3):201–215. doi: 10.1016/j.molmed.2017.01.003.
  • Sharma A, Smith HJ, Yao P, Mair WB. 2019. Causal roles of mitochondrial dynamics in longevity and healthy aging. EMBO Rep. 20(12):e48395. doi: 10.15252/embr.201948395.
  • Sisalli MJ, Ianniello G, Savoia C, Cuomo O, Annunziato L, Scorziello A. 2020. Knocking-out the Siah2 E3 ubiquitin ligase prevents mitochondrial NCX3 degradation, regulates mitochondrial fission and fusion, and restores mitochondrial function in hypoxic neurons. Cell Commun Signal. 18(1):42. doi: 10.1186/s12964-020-0529-x.
  • Stavropoulos F, Sargiannidou I, Potamiti L, Kagiava A, Panayiotidis MI, Bae JH, Yeom SC, Lee JY, Kleopa KA. 2021. Aberrant mitochondrial dynamics and exacerbated response to neuroinflammation in a novel mouse model of CMT2A. Int J Mol Sci. 22:11569. doi: 10.3390/ijms222111569.
  • Wan JZ, Wang R, Zhou ZY, Deng LL, Zhang CC, Liu CQ, Zhao HX, Yuan CF, He YM, Dun YY, et al. 2020. Saponins of Panax japonicus confer neuroprotection against brain aging through mitochondrial related oxidative stress and autophagy in rats. Curr Pharm Biotechnol. 21(8):667–680. doi: 10.2174/1389201021666191216114815.
  • Wan JZ, Yuan D, Wang T. 2018. Study on the protective effect of Panax japonicus saponins on d-galactose induced SH-SY5Y neuron injury. Guizhou Med J. 42:387–389.
  • Wan JZ, Deng LL, Zhang CC, Yuan Q, Liu J, Dun YY, Zhou ZY, Zhao HX, Liu C, Yuan D, et al. 2016. Chikusetsu saponin V attenuates H2O2-induced oxidative stress in human neuroblastoma SH-SY5Y cells through Sirt1/PGC-1alpha/Mn-SOD signaling pathways. Can J Physiol Pharmacol. 94(9):919–928. doi: 10.1139/cjpp-2015-0262.
  • Wang K, Wu D, Ren X, Yu Q, Liu R, Huang S, Pan Y, Zhao S. 2021. Notoginsenoside R1 alleviates T EGDMA-induced mitochondrial apoptosis in preodontoblasts through activation of Akt/Nrf2 pathway-dependent mitophagy. Toxicol Appl Pharmacol;417:115482. doi: 10.1016/j.taap.2021.115482.
  • Wang P, Deng JW, Dong J, Liu JH, Bigio EH, Mesulam M, Wang T, Sun L, Wang L, Lee AYL, et al. 2019. TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response. PLOS Genet. 15(5):e1007947. doi: 10.1371/journal.pgen.1007947.
  • Wang T, Di G, Yang L, Dun Y, Sun Z, Wan J, Peng B, Liu C, Xiong G, Zhang C, et al. 2015. Saponins from Panax japonicus attenuate d-galactose-induced cognitive impairment through its anti-oxidative and anti-apoptotic effects in rats. J Pharm Pharmacol. 67(9):1284–1296. doi: 10.1111/jphp.12413.
  • Wu YY, Liang CY, Liu TT, Liang YM, Li SJ, Lu YY, Liang J, Yuan X, Li CJ, Hou SZ, et al. 2018. Protective roles and mechanisms of polysaccharides from Dendrobium officinal on natural aging-induced premature ovarian failure. Biomed Pharmacother. 101:953–960. doi: 10.1016/j.biopha.2018.03.030.
  • Yan J, Liu X, Han M, Wang Y, Sun X, Yu N, Li T, Su B, Chen Z. 2015. Blockage of GSK3β-mediated Drp1 phosphorylation provides neuroprotection in neuronal and mouse models of Alzheimer’s disease. Neurobiol Aging. 36(1):211–227. doi: 10.1016/j.neurobiolaging.2014.08.005.
  • Yan MZ, Li SG. 2015. Effect of ginsenoside Rg3 on ageing of vascular smooth muscle cells and its mechanism. Chinese J Geriatric Heart Brain Vessel Dis. 17:1079–1082.
  • Yuan D, Wan JZ, Deng LL, Zhang CC, Dun YY, Dai YW, Zhou ZY, Liu CQ, Wang T. 2014. Chikusetsu saponin V attenuates MPP+-induced neurotoxicity in SH-SY5Y cells via regulation of Sirt1/Mn-SOD and GRP78/caspase-12 pathways. Int J Mol Sci. 15(8):13209–13222. doi: 10.3390/ijms150813209.
  • Zaninello M, Palikaras K, Sotiriou A, Tavernarakis N, Scorrano L. 2022. Sustained intracellular calcium rise mediates neuronal mitophagy in models of autosomal dominant optic atrophy. Cell Death Differ. 29(1):167–177. doi: 10.1038/s41418-021-00847-3.
  • Zhou H, Ma J, Shan Y, Qi X, Wang H, Jia L. 2019. A combination of chicken embryo extract and a nutritional supplement protect a rat model of aging against d-galactose-induced dysfunction of mitochondria and autophagy. Food Funct. 10(5):2774–2784. doi: 10.1039/c8fo01734d.