1,178
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Mechanistic exploration of Yiqi Liangxue Shengji prescription on restenosis after balloon injury by integrating metabolomics with network pharmacology

ORCID Icon, , , , , , , , , , & ORCID Icon show all
Pages 1260-1273 | Received 15 Nov 2022, Accepted 31 Jul 2023, Published online: 21 Aug 2023

References

  • Akinkuolie AO, Lawler PR, Chu AY, Caulfield M, Mu J, Ding B, Nyberg F, Glynn RJ, Ridker PM, Hurt-Camejo E, et al. 2019. Group IIA secretory phospholipase A2, vascular inflammation, and incident cardiovascular disease. Arterioscler Thromb Vasc Biol. 39(6):1182–1190. doi: 10.1161/ATVBAHA.118.311894.
  • Bettermann EL, Hartman TJ, Easley KA, Ferranti EP, Jones DP, Quyyumi AA, Vaccarino V, Ziegler TR, Alvarez JA. 2018. Higher Mediterranean diet quality scores and lower body mass index are associated with a less-oxidized plasma glutathione and cysteine redox status in adults. J Nutr. 148(2):245–253. doi: 10.1093/jn/nxx045.
  • Bhaskar S, Sudhakaran PR, Helen A. 2016. Quercetin attenuates atherosclerotic inflammation and adhesion molecule expression by modulating TLR-NF-κB signaling pathway. Cell Immunol. 310:131–140. doi: 10.1016/j.cellimm.2016.08.011.
  • Burtenshaw D, Kitching M, Redmond EM, Megson IL, Cahill PA. 2019. Reactive oxygen species (ROS), intimal thickening, and subclinical atherosclerotic disease. Front Cardiovasc Med. 6:89. doi: 10.3389/fcvm.2019.00089.
  • Cassese S, Byrne RA, Schulz S, Hoppman P, Kreutzer J, Feuchtenberger A, Ibrahim T, Ott I, Fusaro M, Schunkert H, et al. 2015. Prognostic role of restenosis in 10 004 patients undergoing routine control angiography after coronary stenting. Eur Heart J. 36(2):94–99. doi: 10.1093/eurheartj/ehu383.
  • Chen C, Xia J, Feng R, Wan J, Zhou K, Lin Q, Li D. 2021. Randomized controlled clinical study on Yiqi Liangxue Shengji prescription for intervention cardiac function of acute myocardial infarction with ischemia-reperfusion injury. Medicine (Baltimore). 100(10):e24944. doi: 10.1097/MD.0000000000024944.
  • Chen HI, Hu WS, Hung MY, Ou HC, Huang SH, Hsu PT, Day CH, Lin KH, Viswanadha VP, Kuo WW, et al. 2020. Protective effects of luteolin against oxidative stress and mitochondrial dysfunction in endothelial cells. Nutr Metab Cardiovasc Dis. 30(6):1032–1043. doi: 10.1016/j.numecd.2020.02.014.
  • Cui S, Li K, Ang L, Liu J, Cui L, Song X, Lv S, Mahmud E. 2017. Plasma phospholipids and sphingolipids identify stent restenosis after percutaneous coronary intervention. JACC Cardiovasc Interv. 10(13):1307–1316. doi: 10.1016/j.jcin.2017.04.007.
  • Dagher O, Mury P, Thorin-Trescases N, Noly PE, Thorin E, Carrier M. 2021. Therapeutic potential of quercetin to alleviate endothelial dysfunction in age-related cardiovascular diseases. Front Cardiovasc Med. 8:658400. doi: 10.3389/fcvm.2021.658400.
  • Farah C, Michel LYM, Balligand JL. 2018. Nitric oxide signalling in cardiovascular health and disease. Nat Rev Cardiol. 15(5):292–316. doi: 10.1038/nrcardio.2017.224.
  • Feng J, Liu L, Yao F, Zhou D, He Y, Wang J. 2021. The protective effect of tanshinone IIa on endothelial cells: a generalist among clinical therapeutics. Expert Rev Clin Pharmacol. 14(2):239–248. doi: 10.1080/17512433.2021.1878877.
  • Förstermann U, Sessa WC. 2012. Nitric oxide synthases: regulation and function. Eur Heart J. 33(7):829–837d. doi: 10.1093/eurheartj/ehr304.
  • Giustino G, Colombo A, Camaj A, Yasumura K, Mehran R, Stone GW, Kini A, Sharma SK. 2022. Coronary in-stent restenosis: JACC State-of-the-Art Review. J Am Coll Cardiol. 80(4):348–372. doi: 10.1016/j.jacc.2022.05.017.
  • Hasokawa M, Shinohara M, Tsugawa H, Bamba T, Fukusaki E, Nishiumi S, Nishimura K, Yoshida M, Ishida T, Hirata KI. 2012. Identification of biomarkers of stent restenosis with serum metabolomic profiling using gas chromatography/mass spectrometry. Circ J. 76(8):1864–1873. doi: 10.1253/circj.cj-11-0622.
  • Infante T, Costa D, Napoli C. 2021. Novel insights regarding nitric oxide and cardiovascular diseases. Angiology. 72(5):411–425. doi: 10.1177/0003319720979243.
  • Jia WH. 2020. P.R. China: Beijing University of Chinese Medicine. Expore the effect and mechanism of Yiqi Liangxue Shengji recipe on rabbit carotid artery after balloon injury based on NF-κB pathway. Ph.D, Chinese
  • Jia WH, Wan J, Ma Z, Jin JL, Cai Y, Cui XY, Lin Q. 2021. Effects of Yiqi Liangxue Shengji prescription on TCM symptoms and syndrome elements after PCI. World J Integrated Tradit West Med. 16:229–232. Chinese
  • Johnson CH, Ivanisevic J, Siuzdak G. 2016. Metabolomics: beyond biomarkers and towards mechanisms. Nat Rev Mol Cell Biol. 17(7):451–459. doi: 10.1038/nrm.2016.25.
  • Kamishirado H, Inoue T, Sakuma M, Tsuda T, Hayashi T, Takayanagi K, Node K. 2007. Effects of statins on restenosis after coronary stent implantation. Angiology. 58(1):55–60. doi: 10.1177/0003319706295223.
  • Katsaros KM, Kastl SP, Krychtiuk KA, Hutter R, Zorn G, Maurer G, Huber K, Wojta J, Christ G, Speidl WS. 2014. An increase of VEGF plasma levels is associated with restenosis of drug-eluting stents. EuroIntervention. 10(2):224–230. doi: 10.4244/EIJV10I2A36.
  • Khaddaj Mallat R, Mathew John C, Kendrick DJ, Braun AP. 2017. The vascular endothelium: a regulator of arterial tone and interface for the immune system. Crit Rev Clin Lab Sci. 54(7-8):458–470. doi: 10.1080/10408363.2017.1394267.
  • Kim B, Li J, Jang C, Arany Z. 2017. Glutamine fuels proliferation but not migration of endothelial cells. Embo J. 36(16):2321–2333. doi: 10.15252/embj.201796436.
  • Korotaeva AA, Samoilova EV, Kaminny AI, Pirkova AA, Resink TJ, Erne P, Prokazova NV, Tkachuk VA, Chazov EI. 2005. The catalytically active secretory phospholipase A2 type IIA is involved in restenosis development after PTCA in human coronary arteries and generation of atherogenic LDL. Mol Cell Biochem. 270(1-2):107–113. doi: 10.1007/s11010-005-5266-3.
  • Koyama S, Yamashita A, Matsuura Y, Saito Y, Maekawa K, Gi T, Kitamura K, Asada Y. 2021. Intracellular glutamine level determines vascular smooth muscle cell-derived thrombogenicity. Atherosclerosis. 328:62–73. doi: 10.1016/j.atherosclerosis.2021.05.012.
  • Li DJ, Fu H, Tong J, Li YH, Qu LF, Wang P, Shen FM. 2018. Cholinergic anti-inflammatory pathway inhibits neointimal hyperplasia by suppressing inflammation and oxidative stress. Redox Biol. 15:22–33. doi: 10.1016/j.redox.2017.11.013.
  • Li X, Kumar A, Carmeliet P. 2019. Metabolic pathways fueling the endothelial cell drive. Annu Rev Physiol. 81:483–503. doi: 10.1146/annurev-physiol-020518-114731.
  • Li XX, Li LY, Fan ZJ, Cui J, Zhuang R, Liu RP, Wu Y. 2021. Effects of Yiqi Liangxue Shengji prescription on VEGF and hs-CRP in patients with coronary heart disease after PCI. J Tradit Chin Med and Pharm. 36:6898–6900. Chinese
  • Lim Y, Hwang W, Kim JY, Lee CH, Kim YJ, Lee D, Kwon O. 2019. Synergistic mechanisms of Sanghuang-Danshen phytochemicals on postprandial vascular dysfunction in healthy subjects: a network biology approach based on a clinical trial. Sci Rep. 9(1):9746–9754. doi: 10.1038/s41598-019-46289-3.
  • Liu L, Liu J, Gao Q, Wu Y, Lu J, Wan J, Li Y, Cui X, Zhou K, Jia W, et al. 2018. Effectiveness and safety of compound Chinese medicine plus routine western medicine in in-stent restenosis: a meta-analysis and systematic review. Evid Based Complement Alternat Med. 2018:6207524. doi: 10.1155/2018/6207524.
  • Lu J, Chen B, Chen T, Guo S, Xue X, Chen Q, Zhao M, Xia L, Zhu Z, Zheng L, et al. 2017. Comprehensive metabolomics identified lipid peroxidation as a prominent feature in human plasma of patients with coronary heart diseases. Redox Biol. 12:899–907. doi: 10.1016/j.redox.2017.04.032.
  • Lu M, Luo Y, Hu P, Dou L, Huang S. 2018. Tanshinone IIA inhibits AGEs-induced proliferation and migration of cultured vascular smooth muscle cells by suppressing ERK1/2 MAPK signaling. Iran J Basic Med Sci. 21:83–88.
  • Ma Z, Long J, Jia WH, Cui XY, Li Y, Lu JJ, Li D, Wan J, Lin Q. 2019. Randomize-controlled trial of Yiqi Liangxue Shengji formula in preventing major adverse cardiovascular events after percutaneous coronary intervention for coronary heart disease. J Tradi Chin Med. 60:1837–1842. Chinese
  • Matuz-Mares D, Riveros-Rosas H, Vilchis-Landeros MM, Vázquez-Meza H. 2021. Glutathione participation in the prevention of cardiovascular diseases. Antioxidants (Basel). 10:1220–1238. doi: 10.3390/antiox10081220.
  • Neumann FJ, Sousa-Uva M, Ahlsson A, Alfonso F, Banning AP, Benedetto U, Byrne RA, Collet J-P, Falk V, Head SJ, et al. 2019. 2018 ESC/EACTS Guidelines on myocardial revascularization. Eur Heart J. 40(2):87–165. doi: 10.1093/eurheartj/ehy394.
  • Pegg AE. 2006. Regulation of ornithine decarboxylase. J Biol Chem. 281(21):14529–14532. doi: 10.1074/jbc.R500031200.
  • Santiago Hernandez A, Martinez PJ, Agudiez M, Heredero A, Gonzalez-Calero L, Yuste-Montalvo A, Esteban V, Aldamiz Echevarria G, Martin Lorenzo M, Alvarez Llamas G. 2021. Metabolic alterations identified in urine, plasma and aortic smooth muscle cells reflect cardiovascular risk in patients with programmed coronary artery bypass grafting. Antioxidants. 10:1369–1379. doi: 10.3390/antiox10091369.
  • Schmitz G, Ruebsaamen K. 2010. Metabolism and atherogenic disease association of lysophosphatidylcholine. Atherosclerosis. 208(1):10–18. doi: 10.1016/j.atherosclerosis.2009.05.029.
  • Si H, Wyeth RP, Liu D. 2014. The flavonoid luteolin induces nitric oxide production and arterial relaxation. Eur J Nutr. 53(1):269–275. doi: 10.1007/s00394-013-0525-7.
  • Simons M. 2009. VEGF and restenosis: the rest of the story. Arterioscler Thromb Vasc Biol. 29(4):439–440. doi: 10.1161/ATVBAHA.109.183970.
  • Stefanini GG, Holmes DR. 2013. Drug-eluting coronary-artery stents. N Engl J Med. 368(3):254–265. doi: 10.1056/NEJMra1210816.
  • Su D, Liao L, Zeng Q, Liao Z, Liu Y, Jin C, Zhu G, Chen C, Yang M, Ai Z, et al. 2022. Study on the new anti-atherosclerosis activity of different Herba patriniae through down-regulating lysophosphatidylcholine of the glycerophospholipid metabolism pathway. Phytomedicine. 94:153833. doi: 10.1016/j.phymed.2021.153833.
  • Su F, Sun YN, Cui XY, Lin Q. 2015. The effects of Yiqi Liangxue Shengji Formula on cell morphology of injured vascular endothelial cells. J Tradi Chin Med. 56:1691–1694. Chinese
  • Tang WHW, Wang Z, Cho L, Brennan DM, Hazen SL. 2009. Diminished global arginine bioavailability and increased arginine catabolism as metabolic profile of increased cardiovascular risk. J Am Coll Cardiol. 53(22):2061–2067. doi: 10.1016/j.jacc.2009.02.036.
  • Vanani AR, Mahdavinia M, Shirani M, Alizadeh S, Dehghani MA. 2020. Protective effects of quercetin against oxidative stress induced by bisphenol – a in rat cardiac mitochondria. Environ Sci Pollut Res Int. 27(13):15093–15102. doi: 10.1007/s11356-020-08048-0.
  • Yang X, Yang Y, Guo J, Meng Y, Li M, Yang P, Liu X, Aung LHH, Yu T, Li Y. 2021. Targeting the epigenome in in-stent restenosis: from mechanisms to therapy. Mol Ther Nucleic Acids. 23:1136–1160. doi: 10.1016/j.omtn.2021.01.024.
  • Yang YF, Yan XR, Wu RX, Li N, Chu M, Dong Y, Fu SP, Shi JR, Liu Q. 2022. Network pharmacology and experimental evidence reveal the protective mechanism of Yi-Qi Cong-Ming decoction on age-related hearing loss. Pharm Biol. 60(1):1478–1490. doi: 10.1080/13880209.2022.2101671.
  • Zhang W, Chen Y, Jiang H, Yang J, Wang Q, Du Y, Xu H. 2020. Integrated strategy for accurately screening biomarkers based on metabolomics coupled with network pharmacology. Talanta. 211:120710. doi: 10.1016/j.talanta.2020.120710.
  • Zou G, Zhu J, Liu Z, Wu L, Xu R, Chen H, Deng P, Deng C. 2019. Detoxification and activating blood circulation decoction reduces restenosis involving the TLR4/NF-κB pathway after balloon injury. Prostaglandins Other Lipid Mediat. 140:1–8. doi: 10.1016/j.prostaglandins.2018.11.002.