Gemcitabine enhances pharmacokinetic exposure of the major components of Danggui Buxue Decoction in rat via the promotion of intestinal permeability and down-regulation of CYP3A for combination treatment of non-small cell lung cancer

References

• Ahrne S, Hagslatt ML. 2011. Effect of Lactobacilli on paracellular permeability in the gut. Nutrients. 3(1):104–117. doi: 10.3390/nu3010104.
   PubMed Web of Science ®Google Scholar
• Bayman N, Blackhall F, McCloskey P, Taylor P, Faivre-Finn C. 2014. How can we optimise concurrent chemoradiotherapy for inoperable stage III non-small cell lung cancer? Lung Cancer. 83(2):117–125. doi: 10.1016/j.lungcan.2013.11.017.
   PubMed Web of Science ®Google Scholar
• Binenbaum Y, Na’ara S, Gil Z. 2015. Gemcitabine resistance in pancreatic ductal adenocarcinoma. Drug Resist Updat. 23:55–68. doi: 10.1016/j.drup.2015.10.002.
   PubMed Web of Science ®Google Scholar
• Chan K, Lo AC, Yeung JH, Woo KS. 1995. The effects of Danshen (Salvia miltiorrhiza) on warfarin pharmacodynamics and pharmacokinetics of warfarin enantiomers in rats. J Pharm Pharmacol. 47(5):402–406. doi: 10.1111/j.2042-7158.1995.tb05819.x.
   PubMed Web of Science ®Google Scholar
• Chinese Pharmacopoeia Commission. 2020. Pharmacopoeia of the People’s Republic of China. Vol. 1. Beijing (China): Chinese Medical Science and Technology Press; p. 315–316.
   Google Scholar
• Chiu SC, Chiu TL, Huang SY, Chang SF, Chen SP, Pang CY, Hsieh TF. 2017. Potential therapeutic effects of N-butylidenephthalide from Radix Angelica sinensis (Danggui) in human bladder cancer cells. BMC Complement Altern Med. 17(1):523. doi: 10.1186/s12906-017-2034-3.
   PubMedGoogle Scholar
• Du QC, Yang KZ, Sun XF. 2009. Efficacy of auxiliary therapy with Danggui Buxue Decoction No. 1 in treating patients of non-small cell lung cancer at peri-operational stage. Chin J Integr Med. 15(3):184–188. doi: 10.1007/s11655-009-0184-y.
   PubMed Web of Science ®Google Scholar
• [EMA] European Medicines Agency. 2011 Jul 21. Guideline on bioanalytical method validation. EMEA/CHMP/EWP/192217/2009 [Internet] [accessed 2019 Oct 4]. https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-bioanalytical-method-validation_en.pdf.
   Google Scholar
• Fasinu PS, Bouic PJ, Rosenkranz B. 2012. An overview of the evidence and mechanisms of herb–drug interactions. Front Pharmacol. 3:69. doi: 10.3389/fphar.2012.00069.
   PubMed Web of Science ®Google Scholar
• Ferri M, Happel A, Zanaroli G, Bertolini M, Chiesa S, Commisso M, Guzzo F, Tassoni A. 2020. Advances in combined enzymatic extraction of ferulic acid from wheat bran. N Biotechnol. 56:38–45. doi: 10.1016/j.nbt.2019.10.010.
   PubMed Web of Science ®Google Scholar
• Fu J, Wang Z, Huang L, Zheng S, Wang D, Chen S, Zhang H, Yang S. 2014. Review of the botanical characteristics, phytochemistry, and pharmacology of Astragalus membranaceus (Huangqi). Phytother Res. 28(9):1275–1283. doi: 10.1002/ptr.5188.
   PubMed Web of Science ®Google Scholar
• Fugh-Berman A. 2000. Herb–drug interactions. Lancet. 355(9198):134–138. doi: 10.1016/S0140-6736(99)06457-0.
   PubMed Web of Science ®Google Scholar
• Gao QT, Cheung JKH, Li J, Jiang ZY, Chu GKY, Duan R, Cheung AWH, Zhao KJ, Choi RCY, Dong TTX, et al. 2007. A Chinese herbal decoction, Danggui Buxue Tang, activates extracellular signal-regulated kinase in cultured T-lymphocytes. FEBS Lett. 581(26):5087–5093. doi: 10.1016/j.febslet.2007.09.053.
   PubMed Web of Science ®Google Scholar
• Gao S, Li N, Wang S, Zhang F, Wei W, Li N, Bi N, Wang Z, He J. 2020. Lung cancer in People’s Republic of China. J Thorac Oncol. 15(10):1567–1576. doi: 10.1016/j.jtho.2020.04.028.
   PubMed Web of Science ®Google Scholar
• Haberkorn U, Bellemann ME, Altmann A, Gerlach L, Morr I, Oberdorfer F, Brix G, Doll J, Blatter J, van Kaick G. 1997. PET 2-fluoro-2-deoxyglucose uptake in rat prostate adenocarcinoma during chemotherapy with gemcitabine. J Nucl Med. 38(8):1215–1221.
   PubMed Web of Science ®Google Scholar
• Haberkorn U, Morr I, Oberdorfer F, Bellemann ME, Blatter J, Altmann A, Kahn B, van Kaick G. 1994. Fluorodeoxyglucose uptake in vitro: aspects of method and effects of treatment with gemcitabine. J Nucl Med. 35(11):1842–1850.
   PubMed Web of Science ®Google Scholar
• Hong QY, Wu GM, Qian GS, Hu CP, Zhou JY, Chen LA, Li WM, Li SY, Wang K, Wang Q, et al. 2015. Prevention and management of lung cancer in China. Cancer. 121(Suppl. 17):3080–3088. doi: 10.1002/cncr.29584.
   PubMedGoogle Scholar
• Kilani-Jaziri S, Mokdad-Bzeouich I, Krifa M, Nasr N, Ghedira K, Chekir-Ghedira L. 2017. Immunomodulatory and cellular anti-oxidant activities of caffeic, ferulic, and p-coumaric phenolic acids: a structure–activity relationship study. Drug Chem Toxicol. 40(4):416–424. doi: 10.1080/01480545.2016.1252919.
   PubMed Web of Science ®Google Scholar
• Lang F, Qu J, Yin H, Li L, Zhi Y, Liu Y, Fang Z, Hao E. 2018. Apoptotic cell death induced by Z-ligustilide in human ovarian cancer cells and role of NRF2. Food Chem Toxicol. 121:631–638. doi: 10.1016/j.fct.2018.09.041.
   PubMed Web of Science ®Google Scholar
• Liu M, Yuan J, Hu WJ, Ke CQ, Zhang YF, Ye Y, Zhong DF, Zhao GR, Yao S, Liu J. 2019. Pretreatment with broad-spectrum antibiotics alters the pharmacokinetics of major constituents of Shaoyao-Gancao decoction in rats after oral administration. Acta Pharmacol Sin. 40(2):288–296. doi: 10.1038/s41401-018-0011-0.
   PubMed Web of Science ®Google Scholar
• Liu Y, Chang M, Hu Z, Xu X, Wu W, Ning M, Hang T, Song M. 2021. Danggui Buxue Decoction enhances the anticancer activity of gemcitabine and alleviates gemcitabine-induced myelosuppression. J Ethnopharmacol. 273:113965. doi: 10.1016/j.jep.2021.113965.
   PubMed Web of Science ®Google Scholar
• Ma ZC, Hong Q, Wang YG, Tan HL, Xiao CR, Liang QD, Lu BB, Gao Y. 2011. Effects of ferulic acid on hematopoietic cell recovery in whole-body gamma irradiated mice. Int J Radiat Biol. 87(5):499–505. doi: 10.3109/09553002.2011.548438.
   PubMed Web of Science ®Google Scholar
• Nakajima T, Ueda T, Takeyama Y, Yasuda T, Shinzeki M, Sawa H, Kuroda Y. 2007. Protective effects of vascular endothelial growth factor on intestinal epithelial apoptosis and bacterial translocation in experimental severe acute pancreatitis. Pancreas. 34(4):410–416. doi: 10.1097/mpa.0b013e3180335c64.
   PubMed Web of Science ®Google Scholar
• Qian M, Shi LF, Hu JH. 2009. Enzyme kinetics of ligustilide metabolism in rat liver microsomes. Yao Xue Xue Bao. 44(4):395–400.
   PubMedGoogle Scholar
• Rehman SU, Choi MS, Choe K, Yoo HH. 2015. Interactions between herbs and antidiabetics: an overview of the mechanisms, evidence, importance, and management. Arch Pharm Res. 38(7):1281–1298. doi: 10.1007/s12272-014-0517-z.
   PubMed Web of Science ®Google Scholar
• Schild SE, Vokes EE. 2016. Pathways to improving combined modality therapy for stage III non-small cell lung cancer. Ann Oncol. 27(4):590–599. doi: 10.1093/annonc/mdv621.
   PubMed Web of Science ®Google Scholar
• Shang H, Wang Z, Ma H, Sun Y, Ci X, Gu Y, Liu C, Si D. 2021. Influence of verapamil on the pharmacokinetics of rotundic acid in rats and its potential mechanism. Pharm Biol. 59(1):200–208. doi: 10.1080/13880209.2021.1871634.
   PubMed Web of Science ®Google Scholar
• Shi J, Zheng H, Yu J, Zhu L, Yan T, Wu P, Lu L, Wang Y, Hu M, Liu Z. 2016. SGLT-1 transport and deglycosylation inside intestinal cells are key steps in the absorption and disposition of calycosin-7-O-β-d-glucoside in rats. Drug Metab Dispos. 44(3):283–296. doi: 10.1124/dmd.115.067009.
   PubMed Web of Science ®Google Scholar
• Shi X, Tang Y, Zhu H, Li W, Li W, Li Z, Luo N, Duan JA. 2014. Pharmacokinetic comparison of seven major bio-active components in normal and blood deficiency rats after oral administration of Danggui Buxue Decoction by UPLC-TQ/MS. J Ethnopharmacol. 153(1):169–177. doi: 10.1016/j.jep.2014.02.004.
   PubMed Web of Science ®Google Scholar
• Shi XQ, Zhu ZH, Yue SJ, Tang YP, Chen YY, Pu ZJ, Tao HJ, Zhou GS, Yang Y, Guo MJ, et al. 2020. Integration of organ metabolomics and proteomics in exploring the blood enriching mechanism of Danggui Buxue Decoction in hemorrhagic anemia rats. J Ethnopharmacol. 261:113000. doi: 10.1016/j.jep.2020.113000.
   PubMed Web of Science ®Google Scholar
• Subhani S, Jamil K. 2015. Molecular docking of chemotherapeutic agents to CYP3A4 in non-small cell lung cancer. Biomed Pharmacother. 73:65–74. doi: 10.1016/j.biopha.2015.05.018.
   PubMed Web of Science ®Google Scholar
• Sun X, Xu X, Chen Y, Guan R, Cheng T, Wang Y, Jin R, Song M, Hang T. 2019. Danggui Buxue Decoction sensitizes the response of non-small-cell lung cancer to gemcitabine via regulating deoxycytidine kinase and P-glycoprotein. Molecules. 24:2011. doi: 10.3390/molecules24102011.
   PubMed Web of Science ®Google Scholar
• Sun Z, Wang X, Wallen R, Deng X, Du X, Hallberg E, Andersson R. 1998. The influence of apoptosis on intestinal barrier integrity in rats. Scand J Gastroenterol. 33:415–422.
   PubMed Web of Science ®Google Scholar
• Tang Y, Hao J, Fan C, Cao X. 2021. Preparative separation of high-purity trans- and cis-ferulic acid from wheat bran by pH-zone-refining counter-current chromatography. J Chromatogr A. 1636:461772. doi: 10.1016/j.chroma.2020.461772.
   PubMed Web of Science ®Google Scholar
• Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. 2015. Global cancer statistics, 2012. CA Cancer J Clin. 65(2):87–108. doi: 10.3322/caac.21262.
   PubMed Web of Science ®Google Scholar
• Wang P, Liang YZ. 2010. Chemical composition and inhibitory effect on hepatic fibrosis of Danggui Buxue Decoction. Fitoterapia. 81(7):793–798. doi: 10.1016/j.fitote.2010.04.007.
   PubMed Web of Science ®Google Scholar
• Wood SL, Pernemalm M, Crosbie PA, Whetton AD. 2015. Molecular histology of lung cancer: from targets to treatments. Cancer Treat Rev. 41(4):361–375. doi: 10.1016/j.ctrv.2015.02.008.
   PubMed Web of Science ®Google Scholar
• Wu WW, Yeung JH. 2010. Inhibition of warfarin hydroxylation by major tanshinones of Danshen (Salvia miltiorrhiza) in the rat in vitro and in vivo. Phytomedicine. 17(3–4):219–226. doi: 10.1016/j.phymed.2009.05.005.
   PubMed Web of Science ®Google Scholar
• Xu H. 2019. Effect of main active components combination of Astragalus and Angelica on hematopoietic function in mice with bone marrow suppression. Chin Pharmacol Bull. 35:707–713.
   Google Scholar
• Yan R, Ko NL, Li SL, Tam YK, Lin G. 2008. Pharmacokinetics and metabolism of ligustilide, a major bioactive component in rhizoma Chuanxiong, in the rat. Drug Metab Dispos. 36(2):400–408. doi: 10.1124/dmd.107.017707.
   PubMed Web of Science ®Google Scholar
• Yang X, Huang CG, Du SY, Yang SP, Zhang X, Liu JY, Luo XQ, Xu JH. 2014. Effect of Danggui Buxue Tang on immune-mediated aplastic anemia bone marrow proliferation mice. Phytomedicine. 21(5):640–646. doi: 10.1016/j.phymed.2013.10.018.
   PubMed Web of Science ®Google Scholar
• Zduńska K, Dana A, Kolodziejczak A, Rotsztejn H. 2018. Antioxidant properties of ferulic acid and its possible application. Skin Pharmacol Physiol. 31(6):332–336. doi: 10.1159/000491755.
   PubMed Web of Science ®Google Scholar
• Zhang B, Guo Y. 2009. Supplemental zinc reduced intestinal permeability by enhancing occludin and zonula occludens protein-1 (ZO-1) expression in weaning piglets. Br J Nutr. 102(5):687–693. doi: 10.1017/S0007114509289033.
   PubMed Web of Science ®Google Scholar
• Zhang H, Song J, Dai H, Liu Y, Wang L. 2020. Effects of puerarin on the pharmacokinetics of astragaloside IV in rats and its potential mechanism. Pharm Biol. 58(1):328–332. doi: 10.1080/13880209.2020.1746362.
   PubMed Web of Science ®Google Scholar
• Zhao ZH, Egashira Y, Sanada H. 2004. Ferulic acid is quickly absorbed from rat stomach as the free form and then conjugated mainly in liver. J Nutr. 134(11):3083–3088. doi: 10.1093/jn/134.11.3083.
   PubMed Web of Science ®Google Scholar
• Zheng KY, Choi RC, Guo AJ, Bi CW, Zhu KY, Du CY, Zhang ZX, Lau DT, Dong TT, Tsim KW. 2012. The membrane permeability of Astragali Radix-derived formononetin and calycosin is increased by Angelicae sinensis Radix in Caco-2 cells: a synergistic action of an ancient herbal decoction Danggui Buxue Tang. J Pharm Biomed Anal. 70:671–679. doi: 10.1016/j.jpba.2012.05.018.
   PubMed Web of Science ®Google Scholar
• Zhuang XM, Chen L, Tan Y, Yang HY, Lu C, Gao Y, Li H. 2017. Identification of human cytochrome P450 and UGT enzymes involved in the metabolism of ferulic acid, a major bioactive component in traditional Chinese medicines. Chin J Nat Med. 15(9):695–702. doi: 10.1016/S1875-5364(17)30099-7.
   PubMed Web of Science ®Google Scholar