Network pharmacology integrated with experimental verification reveals the antipyretic characteristics and mechanism of Zi Xue powder

References

• Amberger JS, Bocchini CA, Schiettecatte F, Scott AF, Hamosh A. 2015. OMIM.org: online Mendelian Inheritance in Man (OMIM®), an online catalog of human genes and genetic disorders. Nucleic Acids Res. 43(Database issue):D789–798. doi: 10.1093/nar/gku1205.
   PubMed Web of Science ®Google Scholar
• Arabyan E, Hakobyan A, Hakobyan T, Grigoryan R, Izmailyan R, Avetisyan A, Karalyan Z, Jackman JA, Ferreira F, Elrod CC, et al. 2021. Flavonoid library screening reveals kaempferol as a potential antiviral agent against African swine fever virus. Front Microbiol. 12:736780. doi: 10.3389/fmicb.2021.736780.
   PubMed Web of Science ®Google Scholar
• Bajrai LH, Sohrab SS, Alandijany TA, Mobashir M, Reyaz M, Kamal MA, Firoz A, Parveen S, Azhar EI. 2021. Gene expression profiling of early acute febrile stage of dengue infection and its comparative analysis with streptococcus pneumoniae infection. Front Cell Infect Microbiol. 11:707905. doi: 10.3389/fcimb.2021.707905.
   PubMed Web of Science ®Google Scholar
• Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE. 2000. The protein data bank. Nucleic Acids Res. 28(1):235–242. doi: 10.1093/nar/28.1.235.
   PubMed Web of Science ®Google Scholar
• Blomqvist A, Engblom D. 2018. Neural mechanisms of inflammation-induced fever. Neuroscientist. 24(4):381–399. doi: 10.1177/1073858418760481.
   PubMed Web of Science ®Google Scholar
• Chang YW, Hung LC, Chen YC, Wang WH, Lin CY, Tzeng HH, Suen JL, Chen YH. 2020. Insulin reduces inflammation by regulating the activation of the NLRP3 inflammasome. Front Immunol. 11:587229. doi: 10.3389/fimmu.2020.587229.
   PubMed Web of Science ®Google Scholar
• Chen BC, Kang JC, Lu YT, Hsu MJ, Liao CC, Chiu WT, Yeh FL, Lin CH. 2009. Rac1 regulates peptidoglycan-induced nuclear factor-kappaB activation and cyclooxygenase-2 expression in RAW 264.7 macrophages by activating the phosphatidylinositol 3-kinase/Akt pathway. Mol Immunol. 46(6):1179–1188. doi: 10.1016/j.molimm.2008.11.006.
   PubMed Web of Science ®Google Scholar
• Cheng Y, Sun F, Wang L, Gao M, Xie Y, Sun Y, Liu H, Yuan Y, Yi W, Huang Z, et al. 2020. Virus-induced p38 MAPK activation facilitates viral infection. Theranostics. 10(26):12223–12240. doi: 10.7150/thno.50992.
   PubMed Web of Science ®Google Scholar
• Chu X, Ci X, Wei M, Yang X, Cao Q, Guan M, Li H, Deng Y, Feng H, Deng X. 2012. Licochalcone a inhibits lipopolysaccharide-induced inflammatory response in vitro and in vivo. J Agric Food Chem. 60(15):3947–3954. doi: 10.1021/jf2051587.
   PubMed Web of Science ®Google Scholar
• Commission CP. 2020. Pharmacopoeia of people’s Republic of China. Beijing: China Medical Science & Technology Press.
   Google Scholar
• De Souza GE, Cardoso RA, Melo MC, Fabricio AS, Silva VM, Lora M, De Brum-Fernandes AJ, Rae GA, Ferreira SH, Zampronio AR. 2002. A comparative study of the antipyretic effects of indomethacin and dipyrone in rats. Inflamm Res. 51(1):24–32. doi: 10.1007/pl00000278.
   PubMed Web of Science ®Google Scholar
• Dennis G, Jr., Sherman BT, Hosack DA, Yang J, Gao W, Lane HC, Lempicki RA. 2003. DAVID: database for annotation, visualization, and integrated discovery. Genome Biol. 4(5):P3. doi: 10.1186/gb-2003-4-5-p3.
   PubMed Web of Science ®Google Scholar
• Eskilsson A, Mirrasekhian E, Dufour S, Schwaninger M, Engblom D, Blomqvist A. 2014. Immune-induced fever is mediated by IL-6 receptors on brain endothelial cells coupled to STAT3-dependent induction of brain endothelial prostaglandin synthesis. J Neurosci. 34(48):15957–15961. doi: 10.1523/JNEUROSCI.3520-14.2014.
   PubMed Web of Science ®Google Scholar
• Fang S, Dong L, Liu L, Guo J, Zhao L, Zhang J, Bu D, Liu X, Huo P, Cao W, et al. 2021. HERB: a high-throughput experiment- and reference-guided database of traditional Chinese medicine. Nucleic Acids Res. 49(D1):D1197–d1206. doi: 10.1093/nar/gkaa1063.
   PubMed Web of Science ®Google Scholar
• Fanunza E, Iampietro M, Distinto S, Corona A, Quartu M, Maccioni E, Horvat B, Tramontano E. 2020. Quercetin blocks Ebola virus infection by counteracting the VP24 interferon-inhibitory function. Antimicrob Agents Chemother. 64(7):1–32. doi: 10.1128/AAC.00530-20.
   Web of Science ®Google Scholar
• Feng CQ, Yong WX, Liu YQ. 2020. TCM prevention and treatment experience of Corona virus disease 2019(COVID-19) in Gansu Province. J Gansu Univ Chinese Med. 37:10–15.
   Google Scholar
• Fu Y, Chen J, Li YJ, Zheng YF, Li P. 2013. Antioxidant and anti-inflammatory activities of six flavonoids separated from licorice. Food Chem. 141(2):1063–1071. doi: 10.1016/j.foodchem.2013.03.089.
   PubMed Web of Science ®Google Scholar
• Gfeller D, Grosdidier A, Wirth M, Daina A, Michielin O, Zoete V. 2014. SwissTargetPrediction: a web server for target prediction of bioactive small molecules. Nucleic Acids Res. 42(Web Server issue):W32–38. doi: 10.1093/nar/gku293.
   PubMed Web of Science ®Google Scholar
• Guo B, Zhao C, Zhang C, Xiao Y, Yan G, Liu L, Pan H. 2022. Elucidation of the anti-inflammatory mechanism of Er Miao San by integrative approach of network pharmacology and experimental verification. Pharmacol Res. 175:106000. doi: 10.1016/j.phrs.2021.106000.
   PubMed Web of Science ®Google Scholar
• Harikrishnan H, Jantan I, Haque MA, Kumolosasi E. 2018. Anti-inflammatory effects of Phyllanthus amarus Schum. & Thonn. through inhibition of NF-κB, MAPK, and PI3K-Akt signaling pathways in LPS-induced human macrophages. BMC Complement Altern Med. 18(1):224. doi: 10.1186/s12906-018-2289-3.
   PubMedGoogle Scholar
• Hopkins AL. 2008. Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol. 4(11):682–690. doi: 10.1038/nchembio.118.
   PubMed Web of Science ®Google Scholar
• Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, et al. 2020. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 395(10223):497–506. doi: 10.1016/S0140-6736(20)30183-5.
   PubMed Web of Science ®Google Scholar
• Huang Y, Yao P, Leung KW, Wang H, Kong XP, Dong TTX, Chen Y, Qin QW, Tsim KWK. 2020. The Chinese medicinal herbs of spleen-meridian property regulate body temperature in yeast-induced fever rats. Phytomedicine. 74:152815. doi: 10.1016/j.phymed.2018.12.038.
   PubMed Web of Science ®Google Scholar
• Ivanov AI, Steiner AA, Patel S, Rudaya AY, Romanovsky AA. 2005. Albumin is not an irreplaceable carrier for amphipathic mediators of thermoregulatory responses to LPS: compensatory role of alpha1-acid glycoprotein. Am J Physiol Regul Integr Comp Physiol. 288(4):R872–878. doi: 10.1152/ajpregu.00514.2004.
   PubMed Web of Science ®Google Scholar
• Jackson-Bernitsas DG, Ichikawa H, Takada Y, Myers JN, Lin XL, Darnay BG, Chaturvedi MM, Aggarwal BB. 2007. Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappaB activation and proliferation in human head and neck squamous cell carcinoma. ONCOGENE. 26(10):1385–1397. doi: 10.1038/sj.onc.1209945.
   PubMed Web of Science ®Google Scholar
• Khan TH, Ganaie MA, Alharthy KM, Madkhali H, Jan BL, Sheikh IA. 2020. Naringenin prevents doxorubicin-induced toxicity in kidney tissues by regulating the oxidative and inflammatory insult in Wistar rats. Arch Physiol Biochem. 126(4):300–307. doi: 10.1080/13813455.2018.1529799.
   PubMed Web of Science ®Google Scholar
• Kim S, Chen J, Cheng T, Gindulyte A, He J, He S, Li Q, Shoemaker BA, Thiessen PA, Yu B, et al. 2021. PubChem in 2021: new data content and improved web interfaces. Nucleic Acids Res. 49(D1):D1388–d1395. doi: 10.1093/nar/gkaa971.
   PubMed Web of Science ®Google Scholar
• Kirkwood K, Martin T, Andreadis ST, Kim YJ. 2003. Chemically modified tetracyclines selectively inhibit IL-6 expression in osteoblasts by decreasing mRNA stability. Biochem Pharmacol. 66(9):1809–1819. doi: 10.1016/s0006-2952(03)00450-7.
   PubMed Web of Science ®Google Scholar
• Klauder J, Henkel J, Vahrenbrink M, Wohlenberg AS, Camargo RG, Püschel GP. 2020. Direct and indirect modulation of LPS-induced cytokine production by insulin in human macrophages. CYTOKINE. 136:155241. doi: 10.1016/j.cyto.2020.155241.
   PubMed Web of Science ®Google Scholar
• Kuhn M, Szklarczyk D, Franceschini A, Campillos M, von Mering C, Jensen LJ, Beyer A, Bork P. 2010. STITCH 2: an interaction network database for small molecules and proteins. Nucleic Acids Res. 38(Database issue):D552–556. doi: 10.1093/nar/gkp937.
   PubMedGoogle Scholar
• Li L, Liu J, Zhang J. 2016. Therapeutic effect of Zixue Powder on collagen-induced arthritis in rats and its mechanism. Drugs Clinic. 31:1135–1140.
   Google Scholar
• Li MT, Xie L, Jiang HM, Huang Q, Tong RS, Li X, Xie X, Liu HM. 2022. Role of licochalcone A in potential pharmacological therapy: a review. Front Pharmacol. 13:878776. doi: 10.3389/fphar.2022.878776.
   PubMed Web of Science ®Google Scholar
• Li X, Wei S, Niu S, Ma X, Li H, Jing M, Zhao Y. 2022. Network pharmacology prediction and molecular docking-based strategy to explore the potential mechanism of Huanglian Jiedu Decoction against sepsis. Comput Biol Med. 144:105389. doi: 10.1016/j.compbiomed.2022.105389.
   PubMed Web of Science ®Google Scholar
• Li Y, Yang L, Wang Y, Deng Z, Xu S, Xie H, Zhang Y, Li J. 2021. Exploring metformin as a candidate drug for rosacea through network pharmacology and experimental validation. Pharmacol Res. 174:105971. doi: 10.1016/j.phrs.2021.105971.
   PubMed Web of Science ®Google Scholar
• Li Y, Zou L, Li T, Lai D, Wu Y, Qin S. 2019. Mogroside V inhibits LPS-induced COX-2 expression/ROS production and overexpression of HO-1 by blocking phosphorylation of AKT1 in RAW264.7 cells. Acta Biochim Biophys Sin (Shanghai). 51(4):365–374. doi: 10.1093/abbs/gmz014.
   PubMed Web of Science ®Google Scholar
• Liu F, Romantseva T, Park YJ, Golding H, Zaitseva M. 2020. Production of fever mediator PGE(2) in human monocytes activated with MDP adjuvant is controlled by signaling from MAPK and p300 HAT: key role of T cell derived factor. Mol Immunol. 128:139–149. doi: 10.1016/j.molimm.2020.10.008.
   PubMed Web of Science ®Google Scholar
• Liu J, Tao L, Liu X, Yao H, Yu S, Wang Q, Zhang J, Gao Z, Jiang R, Jing W, et al. 2021. GI symptoms and fever increase the risk of severe illness and death in patients with COVID-19. GUT. 70(2):442–444. doi: 10.1136/gutjnl-2020-321751.
   PubMed Web of Science ®Google Scholar
• Ma LL, Liu HM, Luo CH, He YN, Wang F, Huang HZ, Han L, Yang M, Xu RC, Zhang DK. 2021. Fever and antipyretic supported by traditional Chinese medicine: a multi-pathway regulation. Front Pharmacol. 12:583279. doi: 10.3389/fphar.2021.583279.
   PubMed Web of Science ®Google Scholar
• McGuire VA, Gray A, Monk CE, Santos SG, Lee K, Aubareda A, Crowe J, Ronkina N, Schwermann J, Batty IH, et al. 2013. Cross talk between the Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling. Mol Cell Biol. 33(21):4152–4165. doi: 10.1128/MCB.01691-12.
   PubMed Web of Science ®Google Scholar
• Morikawa K, Nonaka M, Narahara M, Torii I, Kawaguchi K, Yoshikawa T, Kumazawa Y, Morikawa S. 2003. Inhibitory effect of quercetin on carrageenan-induced inflammation in rats. Life Sci. 74(6):709–721. doi: 10.1016/j.lfs.2003.06.036.
   PubMed Web of Science ®Google Scholar
• National Health Commission of the People’s Republic of China, National Administration of Traditional Chinese Medicine. 2020. Diagnosis and treatment plan for pneumonia caused by novel coronavirus infection (trial version 3). Tianjin J Trad Chinese Med. 37:1–3.
   Google Scholar
• Nguyen T, Chen X, Chai J, Li R, Han X, Chen X, Liu S, Chen M, Xu X. 2020. Antipyretic, anti-inflammatory and analgesic activities of Periplaneta americana extract and underlying mechanisms. Biomed Pharmacother. 123:109753. doi: 10.1016/j.biopha.2019.109753.
   PubMed Web of Science ®Google Scholar
• Park MY, Ji GE, Sung MK. 2012. Dietary kaempferol suppresses inflammation of dextran sulfate sodium-induced colitis in mice. Dig Dis Sci. 57(2):355–363. doi: 10.1007/s10620-011-1883-8.
   PubMed Web of Science ®Google Scholar
• Perlik V, Li Z, Goorha S, Ballou LR, Blatteis CM. 2005. LPS-activated complement, not LPS per se, triggers the early release of PGE2 by Kupffer cells. Am J Physiol Regul Integr Comp Physiol. 289(2):R332–r339. doi: 10.1152/ajpregu.00567.2004.
   PubMed Web of Science ®Google Scholar
• Pi WM, Han NN, Yuan ZH, Wang ZJ, Lin XY. 2022. Analysis of antipyretic compatibility law and material basis of Gypsum Fibrosum based on “dry-method + wet-method” and “coordination chemistry”. Chinese Trad Herbal Drugs. 53:1471–1482.
   Google Scholar
• Prasad K, Krishnan PR. 2010. Fever is associated with doubling of odds of short-term mortality in ischemic stroke: an updated meta-analysis. Acta Neurol Scand. 122(6):404–408. doi: 10.1111/j.1600-0404.2010.01326.x.
   PubMed Web of Science ®Google Scholar
• Ridder DA, Lang MF, Salinin S, Röderer JP, Struss M, Maser-Gluth C, Schwaninger M. 2011. TAK1 in brain endothelial cells mediates fever and lethargy. J Exp Med. 208(13):2615–2623. doi: 10.1084/jem.20110398.
   PubMed Web of Science ®Google Scholar
• Romanovsky AA, Ivanov AI, Karman EK. 1999. Blood-borne, albumin-bound prostaglandin E2 may be involved in fever. Am J Physiol. 276(6):R1840–1844. doi: 10.1152/ajpregu.1999.276.6.R1840.
   PubMedGoogle Scholar
• Roth J, Blatteis CM. 2014. Mechanisms of fever production and lysis: lessons from experimental LPS fever. Compr Physiol. 4(4):1563–1604. doi: 10.1002/cphy.c130033.
   PubMed Web of Science ®Google Scholar
• Ru J, Li P, Wang J, Zhou W, Li B, Huang C, Li P, Guo Z, Tao W, Yang Y, et al. 2014. TCMSP: a database of systems pharmacology for drug discovery from herbal medicines. J Cheminform. 6(1):13. doi: 10.1186/1758-2946-6-13.
   PubMed Web of Science ®Google Scholar
• Safran M, Dalah I, Alexander J, Rosen N, Iny Stein T, Shmoish M, Nativ N, Bahir I, Doniger T, Krug H, et al. 2010. GeneCards version 3: the human gene integrator. Database (Oxford). 2010(0):baq020–baq020. doi: 10.1093/database/baq020.
   PubMedGoogle Scholar
• Salvi V, Vaira X, Gianello V, Vermi W, Bugatti M, Sozzani S, Bosisio D. 2016. TLR signalling pathways diverge in their ability to induce PGE2. Mediators Inflamm. 2016:5678046–5678010. doi: 10.1155/2016/5678046.
   PubMed Web of Science ®Google Scholar
• Santhi VP, Masilamani P, Sriramavaratharajan V, Murugan R, Gurav SS, Sarasu VP, Parthiban S, Ayyanar M. 2021. Therapeutic potential of phytoconstituents of edible fruits in combating emerging viral infections. J Food Biochem. 45(8):e13851. doi: 10.1111/jfbc.13851.
   PubMed Web of Science ®Google Scholar
• Schortgen F, Clabault K, Katsahian S, Devaquet J, Mercat A, Deye N, Dellamonica J, Bouadma L, Cook F, Beji O, et al. 2012. Fever control using external cooling in septic shock: a randomized controlled trial. Am J Respir Crit Care Med. 185(10):1088–1095. doi: 10.1164/rccm.201110-1820OC.
   PubMed Web of Science ®Google Scholar
• Shen Y, Lou Y, Zhu S. 2020. Hyperthermia is a predictor of high mortality in patients with sepsis. Crit Care. 24(1):543. doi: 10.1186/s13054-020-03263-0.
   PubMed Web of Science ®Google Scholar
• Song YD, Zhou MM, Xie M. 2020. Textual research on natrii sulfas, mirabilite, and nitrostone. Chinese Med Mod Distance Educ China. 18:57–60.
   Google Scholar
• Sreekanth GP, Yenchitsomanus PT, Limjindaporn T. 2018. Role of mitogen-activated protein kinase signaling in the pathogenesis of dengue virus infection. Cell Signal. 48:64–68. doi: 10.1016/j.cellsig.2018.05.002.
   PubMed Web of Science ®Google Scholar
• Stosser S, Gotthardt M, Lindner-Pfleghar B, Juttler E, Kassubek R, Neugebauer H. 2021. Severe dysphagia predicts poststroke fever. STROKE. 52(7):2284–2291. doi: 10.1161/STROKEAHA.120.033396.
   PubMed Web of Science ®Google Scholar
• Tan E, Braithwaite I, McKinlay CJD, Dalziel SR. 2020. Comparison of acetaminophen (paracetamol) with ibuprofen for treatment of fever or pain in children younger than 2 years: a systematic review and meta-analysis. JAMA Netw Open. 3(10):e2022398. doi: 10.1001/jamanetworkopen.2020.22398.
   PubMed Web of Science ®Google Scholar
• Telegdy G, Adamik A. 2008. Involvement of CRH receptors in urocortin-induced hyperthermia. PEPTIDES. 29(11):1937–1942. doi: 10.1016/j.peptides.2008.07.028.
   PubMed Web of Science ®Google Scholar
• von Mering C, Huynen M, Jaeggi D, Schmidt S, Bork P, Snel B. 2003. STRING: a database of predicted functional associations between proteins. Nucleic Acids Res. 31(1):258–261. doi: 10.1093/nar/gkg034.
   PubMed Web of Science ®Google Scholar
• Wang H, Tian L, Han Y, Ma X, Hou Y, Bai G. 2022. Mechanism assay of honeysuckle for heat-clearing based on metabolites and metabolomics. Metabolites. 12(2):1–11. doi: 10.3390/metabo12020121.
   Web of Science ®Google Scholar
• Wang JY, Liu JL, Liu P. 1998. Comparison of pharmacological effects of Zixue San suspension administered in different way. Pharmacol Clin Chinese Materia Med. 14:10–11.
   Google Scholar
• Wang SL, Liao HR, Cheng MJ, Shu CW, Chen CL, Chung MI, Chen JJ. 2018. Four new 2-(2-phenylethyl)-4H-chromen-4-one derivatives from the resinous wood of Aquilaria sinensis and their inhibitory activities on neutrophil pro-inflammatory responses. Planta Med. 84(18):1340–1347. doi: 10.1055/a-0645-1437.
   PubMed Web of Science ®Google Scholar
• Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, et al. 2018. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 46(D1):D1074–d1082. doi: 10.1093/nar/gkx1037.
   PubMed Web of Science ®Google Scholar
• Wrotek S, Jędrzejewski T, Nowakowska A, Kozak W. 2015. Glutathione deficiency attenuates endotoxic fever in rats. Int J Hyperthermia. 31(7):793–799. doi: 10.3109/02656736.2015.1067333.
   PubMed Web of Science ®Google Scholar
• Wu DY, Lu SQ. 2020. The effects of abnormal body temperature on the prognosis of patients with septic shock. Ther Hypothermia Temp Manag. 10(3):148–152. doi: 10.1089/ther.2019.0012.
   PubMed Web of Science ®Google Scholar
• Wu JB, Gong J, Ni SF. 2010. Survey of pharmacological study of magnetitum. J Anhui Agric Sci. 38:9375–9376.
   Google Scholar
• Yang DJ, Zhao YK, Lu YQ. 2002. Determination of primary and secondary components in talcum by ICP-AES. Spectroscopy Spectral Anal. 22:86–88.
   Web of Science ®Google Scholar
• Yang Y, Ding Z, Wang Y, Zhong R, Feng Y, Xia T, Xie Y, Yang B, Sun X, Shu Z. 2020. Systems pharmacology reveals the mechanism of activity of Physalis alkekengi L. var. franchetii against lipopolysaccharide-induced acute lung injury. J Cell Mol Med. 24(9):5039–5056. doi: 10.1111/jcmm.15126.
   PubMed Web of Science ®Google Scholar
• Yi Z, Jia Q, Lin Y, Wang Y, Cong J, Gu Z, Ling J, Cai G. 2022. Mechanism of Elian granules in the treatment of precancerous lesions of gastric cancer in rats through the MAPK signaling pathway based on network pharmacology. Pharm Biol. 60(1):87–95. doi: 10.1080/13880209.2021.2017980.
   PubMed Web of Science ®Google Scholar
• Yu J. 2019. Gas chromatographic fingerprints of different musk. Chinese J Experi Trad Med Formulae. 25:175–182.
   Google Scholar
• Zhang GB, Li QY, Chen QL, Su SB. 2013. Network pharmacology: a new approach for Chinese herbal medicine research. Evid Based Complement Alternat Med. 2013:621423. doi: 10.1155/2013/621423.
   PubMed Web of Science ®Google Scholar
• Zhang HY, Hu J, Han X. 2022a. Anticonvulsant effect of different processes of Zixue Powder in mice and its mechanism. Drug Eval Res. 45:84–89.
   Google Scholar
• Zhang LX, Liu YJ. 2021. Mineralogical identification and composition comparison of cinnabaris. Chinese Trad Patent Med. 43:551–553.
   Google Scholar
• Zhang SQ, Zhao ZJ, Zheng LW. 1986. Determination of the content of the main components in the Chinese medicine calcitum. J Chinese Med Materials. 4:42–43.
   Google Scholar
• Zhang X, Lian X, Li H, Zhao W, Li X, Zhou F, Zhou Y, Cui T, Wang Y, Liu C. 2022b. Taxifolin attenuates inflammation via suppressing MAPK signal pathway in vitro and in silico analysis. Chin Herb Med. 14(4):554–562. doi: 10.1016/j.chmed.2021.03.002.
   PubMed Web of Science ®Google Scholar
• Zhang YP, Lu YL, Su D, Chen ZM. 2022c. Clinical observation on prevention of recurrent febrile seizure in children by short-term administration of ZiXue. Inner Mongolia J Trad Chinese Med. 41:1–3.
   Google Scholar
• Ziesenitz VC, Welzel T, van Dyk M, Saur P, Gorenflo M, van den Anker JN. 2022. Efficacy and safety of NSAIDs in infants: a comprehensive review of the literature of the past 20 years. Paediatr Drugs. 24(6):603–655. doi: 10.1007/s40272-022-00514-1.
   PubMed Web of Science ®Google Scholar