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International Journal of Cardiovascular Interventions Volume 3, 2000 - Issue 2
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Research Article

Catheter-based transendocardial gene delivery for therapeutic myocardial angiogenesis

Ran Kornowski Director, Myocardial Revascularization and Angiogenesis Cardiovascular ResearchInstitute Washington Hospital Center 110 IrvingSt, NW, Suite 4B-1 Washington, DC 20010, USA
Pages 67-70 | Published online: 10 Jul 2009

  • Mack CA, Patel SR, Schwarte EA et al. Biologic bypass with the use of adenovirus-mediated gene transfer of the complementary deoxyribonucleic acid for VEGF-12, improves myocardial perfusion and function in the ischemic porcine heart. J Thorac Cardiovasc Surg 1998; 115: 168-177.
  • Schumacher B, Pecher P, von Specht BU, Stegman T. Induction of neoangiogenesis in ischemic myocardium by human growth factors. First clinical results of a new treatment of coronary heart disease. Circulation 1998; 97: 645-650.
  • Losordo DW, Vale PR, Symes JF et al. Gene therapy for myocardial angiogenesis: initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia. Circulation 1998; 98: 2800-2804.
  • Rosengart TK, Lee EY, Patel SR et al. Angiogenesis gene therapy: phase 1 assessment of direct intramyocardial administration of an adenovirus vector expressing VEGF121 cDNA to individuals with clinically significant severe coronary artery disease. Circulation 1999; 100: 468-474.
  • Li JJ, Ueno H, Pan Y et al. Percutaneous transluminal gene transfer into canine myocardium in vivo by replication-defective adenovirus. Cardiovasc Res 1995; 30: 97-105.
  • Sanborn TA, Tarazona N, Deutsch E et al. Percutaneous endocardial gene therapy: in vivo gene transfer and expression. J Am Coll Cardiol 1999; 33(suppl A): 262A.
  • Vale PR, Losordo DW, Tkebuchava T, Chen D, Milliken CE, lsner JM. Catheter-based myocardial gene-transfer utilizing nonfluoroscopic electromechanical left ventricular mapping. J Am Coll Cardiol 1999; 34: 246-254.
  • Kornowski R, Fuchs S, Vodovotz Y et al. Successful gene transfer in a porcine ischemia model using the Biosense guided transendocardial injection catheter. J Am Coll Cardiol 1999; 33: 355A.
  • Kornowski R, Fuchs S, Tio FO, Pierre A, Epstein SE, Leon MB. Evaluation of the acute and chronic safety of the biosense injection catheter system in porcine hearts. Cathet Cardiovasc Intervent 1999; 48: 447-453.
  • Kornowski R, Leon MB, Vodovotz Y et al. Electromagnetic-guidance for catheter-based trans-endocardial injection: a platform for myocardial angiogenesis therapy: results in normal and ischemic porcine model. J Am Coll Cardiol 2000; 35; 1031-1039.

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