9
Views
3
CrossRef citations to date
0
Altmetric
Research Article

A nonsurgical porcine model of left ventricular dysfunction. Validation of myocardial viability using dobutamine stress echocardiography and positron emission tomography

, , , , , , , , , , , , , , & show all
Pages 111-120 | Published online: 10 Jul 2009

  • Kloner RA, Bolli R, Marban E, Reinlib E, Braunwald E and participants. Medical and cellular implications of stunning, hibernation, and preconditioning. An NHLBI Workshop. Circulation 1998; 97: 1848-1867.
  • Rahimtoola SH. The hibernating myocardium. Am Heart J 1989; 117: 211-221.
  • Rahimtoola SH. Myocardial hibernation: clinical manifestations and importance. Dial in Cardiovasc Med 1997; 2: 59-75.
  • Camici PG, Wijns W, Borgers M et al. Pathophysiological mechanisms of chronic reversible left ventricular dysfunction due to coronary artery disease (Hibernating Myocardium). Circulation 1997; 96: 3205-3214.
  • Iskandrian AS. Myocardial viability: unresolved issues. J Nucl Med 1996; 37: 794-797.
  • Schultz R, Rose J, Martin C, Brode OE, Heusch G. Development of short-term myocardial hibernation: its limitation by the severity of ischemia and inotropic stimulation. Circulation 1993; 88:684-695.
  • Chen C, Li L, Chen LL et al. Incremental doses of dobutamine induce biphasic response in dysfunctional left ventricular regions subtending coronary stenosis. Circulation 1995; 92: 756-766.
  • Chen C, Chen E, Fallon JT et al. Functional and structural alterations with 24-hour myocardial hibernation and recovery after reperfusion. A pig model of myocardial hibernation. Circulation 1996; 4: 507-516.
  • Kudej RK, Ghaleh B, Sato N, Bishop SP, Vatner SF. Perfusion contraction matching with coronary stenosis induces necrosis rather than hibernating myocardium in conscious pigs. Circulation 1996; 94(suppl 1): 1-186 (abstr).
  • Fallavollita JA, Perry BJ, Canty JM. 18FDG deposition and regional flow in pigs with chronically dysfunctional myocardium. Evidence for transmural variations in chronic hibernating myocardium. Circulation 1997; 95: 1900-1909.
  • Mills 1, Fallon JT, Wrenn D et al. Adaptive responses of coronary circulation and myocardium to chronic reduction in perfusion pressure and flow. Am J Physiol 1994; 266: H447-H457.
  • Shen YT, Vatner SF. Mechanism of impaired myocardial function during progressive coronary stenosis in conscious pigs. Circ Res 1995; 76: 479-488.
  • Shen YT, Kudej RK, Bishop SP, Vatner SF. Inotropic reserve and histological appearance of hibernating myocardium in conscious pigs with ameroid-induced coronary stenosis. Basic Res Cardiol 1996; 91: 479-485.
  • White FC, Carroll SM, Magnet A, Bloor CM. Coronary collateral development in swine after coronary artery occlusion. Circ Res 1992; 71: 1490-1500.
  • Roth DM, Mauroka Y, Rogers J, White FC, Longhurst JC, Bloor CM. Development of coronary collateral circulation in left circumflex ameroid-occluded swine myocardium. Am J Physiol 1987; 253: H1279-H1288.
  • Afridi I, Kleiman NS, Raizner AE, Zoghbi A. Dobutamine echocardiography in myocardial hibernation. Optimal dose and accuracy in predicting recovery of ventricular function after coronaiy angioplasty. Circulation 1995; 91: 663-670.
  • Henrich M, Vester E, Julicher F. Myocardial glucose metabolism in patients with a coronary artery occlusion: an FDG-PET study in the fasted state and after glucose load. J Nucl Med 1991; 32: 909 (abstr).
  • Knuuti JM, Nuutila P, Ruotsalainen U et al. Euglycemic hyperinsulinemic clamp and oral glucose load in stimulating myocardial glucose utilization during positron emission tomography. J Nucl Med 1992; 33: 1255-1262.
  • Nuyts J, Suetens P, Oosterlinck A, De Roo M, Mortelmans L Delineation of ECT images using global constraints and dynamic programming. Trans Med Imaging 1991; 10: 489-498.
  • Maes A, Flameng W, Nuyts J et al. Histological alterations in chronically hypoperfused myocardium. Correlation with PET findings. Circulation 1994; 90: 735-745.
  • Barth K, Eicker B, Bittner U, Marhoff P. The improvement of vessel quantification with image processing equipment for high resolution digital angiography. In: Lemke HV, ed., Computer-Assisted Radiology. Berlin: Springer-Verlag, 1989: 220-225.
  • Borgers M, Thone F, Wouters L Structural correlates of regional myocardial dysfunction in patients with critical coronaiy artery stenosis: chronic hibernation? Cardiovasc Pathol 1993; 2: 237-245.
  • SAS Institute Inc. SAS/STATTM User's Guide, release 6.03 edition. Caey, NC: SAS Institute Inc., 1988.
  • SAS Institute Inc. SAS® Procedures Guide, release 6.03 edition. Gary, NC: SAS Institute Inc., 1988.
  • Schwartz RS, Huber KC, Murphy JG et al. Restenosis and the proportional neointimal response to coronary artery injury: results in a porcine model. J Am Coll Cardiol 1992; 19: 267-274.
  • De Scheerder IK, Wilczek KL, Verbeken EV et al. Biocompatibility of polymer-coated oversized metallic stents implanted in normal porcine coronary arteries. Atherosclerosis 1995; 114: 105-114.
  • Klocke FJ. Measurements of coronary blood flow and degree of stenosis: current clinical implications and continuing uncertainties. J Am Coll Cardiol 1983; 1:31-41.
  • Could LK, Kirkeeide RE, Buchi M. Coronary flow reserve as a physiologic marker of stenosis severity. J Am Coll Cardiol 1990; 15:459-474.
  • Firozan S, Wei K, Linka A, Skyba D, Goodman NC, Kaul S. A canine model of chronic ischemic cardiomyopathy: characterization of regional flow-function relations. Am J Physiol 1999; 276: H446-H455.
  • Foils JD, Gallagher K, Rowe GG. Blood flow reductions in stenosed canine coronary arteries: vasospasm or platelet aggregation. Circulation 1982; 65: 248-254.
  • Vanoverschelde J-LJ, Wijns W, Borgers M et al. Chronic hibernation in humans. Circulation 1997; 95: 1961-1971.
  • Fallavollita JA, Canty JM. Differential 18F-2-deoxyglucose uptake in viable dysfunctional myocardium with normal resting perfusion: evidence for chronic stunning in pigs. Circulation. 1999; 99: 2798-2805.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.