SARS-CoV-2 effects on male reproduction: should men be worried??

References

• Almeida, R., Braz-de-Melo, H. A., Santos, I. O., Corrêa, R., Kobinger, G. P., & Magalhaes, K. G. (2020). The cellular impact of the ZIKA virus on male reproductive tract immunology and physiology. Cells, 9(4), 1006. https://doi.org/10.3390/cells9041006
   PubMed Web of Science ®Google Scholar
• Chen, Y. W., Lee, M. S., Lucht, A., Chou, F. P., Huang, W., Havighurst, T. C., Kim, K., Wang, J. K., Antalis, T. M., Johnson, M. D., & Lin, C. Y. (2010). TMPRSS2, a serine protease expressed in the prostate on the apical surface of luminal epithelial cells and released into semen in prostasomes, is misregulated in prostate cancer cells. The American Journal of Pathology, 176(6), 2986–2996. https://doi.org/10.2353/ajpath.2010.090665
   PubMed Web of Science ®Google Scholar
• Chen, Z., Song, X., Li, Q., Xie, L., Guo, T., Su, T., Tang, C., Chang, X., Liang, B., & Huang, D. (2019). Androgen receptor-activated enhancers simultaneously regulate oncogene TMPRSS2 and lncRNA PRCAT38 in Prostate Cancer. Cells, 8(8), 864. https://doi.org/10.3390/cells808086
   PubMed Web of Science ®Google Scholar
• Cheng, C. Y., & Mruk, D. D. (2012). The blood-testis barrier and its implications for male contraception. Pharmacological Reviews, 64(1), 16–64. https://doi.org/10.1124/pr.110.002790
   PubMed Web of Science ®Google Scholar
• De Plato, F., Fontana, C., Gherardi, G., Privitera, G. P., Puro, V., Rigoli, R., Viaggi, B., & Viale, P. (2019). Collection, transport and storage procedures for blood culture specimens in adult patients: Recommendations from a board of Italian experts. Clinical Chemistry and Laboratory Medicine, 57(11), 1680–1689. https://doi.org/10.1515/cclm-2018-1146
   PubMed Web of Science ®Google Scholar
• Douglas, G. C., O'Bryan, M. K., Hedger, M. P., Lee, D. K., Yarski, M. A., Smith, A. I., & Lew, R. A. (2004). The novel angiotensin-converting enzyme (ACE) homolog, ACE2, is selectively expressed by adult Leydig cells of the testis. Endocrinology, 145(10), 4703–4711. https://doi.org/10.1210/en.2004-0443
   PubMed Web of Science ®Google Scholar
• Fan, C., Lu, W., Li, K., Ding, Y., & Wang, J. (2020). ACE2 expression in kidney and testis may cause kidney and testis infection in COVID-19 patients. Frontiers in Medicine, 7, 563893. https://doi.org/10.3389/fmed.2020.563893
   PubMed Web of Science ®Google Scholar
• Farsimadan, M., & Motamedifar, M. (2020). Bacterial infection of the male reproductive system causing infertility. Journal of Reproductive Immunology, 142, 103183. https://doi.org/10.1016/j.jri.2020.103183
   PubMed Web of Science ®Google Scholar
• Farsimadan, M., & Motamedifar, M. (2021). The effects of human immunodeficiency virus, human papillomavirus, herpes simplex virus-1 and -2, human herpesvirus-6 and -8, cytomegalovirus, and hepatitis B and C virus on female fertility and pregnancy. British Journal of Biomedical Science, 78(1), 1–11. https://doi.org/10.1080/09674845.2020.1803540
   PubMed Web of Science ®Google Scholar
• Farsimadan, M., Ismail Haje, M., Khudhur Mawlood, C., Arabipour, I., Emamvirdizadeh, A., Takamoli, S., Masumi, M., & Vaziri, H. (2021). MicroRNA variants in endometriosis and its severity. British Journal of Biomedical Science, 78, 1–5. https://doi.org/10.1080/09674845.2021.1889157
   Google Scholar
• Farsimadan, M., Moammadzadeh Ghosi, F., Takamoli, S., & Vaziri, H. (2021). Association analysis of KISS1 polymorphisms and haplotypes with polycystic ovary syndrome. British Journal of Biomedical Science, 78, 1–5. https://doi.org/10.1080/09674845.2020.1864109
   Google Scholar
• Farsimadan, M., Riahi, S. M., Muhammad, H. M., Emamvirdizadeh, A., Tabasi, M., Motamedifar, M., & Roviello, G. (2021). The effects of hepatitis B virus infection on natural and IVF pregnancy: A meta-analysis study. Journal of Viral Hepatitis. PMID: 34216533. https://doi.org/10.1111/jvh.13565
   Google Scholar
• Gaskell, K. M., Houlihan, C., Nastouli, E., & Checkley, A. M. (2017). Persistent zika virus detection in semen in a traveler returning to the United Kingdom from Brazil, 2016. Emerging Infectious Diseases, 23(1), 137–139. https://doi.org/10.3201/eid2301.161300
   PubMed Web of Science ®Google Scholar
• Ghosh, S., & Ghosh, D. (2020). Current perspectives of male infertility induced by immunomodulation due to reproductive tract infections. Chemical Biology Letters, 7(2), 85–91. https://pubs.thesciencein.org/journal/index.php/cbl/article/view/174
   Web of Science ®Google Scholar
• Guo, L., Zhao, S., Li, W., Wang, Y., Li, L., Jiang, S., Ren, W., Yuan, Q., Zhang, F., Kong, F., Lei, J., & Yuan, M. (2021). Absence of SARS-CoV-2 in semen of a COVID-19 patient cohort. Andrology, 9(1), 42–47. https://doi.org/10.1111/andr.12848
   PubMed Web of Science ®Google Scholar
• Haghpanah, A., Masjedi, F., Alborzi, S., Hosseinpour, A., Dehghani, A., Malekmakan, L., & Roozbeh, J. (2021). Potential mechanisms of SARS-CoV-2 action on male gonadal function and fertility: Current status and future prospects. Andrologia, 53(1), e13883. https://doi.org/10.1111/and.13883
   PubMed Web of Science ®Google Scholar
• Hales, D. B. (1992). Interleukin-1 inhibits Leydig cell steroidogenesis primarily by decreasing 17 alpha-hydroxylase/C17-20 lyase cytochrome P450 expression. Endocrinology, 131(5), 2165–2172. https://doi.org/10.1210/endo.131.5.1425417
   PubMed Web of Science ®Google Scholar
• Hales, D. B., Xiong, Y., & Tur-Kaspa, I. (1992). The role of cytokines in the regulation of Leydig cell P450c17 gene expression. The Journal of Steroid Biochemistry and Molecular Biology, 43(8), 907–914. https://doi.org/10.1016/0960-0760(92)90318-D
   PubMed Web of Science ®Google Scholar
• Han, H., Ma, Q., Li, C., Liu, R., Zhao, L., Wang, W., Zhang, P., Liu, X., Gao, G., Liu, F., Jiang, Y., Cheng, X., Zhu, C., & Xia, Y. (2020). Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors. Emerging Microbes & Infections, 9(1), 1123–1130. https://doi.org/10.1080/22221751.2020.1770129
   PubMed Web of Science ®Google Scholar
• Han, H., Yang, L., Liu, R., Liu, F., Wu, K. L., Li, J., Liu, X. H., & Zhu, C. L. (2020). Prominent changes in blood coagulation of patients with SARS-CoV-2 infection. Clinical Chemistry and Laboratory Medicine, 58(7), 1116–1120. https://doi.org/10.1515/cclm-2020-0188
   PubMed Web of Science ®Google Scholar
• He, J. L., Luo, L., Luo, Z. D., Lyu, J. X., Ng, M. Y., Shen, X. P., & Wen, Z. (2020). Diagnostic performance between CT and initial real-time RT-PCR for clinically suspected 2019 coronavirus disease (COVID-19) patients outside Wuhan, China. Respiratory Medicine, 168, 105980. https://doi.org/10.1016/j.rmed.2020.105980
   PubMed Web of Science ®Google Scholar
• Hikmet, F., Méar, L., Edvinsson, Å., Micke, P., Uhlén, M., & Lindskog, C. (2020). The protein expression profile of ACE2 in human tissues. Molecular Systems Biology, 16(7), e9610. https://doi.org/10.15252/msb.20209610
   PubMed Web of Science ®Google Scholar
• Holtmann, N., Edimiris, P., Andree, M., Doehmen, C., Baston-Buest, D., Adams, O., Kruessel, J. S., & Bielfeld, A. P. (2020). Assessment of SARS-CoV-2 in human semen-a cohort study. Fertility and Sterility, 114(2), 233–238. https://doi.org/10.1016/j.fertnstert.2020.05.028
   PubMed Web of Science ®Google Scholar
• Hu, B., Huang, S., & Yin, L. (2021). The cytokine storm and COVID-19. Journal of Medical Virology, 93(1), 250–256. https://doi.org/10.1002/jmv.26232
   PubMed Web of Science ®Google Scholar
• Huang, C., Ji, X., Zhou, W., Huang, Z., Peng, X., Fan, L., Lin, G., & Zhu, W. (2021). Coronavirus: A possible cause of reduced male fertility. Andrology, 9(1), 80–87. https://doi.org/10.1111/andr.12907
   PubMed Web of Science ®Google Scholar
• Hui, L., Nie, Y., Li, S., Guo, M., Yang, W., Huang, R., Chen, J., Liu, Y., Lu, X., Chen, Z., Yang, Q., & Wu, Y. (2020). Matrix metalloproteinase 9 facilitates Zika virus invasion of the testis by modulating the integrity of the blood-testis barrier. PLoS Pathogens, 16(4), e1008509. https://doi.org/10.1371/journal.ppat.1008509
   PubMed Web of Science ®Google Scholar
• Irez, T., Bicer, S., Sahin, E., Dutta, S., & Sengupta, P. (2020). Cytokines and adipokines in the regulation of spermatogenesis and semen quality. Chemical Biology Letters, 7(2), 131–139. http://pubs.iscience.in/journal/index.php/cbl/article/view/999
   Web of Science ®Google Scholar
• Kadihasanoglu, M., Aktas, S., Yardimci, E., Aral, H., & Kadioglu, A. (2021). SARS-CoV-2 Pneumonia Affects Male Reproductive Hormone Levels: A Prospective, Cohort Study. The Journal of Sexual Medicine, 18(2), 256–264. https://doi.org/10.1016/j.jsxm.2020.11.007
   Google Scholar
• Kissler, S. M., Tedijanto, C., Goldstein, E., Grad, Y. H., & Lipsitch, M. (2020). Projecting the transmission dynamics of SARS-CoV-2 through the postpandemic period. Science, 368(6493), 860–868. https://doi.org/10.1126/science.abb5793
   PubMed Web of Science ®Google Scholar
• Knuuttila, M., Mehmood, A., Mäki-Jouppila, J., Ryberg, H., Taimen, P., Knaapila, J., Ettala, O., Boström, P. J., Ohlsson, C., Venäläinen, M. S., Laiho, A., Elo, L. L., Sipilä, P., Mäkelä, S. I., & Poutanen, M. (2018). Intratumoral androgen levels are linked to TMPRSS2-ERG fusion in prostate cancer. Endocrine-Related Cancer, 25(9), 807–819. https://doi.org/10.1530/ERC-18-0148
   PubMed Web of Science ®Google Scholar
• Kurscheidt, F. A., Damke, E., Bento, J. C., Balani, V. A., Takeda, K. I., Piva, S., Piva, J. P., Irie, M., Gimenes, F., & Consolaro, M. (2018). Effects of herpes simplex virus infections on seminal parameters in male partners of infertile couples. Urology, 113, 52–58. https://doi.org/10.1016/j.urology.2017.11.050
   PubMed Web of Science ®Google Scholar
• Lai, C. C., Shih, T. P., Ko, W. C., Tang, H. J., & Hsueh, P. R. (2020). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges. International Journal of Antimicrobial Agents, 55(3), 105924. https://doi.org/10.1016/j.ijantimicag.2020.105924
   PubMed Web of Science ®Google Scholar
• Leisman, D. E., Deutschman, C. S., & Legrand, M. (2020). Facing COVID-19 in the ICU: Vascular dysfunction, thrombosis, and dysregulated inflammation. Intensive Care Medicine, 46(6), 1105–1108. https://doi.org/10.1007/s00134-020-06059-6
   PubMed Web of Science ®Google Scholar
• Li, D., Jin, M., Bao, P., Zhao, W., & Zhang, S. (2020). Clinical characteristics and results of semen tests among men with coronavirus disease 2019. JAMA Network Open, 3(5), e208292. https://doi.org/10.1001/jamanetworkopen.2020.8292
   PubMed Web of Science ®Google Scholar
• Li, N., Wang, T., & Han, D. (2012). Structural, cellular and molecular aspects of immune privilege in the testis. Frontiers in Immunology, 3, 152. https://doi.org/10.3389/fimmu.2012.00152
   PubMed Web of Science ®Google Scholar
• Li, R., Yin, T., Fang, F., Li, Q., Chen, J., Wang, Y., Hao, Y., Wu, G., Duan, P., Wang, Y., Cheng, D., Zhou, Q., Zafar, M. I., Xiong, C., Li, H., Yang, J., & Qiao, J. (2020). Potential risks of SARS-CoV-2 infection on reproductive health. Reproductive BioMedicine Online, 41(1), 89–95. https://doi.org/10.1016/j.rbmo.2020.04.018
   PubMed Web of Science ®Google Scholar
• Li, W., Shi, Z., Yu, M., Ren, W., Smith, C., Epstein, J. H., Wang, H., Crameri, G., Hu, Z., Zhang, H., Zhang, J., McEachern, J., Field, H., Daszak, P., Eaton, B. T., Zhang, S., & Wang, L. F. (2005). Bats are natural reservoirs of SARS-like coronaviruses. Science, 310(5748), 676–679. https://doi.org/10.1126/science.1118391
   PubMed Web of Science ®Google Scholar
• Li, Y., Zhou, W., Yang, L., & You, R. (2020). Physiological and pathological regulation of ACE2, the SARS-CoV-2 receptor. Pharmacological Research, 157, 104833. https://doi.org/10.1016/j.phrs.2020.104833
   PubMed Web of Science ®Google Scholar
• Lin, L., Jiang, X., Zhang, Z., Huang, S., Zhang, Z., Fang, Z., Gu, Z., Gao, L., Shi, H., Mai, L., Liu, Y., Lin, X., Lai, R., Yan, Z., Li, X., & Shan, H. (2020). Gastrointestinal symptoms of 95 cases with SARS-CoV-2 infection. Gut, 69(6), 997–1001. https://doi.org/10.1136/gutjnl-2020-321013
   PubMed Web of Science ®Google Scholar
• Liu, X., Chen, Y., Tang, W., Zhang, L., Chen, W., Yan, Z., Yuan, P., Yang, M., Kong, S., Yan, L., & Qiao, J. (2020). Single-cell transcriptome analysis of the novel coronavirus (SARS-CoV-2) associated gene ACE2 expression in normal and non-obstructive azoospermia (NOA) human male testes. Science China Life Sciences, 63(7), 1006–1015. https://doi.org/10.1007/s11427-020-1705-0
   PubMed Web of Science ®Google Scholar
• Liu, Y. C., Kuo, R. L., & Shih, S. R. (2020). COVID-19: The first documented coronavirus pandemic in history. Biomedical Journal, 43(4), 328–333. https://doi.org/10.1016/j.bj.2020.04.007
   PubMed Web of Science ®Google Scholar
• Ma, L., Xie, W., Li, D., Shi, L., Ye, G., Mao, Y., Xiong, Y., Sun, H., Zheng, F., Chen, Z., Qin, J., Lyu, J., Zhang, Y., & Zhang, M. (2021). Evaluation of sex-related hormones and semen characteristics in reproductive-aged male COVID-19 patients. Journal of Medical Virology, 93(1), 456–462. https://doi.org/10.1002/jmv.26259
   Google Scholar
• Manganaro, L., Saldari, M., Pozza, C., Vinci, V., Gianfrilli, D., Greco, E., Franco, G., Sergi, M. E., Scialpi, M., Catalano, C., & Isidori, A. M. (2018). Dynamic contrast-enhanced and diffusion-weighted MR imaging in the characterisation of small, non-palpable solid testicular tumours. European Radiology, 28(2), 554–564. https://doi.org/10.1007/s00330-017-5013-7
   PubMed Web of Science ®Google Scholar
• Mansuy, J. M., Suberbielle, E., Chapuy-Regaud, S., Mengelle, C., Bujan, L., Marchou, B., Delobel, P., Gonzalez-Dunia, D., Malnou, C. E., Izopet, J., & Martin-Blondel, G. (2016). Zika virus in semen and spermatozoa. The Lancet Infectious Diseases, 16(10), 1106–1107. https://doi.org/10.1016/S1473-3099(16)30336-X
   PubMed Web of Science ®Google Scholar
• McElvaney, O. J., McEvoy, N. L., McElvaney, O. F., Carroll, T. P., Murphy, M. P., Dunlea, D. M., Ní Choileáin, O., Clarke, J., O'Connor, E., Hogan, G., Ryan, D., Sulaiman, I., Gunaratnam, C., Branagan, P., O'Brien, M. E., Morgan, R. K., Costello, R. W., Hurley, K., Walsh, S., … McElvaney, N. G. (2020). Characterization of the Inflammatory Response to Severe COVID-19 Illness. American Journal of Respiratory and Critical Care Medicine, 202(6), 812–821. https://doi.org/10.1164/rccm.202005-1583OC
   PubMed Web of Science ®Google Scholar
• Moradi, M., Moochani, S. S., Yamini, N., Javanmard, D., Marjani, A., Tabibzadeh, A., Tavakoli, A., & Monavari, S. H. (2021). Molecular detection of human cytomegalovirus in semen of infertile men in Tehran. International Journal of Medical Laboratory, 8, 55–61. https://doi.org/10.18502/ijml.v8i1.5673
   Google Scholar
• Mruk, D. D., & Cheng, C. Y. (2015). The mammalian blood-testis barrier: Its biology and regulation. Endocrine Reviews, 36(5), 564–591. https://doi.org/10.1210/er.2014-1101
   PubMed Web of Science ®Google Scholar
• Ng, S. C., & Tilg, H. (2020). COVID-19 and the gastrointestinal tract: More than meets the eye. Gut, 69(6), 973–974. https://doi.org/10.1136/gutjnl-2020-321195
   PubMed Web of Science ®Google Scholar
• Ning, J., Li, W., Ruan, Y., Xia, Y., Wu, X., Hu, K., Ding, X., Wu, X., Yu, L., Zhou, J., Mao, Z., Xu, W., Yu, W., & Cheng, F. (2020). Effects of 2019 novel coronavirus on male reproductive system: A retrospective study. Preprints, 2020, 2020040280. https://doi.org/10.20944/preprints202004.0280.v1
   Google Scholar
• Ou, X., Liu, Y., Lei, X., Li, P., Mi, D., Ren, L., Guo, L., Guo, R., Chen, T., Hu, J., Xiang, Z., Mu, Z., Chen, X., Chen, J., Hu, K., Jin, Q., Wang, J., & Qian, Z. (2020). Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV. Nature Communications, 11(1), 1620. https://doi.org/10.1038/s41467-020-15562-9
   PubMed Web of Science ®Google Scholar
• Öztürk, R., Taşova, Y., & Ayaz, A. (2020). COVID-19: Pathogenesis, genetic polymorphism, clinical features and laboratory findings. Turkish Journal of Medical Sciences, 50(SI-1), 638–657. https://doi.org/10.3906/sag-2005-287
   PubMedGoogle Scholar
• Pan, F., Xiao, X., Guo, J., Song, Y., Li, H., Patel, D. P., Spivak, A. M., Alukal, J. P., Zhang, X., Xiong, C., Li, P. S., & Hotaling, J. M. (2020). No evidence of severe acute respiratory syndrome-coronavirus 2 in semen of males recovering from coronavirus disease 2019. Fertility and Sterility, 113(6), 1135–1139. https://doi.org/10.1016/j.fertnstert.2020.04.024
   PubMed Web of Science ®Google Scholar
• Paoli, D., Pallotti, F., Colangelo, S., Basilico, F., Mazzuti, L., Turriziani, O., Antonelli, G., Lenzi, A., & Lombardo, F. (2020). Study of SARS-CoV-2 in semen and urine samples of a volunteer with positive naso-pharyngeal swab. Journal of Endocrinological Investigation, 43(12), 1819–1822. https://doi.org/10.1007/s40618-020-01261-1
   PubMed Web of Science ®Google Scholar
• Pedersen, S. F., & Ho, Y. C. (2020). SARS-CoV-2: A storm is raging. The Journal of Clinical Investigation, 130(5), 2202–2205. https://doi.org/10.1172/JCI137647
   PubMed Web of Science ®Google Scholar
• Peng, L., Liu, J., Xu, W., Luo, Q., Chen, D., Lei, Z., Huang, Z., Li, X., Deng, K., Lin, B., & Gao, Z. (2020). SARS-CoV-2 can be detected in urine, blood, anal swabs, and oropharyngeal swabs specimens. Journal of Medical Virology, 92(9), 1676–1680. https://doi.org/10.1002/jmv.25936
   PubMed Web of Science ®Google Scholar
• Perlman, S., & Netland, J. (2009). Coronaviruses post-SARS: Update on replication and pathogenesis. Nature Reviews. Microbiology, 7(6), 439–450. https://doi.org/10.1038/nrmicro2147
   PubMed Web of Science ®Google Scholar
• Pingili, A. K., Thirunavukkarasu, S., Kara, M., Brand, D. D., Katsurada, A., Majid, D. S., Navar, L. G., Gonzalez, F. J., & Malik, K. U. (2016). 6β-Hydroxytestosterone, a cytochrome P450 1B1-testosterone-metabolite, mediates angiotensin ii-induced renal dysfunction in male mice. Hypertension, 67(5), 916–926. https://doi.org/10.1161/HYPERTENSIONAHA.115.06936
   PubMed Web of Science ®Google Scholar
• Piroozmand, A., Mousavi Nasab, S. D., Erami, M., Hashemi, S., Khodabakhsh, E., Ahmadi, N., & Vahedpoor, Z. (2020). Distribution of human papillomavirus and antisperm antibody in semen and its association with semen parameters among infertile men. Journal of Reproduction & Infertility, 21(3), 183–188. https://www.jri.ir/article/60078
   PubMedGoogle Scholar
• Pozzilli, P., & Lenzi, A. (2020). Commentary: Testosterone, a key hormone in the context of COVID-19 pandemic. Metabolism: Clinical and Experimental, 108, 154252. https://doi.org/10.1016/j.metabol.2020.154252
   PubMed Web of Science ®Google Scholar
• Rastrelli, G., Di Stasi, V., Inglese, F., Beccaria, M., Garuti, M., Di Costanzo, D., Spreafico, F., Greco, G. F., Cervi, G., Pecoriello, A., Magini, A., Todisco, T., Cipriani, S., Maseroli, E., Corona, G., Salonia, A., Lenzi, A., Maggi, M., De Donno, G., & Vignozzi, L. (2021). Low testosterone levels predict clinical adverse outcomes in SARS-CoV-2 pneumonia patients. Andrology, 9(1), 88–98. https://doi.org/10.1111/andr.12821
   PubMed Web of Science ®Google Scholar
• Rubino, S., Kelvin, N., Bermejo-Martin, J. F., & Kelvin, D. (2020). As COVID-19 cases, deaths and fatality rates surge in Italy, underlying causes require investigation. Journal of Infection in Developing Countries, 14(3), 265–267. https://doi.org/10.3855/jidc.12734
   PubMed Web of Science ®Google Scholar
• Sengupta, P., Dutta, S., Alahmar, A., & D’souza, U. (2020). Reproductive tract infection, inflammation and male infertility. Chemical Biology Letters, 7(2), 75–84. http://pubs.iscience.in/journal/index.php/cbl/article/view/1004
   Web of Science ®Google Scholar
• Shang, J., Wan, Y., Liu, C., Yount, B., Gully, K., Yang, Y., Auerbach, A., Peng, G., Baric, R., & Li, F. (2020). Structure of mouse coronavirus spike protein complexed with receptor reveals mechanism for viral entry. PLoS Pathogens, 16(3), e1008392. https://doi.org/10.1371/journal.ppat.1008392
   PubMed Web of Science ®Google Scholar
• Shen, Q., Xiao, X., Aierken, A., Yue, W., Wu, X., Liao, M., & Hua, J. (2020). The ACE2 expression in Sertoli cells and germ cells may cause male reproductive disorder after SARS-CoV-2 infection. Journal of Cellular and Molecular Medicine, 24(16), 9472–9477. https://doi.org/10.1111/jcmm.15541
   PubMed Web of Science ®Google Scholar
• Song, C., Wang, Y., Li, W., Hu, B., Chen, G., Xia, P., Wang, W., Li, C., Diao, F., Hu, Z., Yang, X., Yao, B., & Liu, Y. (2020). Absence of 2019 novel coronavirus in semen and testes of COVID-19 patients†. Biology of Reproduction, 103(1), 4–6. https://doi.org/10.1093/biolre/ioaa050
   Google Scholar
• Song, H., Seddighzadeh, B., Cooperberg, M. R., & Huang, F. W. (2020). Expression of ACE2, the SARS-CoV-2 receptor, and TMPRSS2 in prostate epithelial cells. European Urology, 78(2), 296–298. https://doi.org/10.1016/j.eururo.2020.04.065
   PubMed Web of Science ®Google Scholar
• Stanley, K. E., Thomas, E., Leaver, M., & Wells, D. (2020). Coronavirus disease-19 and fertility: Viral host entry protein expression in male and female reproductive tissues. Fertility and Sterility, 114(1), 33–43. https://doi.org/10.1016/j.fertnstert.2020.05.001
   PubMed Web of Science ®Google Scholar
• Tan, M., Liu, Y., Zhou, R., Deng, X., Li, F., Liang, K., & Shi, Y. (2020). Immunopathological characteristics of coronavirus disease 2019 cases in Guangzhou, China. Immunology, 160(3), 261–268. https://doi.org/10.1111/imm.13223
   PubMed Web of Science ®Google Scholar
• Varga, Z., Flammer, A. J., Steiger, P., Haberecker, M., Andermatt, R., Zinkernagel, A. S., Mehra, M. R., Schuepbach, R. A., Ruschitzka, F., & Moch, H. (2020). Endothelial cell infection and endotheliitis in COVID-19. The Lancet, 395(10234), 1417–1418. https://doi.org/10.1016/S0140-6736(20)30937-5
   PubMed Web of Science ®Google Scholar
• Vijgen, L., Keyaerts, E., Moës, E., Thoelen, I., Wollants, E., Lemey, P., Vandamme, A. M., & Van Ranst, M. (2005). Complete genomic sequence of human coronavirus OC43: Molecular clock analysis suggests a relatively recent zoonotic coronavirus transmission event. Journal of Virology, 79(3), 1595–1604. https://doi.org/10.1128/JVI.79.3.1595-1604.2005
   PubMed Web of Science ®Google Scholar
• Walls, A. C., Park, Y. J., Tortorici, M. A., Wall, A., McGuire, A. T., & Veesler, D. (2020). Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein. Cell, 181(2), 281–292.e6. https://doi.org/10.1016/j.cell.2020.02.058
   PubMed Web of Science ®Google Scholar
• Walls, A. C., Park, Y. J., Tortorici, M. A., Wall, A., McGuire, A. T., & Veesler, D. (2020). Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein. Cell, 183(6), 1735. https://doi.org/10.1016/j.cell.2020.11.032
   PubMed Web of Science ®Google Scholar
• Wang, Q., Qiu, Y., Li, J. Y., Liao, C. H., Zhou, Z. J., & Ge, X. Y. (2021). Receptor utilization of angiotensin-converting enzyme 2 (ACE2) indicates a narrower host range of SARS-CoV-2 than that of SARS-CoV. Transboundary and Emerging Diseases, 68(3), 1046–1053. https://doi.org/10.1111/tbed.13792
   PubMed Web of Science ®Google Scholar
• Wang, W., Xu, Y., Gao, R., Lu, R., Han, K., Wu, G., & Tan, W. (2020). Detection of SARS-CoV-2 in different types of clinical specimens. JAMA, 323(18), 1843–1844. https://doi.org/10.1001/jama.2020.3786
   PubMed Web of Science ®Google Scholar
• Wang, Z., & Xu, X. (2020). scRNA-seq profiling of human testes reveals the presence of the ACE2 receptor, a target for SARS-CoV-2 infection in spermatogonia, leydig and sertoli cells. Cells, 9(4), 920. https://doi.org/10.3390/cells9040920
   PubMed Web of Science ®Google Scholar
• Welsh, M., Sharpe, R. M., Moffat, L., Atanassova, N., Saunders, P. T., Kilter, S., Bergh, A., & Smith, L. B. (2010). Androgen action via testicular arteriole smooth muscle cells is important for Leydig cell function, vasomotion and testicular fluid dynamics. PloS One, 5(10), e13632. https://doi.org/10.1371/journal.pone.0013632
   PubMed Web of Science ®Google Scholar
• Wen, Z.-N., Cui, S.-Y., Duan, L., Lu, F.-J., Tang, H.-B., Dong, M., Jia, H.-J., & Zhong, Y. (2020). Semen quality of infertile men carrying hepatitis B virus. Zhonghua Nan ke Xue = National Journal of Andrology, 26, 59–62.
   PubMedGoogle Scholar
• Xiao, F., Sun, J., Xu, Y., Li, F., Huang, X., Li, H., Zhao, J., Huang, J., & Zhao, J. (2020). Infectious SARS-CoV-2 in feces of patient with severe COVID-19. Emerging Infectious Diseases, 26(8), 1920–1922. https://doi.org/10.3201/eid2608.200681
   PubMed Web of Science ®Google Scholar
• Yan, R., Zhang, Y., Li, Y., Xia, L., Guo, Y., & Zhou, Q. (2020). Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Science, 367(6485), 1444–1448. https://doi.org/10.1126/science.abb2762
   PubMed Web of Science ®Google Scholar
• Yang, M., Chen, S., Huang, B., Zhong, J. M., Su, H., Chen, Y. J., Cao, Q., Ma, L., He, J., Li, X. F., Li, X., Zhou, J. J., Fan, J., Luo, D. J., Chang, X. N., Arkun, K., Zhou, M., & Nie, X. (2020). Pathological findings in the testes of COVID-19 patients: Clinical implications. European Urology Focus, 6(5), 1124–1129. https://doi.org/10.1016/j.euf.2020.05.009
   PubMedGoogle Scholar
• Zhang, H., Penninger, J. M., Li, Y., Zhong, N., & Slutsky, A. S. (2020). Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: Molecular mechanisms and potential therapeutic target. Intensive Care Medicine, 46(4), 586–590. https://doi.org/10.1007/s00134-020-05985-9
   PubMed Web of Science ®Google Scholar
• Zhang, H., Yin, Y., Wang, G., Liu, Z., Liu, L., & Sun, F. (2014). Interleukin-6 disrupts blood-testis barrier through inhibiting protein degradation or activating phosphorylated ERK in Sertoli cells. Scientific Reports, 4, 4260. https://doi.org/10.1038/srep04260
   PubMed Web of Science ®Google Scholar
• Zhang, J., Wu, Y., Wang, R., Lu, K., Tu, M., Guo, H., Xie, W., Qin, Z., Li, S., Zhu, P., & Wang, X. (2020). Bioinformatic analysis reveals that the reproductive system is potentially at risk from SARS-CoV-2. Preprints, 2020, 2020020307. https://doi.org/10.20944/preprints202002.0307.v1
   Google Scholar
• Zhang, S., Wang, X., Zhang, H., Xu, A., Fei, G., Jiang, X., Tu, J., Qu, G., Xu, X., & Li, Y. (2020). The absence of coronavirus in expressed prostatic secretion in COVID-19 patients in Wuhan city. Reproductive Toxicology, 96, 90–94. https://doi.org/10.1016/j.reprotox.2020.06.006
   PubMed Web of Science ®Google Scholar
• Zhou, Y., Fu, B., Zheng, X., Wang, D., Zhao, C., Qi, Y., Sun, R., Tian, Z., Xu, X., & Wei, H. (2020). Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients. National Science Review, 7(6), 998–1002. https://doi.org/10.1093/nsr/nwaa041
   PubMed Web of Science ®Google Scholar
• Zou, X., Chen, K., Zou, J., Han, P., Hao, J., & Han, Z. (2020). Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection. Frontiers of Medicine, 14(2), 185–192. https://doi.org/10.1007/s11684-020-0754-0
   PubMed Web of Science ®Google Scholar