Human umbilical cord blood cells: a new alternative for myocardial repair?

References

• American Heart Association. Heart and Stroke Statistical Update. Dallas, TX: American Heart Association, 1999.
   Google Scholar
• Cleland JG, Khand A, Clark A. The heart failure epidemic: exactly how big is it?. Eur Heart J 2001; 22: 623–6
   PubMed Web of Science ®Google Scholar
• Hoes AW, Mosterd A, Grobbee DE. An epidemic of heart failure? Recent evidence from Europe. Eur Heart J 1998; 19(suppl L)L2–9
   Google Scholar
• Redfield MM. Heart failure: an epidemic of uncertain proportions. N Engl J Med 2002; 347: 1442–4
   PubMed Web of Science ®Google Scholar
• Mann DL. Mechanisms and models in heart failure: a combinatorial approach. Circulation 1999; 100: 999–1008
   PubMed Web of Science ®Google Scholar
• Etzion S, Kedes LH, Kloner RA, et al. Myocardial regeneration: present and future trends. Am J Cardiovasc Drugs 2001; 1: 233–44
   PubMedGoogle Scholar
• Lee MS, Makkar RR. Stem-cell transplantation in myocardial infarction: a status report. Ann Intern Med 2004; 140: 729–737
   PubMed Web of Science ®Google Scholar
• Minatoguchi S, Takemura G, Chen XH, et al. Acceleration of the healing process and myocardial regeneration may be important as a mechanism of improvement of cardiac function and remodeling by postinfarction granulocyte colony-stimulating factor treatment. Circulation 2004; 109: 2572–80
   PubMed Web of Science ®Google Scholar
• Askari AT, Unzek S, Popovic ZB, et al. Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy. Lancet 2003; 362: 697–703
   PubMed Web of Science ®Google Scholar
• Beltrami AP, Barlucchi L, Torella D, et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 2003; 114: 763–76
   PubMed Web of Science ®Google Scholar
• Oh H, Bradfute SB, Gallardo TD, et al. Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc Natl Acad Sci USA 2003; 100: 12313–18
   PubMed Web of Science ®Google Scholar
• Matsuura K, Nagai T, Nishigaki N, et al. Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes. J Biol Chem 2004; 279: 11384–91
   PubMed Web of Science ®Google Scholar
• Messina E, De Angelis L, Frati G, et al. Isolation and expansion of adult cardiac stem cells from human and murine heart. Circ Res 2004; 95: 911–21
   PubMed Web of Science ®Google Scholar
• Kehat I, Kenyagin-Karsenti D, Snir M, et al. Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes. J Clin Invest 2001; 108: 407–14
   PubMed Web of Science ®Google Scholar
• Scheubel RJ, Zorn H, Silber RE, et al. Age-dependent depression in circulating endothelial progenitor cells in patients undergoing coronary artery bypass grafting. J Am Coll Cardiol 2003; 42: 2073–80
   PubMed Web of Science ®Google Scholar
• Rauscher FM, Goldschmidt-Clermont PJ, Davis BH, et al. Aging, progenitor cell exhaustion, and atherosclerosis. Circulation 2003; 108: 457–63
   PubMed Web of Science ®Google Scholar
• Dimmeler S, Vasa-Nicotera M. Aging of progenitor cells: limitation for regenerative capacity?. J Am Coll Cardiol 2003; 42: 2081–2
   PubMed Web of Science ®Google Scholar
• Leor J, Barbash IM. Cell transplantation and genetic engineering: new approaches to cardiac pathology. Expert Opin Biol Ther 2003; 3: 1023–39
   PubMed Web of Science ®Google Scholar
• Menasche P. Cellular transplantation: hurdles remaining before widespread clinical use. Curr Opin Cardiol 2004; 19: 154–61
   PubMed Web of Science ®Google Scholar
• Smits PC, van Geuns RJ, Poldermans D, et al. Catheter-based intramyocardial injection of autologous skeletal myoblasts as a primary treatment of ischemic heart failure. Clinical experience with six-month follow-up. J Am Coll Cardiol 2003; 42: 2063–9
   PubMed Web of Science ®Google Scholar
• Yoon, Y-S, Park, J-S, Tkebuchava, T, , et al. Unexpected severe calcification after transplantation of bone marrow cells in acute myocardial infarction. Circulation 2004;109:3154–7.
   PubMed Web of Science ®Google Scholar
• Vulliet PR, Greeley M, Halloran SM, et al. Intra-coronary arterial injection of mesenchymal stromal cells and microinfarction in dogs. Lancet 2004; 363: 783–4
   PubMed Web of Science ®Google Scholar
• Thomson JA, Itskovitz-Eldor J, Shapiro SS, et al. Embryonic stem cell lines derived from human blastocysts. Science 1998; 282: 1145–7
   PubMed Web of Science ®Google Scholar
• Mummery C, Ward-Van Oostwaard D, Doevendans P, et al. Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells. Circulation 2003; 107: 2733–40
   PubMed Web of Science ®Google Scholar
• Takahashi T, Lord B, Schulze PC, et al. Ascorbic acid enhances differentiation of embryonic stem cells into cardiac myocytes. Circulation 2003; 107: 1912–16
   PubMed Web of Science ®Google Scholar
• Nieda M, Nicol A, Denning-Kendall P, et al. Endothelial cell precursors are normal components of human umbilical cord blood. Br J Haematol 1997; 98: 775–7
   PubMed Web of Science ®Google Scholar
• Lewis ID, Verfaillie CM. Multi-lineage expansion potential of primitive hematopoietic progenitors: superiority of umbilical cord blood compared to mobilized peripheral blood. Exp Hematol 2000; 28: 1087–95
   PubMed Web of Science ®Google Scholar
• Murohara T, Ikeda H, Duan J, et al. Transplanted cord blood-derived endothelial precursor cells augment postnatal neovascularization. J Clin Invest 2000; 105: 1527–36
   PubMed Web of Science ®Google Scholar
• Hristov M, Erl W, Weber PC. Endothelial progenitor cells: isolation and characterization. Trends Cardiovasc Med 2003; 13: 201–6
   PubMed Web of Science ®Google Scholar
• Jaroscak J, Goltry K, Smith A, et al. Augmentation of umbilical cord blood (UCB) transplantation with ex vivo-expanded UCB cells: results of a phase 1 trial using the AastromReplicell System. Blood 2003; 101: 5061–7
   PubMed Web of Science ®Google Scholar
• Pesce M, Orlandi A, Iachininoto MG, et al. Myoendothelial differentiation of human umbilical cord blood-derived stem cells in ischemic limb tissues. Circ Res 2003; 93: 51–62
   PubMed Web of Science ®Google Scholar
• Shpall EJ, Quinones R, Giller R, et al. Transplantation of ex vivo expanded cord blood. Biol Blood Marrow Transplant 2002; 8: 368–76
   PubMed Web of Science ®Google Scholar
• Kogler G, Sensken S, Airey JA, et al. A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential. J Exp Med 2004; 200: 123–35
   PubMed Web of Science ®Google Scholar
• Murohara T. Therapeutic vasculogenesis using human cord blood-derived endothelial progenitors. Trends Cardiovasc Med 2001; 11: 303–7
   PubMed Web of Science ®Google Scholar
• Tsafrir A, Brautbar C, Nagler A, et al. Alloreactivity of umbilical cord blood mononuclear cells: specific hyporesponse to noninherited maternal antigens. Hum Immunol 2000; 61: 548–54
   Google Scholar
• Cohen Y, Nagler A. Hematopoietic stem-cell transplantation using umbilical-cord blood. Leuk Lymphoma 2003; 44: 1287–99
   PubMed Web of Science ®Google Scholar
• Kocher AA, Schuster MD, Szabolcs MJ, et al. Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med 2001; 7: 430–6
   PubMed Web of Science ®Google Scholar
• Hristov M, Erl W, Weber PC. Endothelial progenitor cells: mobilization, differentiation, and homing. Arterioscler Thromb Vasc Biol 2003; 23: 1185–9
   PubMed Web of Science ®Google Scholar
• Vendrame M, Cassady J, Newcomb J, et al. Infusion of human umbilical cord blood cells in a rat model of stroke dose-dependently rescues behavioral deficits and reduces infarct volume. Stroke 2004; 35: 2390–5
   PubMed Web of Science ®Google Scholar
• Willing AE, Lixian J, Milliken M, et al. Intravenous versus intrastriatal cord blood administration in a rodent model of stroke. J Neurosci Res 2003; 73: 296–307
   PubMed Web of Science ®Google Scholar
• Borlongan CV, Hadman M, Davis Sanberg C, et al. Central nervous system entry of peripherally injected umbilical cord blood cells is not required for neuroprotection in stroke. Stroke 2004; 35: 2385–9
   PubMed Web of Science ®Google Scholar
• Taguchi A, Soma T, Tanaka H, et al. Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesisin a mouse model. J Clin Invest 2004; 114: 330–8
   PubMed Web of Science ®Google Scholar
• Henning RM, Abu-Ali H, Balis JU, et al. Human umbilical cord blood mononuclear cells for the treatment of acute myocardial infarction. Cell Transplant 2004; 13: 729–39
   PubMed Web of Science ®Google Scholar
• Hirata Y, Sata M, Motomura N, et al. Human umbilical cord blood cells improve cardiac function after myocardial infarction. Biochem Biophys Res Commun 2005; 327: 609–14
   PubMed Web of Science ®Google Scholar
• Yeh ET, Zhang S, Wu HD, et al. Transdifferentiation of human peripheral blood CD34+-enriched cell population into cardiomyocytes, endothelial cells, and smooth muscle cells in vivo. Circulation 2003; 108: 2070–3
   PubMed Web of Science ®Google Scholar
• Zhang S, Wang D, Estrov Z, et al. Both cell fusion and transdifferentiation account for the transformation of human peripheral blood CD34-positive cells into cardiomyocytes in vivo. Circulation 2004; 110: 3803–7
   PubMed Web of Science ®Google Scholar
• Balsam LB, Wagers AJ, Christensen JL, et al. Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature 2004; 428: 668–73
   PubMed Web of Science ®Google Scholar
• Agbulut O, Vandervelde S, Al Attar N, et al. Comparison of human skeletal myoblasts and bone marrow-derived CD133+ progenitors for the repair of infarcted myocardium. J Am Coll Cardiol 2004; 44: 458–463
   PubMed Web of Science ®Google Scholar
• Kinnaird T, Stabile E, Burnett MS, et al. Bone marrow-derived cells for enhancing collateral development: mechanisms, animal data, and initial clinical experiences. Circ Res 2004; 95: 354–63
   PubMed Web of Science ®Google Scholar
• Kinnaird T, Stabile E, Burnett MS, et al. Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms. Circ Res 2004; 94: 678–85
   PubMed Web of Science ®Google Scholar
• Muller-Ehmsen J, Peterson KL, Kedes L, et al. Rebuilding a damaged heart: long-term survival of transplanted neonatal rat cardiomyocytes after myocardial infarction and effect on cardiac function. Circulation 2002; 105: 1720–6
   PubMed Web of Science ®Google Scholar
• Yao M, Dieterle T, Hale SL, et al. Long-term outcome of fetal cell transplantation on postinfarction ventricular remodeling and function. J Mol Cell Cardiol 2003; 35: 661–70
   PubMed Web of Science ®Google Scholar
• Migrino RQ, Young JB, Ellis SG, et al. End-systolic volume index at 90 to 180 minutes into reperfusion therapy for acute myocardial infarction is a strong predictor of early and late mortality. The global utilization of streptokinase and t-PA for occluded coronary arteries (GUSTO)-I angiographic investigators. Circulation 1997; 96: 116–21
   Google Scholar
• Taylor, DA, Atkins, BZ, Hungspreugs, P, , et al. Regenerating functional myocardium: improved performance after skeletal myoblast transplantation. Nat Med 1998;4:929–33, [published erratum appears in Nat Med 1998;4:1200].
   PubMed Web of Science ®Google Scholar
• Perin EC, Dohmann HF, Borojevic R, et al. Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure. Circulation 2003; 107: 2294–302
   PubMed Web of Science ®Google Scholar
• Orlic D, Kajstura J, Chimenti S, et al. Bone marrow cells regenerate infarcted myocardium. Nature 2001; 410: 701–5
   PubMed Web of Science ®Google Scholar
• Stamm C, Westphal B, Kleine HD, et al. Autologous bone-marrow stem-cell transplantation for myocardial regeneration. Lancet 2003; 361: 45–6
   PubMed Web of Science ®Google Scholar
• Davani S, Marandin A, Mersin N, et al. Mesenchymal progenitor cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a rat cellular cardiomyoplasty model. Circulation 2003; 108(suppl 1)253–58
   Google Scholar
• Matsubayashi K, Fedak PW, Mickle DA, et al. Improved left ventricular aneurysm repair with bioengineered vascular smooth muscle grafts. Circulation 2003; 108(suppl 1)219–25
   Google Scholar
• Kellar RS, Landeen LK, Shepherd BR, et al. Scaffold-based three-dimensional human fibroblast culture provides a structural matrix that supports angiogenesis in infarcted heart tissue. Circulation 2001; 104: 2063–8
   PubMed Web of Science ®Google Scholar
• Kehat I, Khimovich L, Caspi O, et al. Electromechanical integration of cardiomyocytes derived from human embryonic stem cells. Nat Biotechnol 2004; 22: 1282–9
   PubMed Web of Science ®Google Scholar
• Li RK, Jia ZQ, Weisel RD, et al. Survival and function of bioengineered cardiac grafts. Circulation 1999; 100: 63–9
   Web of Science ®Google Scholar
• Leor J, Aboulafia-Etzion S, Dar A, et al. Bioengineered cardiac grafts: a new approach to repair the infarcted myocardium?. Circulation 2000; 102: 56–61
   Web of Science ®Google Scholar
• Lanza R, Moore MA, Wakayama T, et al. Regeneration of the infarcted heart with stem cells derived by nuclear transplantation. Circ Res 2004; 94: 820–7
   PubMed Web of Science ®Google Scholar