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COMMENTARY

Manipulating regulatory T cells

Pages 109-110 | Published online: 07 Jul 2009

References

  • Shevach EM. From vanilla to 28 flavors: multiple varieties of T regulatory cells. Immunity 2006; 25: 195–201
  • Sakaguchi S, Sakaguchi N, Asano M, et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995; 155: 1151–64
  • Taylor PA, Lees CJ, Blazar BR. The infusion of ex vivo activated and expanded CD4(+), CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality. Blood 2002; 99: 3493–99
  • Rezvani K, Mielke S, Ahmadzadeh M, et al. High donor FOXP3-positive regulatory T-cell (Treg) content is associated with a low risk of GVHD following HLA-matched allogeneic SCT. Blood 2006; 108: 1291–7
  • Solomou E, Rezvani K, Mielke S, et al. FOXP3-positive regulatory T cells in acquired aplastic anemia. Blood 2006; 108(Suppl 1)636a
  • Scheffold A, Hühn J, Höfer T. Regulation of CD4+ CD25+ regulatory T cell activity: it takes (IL-) two to tango. Eur J Immunol 2005; 35: 1336–41

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