Loss of Thy-1 (CD90) antigen expression on mesenchymal stromal cells from hematologic malignancies is induced by in vitro angiogenic stimuli and is associated with peculiar functional and phenotypic characteristics

References

• Horwitz EM, Le Blanc K, Dominici M, et al. Clarification of the nomenclature of MSC: the International Society for Cellular Therapy position statement. Cytotherapy 2005; 7: 393–95
   PubMed Web of Science ®Google Scholar
• Orkin SH. Stem cell alchemy. Nat Med 2000; 6: 1212–13
   Google Scholar
• Wulf GG, Jackson KA, Goodell MA. Somatic stem cell plasticity: current evidence and emerging concepts. Exp Hematol 2001; 9: 1361–70
   Google Scholar
• Pittenger M, Mackay A, Beck S, et al. Multilineage potential of adult human mesenchymal stem cells. Science 2000; 284: 143–7
   Web of Science ®Google Scholar
• Reyes M, Lund T, Lenvik T, et al. Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells. Blood 2001; 98: 2615–25
   PubMed Web of Science ®Google Scholar
• Di Nicola M, Carlo-Stella C, Magni M, et al. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 2000; 99: 3838–43
   Google Scholar
• Le Blanc K, Tammik C, Rosendahl K, et al. HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal cells. Exp Hematol 2003; 31: 890–6
   PubMed Web of Science ®Google Scholar
• Almeida-Porada G, Flake AW, Glimp HA, et al. Cotransplantation of stroma results in enhancement of engraftment and early expression of donor hematopoietic stem cells in utero. Exp Hematol 1999; 27: 1569–75
   PubMed Web of Science ®Google Scholar
• Devine SM, Cobbs C, Jennings M. Mesenchymal stem cells distribute to a wide range of tissue following systemic infusion into nonhuman primates. Blood 2003; 101: 2999–3001
   PubMed Web of Science ®Google Scholar
• Horwitz EM, Gordon PL, Koo WKK, et al. Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone. Proc Natl Acad Sci USA 2002; 99: 8932–7
   PubMed Web of Science ®Google Scholar
• Rafii S, Lyden D. Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration. Nat Med 2003; 9: 702–12
   PubMed Web of Science ®Google Scholar
• Oswald J, Boxberger S, Jorgensen B, et al. Mesenchymal stem cells can be differentiated into endothelial cells in vitro. Stem Cells 2004; 22: 377–84
   PubMed Web of Science ®Google Scholar
• Ventura C, Cantoni S, Bianchi F , et al. Hyaluronan mixed esters of butyric and retinoic acid drive cardiac and endothelial fate in term placenta human mesenchymal cells and enhance cardiac repair in infracted rat hearts. JBC 2007 in press.
   Google Scholar
• Berry MF, Engler AJ, Woo YJ, et al. Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance. Am J Physiol Heart Circ Physiol 2006; 290: 2196–203
   PubMed Web of Science ®Google Scholar
• Gregory CA, Ylostalo J, Prockop DJ. Adult bone marrow stem/progenitor cells (MSCs) are preconditioned by microenvironmental ‘niches’ in culture: a two stage hypothesis for regulation of MSC fate. Sci STKE 2005; 294: 37
   Google Scholar
• Di Girolamo CM, Stokes D, Colter D, et al. Propagation and senescence of human marrow stromal cells in culture: a simple colony-forming assay identifies samples with the greatest potential to propagate and differentiate. Br J Haematol 1999; 107: 275–81
   Google Scholar
• Meuleman N, Tondreau T, Delforge A, et al. Human marrow mesenchymal stem cell culture: serum-free medium allows better expansion than classical a-MEM medium. Eur J Haematol 2006; 76: 309–16
   PubMed Web of Science ®Google Scholar
• Mueller I, Kordowich S, Holzwarth C, et al. Animal serum-free culture conditions for isolation and expansion of multipotent mesenchymal stromal cells from human BM. Cytotherapy 2006; 8: 437–44
   Google Scholar
• Sotiropoulou PA, Perez SA, Salagianni M, et al. Characterization of the optimal culture conditions for clinical scale production of human mesenchymal stem cells. Stem Cells 2006; 24: 74–85
   PubMed Web of Science ®Google Scholar
• Lanza F, Campioni D, Moretti S, et al. Aberrant expression of HLA-DR antigen by bone marrow-derived mesenchymal stromal cells from patients affected by acute lymphoproliferative disorders. Leukemia 2007; 21: 378–81
   Google Scholar
• Tremain N, Korkko J, Ibberson D, et al. Micro-SAGE analysis of 2,353 expressed genes in a single cell derived colony of undifferentiated human mesenchymal stem cells reveals mRNAs of multiple cell lineages. Stem Cells 2001; 19: 408–18
   PubMed Web of Science ®Google Scholar
• Götherström C, West A, Liden J, et al. Differences in gene expression between human fetal liver and adult bone marrow mesenchymal stem cells. Haematologica 2005; 90: 1017–26
   PubMed Web of Science ®Google Scholar
• Wagner W, Wein F, Seckinger A, et al. Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood. Exp Hematol 2005; 11: 1402–16
   Google Scholar
• Campioni D, Moretti S, Ferrari L, et al. Immunophenotypic heterogeneity of bone marrow-derived mesenchymal stromal cells from patients with hematologic disorders: correlation with bone marrow microenvironment. Haematologica 2006; 91: 364–8
   PubMedGoogle Scholar
• Castro-Malaspina H, Gay RE, Resnick G, et al. Characterization of human bone marrow fibroblast colony-forming cells (CFU-F) and their progeny. Blood 1980; 56: 289–301
   PubMed Web of Science ®Google Scholar
• Shibata A, Bennet JM, Castoldi GL, et al. Recommended methods for cytological procedures in haematology. Clin Lab Haematol 1985; 7: 55–74
   PubMedGoogle Scholar
• Lanza F, Latorraca A, Moretti S . Colorazioni e tecniche di indagine morfologica e immunologia. In: Piccin, et al. Trattato Italiano di Medicina di Laboratorio, Vol. V. Padova:1999.
   Google Scholar
• Lanza F, Campioni D, Moretti S, et al. CD34+ cell subsets and long-term culture colony-forming cells evaluated on both autologous and normal bone marrow stroma predict long-term hemopoietic engraftment in patients undergoing autologous peripheral blood stem cell transplantation. Exp Hematol 2001; 29: 1–10
   Google Scholar
• Chang H, Chi JT, Dudoit S, et al. Diversity, topographic differentiation, and positional memory in human fibroblasts. Proc Natl Acad Sci USA 2002; 99: 12877–82
   PubMed Web of Science ®Google Scholar
• Peister A, Mellad JA, Larson BL, et al. Adult stem cells from bone marrow (MSCs) isolated from different strains of inbred mice vary in surface epitopes, rates of proliferation, and differentiation potential. Blood 2004; 103: 1662–8
   PubMed Web of Science ®Google Scholar
• In'T Anker PS, Noort WA, Sherjon SA, et al. Mesenchymal stem cells in human second-trimester bone marrow, liver, lung and spleen exhibit a similar immunophenotype but heterogenous multilineage differentiation potential. Haematologica 2003; 88: 845–52
   PubMed Web of Science ®Google Scholar
• Majumdar MK, Keane-Moore M, Buyaner D, et al. Characterization and functionality of cell surface molecules on human mesenchymal stem cells. J Biomed Sci 2003; 10: 228–41
   PubMed Web of Science ®Google Scholar
• Conget PA, Minguell JJ. Phenotypical and functional properties of human bone marrow mesenchymal progenitor cells. J Cell Physiol 1999; 181: 67–73
   PubMed Web of Science ®Google Scholar
• Bhuring HJ, Kuci S, Conze T, et al. CDCP1 identifies a broad spectrum of normal and malignant stem/progenitor cell subsets of hematopoietic and non-hematopoietic origin. Stem Cells 2004; 22: 334–43
   Google Scholar
• Vogel W, Grunebach F, Messam CA, et al. Heterogeneity among human bone marrow derived mesenchymal stem cells and neural progenitors. Haematologica 2003; 88: 126–32
   PubMed Web of Science ®Google Scholar
• Sordi V, Malosio ML, Marchesi F, et al. Bone marrow mesenchymal stem cells express a restricted set of functionally active chemokine receptors capable of promoting migration to pancreatic islet. Blood 2005; 106: 419–25
   PubMed Web of Science ®Google Scholar
• Lee RH, Hsu SC, Munoz J, et al. A subset of human rapidly-self renewing marrow stromal cells (MSCs) preferentially engraft in mice. Blood 2006; 107: 2153–61
   PubMed Web of Science ®Google Scholar
• Koumas L, Smith TJ, Phipps RP. Fibroblast subset in the human orbit: Thy-1+ and Thy-1− subpopulations exhibit distinct phenotypes. Eur J Immunol 2002; 32: 477–85
   PubMed Web of Science ®Google Scholar
• Koumas L, King AE, Critchley HOD, et al. Existence of functionally distinct Thy-1 and Thy-1– human female reproductive tract fibroblasts. Am J Pathol 2001; 159: 925–35
   PubMed Web of Science ®Google Scholar
• Quirici N, Soligo D, Bossolasco P, et al. Isolation of bone marrow mesenchymal stem cells by anti-nerve growth factor receptor antibodies. Exp Hematol 2002; 30: 783–91
   PubMed Web of Science ®Google Scholar
• Meyer H, Bertram H, Lindenmaier W, et al. Vascular endothelial growth factor (VEGF-A) expression in human mesenchymal stem cells: autocrine and paracrine role on osteoblastic and endothelial differentiation. J Cell Biochem 2005; 95: 827–39
   Google Scholar