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Original papers

Mesenchymal stroma cells improve hyperglycemia and insulin deficiency in the diabetic porcine pancreatic microenvironment

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Pages 796-805 | Published online: 07 Jul 2009

References

  • Oh SH, Muzzonigro TM, Bae SH, et al. Adult bone marrow-derived cells trans-differentiating into insulin-producing cells for the treatment of type I diabetes. Lab Invest 2004; 84: 607–17
  • Choi KS, Shin JS, Lee JJ, et al. In vitro trans-differentiation of rat mesenchymal cells into insulin-producing cells by rat pancreatic extract. Biochem Biophys Res Commun 2005; 330: 1299–305
  • Wolfe-Coote S, Louw J, Woodroof C, et al. Development, differentiation, and regeneration potential of the Vervet monkey endocrine pancreas. Microsc Res Tech 1998; 43: 322–31
  • Rosenberg L, Brown RA, Duguid WP. A new approach to the induction of duct epithelial hyperplasia and nesidioblastosis by cellophane wrapping of the hamster pancreas. J Surg Res 1983; 35: 63–72
  • Chen L-B, Jiang X-B, Yang L. Differentiation of rat marrow mesenchymal stem cells into pancreatic islet beta-cells. World J Gastroenterol 2004; 10: 301–20
  • Tang D-Q, Gao L-Z, Burk Hardt BR, et al. In vivo and vitro characterization of insulin-producing cells obtained from murine bone marrow. Diabetes 2004; 53: 1721–32
  • Ianus A, Holz GG, Theise ND, et al. In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J Clin Invest 2003; 111: 843–50
  • Lechner A, Yang Y-G, Blacken RA. No evidence for significant transdifferentiation of bone marrow into pancreatic β-cells in vivo. Diabetes 2004; 53: 616–23
  • Choi JB, Uchino H, Azuma K, et al. Little evidence of transdifferentiation of bone marrow-derived cells into pancreatic beta cells. Diabetes 2003; 46: 1366–74
  • Taneera J, Rosengren A, Renstrom E. Failure of transplanted bone marrow cells to adopt a pancreatic β-cell fate. Diabetes 2006; 55: 290–6
  • Li L, Xie T. Stem cell niche structure and function. Biol 2005; 21: 616–23
  • Wilson A, Trumpp A. Bone marrow haematopoietic stem cell niches. Nature 2006; 6: 93–5
  • Gregory CA, Ylostalo J, Prockop DJ. Adult bone marrow stem/progenitor cells (MSCs) are preconditioned by microenvironmental niches in culture: a two-stage hypothesis for regulation of MSC fate. Sci Stke 2005; 294: 37–9
  • Wang J, Song LJ, Gerber DA, et al. A model utilizing adult murine stem cells for creation of personalized islets for transplantation. Transplant Proc 2004; 25: 1188–95
  • Moriscot M, de Fraipont F, Richard M-J, et al. Human bone marrow mesenchymal stem cells can express insulin and key transcription factors of the endocrine pancreas developmental pathway upon genetic and/or microenvironmental manipulation in vitro. Stem Cells 2005; 23: 594–13
  • Walde SS, Dohle C, Schott-Ohly P, et al. Molecular target structures in alloxan-induced diabetes in mice. Life Sci 2002; 71: 1681–94
  • Gai W, Schott-Ohly P, Schulte im Walde S, et al. Differential target molecules for toxicity induced by streptozotocin and alloxan in pancreatic islets of mice in vitro. Exp Clin Endocrinol Diabetes 2004; 112: 29–37
  • Chang C, Niu D, Zhou H, et al. Mesenchymal stem cells contribute to insulin-producing cells upon microenvironmental manipulation in vitro. Transplant Proc 2007; 39: 3363–8
  • Lee RH, Seo MJ, Reger RL. Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice. Proc Natl Acad Sci USA 2006; 103: 17438–43
  • Roloff TC, Nuber UA. Chromatin epigenetics and stem cells. Eur J Cell Biol 2005; 84: 123–35
  • DiGirolamo CM, Stokes D, Colter D, et al. Propagation and senescence of human marrow stromal cells in culture: a simple colony-forming assay identifies samples with the greatest potential to propagate and differentiate. Br J Haematol 1999; 107: 275–81
  • Tremain N, Korkko J, Ibberson D, et al. Micro SAGE analysis of 2,353 expressed genes in a single cell-derived colony of undifferentiated human mesenchymal stem cells reveals mRNAs of multiple cell lineages. Stem Cells 2001; 19: 408–18
  • Li JY, Meng LJ, Zhu Y. Immunosuppressive property of mesenchymal stem cells (MSCs) in mixed lymphocyte reactions in vitro. Blood 2005; 106: 4313–25
  • Zhang W, Ge W, Li C, et al. Effects of mesenchymal stem cells on differentiation, maturation, and function of human monocyte-derived dendritic cells. Stem Cells 2004; 13: 263–71
  • Zhao RC, Liao L, Han Q. Mechanisms of and perspectives on the mesenchymal stem cell in immunotherapy. J Lab Clin Med 2004; 143: 284–91
  • Beyth S, Borovsky Z, Mevorach D, et al. Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness. Blood 2005; 105: 2214–19
  • Uccelli A, Moretta L, Pistoia V. Immunoregulatory function of mesenchymal stem cells. Eur J Immunol 2006; 36: 2566–73
  • Itakura S, Asari S, Rawson J, et al. Mesenchymal stem cells facilitate the induction of mixed hematopoietic chimerism and islet allograft tolerance without GVHD in the rat. Am J Transplant 2007; 7: 336–46

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