Cell therapy for disorders of bone

References

• Coccia PF, Krivit W, Cervenka J, Clawson C, Kersey JH, Kim TH, et al. Successful bone-marrow transplantation for infantile malignant osteopetrosis. N Engl J Med. 1980; 302: 701–8
   PubMed Web of Science ®Google Scholar
• Horwitz EM, Prockop DJ, Fitzpatrick LA, Koo WW, Gordon PL, Neel M, et al. Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat Med. 1999; 5: 309–13
   PubMed Web of Science ®Google Scholar
• Whyte MP, Kurtzberg J, McAlister WH, Mumm S, Podgornik MN, Coburn SP, et al. Marrow cell transplantation for infantile hypophosphatasia. J Bone Miner Res. 2003; 18: 624–36
   PubMed Web of Science ®Google Scholar
• Bar-Shavit Z. The osteoclast: a multinucleated, hematopoietic-origin, bone-resorbing osteoimmune cell. J Cell Biochem. 2007; 102: 1130–9
   PubMed Web of Science ®Google Scholar
• Boskey AL. Mineralization, structure, and function of bone. Dynamics of Bone and Cartilage Metabolism, MJ Seibel, SP Robins, JP Bilezikian. Academic Press, New York 1999; 153–64
   Google Scholar
• Lian JB GS. The cells of bone. Seibel MJ, Robins SP, Bilezikian JP. “Dynamics of Bone and Cartilage Metabolism. Academic Press, New York 1999; 165–85
   Google Scholar
• Taichman RS. Blood and bone: two tissues whose fates are intertwined to create the hematopoietic stem-cell niche. Blood. 2005; 105: 2631–9
   PubMed Web of Science ®Google Scholar
• Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, et al. Multilineage potential of adult human mesenchymal stem cells. Science. 1999; 284: 143–7
   PubMed Web of Science ®Google Scholar
• Prockop DJ. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science. 1997; 276: 71–4
   PubMed Web of Science ®Google Scholar
• Dominici M, Pritchard C, Garlits JE, Hofmann TJ, Persons DA, Horwitz EM. Hematopoietic cells and osteoblasts are derived from a common marrow progenitor after bone marrow transplantation. Proc Natl Acad Sci USA. 2004; 101: 11761–6
   PubMed Web of Science ®Google Scholar
• Calvi LM, Adams GB, Weibrecht KW, Weber JM, Olson DP, Knight MC, et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature. 2003; 425: 841–6
   PubMed Web of Science ®Google Scholar
• Yin T, Li L. The stem cell niches in bone. J Clin Invest. 2006; 116: 1195–201
   PubMed Web of Science ®Google Scholar
• Zhang J, Niu C, Ye L, Huang H, He X, Tong WG, et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature. 2003; 425: 836–41
   PubMed Web of Science ®Google Scholar
• Bielby R, Jones E, McGonagle D. The role of mesenchymal stem cells in maintenance and repair of bone. Injury. 2007; 38(Suppl 1)S26–32
   PubMedGoogle Scholar
• Harrison DE, Stone M, Astle CM. Effects of transplantation on the primitive immunohematopoietic stem cell. J Exp Med. 1990; 172: 431–7
   PubMed Web of Science ®Google Scholar
• Christensen JL, Weissman IL. Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells. Proc Natl Acad Sci USA. 2001; 98: 14541–6
   PubMed Web of Science ®Google Scholar
• Morrison SJ, Weissman IL. The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype. Immunity. 1994; 1: 661–73
   PubMed Web of Science ®Google Scholar
• Nakauchi H, Takano H, Ema H, Osawa M. Further characterization of CD34-low/negative mouse hematopoietic stem cells. Ann NY Acad Sci. 1999; 872: 57–70
   PubMed Web of Science ®Google Scholar
• Spangrude GJ, Heimfeld S, Weissman IL. Purification and characterization of mouse hematopoietic stem cells. Science. 1988; 241: 58–62
   PubMed Web of Science ®Google Scholar
• Goodell MA, Brose K, Paradis G, Conner AS, Mulligan RC. Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J Exp Med. 1996; 183: 1797–806
   PubMed Web of Science ®Google Scholar
• Goodell MA, Rosenzweig M, Kim H, Marks DF, DeMaria M, Paradis G, et al. Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of cd34 antigen exist in multiple species. Nat Med. 1997; 3: 1337–45
   PubMed Web of Science ®Google Scholar
• Kiel MJ, Yilmaz OH, Iwashita T, Yilmaz OH, Terhorst C, Morrison SJ. Slam family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell. 2005; 121: 1109–21
   PubMed Web of Science ®Google Scholar
• Yilmaz OH, Kiel MJ, Morrison SJ. Slam family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity. Blood. 2006; 107: 924–30
   PubMed Web of Science ®Google Scholar
• Friedenstein AJ, Chailakhjan RK, Lalykina KS. The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. Cell Tissue Kinet. 1970; 3: 393–403
   PubMedGoogle Scholar
• Kuznetsov SA, Mankani MH, Gronthos S, Satomura K, Bianco P, Robey PG. Circulating skeletal stem cells. J Cell Biol. 2001; 153: 1133–40
   PubMed Web of Science ®Google Scholar
• Jones EA, Kinsey SE, English A, Jones RA, Straszynski L, Meredith DM, et al. Isolation and characterization of bone marrow multipotential mesenchymal progenitor cells. Arthritis Rheum. 2002; 46: 3349–60
   PubMed Web of Science ®Google Scholar
• Shiozawa Y, Havens AM, Pienta KJ, Taichman RS. The bone marrow niche: habitat to hematopoietic and mesenchymal stem cells, and unwitting host to molecular parasites. Leukemia. 2008; 22: 941–50
   PubMed Web of Science ®Google Scholar
• Uccelli A, Moretta L, Pistoia V. Mesenchymal stem cells in health and disease. Nat Rev Immunol. 2008; 8: 726–36
   PubMed Web of Science ®Google Scholar
• Guillot PV, Abass O, Bassett JH, Shefelbine SJ, Bou-Gharios G, Chan J, et al. Intrauterine transplantation of human fetal mesenchymal stem cells from first-trimester blood repairs bone and reduces fractures in osteogenesis imperfecta mice. Blood. 2008; 111: 1717–25
   PubMed Web of Science ®Google Scholar
• Li F, Wang X, Niyibizi C. Distribution of single-cell expanded marrow derived progenitors in a developing mouse model of osteogenesis imperfecta following systemic transplantation. Stem Cells. 2007; 25: 3183–93
   PubMed Web of Science ®Google Scholar
• Pereira RF, O'Hara MD, Laptev AV, Halford KW, Pollard MD, Class R, et al. Marrow stromal cells as a source of progenitor cells for nonhematopoietic tissues in transgenic mice with a phenotype of osteogenesis imperfecta. Proc Natl Acad Sci USA. 1998; 95: 1142–7
   PubMed Web of Science ®Google Scholar
• McCulloch CA, Heersche JN. Lifetime of the osteoblast in mouse periodontium. Anat Rec. 1988; 222: 128–35
   PubMedGoogle Scholar
• Weinstein RS, Jilka RL, Parfitt AM, Manolagas SC. Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone. J Clin Invest. 1998; 102: 274–82
   PubMed Web of Science ®Google Scholar
• Friedenstein AJ, Chailakhyan RK, Gerasimov UV. Bone marrow osteogenic stem cells: in vitro cultivation and transplantation in diffusion chambers. Cell Tissue Kinet. 1987; 20: 263–72
   PubMedGoogle Scholar
• Horwitz EM, Le Blanc K, Dominici M, Mueller I, Slaper-Cortenbach I, Marini FC, et al. Clarification of the nomenclature for MSC: the International Society for Cellular Therapy position statement. Cytotherapy. 2005; 7: 393–5
   PubMed Web of Science ®Google Scholar
• Long MW, Williams JL, Mann KG. Expression of human bone-related proteins in the hematopoietic microenvironment. J Clin Invest. 1990; 86: 1387–95
   PubMed Web of Science ®Google Scholar
• Petersen BE, Bowen WC, Patrene KD, Mars WM, Sullivan AK, Murase N, et al. Bone marrow as a potential source of hepatic oval cells. Science. 1999; 284: 1168–70
   PubMed Web of Science ®Google Scholar
• Theise ND, Badve S, Saxena R, Henegariu O, Sell S, Crawford JM, et al. Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation. Hepatology. 2000; 31: 235–40
   PubMed Web of Science ®Google Scholar
• Alison MR, Poulsom R, Jeffery R, Dhillon AP, Quaglia A, Jacob J, et al. Hepatocytes from non-hepatic adult stem cells. Nature. 2000; 406: 257
   PubMed Web of Science ®Google Scholar
• Theise ND, Nimmakayalu M, Gardner R, Illei PB, Morgan G, Teperman L, et al. Liver from bone marrow in humans. Hepatology. 2000; 32: 11–6
   PubMed Web of Science ®Google Scholar
• Krause DS, Theise ND, Collector MI, Henegariu O, Hwang S, Gardner R, et al. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell. 2001; 105: 369–77
   PubMed Web of Science ®Google Scholar
• Olmsted-Davis EA, Gugala Z, Camargo F, Gannon FH, Jackson K, Kienstra KA, et al. Primitive adult hematopoietic stem cells can function as osteoblast precursors. Proc Natl Acad Sci USA. 2003; 100: 15877–82
   PubMed Web of Science ®Google Scholar
• Marino R, Martinez C, Boyd K, Dominic M, Hofman TJ, Horwitz EM. Transplantable marrow osteoprogenitors engraft in discrete saturable sites in the marrow microenvironment. Exp Hematol. 2008; 36: 360–8
   PubMed Web of Science ®Google Scholar
• Dominici M, Marino R, Rasini V, Spano C, Paolucci P, Conte P, et al. Donor cell-derived osteopoiesis originates from a self-renewing stem cell with a limited regenerative contribution after transplantation. Blood. 2008; 111: 4386–91
   PubMed Web of Science ®Google Scholar
• Cheung MS, Glorieux FH. Osteogenesis imperfecta: update on presentation and management. Rev Endocr Metab Disord. 2008; 9: 153–60
   PubMed Web of Science ®Google Scholar
• von der Mark K. Structure and biosynthesis of collagens. Dynamics of Bone and Cartilage Metabolism, MJ Seibel, SP Robins, JP Bilezikian. Academic Press, New York 1999; 3–29
   Google Scholar
• Robins SP. Fibrillogenesis and maturation of collagens. Dynamics of Bone and Cartilage Metabolism, MJ Seibel, SP Robins, JP Bilezikian. Academic Press, New York 1999; 31–42
   Google Scholar
• Letocha AD, Cintas HL, Troendle JF, Renolds JC, Cann CE, Chernoff EJ, et al. Controlled trial of pamidronate in children with types III and IV osteogenesis imperfecta confirms vertebral gains but not short-term functional improvement. J Bone Miner Res. 2005; 20: 977–86
   PubMed Web of Science ®Google Scholar
• Munns CF, Rauch F, Travers R, Glorieux FH. Effects of intravenous pamidronate treatment in infants with osteogenesis imperfecta: clinical and histomorphometric outcome. J Bone Miner Res. 2005; 20: 1235–43
   PubMed Web of Science ®Google Scholar
• Marini JC. Do bisphosphonates make children's bones better or brittle?. N Engl J Med. 2003; 349: 423–6
   PubMed Web of Science ®Google Scholar
• Uveges TE, Kozloff KM, Ty JM, Ledgard F, Raggio CL, Gronowicz G, , et al. Alendronate treatment of Brtl osteogenesis imperfecta mouse improves femoral geometry and load response before fracture but decreases predicted material properties and has detrimental effects on osteoblasts and bone formation. J Bone Miner Res. 2008; in press.
   PubMed Web of Science ®Google Scholar
• Papapoulos SE, Cremers SC. Prolonged bisphosphonate release after treatment in children. N Engl J Med. 2007; 356: 1075–6
   PubMed Web of Science ®Google Scholar
• Whyte MP, McAlister WH, Novack DV, Clements KL, Schoenecker PL, Wenkert D. Bisphosphonate-induced osteopetrosis: novel bone modeling defects, metaphyseal osteopenia, and osteosclerosis fractures after drug exposure ceases. J Bone Miner Res. 2008; 23: 1698–707
   PubMed Web of Science ®Google Scholar
• Whyte MP, Wenkert D, Clements KL, McAlister WH, Mumm S. Bisphosphonate-induced osteopetrosis. N Engl J Med. 2003; 349: 457–63
   PubMed Web of Science ®Google Scholar
• Horwitz EM, Prockop DJ, Gordon PL, Koo WW, Fitzpatrick LA, Neel MD, et al. Clinical responses to bone marrow transplantation in children with severe osteogenesis imperfecta. Blood. 2001; 97: 1227–31
   PubMed Web of Science ®Google Scholar
• Horwitz EM, Gordon PL, Koo WK, Marx JC, Neel MD, McNall RY, et al. Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone. Proc Natl Acad Sci USA. 2002; 99: 8932–7
   PubMed Web of Science ®Google Scholar
• Le Blanc K, Gotherstrom C, Ringden O, Hassan M, McMohan R, Horwitz E, et al. Fetal mesenchymal stem-cell engraftment in bone after in utero transplantation in a patient with severe osteogenesis imperfecta. Transplantation. 2005; 79: 1607–14
   PubMed Web of Science ®Google Scholar
• Online Mendelian Inheritance in Man, OMIM (TM). Johns Hopkins University, Baltimore, MD. MIM Number: 241500. 10/17/2008: World Wide Web http://proxy.library.upenn.edu5567/omim/. Accessed date 14 January 2009.
   Google Scholar
• Millan JL, Narisawa S, Lemire I, Loisel TP, Boileau G, Leonard P, et al. Enzyme replacement therapy for murine hypophosphatasia. J Bone Miner Res. 2008; 23: 777–87
   PubMed Web of Science ®Google Scholar
• Cahill RA, Jones OY, Klemperer M, Steele A, Mueller TO, el-Badri N, et al. Replacement of recipient stromal/mesenchymal cells after bone marrow transplantation using bone fragments and cultured osteoblast-like cells. Biol Blood Marrow Transplant. 2004; 10: 709–17
   PubMed Web of Science ®Google Scholar
• Cahill RA, Wenkert D, Perlman SA, Steele A, Coburn SP, McAlister WH, et al. Infantile hypophosphatasia: transplantation therapy trial using bone fragments and cultured osteoblasts. J Clin Endocrinol Metab. 2007; 92: 2923–30
   PubMed Web of Science ®Google Scholar
• Online Mendelian Inheritance in Man, OMIM (TM). Johns Hopkins University, Baltimore, MD. MIM Number: 259700. 9/18/2008: World Wide Web http://proxy.library.upenn.edu5567/omim ( accessed date 14 January 2009).
   Google Scholar
• Askmyr MK, Fasth A, Richter J. Towards a better understanding and new therapeutics of osteopetrosis. Br J Haematol. 2008; 140: 597–609
   PubMed Web of Science ®Google Scholar
• Key LL, Jr, Rodriguiz RM, Willi SM, Wright NM, Hatcher HC, Eyre DR, et al. Long-term treatment of osteopetrosis with recombinant human interferon gamma. N Engl J Med. 1995; 332: 1594–9
   PubMed Web of Science ®Google Scholar
• Kapelushnik J, Shalev C, Yaniv I, Aker M, Carmi R, Cohen Z, et al. Osteopetrosis: a single centre experience of stem cell transplantation and prenatal diagnosis. Bone Marrow Transplant. 2001; 27: 129–32
   PubMed Web of Science ®Google Scholar
• Driessen GJ, Gerritsen EJ, Fischer A, Fasth A, Hop WC, Veys P, et al. Long-term outcome of haematopoietic stem cell transplantation in autosomal recessive osteopetrosis: an EBMT report. Bone Marrow Transplant. 2003; 32: 657–63
   PubMed Web of Science ®Google Scholar
• Gerritsen EJ, Vossen JM, Fasth A, Friedrich W, Morgan G, Padmos A, et al. Bone marrow transplantation for autosomal recessive osteopetrosis. A report from the working party on inborn errors of the European Bone Marrow Transplantation Group. J Pediatr. 1994; 125: 896–902
   PubMed Web of Science ®Google Scholar
• Askmyr M, Holmberg J, Flores C, Ehinger M, Hjalt T, Richter J. Low-dose busulphan conditioning and neonatal stem cell transplantation preserves vision and restores hematopoiesis in severe murine osteopetrosis. Exp Hematol. 2009; 37: 302–308
   PubMed Web of Science ®Google Scholar
• Johansson M, Jansson L, Ehinger M, Fasth A, Karlsson S, Richter J, et al. Neonatal hematopoietic stem cell transplantation cures oc/oc mice from osteopetrosis. Exp Hematol. 2006; 34: 242–9
   PubMed Web of Science ®Google Scholar
• Frattini A, Blair HC, Sacco MG, Cerisoli F, Faggioli F, Cato EM, et al. Rescue of atpa3-deficient murine malignant osteopetrosis by hematopoietic stem cell transplantation in utero. Proc Natl Acad Sci USA. 2005; 102: 14629–34
   PubMed Web of Science ®Google Scholar
• Online Mendelian Inheritance in Man, OMIM (TM). Johns Hopkins University, Baltimore, MD. MIM Number: 166710. 6/16/2008: World Wide Web http://proxy.library.upenn.edu5567/omim ( accessed date 14 January 2009).
   Google Scholar
• Eastell R, Yergey AL, Vieira NE, Cedel SL, Kumar R, Riggs BL. Interrelationship among vitamin D metabolism, true calcium absorption, parathyroid function, and age in women: evidence of an age-related intestinal resistance to 1,25-dihydroxyvitamin D action. J Bone Miner Res. 1991; 6: 125–32
   PubMed Web of Science ®Google Scholar
• Orwoll ES, Meier DE. Alterations in calcium, vitamin D, and parathyroid hormone physiology in normal men with aging: relationship to the development of senile osteopenia. J Clin Endocrinol Metab. 1986; 63: 1262–9
   PubMed Web of Science ®Google Scholar
• Sherman SS, Tobin JD, Hollis BW, Gundberg CM, Roy TA, Plato CC. Biochemical parameters associated with low bone density in healthy men and women. J Bone Miner Res. 1992; 7: 1123–30
   PubMed Web of Science ®Google Scholar
• Ichioka N, Inaba M, Kushida T, Esumi T, Takahara K, Inaba K, et al. Prevention of senile osteoporosis in samp6 mice by intrabone marrow injection of allogeneic bone marrow cells. Stem Cells. 2002; 20: 542–51
   PubMed Web of Science ®Google Scholar
• Takada K, Inaba M, Ichioka N, Ueda Y, Taira M, Baba S, et al. Treatment of senile osteoporosis in samp6 mice by intrabone marrow injection of allogeneic bone marrow cells. Stem Cells. 2006; 24: 399–405
   PubMed Web of Science ®Google Scholar
• Walker DG. Bone resorption restored in osteopetrotic mice by transplants of normal bone marrow and spleen cells. Science. 1975; 190: 784–5
   PubMed Web of Science ®Google Scholar
• Walker DG. Abrogation of congenital osteopetrosis by leukocyte subpopulations. Mechanisms of Localized Bone Loss, JE Horton, TM Tarpley, WF Davis. Information Retrieval, Arlington 1978; 383–87
   Google Scholar
• Marks SC, Jr. Studies of the cellular cure for osteopetrosis by transplanted cells: specificity of the cell type in IA rats. Am J Anat. 1978; 151: 131–7
   PubMedGoogle Scholar