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Review

Healing of the bone with anti-fracture drugs

&
Pages 2267-2272 | Received 28 Jul 2016, Accepted 23 Sep 2016, Published online: 11 Oct 2016

References

  • Copuroglu C, Calori GM, Giannoudis PV. Fracture non-union: who is at risk? Injury. 2013;44:1379–1382.
  • Kuyucu E, Koçyiğit F, Ciftçi L. The importance of patient compliance in nonunion of forearm fracture. Int J Surg Case Rep. 2014;5:598–600.
  • Fazzalari NL. Bone fracture and bone fracture repair [Review]. Osteoporos Int. 2011;22:2003–2006.
  • Féron JM, Mauprivez R. Fracture repair: general aspects and influence of osteoporosis and anti-osteoporosis treatment. Injury. 2016;47(Suppl 1):S10–S14.
  • Gerstenfeld LC, Sacks DJ, Pelis M, et al. Comparison of effects of the bisphosphonate alendronate versus the RANKL inhibitor denosumab on murine fracture healing. J Bone Miner Res. 2009;24:196–208.
  • Sloan AV, Martin JR, Li S, et al. Parathyroid hormone and bisphosphonate have opposite effects on stress fracture repair. Bone. 2010;47:235–240.
  • Kidd LJ, Cowling NR, Wu AC, et al. Bisphosphonate treatment delays stress fracture remodeling in the rat ulna. J Orthop Res. 2011;29:1827–1833.
  • Brandi ML. Drugs for bone healing [Review]. Expert Opin Investig Drugs. 2012;21:1169–1176.
  • Campbell EJ, Campbell GM, Hanley DA. The effect of parathyroid hormone and teriparatide on fracture healing [Review]. Expert Opin Biol Ther. 2015;15:119–129.
  • Giannotti S, Bottai V, Dell’osso G, et al. Current medical treatment strategies concerning fracture healing [Review]. Clin Cases Miner Bone Metab. 2013;10:116–120.
  • Gorter EA, Hamdy NA, Appelman-Dijkstra NM, et al. The role of vitamin D in human fracture healing: a systematic review of the literature [Review]. Bone. 2014;64:288–297.
  • Kolb JP, Schilling AF, Bischoff J, et al. Calcium homeostasis influences radiological fracture healing in postmenopausal women. Arch Orthop Trauma Surg. 2013;133:187–192.
  • Parchi P, Andreani L, Piolanti N, et al. Effect of vitamin D in fracture healing in a child: case report. Arch Osteoporos. 2014;9:170.
  • Doetsch AM, Faber J, Lynnerup N, et al. The effect of calcium and vitamin D3 supplementation on the healing of the proximal humerus fracture: a randomized placebo-controlled study. Calcif Tissue Int. 2004;75:183–188.
  • Aydoğan NH, Őzel I, Iltar S, et al. The effect of vitamin D and bisphosphonate on fracture healing: an experimental study. J Clin Orthop Trauma. 2016;7:90–94.
  • Shuid AN, Mohamad S, Mohamed N, et al. Effects of calcium supplements on fracture healing in a rat osteoporotic model. J Orthop Res. 2010;28:1651–1656.
  • Solomon DH, Hochberg MC, Mogun H, et al. The relation between bisphosphonate use and non-union of fractures of the humerus in older adults. Osteoporos Int. 2009;20:895–901.
  • Kates SL, Ackert-Bicknell CL. How do bisphosphonates affect fracture healing? Injury. 2016;47(Suppl 1):S65–S68.
  • Fu LJ, Tang TT, Hao YQ, et al. Long-term effects of alendronate on fracture healing and bone remodeling of femoral shaft in ovariectomized rats. Acta Pharmacol Sin. 2013;34:387–392.
  • Goldhahn J, Féron JM, Kanis J, et al. Implications for fracture healing of current and new osteoporosis treatments: an ESCEO consensus paper. Calcif Tissue Int. 2012;90:343–353.
  • Goldhahn J, Little D, Mitchell P, et al. Evidence for anti-osteoporosis therapy in acute fracture situations – recommendations of a multidisciplinary workshop of the International Society for Fracture Repair. Bone. 2010;46:267–271.
  • Bukata SV. Systemic administration of pharmacological agents and bone repair: what can we expect [Review]. Injury. 2011;42:605–608.
  • Manabe T, Mori S, Mashiba T, et al. Effect of dosing interval duration of intermittent ibandronate treatment on the healing process of femoral osteotomy in a rat fracture model. Calcif Tissue Int. 2012;90:193–201.
  • Matos MA, Tannuri U, Guarniero R. The effect of zoledronate during bone healing. J Orthop Traumatol. 2010;11:7–12.
  • Hao Y, Wang X, Wang L, et al. Zoledronic acid suppresses callus remodeling but enhances callus strength in an osteoporotic rat model of fracture healing. Bone. 2015;81:702–711.
  • Cao Y, Mori S, Mashiba T, et al. Raloxifene, estrogen, and alendronate affect the processes of fracture repair differently in ovariectomized rats. J Bone Miner Res. 2002;17:2237–2246.
  • Türker M, Aslan A, Çirpar M, et al. Histological and biomechanical effects of zoledronate on fracture healing in an osteoporotic rat tibia model. Eklem Hastalik Cerrahisi. 2016;27:9–15.
  • Tatli U, Ustün Y, Kürkçü M, et al. Effects of zoledronic acid on healing of mandibular fractures: an experimental study in rabbits. J Oral Maxillofac Surg. 2011;69:1726–1735.
  • Manabe T, Mori S, Mashiba T, et al. Eel calcitonin (elcatonin) suppressed callus remodeling but did not interfere with fracture healing in the femoral fracture model of cynomolgus monkeys. J Bone Miner Metab. 2009;27:295–302.
  • Amanat N, McDonald M, Godfrey C, et al. Optimal timing of a single dose of zoledronic acid to increase strength in rat fracture repair. J Bone Miner Res. 2007;22:867–876.
  • Li J, Mori S, Kaji Y, et al. Concentration of bisphosphonate (incadronate) in callus area and its effects on fracture healing in rats. J Bone Miner Res. 2000;15:2042–2051.
  • Savaridas T, Wallace RJ, Salter DM, et al. Do bisphosphonates inhibit direct fracture healing? A laboratory investigation using an animal model. Bone Joint J. 2013;95-B:1263–1268.
  • Xue D, Li F, Chen G, et al. Do bisphosphonates affect bone healing? A meta-analysis of randomized controlled trials. J Orthop Surg Res. 2014;9:45.
  • Li YT, Cai HF, Zhang ZL. Timing of the initiation of bisphosphonates after surgery for fracture healing: a systematic review and meta-analysis of randomized controlled trials [Review]. Osteoporos Int. 2015;26:431–441.
  • Kim TY, Ha YC, Kang BJ, et al. Does early administration of bisphosphonate affect fracture healing in patients with intertrochanteric fractures? J Bone Joint Surg Br. 2012;94:956–960.
  • Colón-Emeric C, Nordsletten L, Olson S, et al. Association between timing of zoledronic acid infusion and hip fracture healing. Osteoporos Int. 2011;22:2329–2336.
  • Ha KY, Park KS, Kim SI, et al. Does bisphosphonate-based anti-osteoporosis medication affect osteoporotic spinal fracture healing? Osteoporos Int. 2016;27:483–488.
  • Rozental TD, Vazquez MA, Chacko AT, et al. Comparison of radiographic fracture healing in the distal radius for patients on and off bisphosphonate therapy. J Hand Surg Am. 2009;34:595–602.
  • Uchiyama S, Itsubo T, Nakamura K, et al. Effect of early administration of alendronate after surgery for distal radial fragility fracture on radiological fracture healing time. Bone Joint J. 2013;95-B:1544–1550.
  • Black DM, Rosen CJ. Clinical practice. Postmenopausal osteoporosis [Review]. N Engl J Med. 2016;374:254–262.
  • Adami S, Libanati C, Boonen S, et al. Denosumab treatment in postmenopausal women with osteoporosis does not interfere with fracture-healing: results from the FREEDOM trial. J Bone Joint Surg Am. 2012;94:2113–2119.
  • Tarantino U, Celi M, Feola M, et al. A new antiresorptive approach to the treatment of fragility fractures: long-term efficacy and safety of denosumab. Aging Clin Exp Res. 2013;25(Suppl 1):S65–S69.
  • Stuermer EK, Sehmisch S, Rack T, et al. Estrogen and raloxifene improve metaphyseal fracture healing in the early phase of osteoporosis. A new fracture-healing model at the tibia in rat. Langenbecks Arch Surg. 2010;395:163–172.
  • Brandi ML. Healing of the bone with anti-fracture drugs [Review]. Expert Opin Pharmacother. 2013;14:1441–1447.
  • Hegde V, Jo JE, Andreopoulou P, et al. Effect of osteoporosis medications on fracture healing. Osteoporos Int. 2016;27:861–871.
  • Manabe T, Mori S, Mashiba T, et al. Human parathyroid hormone (1-34) accelerates natural fracture healing process in the femoral osteotomy model of cynomolgus monkeys. Bone. 2007;40:1475–1482.
  • Nakajima A, Shimoji N, Shiomi K, et al. Mechanisms for the enhancement of fracture healing in rats treated with intermittent low-dose human parathyroid hormone (1-34). J Bone Miner Res. 2002;17:2038–2047.
  • Nozaka K, Miyakoshi N, Kasukawa Y, et al. Intermittent administration of human parathyroid hormone enhances bone formation and union at the site of cancellous bone osteotomy in normal and ovariectomized rats. Bone. 2008;42:90–97.
  • Nakazawa T, Nakajima A, Shiomi K, et al. Effects of low-dose, intermittent treatment with recombinant human parathyroid hormone (1-34) on chondrogenesis in a model of experimental fracture healing. Bone. 2005;37:711–719.
  • Andreassen TT, Ejersted C, Oxlund H. Intermittent parathyroid hormone (1-34) treatment increases callus formation and mechanical strength of healing rat fractures. J Bone Miner Res. 1999;14:960–968.
  • Miyakoshi N, Horikawa A, Shimada Y. Nonsurgical corrective union of osteoporotic vertebral fracture with once-weekly teriparatide. Case Rep Orthop. 2015;2015:784360.
  • Chintamaneni S, Finzel K, Gruber BL. Successful treatment of sternal fracture nonunion with teriparatide. Osteoporos Int. 2010;21:1059–1063.
  • Oteo-Alvaro A, Moreno E. Atrophic humeral shaft nonunion treated with teriparatide (rh PTH 1-34): a case report. J Shoulder Elbow Surg. 2010;19:e22–8.
  • Huang TW, Chuang PY, Lin SJ, et al. Teriparatide improves fracture healing and early functional recovery in treatment of osteoporotic intertrochanteric fractures. Medicine (Baltimore). 2016;95:e3626.
  • Peichl P, Holzer LA, Maier R, et al. Parathyroid hormone 1-84 accelerates fracture-healing in pubic bones of elderly osteoporotic women. J Bone Joint Surg Am. 2011;93:1583–1587.
  • Aspenberg P, Genant HK, Johansson T, et al. Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures. J Bone Miner Res. 2010;25:404–414.
  • Johansson T. PTH 1-34 (teriparatide) may not improve healing in proximal humerus fractures. A randomized, controlled study of 40 patients. Acta Orthop. 2016;87:79–82.
  • Scaglione M, Fabbri L, Casella F, et al. Strontium ranelate as an adjuvant for fracture healing: clinical, radiological, and ultrasound findings in a randomized controlled study on wrist fractures. Osteoporos Int. 2016;27:211–218.
  • Komrakova M, Weidemann A, Dullin C, et al. The impact of strontium ranelate on metaphyseal bone healing in ovariectomized rats. Calcif Tissue Int. 2015;97:391–401.
  • Brüel A, Olsen J, Birkedal H, et al. Strontium is incorporated into the fracture callus but does not influence the mechanical strength of healing rat fractures. Calcif Tissue Int. 2011;88:142–152.
  • Li YF, Luo E, Feng G, et al. Systemic treatment with strontium ranelate promotes tibial fracture healing in ovariectomized rats. Osteoporos Int. 2010;21:1889–1897.

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