1,799
Views
24
CrossRef citations to date
0
Altmetric
Review

Pharmacological treatment of children and adolescents with depression

&
Pages 2273-2279 | Received 01 Sep 2016, Accepted 29 Sep 2016, Published online: 14 Oct 2016

References

  • World Health Organization. The global burden of disease: 2004 update. Geneva: World Health Organization; 2008.
  • Merikangas KR, He JP, Brody D, et al. Prevalence and treatment of mental disorders among US children in the 2001-2004 NHANES. Pediatrics. 2010;125:75–81.
  • Avenevoli S, Swendsen J, He JP, et al. Major depression in the national comorbidity survey-adolescent supplement: prevalence, correlates, and treatment. J Am Acad Child Adolesc Psychiatry. 2015;54:37–44.
  • Merikangas KR, He JP, Burstein M, et al. Lifetime prevalence of mental disorders in U.S. adolescents: results from the National Comorbidity Survey Replication–Adolescent Supplement (NCS-A). J Am Acad Child Adolesc Psychiatry. 2010;49:980–989.
  • Olfson M, Druss BG, Marcus SC. Trends in mental health care among children and adolescents. N Engl J Med. 2015;372:2029–2038.
  • Adegbite-Adeniyi C, Gron B, Rowles BM, et al. An update on antidepressant use and suicidality in pediatric depression. Expert Opin Pharmacother. 2012;13:2119–21130.
  • Valluri S, Zito JM, Safer DJ, et al. Impact of the 2004 food and drug administration pediatric suicidality warning on antidepressant and psychotherapy treatment for new-onset depression. Med Care. 2010;48:947–954.
  • U.S. 105th Congress. The Food and Drug Administration Modernization Act of 1997. Public Law 105-115, 1997
  • Mosholder AD, Willy M. Suicidal adverse events in pediatric randomized, controlled clinical trials of antidepressants drugs are associated with active drug treatment: a meta-analysis. J Child Adolesc Psychopharmacol. 2006;16:25–32.
  • Hammad TA, Laughren T, Racoosin J. Suicidality in pediatric patients treated with antidepressant drugs. Arch Gen Psychiatry. 2006;63:332–339.
  • Bridge J, Iyengar S, Salary C, et al. Clinical response and risk for reported suicidal ideation and suicide attempts in pediatric antidepressant treatment: a meta-analysis of randomized clinical trials. JAMA. 2007;297:1683–1696.
  • Stone M, Laughren T, Jones ML, et al. Risk of suicidality in clinical trials of antidepressants in adults: analysis of proprietary data submitted to US food and drug administration. BMJ. 2009;339:b2880.
  • Cipriani A, Zhou X, Del Giovane C, et al. Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents: a network meta-analysis. Lancet 2016;388:881–890.
  • Le NJ, Nardo JM, Healy D, et al. Restoring study 329: efficacy and harms of paroxetine and imipramine in treatment of major depression in adolescence. BMJ. 2015;351:h4320.
  • Xu Y, Bai SJ, Lan XH, et al. Randomized controlled trials of serotonin-norepinephrine reuptake inhibitor in treating major depressive disorder in children and adolescents: a meta-analysis of efficacy and acceptability. Braz J Med Biol Res. 2016;49(6). pii: S0100-879X2016000600704. doi:10.1590/1414-431X20164806.
  • Sharma T, Guski LS, Freund N, et al. Suicidality and aggression during antidepressant treatment: systematic review and meta-analyses based on clinical study reports. BMJ. 2016;352:i65.
  • Varigonda AL, Jakubovski E, Taylor MJ, et al. Early treatment responses of selective serotonin reuptake inhibitors in pediatric major depressive disorder. J Am Acad Child Adolesc Psychiatry. 2015;54:557–564.
  • Zhou X, Qin B, Del Giovane C, et al. Efficacy and tolerability of antidepressants in the treatment of adolescents and young adults with depression and substance use disorders: a systematic review and meta-analysis. Addiction. 2015;110:38–48.
  • Rojas-Mirquez JC, Rodriguez-Zuñiga MJ, Bonilla-Escobar FJ, et al. Nocebo effect in randomized clinical trials of antidepressants in children and adolescents: systematic review and meta-analysis. Front Behav Neurosci. 2014 Nov;3(8):375.
  • Cox GR, Callahan P, Churchill R, et al. Psychological therapies versus antidepressant medication, alone and in combination for depression in children and adolescents. Cochrane Database Syst Rev. 2014;11:CD008324.
  • Qin B, Zhang Y, Zhou X, et al. Selective serotonin reuptake inhibitors versus tricyclic antidepressants in young patients: a meta-analysis of efficacy and acceptability. Clin Ther. 2014;36:1087–1095.
  • Spielmans GI, Gerwig K. The efficacy of antidepressants on overall well-being and self-reported depression symptom severity in youth: a meta-analysis. Psychother Psychosom. 2014;83:158–164.
  • Ma D, Zhang Z, Zhang X, et al. Comparative efficacy, acceptability, and safety of medicinal, cognitive-behavioral therapy, and placebo treatments for acute major depressive disorder in children and adolescents: a multiple-treatments meta-analysis. Curr Med Res Opin. 2014;30:971–979.
  • Stevanovic D, Tadic I, Knez R. Are antidepressants effective in quality of life improvement among children and adolescents? A systematic review. CNS Spectr. 2014;19:134–141.
  • Hazell P, Mirzaie M. Tricyclic drugs for depression in children and adolescents. Cochrane Database Syst Rev. 2013;6:CD002317.
  • Zhou X, Michael KD, Liu Y, et al. Systematic review of management for treatment-resistant depression in adolescents. BMC Psychiatry. 2014;49:340.
  • Offidani E, Fava GA, Tomba E, et al. Excessive mood elevation and behavioral activation with antidepressant treatment of juvenile depressive and anxiety disorders: a systematic review. Psychother Psychosom. 2013;82(3):132–141.
  • Dolle K, Schulte-Körne G. The treatment of depressive disorders in children and adolescents. Dtsch Arztebl Int. 2013;110(50):854–860.
  • Julious SA. Efficacy and suicidal risk for antidepressants in paediatric and adolescent patients. Stat Methods Med Res. 2013;22(2):190–218.
  • Cox GR, Fisher CA, De Silva S, et al. Interventions for preventing relapse and recurrence of a depressive disorder in children and adolescents. Cochrane Database Syst Rev. 2012;11:CD007504.
  • Hetrick SE, McKenzie JE, Cox GR, et al. Newer generation antidepressants for depressive disorders in children and adolescents. Cochrane Database Syst Rev. 2012;11:CD004851.
  • Hetrick SE, Cox GR, Merry SN. Treatment-resistant depression in adolescents: is the addition of cognitive behavioral therapy of benefit? Psychol Res Behav Manag. 2011;4:97–112.
  • Rutherford BR, Sneed JR, Tandler JM, et al. Deconstructing pediatric depression trials: an analysis of the effects of expectancy and therapeutic contact. J Am Acad Child Adolesc Psychiatry. 2011;50(8):782–795.
  • Reyes MM, Panza KE, Martin A, et al. Time-lag bias in trials of pediatric antidepressants: a systematic review and meta-analysis. J Am Acad Child Adolesc Psychiatry. 2011;50(1):63–72.
  • Dubicka B, Elvins R, Roberts C, et al. Combined treatment with cognitive-behavioural therapy in adolescent depression: meta-analysis. Br J Psychiatry. 2010;197:433–440.
  • Gentile S. Antidepressant use in children and adolescents diagnosed with major depressive disorder: what can we learn from published data? Rev Recent Clin Trials. 2010;5(1):63–75.
  • Bridge JA, Birmaher B, Iyengar S, et al. Placebo response in randomized controlled trials of antidepressants for pediatric major depressive disorder. Am J Psychiatry. 2009;166:42–49.
  • Papakostas GI, Fava M. Does the probability of receiving placebo influence clinical trial outcome? A meta-regression of double-blind, randomized clinical trials in MDD. Eur Neuropsychopharmacol. 2009;19:34–40.
  • Emslie GJ, Prakash A, Zhang Q, et al. A double-blind efficacy and safety study of duloxetine fixed doses in children and adolescents with major depressive disorder. J Child Adolesc Psychopharmacol. 2014;24:170–179.
  • Atkinson SD, Prakash A, Zhang Q, et al. A double-blind efficacy and safety study of duloxetine flexible dosing in children and adolescents with major depressive disorder. J Child Adolesc Psychopharmacol. 2014;24:180–189.
  • TADS Team. Fluoxetine, cognitive-behavioral therapy, and their combination for adolescents with depression. JAMA. 2004;292:807–820.
  • Emslie GJ, Kratochvil CJ, Vitiello B, et al. Treatment for Adolescents with Depression Study (TADS): safety results. J Am Acad Child Adolesc Psychiatry. 2006;45:1440–1455.
  • Kennard BD, Silva S, Vitiello B, et al. Remission and residual symptoms after acute treatment of adolescents with major depressive disorder. J Am Acad Child Adolesc Psychiatry. 2006;45:1404–1411.
  • Vitiello B, Rohde P, Silva SG, et al. Effects of treatment on level of functioning, global health, and quality of life in depressed adolescents. J Am Acad Child Adolesc Psychiatry. 2006;45:1419–1426.
  • Goodyer I, Dubicka B, Wilkinson P, et al. Selective serotonin reuptake inhibitors (SSRIs) and routine specialist care with and without cognitive behaviour therapy in adolescents with major depression: randomized controlled trial. BMJ. 2007;335:142.
  • Gibbons RD, Brown CH, Hur K, et al. Suicidal thoughts and behavior with antidepressant treatment: reanalysis of the randomized placebo-controlled studies of fluoxetine and venlafaxine. Arch Gen Psychiatry. 2012;69:580–587.
  • Vitiello B, Silva S, Rohde P, et al. Suicidal events in the Treatment for Adolescents with Depression Study (TADS). J Clin Psychiatry. 2009;70:741–747.
  • Vitiello B, Brent D, Greenhill LL, et al. Depressive symptoms and clinical status during the Treatment of Adolescent Suicide Attempters Study (TASA). J Am Acad Child Adolesc Psychiatry. 2009;48:997–1004.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.