122
Views
6
CrossRef citations to date
0
Altmetric
Drug Evaluation

Efficacy of the combination of carteolol hydrochloride + latanoprost in the treatment of glaucoma and ocular hypertension

& ORCID Icon
Pages 1731-1738 | Received 22 Apr 2018, Accepted 02 Aug 2018, Published online: 08 Oct 2018

References

  • Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol. 2006;90(3):262–267.
  • Primary open-angle glaucoma preferred practice pattern - 2015. American Academy of Ophthalmology; Published 2015 Nov 13 [cited 2018 Mar 8]. https://www.aao.org/preferred-practice-pattern/primary-open-angle-glaucoma-ppp-2015
  • Global Data on Visual Impairments 2010. World Health Organization; 2010; [cited 2018 Mar 8]. http://www.who.int/blindness/publications/globaldata/en/
  • Friedman DS, Wolfs RC, O'Colmain BJ, et al. Prevalence of open-angle glaucoma among adults in the United States. Arch Ophthalmol. 2004;122(4):532–538.
  • Tielsch JM, Sommer A, Katz J, et al. Racial variations in the prevalence of primary open-angle glaucoma. The baltimore eye survey. JAMA. 1991;266(3):369–374.
  • Gordon MO, Kass MA. What we have learned from the ocular hypertension treatment study. Am J Ophthalmol. 2018 May. DOI:10.1016/j.ajo.2018.02.016
  • The effectiveness of intraocular pressure reduction in the treatment of normal-tension glaucoma. Collaborative Normal-Tension Glaucoma Study Group. Am J Ophthalmol. 1998;126(4):498–505.
  • Schulzer M. Intraocular pressure reduction in normal-tension glaucoma patients. The Normal Tension Glaucoma Study Group. Ophthalmology. 1992 Sep;99(9):1468–1470.
  • Heijl A, Leske MC, Bengtsson B, et al. Reduction of intraocular pressure and glaucoma progression: results from the early manifest glaucoma trial. Arch Ophthalmol Chic Ill 1960. 2002;120(10):1268–1279.
  • Kass MA, Heuer DK, Higginbotham EJ, et al. The ocular hypertension treatment study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma. Arch Ophthalmol Chic Ill 1960. 2002;120(6):701–713. discussion 829-830.
  • Leske MC, Heijl A, Hyman L, et al. Factors for progression and glaucoma treatment: the early manifest glaucoma trial. Curr Opin Ophthalmol. 2004;15(2):102–106.
  • Leske MC, Hyman L, Hussein M, et al. Comparison of glaucomatous progression between untreated patients with normal-tension glaucoma and patients with therapeutically reduced intraocular pressures. The effectiveness of intraocular pressure reduction in the treatment of normal-tension glaucoma. Am J Ophthalmol. 1999;127(5):625–626.
  • The Advanced Glaucoma Intervention Study (AGIS): 7. The relationship between control of intraocular pressure and visual field deterioration. The AGIS Investigators. Am J Ophthalmol. 2000;130(4):429–440.
  • Gordon MO, Kass MA. The ocular hypertension treatment study: design and baseline description of the participants. Arch Ophthalmol. 1999;117(5):573–583.
  • Aliancy J, Stamer WD, Wirostko BA. Review of nitric oxide for the treatment of glaucomatous disease. Ophthalmol Ther. 2017;6(2):221–232.
  • Serle JB, Katz LJ, McLaurin E, et al. Two phase 3 clinical trials comparing the safety and efficacy of netarsudil to timolol in patients with elevated intraocular pressure: rho kinase elevated IOP treatment trial 1 and 2 (ROCKET-1 and ROCKET-2). Am J Ophthalmol. 2018;186:116–127.
  • Barnebey HS, Robin AL. Adherence to fixed-combination versus unfixed travoprost 0.004%/Timolol 0.5% for glaucoma or ocular hypertension: a randomized trial. Am J Ophthalmol. 2017;176:61–69.
  • Reardon G, Kotak S, Schwartz GF. Objective assessment of compliance and persistence among patients treated for glaucoma and ocular hypertension: a systematic review. Patient Prefer Adherence. 2011;5:441–463.
  • Waterman H, Evans JR, Gray TA, et al. Interventions for improving adherence to ocular hypotensive therapy. Cochrane Database Syst Rev. 2013;(4):CD006132. DOI:10.1002/14651858.CD006132.pub3
  • Olthoff CMG, Schouten JSAG, Van De Borne BW, et al. Noncompliance with ocular hypotensive treatment in patients with glaucoma or ocular hypertension: an evidence-based review. Ophthalmology. 2005;112(6):953–961.e7.
  • Blumberg DM, Prager AJ, Liebmann JM, et al. Cost-related medication nonadherence and cost-saving behaviors among patients with glaucoma before and after the implementation of medicare part D. JAMA Ophthalmol. 2015;133(9):985–996.
  • Khouri AS, Realini T, Fechtner RD. Use of fixed-dose combination drugs for the treatment of glaucoma. Drugs Aging. 2007;24(12):1007–1016.
  • Razeghinejad MR, Sawchyn AK, Katz LJ. Fixed combinations of dorzolamide-timolol and brimonidine-timolol in the management of glaucoma. Expert Opin Pharmacother. 2010;11(6):959–968.
  • Hatanaka M, Grigera DE, Barbosa WL, et al. An eight-week, multicentric, randomized, interventional, open-label, phase 4, parallel comparison of the efficacy and tolerability of the fixed combination of timolol maleate 0.5%/brimonidine tartrate 0.2% versus fixed combination of timolol maleate 0.5%/dorzolamide 2% in patients with elevated intraocular pressure. J Glaucoma. 2008;17(8):674–679.
  • Li T, Lindsley K, Rouse B, et al. Comparative effectiveness of first-line medications for primary open-angle glaucoma: a systematic review and network meta-analysis. Ophthalmology. 2016;123(1):129–140.
  • Webers CAB, Beckers HJM, Zeegers MP, et al. The intraocular pressure-lowering effect of prostaglandin analogs combined with topical β-blocker therapy: a systematic review and meta-analysis. Ophthalmology. 2010;117(11):2067–2074.e1-6.
  • MIKELAN® LA ophthalmic solution 1%; MIKELAN® LA ophthalmic solution 2%. Tokyo, Japan: Otsuka Pharmaceutical Co., Ltd.; 2008.
  • Henness S, Harrison TS, Keating GM. Ocular carteolol. Drugs Aging. 2007;24(6):509–528.
  • Sharif NA, Xu SX, Crider JY, et al. Levobetaxolol (Betaxon) and other beta-adrenergic antagonists: preclinical pharmacology, IOP-lowering activity and sites of action in human eyes. J Ocul Pharmacol Ther Off J Assoc Ocul Pharmacol Ther. 2001;17(4):305–317.
  • Van Buskirk EM, Bacon DR, Fahrenbach WH. Ciliary vasoconstriction after topical adrenergic drugs. Am J Ophthalmol. 1990;109(5):511–517.
  • Floreani M, Froldi G, Cavalli M, et al. Characterization of intrinsic sympathomimetic activity of carteolol in rat cardiovascular preparations. J Pharmacol Sci. 2004;95(1):115–123.
  • Tham Y-C, Lim S-H, Gupta P, et al. Inter-relationship between ocular perfusion pressure, blood pressure, intraocular pressure profiles and primary open-angle glaucoma: the Singapore epidemiology of eye diseases study. Br J Ophthalmol. 2018 January. DOI:10.1136/bjophthalmol-2017-311359
  • Mizuki K, Yamazaki Y. Effect of carteolol hydrochloride on ocular blood flow dynamics in normal human eyes. Jpn J Ophthalmol. 2000;44(5):570.
  • Tamaki Y, Araie M, Tomita K, et al. Effect of topical carteolol on tissue circulation in the optic nerve head. Jpn J Ophthalmol. 1998;42(1):27–32.
  • Sugiyama T, Azuma I, Araie M, et al. Effect of continuous intravenous infusion of carteolol chloride on tissue blood flow in rabbit optic nerve head. Jpn J Ophthalmol. 1999;43(6):490–494.
  • Fuchsjäger-Mayrl G, Wally B, Rainer G, et al. Effect of dorzolamide and timolol on ocular blood flow in patients with primary open angle glaucoma and ocular hypertension. Br J Ophthalmol. 2005;89(10):1293–1297.
  • Lübeck P, Orgül S, Gugleta K, et al. Effect of timolol on anterior optic nerve blood flow in patients with primary open-angle glaucoma as assessed by the Heidelberg retina flowmeter. J Glaucoma. 2001;10(1):13–17.
  • Netland PA, Schwartz B, Feke GT, et al. Diversity of response of optic nerve head circulation to timolol maleate in gel-forming solution. J Glaucoma. 1999;8(3):164–171.
  • Toris CB, Zhan GL, Zhao J, et al. Potential mechanism for the additivity of pilocarpine and latanoprost. Am J Ophthalmol. 2001;131(6):722–728.
  • Lim KS, Nau CB, O’Byrne MM, et al. Mechanism of action of bimatoprost, latanoprost, and travoprost in healthy subjects. A crossover study. Ophthalmology. 2008;115(5):790–795.e4.
  • Ocklind A. Effect of latanoprost on the extracellular matrix of the ciliary muscle. A study on cultured cells and tissue sections. Exp Eye Res. 1998;67(2):179–191.
  • Sagara T, Gaton DD, Lindsey JD, et al. Topical prostaglandin F2alpha treatment reduces collagen types I, III, and IV in the monkey uveoscleral outflow pathway. Arch Ophthalmol Chic Ill 1960. 1999;117(6):794–801.
  • Toris CB, Gabelt BT, Kaufman PL. Update on the mechanism of action of topical prostaglandins for intraocular pressure reduction. Surv Ophthalmol. 2008;53(SUPPL1):S107–S120.
  • Poyer JF, Millar C, Kaufman PL. Prostaglandin F2 alpha effects on isolated rhesus monkey ciliary muscle. Invest Ophthalmol Vis Sci. 1995;36(12):2461–2465.
  • Fujio N, Kusumoto N, Odomi M. Ocular distribution of carteolol after single and repeated ocular instillation in pigmented rabbits. Acta Ophthalmol (Copenh). 1994;72(6):688–693.
  • Renard P, Kovalski JL, Cochereau I, et al. Comparison of carteolol plasmatic levels after repeated instillations of long-acting and regular formulations of carteolol 2% in glaucoma patients. Graefes Arch Clin Exp Ophthalmol. 2005;243(12):1221–1227.
  • Passo MS, Palmer EA, Van Buskirk EM. Plasma timolol in glaucoma patients. Ophthalmology. 1984;91(11):1361–1363.
  • Amemiya M, Tabei K, Furuya H, et al. Pharmacokinetics of carteolol in patients with impaired renal function. Eur J Clin Pharmacol. 1992;43(4):417–421.
  • Ishii Y, Nakamura K, Matsuki S, et al. Pharmacokinetic and pharmacodynamic differences between ocular and nasal instillation of carteolol on intraocular pressure and heart rate in Japanese men with high CYP2D6 activity. J Clin Pharmacol. 2002;42(9):1020–1026.
  • Kawase K, Yamamoto T, Muramatsu T, et al. [Long-acting carteolol hydrochloride 2% ophthalmic solution phase IV study–investigation of the effectiveness, safety and plasma concentration]. Nippon Ganka Gakkai Zasshi. 2010;114(11):976–982.
  • Xalatan (Latanoprost) ophthalmic solution: package insert for the 2.5 ML fill. FDA; 2011. [cited 2018 Aug 31]. https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&applno=201006
  • MIKELUNA Combination ophthalmic solution. Tokyo, Japan: Otsuka Pharmaceutical Co., Ltd.; 2018. Available from: http://www.info.pmda.go.jp/downfiles/ph/PDF/180078_1319823Q1026_1_04.pdf
  • Yamamoto T, Ikegami T, Ishikawa Y, et al. Randomized, controlled, phase 3 trials of carteolol/latanoprost fixed combination in primary open-angle glaucoma or ocular hypertension. Am J Ophthalmol. 2016;171:35–46.
  • Quaranta L, Biagioli E, Riva I, et al. Prostaglandin analogs and timolol-fixed versus unfixed combinations or monotherapy for open-angle glaucoma: a systematic review and meta-analysis. J Ocul Pharmacol Ther. 2013;29(4):382–389.
  • Stewart WC, Shields MB, Allen RC, et al. A 3-month comparison of 1% and 2% carteolol and 0.5% timolol in open-angle glaucoma. Graefes Arch Clin Exp Ophthalmol. 1991;229(3):258–261.
  • Maruyama K, Shirato S. Additive effect of dorzolamide or carteolol to latanoprost in primary open-angle glaucoma: a prospective randomized crossover trial. J Glaucoma. 2006;15(4):341–345.
  • Haneda M, Shirato S, Maruyama K, et al. Comparison of the additive effects of nipradilol and carteolol to latanoprost in open-angle glaucoma. Jpn J Ophthalmol. 2006;50(1):33–37.
  • Kitazawa Y, Group KS. Phase III double-blind study of latanoprost/timolol combination (KP2035) in patients with primary open-angle glaucoma or ocular hypertension. Jpn J Clin Ophthalmol. 2009;63(5):807–815.
  • Takmaz T, Aşik S, Kürkçüoğlu P, et al. Comparison of intraocular pressure lowering effect of once daily morning vs evening dosing of latanoprost/timolol maleate combination. Eur J Ophthalmol. 2008;18(1):60–65.
  • Warwar RE, Bullock JD, Ballal D. Cystoid macular edema and anterior uveitis associated with latanoprost use. Experience and incidence in a retrospective review of 94 patients. Ophthalmology. 1998;105(2):263–268.
  • Smith SL, Pruitt CA, Sine CS, et al. Latanoprost 0.005% and anterior segment uveitis. Acta Ophthalmol Scand. 1999;77(6):668–672.
  • Arcieri ES, Santana A, Rocha FN, et al. Blood-aqueous barrier changes after the use of prostaglandin analogues in patients with pseudophakia and aphakia: a 6-month randomized trial. Arch Ophthalmol Chic Ill 1960. 2005;123(2):186–192.
  • Chu CJ, Johnston RL, Buscombe C, et al. Risk factors and incidence of macular edema after cataract surgery: a database study of 81984 eyes. Ophthalmology. 2016;123(2):316–323.
  • Alm A, Stjernschantz J. Effects on intraocular pressure and side effects of 0.005% latanoprost applied once daily, evening or morning. A comparison with timolol. Scandinavian latanoprost study group. Ophthalmology. 1995;102(12):1743–1752.
  • Mishima HK, Masuda K, Kitazawa Y, et al. A comparison of latanoprost and timolol in primary open-angle glaucoma and ocular hypertension a 12-week study. Arch Ophthalmol Chic Ill 1960. 1996;114(8):929–932.
  • Watson P, Stjernschantz J. A six-month, randomized, double-masked study comparing latanoprost with timolol in open-angle glaucoma and ocular hypertension the Latanoprost study group. Ophthalmology. 1996;103(1):126–137.
  • Taniguchi T, Kitazawa Y. The potential systemic effect of topically applied [beta]-blockers in glaucoma therapy [Editorial]. Curr Opin Ophthalmol. 1997;8(2):55–58.
  • Zimmerman TJ. Topical ophthalmic beta blockers: a comparative review. J Ocul Pharmacol. 1993;9(4):373–384.
  • Diggory P, Cassels-Brown A, Fernandez C. Topical beta-blockade with intrinsic sympathomimetic activity offers no advantage for the respiratory and cardiovascular function of elderly people. Age Ageing. 1996;25(6):424–428.
  • Hugues FC, Le Jeunne C, Munera Y, et al. [Comparison of the effects of carteolol and metipranolol eyedrops on the ventilatory and cardiovascular functions in asthmatics]. J Fr Ophtalmol. 1987;10(8–9):485–490.
  • Le Jeunne CL, Hugues FC, Dufier JL, et al. Bronchial and cardiovascular effects of ocular topical B-antagonists in asthmatic subjects: comparison of timolol, carteolol, and metipranolol. J Clin Pharmacol. 1989;29(2):97–101.
  • Stewart WC, Dubiner HB, Mundorf TK, et al. Effects of carteolol and timolol on plasma lipid profiles in older women with ocular hypertension or primary open-angle glaucoma. Am J Ophthalmol. 1999;127(2):142–147.
  • Putterman GJ, Davidson J, Albert J. Lack of metabolism of timolol by ocular tissues. J Ocul Pharmacol. 1985;1(3):287–296.
  • Razeghinejad MR, Tania Tai TY, Fudemberg SJ, et al. Pregnancy and glaucoma. Surv Ophthalmol. 2011;56(4):324–335.
  • OCUPRESS- carteolol hydrochloride solution : drug label information. National Institute of Health; 2006 [cited 2018 Mar 25]. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5f82e53e-d6db-432f-af68-9de88d1b1720
  • Salamalekis E, Kassanos D, Hassiakos D, et al. Intra/extra-amniotic administration of prostaglandin F2a in fetal death, missed and therapeutic abortions. Clin Exp Obstet Gynecol. 1990;17(1):17–21.
  • Lustgarten JS, Podos SM. Topical. Timolol and the nursing mother. Arch Ophthalmol. 1983;101(9): 1381–1382.
  • Madadi P, Koren G, Freeman DJ, et al. Timolol concentrations in breast milk of a woman treated for glaucoma: calculation of neonatal exposure. J Glaucoma. 2008;17(4):329–331.
  • Maeda-Chubachi T, Chi-Burris K, Simons BD, et al. Comparison of latanoprost and timolol in pediatric glaucoma: a phase 3, 12-week, randomized, double-masked multicenter study. Ophthalmology. 2011;118(10):2014–2021.
  • Enyedi LB, Freedman SF, Buckley EG. The effectiveness of latanoprost for the treatment of pediatric glaucoma. J AAPOS Off Publ Am Assoc Pediatr Ophthalmol Strabismus. 1999;3(1):33–39.
  • Black AC, Jones S, Yanovitch TL, et al. Latanoprost in pediatric glaucoma—pediatric exposure over a decade. J Am Assoc Pediatr Ophthalmol Strabismus. 2009;13(6):558–562.
  • Nguyen QH, Earl M. Fixed-combination brimonidine/timolol as adjunctive therapy to a prostaglandin analog: a 3-month, open-label, replacement study in glaucoma patients. J Ocul Pharmacol Ther Off J Assoc Ocul Pharmacol Ther. 2009;25(6):541–544.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.