Current pharmacotherapeutic approaches for dysthymic disorder and persistent depressive disorder

References

• American Psychiatric Association. Diagnostic and statistical manual of mental disorders (4th ed., Text Revision). Washington, DC: Author;2000 .
   Google Scholar
• American Psychiatric Association. Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC: Author; 2013.
   Google Scholar
• Blanco C, Okuda M, Markowitz JC, et al. The epidemiology of chronic major depressive disorder and dysthymic disorder. J Clin Psychiatry. 2010;71:1645–1656.
   PubMed Web of Science ®Google Scholar
• Alonso J, Angermeyer MC, Bernert S, et al. Prevalence of mental disorders in Europe: results from the European study of the epidemiology of mental disorders (ESEMeD) project. Acta Psychiatr Scand Suppl. 2004;420:21–27.
   PubMedGoogle Scholar
• Harvard Medical School. National Comorbidity Survey (NCS). (2017).
   Google Scholar
• Kessler RC, Berglund P, Demler O, et al. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the national comorbidity survey replication. Arch Gen Psychiatry. 2005;62:593–602.
   PubMed Web of Science ®Google Scholar
• Carta MG, Carpiniello B, Kovess V, et al. Lifetime prevalence of major depression and dysthymia: results of a community survey in Sardinia. Eur Neuropsychopharmacol. 1995;5(Suppl):103–107.
   PubMed Web of Science ®Google Scholar
• Klein DN. Chronic depression. Curr Dir Psychol Sci. 2010;19:96–100.
   Web of Science ®Google Scholar
• Murphy JA, Byrne GJ. Prevalence and correlates of the proposed DSM-5 diagnosis of chronic depressive disorder. J Affect Disord. 2012;139:172–180.
   PubMed Web of Science ®Google Scholar
• Rubio JM, Markowitz JC, Alegría A, et al. Epidemiology of chronic and nonchronic major depressive disorder: results from the national epidemiologic survey on alcohol and related conditions. Depress Anxiety. 2011;28:622–631.
   PubMed Web of Science ®Google Scholar
• Rapaport MH, Clary C, Fayyad R, et al. Quality-of-life impairment in depressive and anxiety disorders. Am J Psychiatry. 2005;162:1171–1178.
   PubMed Web of Science ®Google Scholar
• Hellerstein DJ, Agosti V, Bosi M, et al. Impairment in psychosocial functioning associated with dysthymic disorder in the NESARC study. J Affect Disord. 2010;127:84–88.
   PubMed Web of Science ®Google Scholar
• Klein DN, Schwartz JE, Rose S, et al. Five-year course and outcome of dysthymic disorder: A prospective, naturalistic follow-up study. Am J Psychiatry. 2000;157:931–939.
   PubMed Web of Science ®Google Scholar
• Byers AL, Covinsky KE, Barnes DE, et al. Dysthymia and depression increase risk of dementia and mortality among older veterans. Am J Geriatr Psychiatry. 2012;20:664–672.
   PubMed Web of Science ®Google Scholar
• Baune BT, Adrian I, Arolt V, et al. Associations between major depression, bipolar disorders, dysthymia and cardiovascular diseases in the general adult population. Psychother Psychosom. 2006;75:319–326.
   PubMed Web of Science ®Google Scholar
• Larson SL, Owens PL, Ford D, et al. Depressive disorder, dysthymia, and risk of stroke: thirteen-year follow-up from the Baltimore epidemiologic catchment area study. Stroke. 2001;32:1979–1983.
   PubMed Web of Science ®Google Scholar
• Freeman HL. Historical and nosological aspects of dysthymia. Acta Psychiatr Scand Suppl. 1994;383:7–11.
   PubMedGoogle Scholar
• Akiskal HS. The nosological status of neurotic depression. Arch Gen Psychiatry. 1978;35:756.
   PubMed Web of Science ®Google Scholar
• Keller MB. Dysthymia in clinical practice: course,outcome and impact on the community. Acta Psychiatr Scand Suppl. 1994;383:24–34.
   PubMedGoogle Scholar
• Rhebergen D, Graham R. The re-labelling of dysthymic disorder to persistent depressive disorder in DSM-5: old wine in new bottles?. Curr Opin Psychiatry. 2014;27:27–31.
   PubMed Web of Science ®Google Scholar
• Köhler S, Chrysanthou S, Guhn A, et al. Differences between chronic and nonchronic depression: systematic review and implications for treatment. Depress Anxiety. 2019;36:18–30.
   PubMed Web of Science ®Google Scholar
• Klein DN, Shankman SA, Rose S. Ten-year prospective follow-up study of the naturalistic course of dysthymic disorder and double depression. Am J Psychiatry. 2006;163:872–880.
   PubMed Web of Science ®Google Scholar
• Klein DN, Riso LP, Donaldson SK, et al. Family study of early-onset dysthymia. Mood and personality disorders in relatives of outpatients with dysthymia and episodic major depression and normal controls. Arch Gen Psychiatry. 1995;52:487–496.
   PubMed Web of Science ®Google Scholar
• Riso LP, Klein DN, Ferro T, et al. Understanding the comorbidity between early-onset dysthymia and cluster B personality disorders: a family study. Am J Psychiatry. 1996;153:900–906.
   PubMed Web of Science ®Google Scholar
• Sang W, Li Y, Su L, et al. A comparison of the clinical characteristics of Chinese patients with recurrent major depressive disorder with and without dysthymia. J Affect Disord. 2011;135:106–110.
   PubMed Web of Science ®Google Scholar
• Kriston L, von Wolff A, Westphal A, et al. Efficacy and acceptability of acute treatments for persistent depressive disorder: a network meta-analysis. Depress Anxiety. 2014;31:621–630.
   PubMed Web of Science ®Google Scholar
• von Wolff A, Hölzel LP, Westphal A, et al. Combination of pharmacotherapy and psychotherapy in the treatment of chronic depression: A systematic review and meta-analysis. BMC Psychiatry. 2012;12:61.
   PubMed Web of Science ®Google Scholar
• Cuijpers P, van Straten A, Schuurmans J, et al. Psychotherapy for chronic major depression and dysthymia: a meta-analysis. Clin Psychol Rev. 2010;30:51–62.
   PubMed Web of Science ®Google Scholar
• Akiskal HS. Dysthymia and cyclothymia in psychiatric practice a century after Kraepelin. J Affect Disord. 2001;62:17–31.
   PubMed Web of Science ®Google Scholar
• Klein DN, Kocsis JH, McCullough JP, et al. Symptomatology in dysthymic and major depressive disorder. Psychiatr Clin North Am. 1996;19:41–53.
   PubMed Web of Science ®Google Scholar
• Griffiths J, Ravindran AV, Merali Z, et al. Dysthymia: a review of pharmacological and behavioral factors. Mol Psychiatry. 2000;5:242–261.
   PubMed Web of Science ®Google Scholar
• Preti MG, Bolton TA, Van De Ville D. The dynamic functional connectome: state-of-the-art and perspectives. Neuroimage. 2017;160:41–54.
   PubMed Web of Science ®Google Scholar
• Broyd SJ, Demanuele C, Debener S, et al. Default-mode brain dysfunction in mental disorders: a systematic review. Neurosci Biobehav Rev. 2009;33:279–296.
   PubMed Web of Science ®Google Scholar
• Greicius MD, Flores BH, Menon V, et al. Resting-state functional connectivity in major depression: abnormally increased contributions from subgenual cingulate cortex and thalamus. Biol Psychiatry. 2007;62:429–437.
   PubMed Web of Science ®Google Scholar
• Sheline YI, Price JL, Yan Z, et al. Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus. Proc Natl Acad Sci U S A. 2010;107:11020–11025.
   PubMed Web of Science ®Google Scholar
• Dunlop BW, Rajendra JK, Craighead WE, et al. Functional connectivity of the subcallosal cingulate cortex and differential outcomes to treatment with cognitive-behavioral therapy or antidepressant medication for major depressive disorder. Am J Psychiatry. 2017;174:533–545.
   PubMed Web of Science ®Google Scholar
• Zhao Q, Swati ZNK, Metmer H, et al. Investigating executive control network and default mode network dysfunction in major depressive disorder. Neurosci Lett. 2019;701:154–161.
   PubMed Web of Science ®Google Scholar
• Posner J, Hellerstein DJ, Gat I, et al. Antidepressants normalize the default mode network in patients with dysthymia. JAMA Psychiatry. 2013;70:373–382.
   PubMed Web of Science ®Google Scholar
• Anderson G. Linking the biological underpinnings of depression: role of mitochondria interactions with melatonin, inflammation, sirtuins, tryptophan catabolites, DNA repair and oxidative and nitrosative stress, with consequences for classification and cognition. Prog Neuropsychopharmacol Biol Psychiatry. 2018;80:255–266.
   PubMed Web of Science ®Google Scholar
• Ho PS, Yen CH, Chen CY, et al. Changes in cytokine and chemokine expression distinguish dysthymic disorder from major depression and healthy controls. Psychiatry Res. 2017;248:20–27.
   PubMed Web of Science ®Google Scholar
• Jobst A, Brakemeier EL, Buchheim A, et al. European psychiatric association guidance on psychotherapy in chronic depression across Europe. Eur Psychiatry. 2016;33:18–36.
   PubMed Web of Science ®Google Scholar
• Nemeroff CB, Heim CM, Thase ME, et al. Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma. Proc Natl Acad Sci. 2003;100:14293–14296.
   PubMed Web of Science ®Google Scholar
• Kocsis JH, Leon AC, Markowitz JC, et al. Patient preference as a moderator of outcome for chronic forms of major depressive disorder treated with nefazodone, cognitive behavioral analysis system of psychotherapy, or their combination. J Clin Psychiatry. 2009;70:354–361.
   PubMed Web of Science ®Google Scholar
• Kamenov K, Twomey C, Cabello M, et al. The efficacy of psychotherapy, pharmacotherapy and their combination on functioning and quality of life in depression: a meta-analysis. Psychol Med. 2017;47:414–425.
   PubMed Web of Science ®Google Scholar
• MacQueen G, Santaguida P, Keshavarz H, et al. Systematic review of clinical practice guidelines for failed antidepressant treatment response in major depressive disorder, dysthymia, and subthreshold depression in adults. Can J Psychiatry. 2017;62:11–23.
   PubMed Web of Science ®Google Scholar
• National Collaborating Centre for Mental Health (UK). Depression: the treatment and management of depression in adults (Updated Edition). Leicester (UK): British Psychological Society; 2010. (NICE Clinical Guidelines, No. 90.) 13, THE MANAGEMENT OF SUBTHR. (2010).
   Google Scholar
• Cleare A, Pariante CM, Young AH, et al. Evidence-based guidelines for treating depressive disorders with antidepressants: A revision of the 2008 British Association for Psychopharmacology guidelines. J Psychopharmacol. 2015;29:459–525.
   PubMed Web of Science ®Google Scholar
• Machmutow K, Meister R, Jansen A, et al. Comparative effectiveness of continuation and maintenance treatments for persistent depressive disorder in adults. Cochrane Database Syst Rev. 2019.
   PubMed Web of Science ®Google Scholar
• Ruhé HG, van Rooijen G, Spijker J, et al. Staging methods for treatment resistant depression. A systematic review. J Affect Disord. 2012;137:35–45.
   PubMed Web of Science ®Google Scholar
• Kocsis JH, Gelenberg AJ, Rothbaum B, et al. Chronic forms of major depression are still undertreated in the 21st century: systematic assessment of 801 patients presenting for treatment. J Affect Disord. 2008;110:55–61.
   PubMed Web of Science ®Google Scholar
• Constantino MJ, Manber R, Degeorge J, et al. Interpersonal styles of chronically depressed outpatients: profiles and therapeutic change. Psychotherapy (Chic). 2008;45:491–506.
   PubMed Web of Science ®Google Scholar
• Wiersma JE, Van Schaik DJ, Hoogendorn AW, et al. The effectiveness of the cognitive behavioral analysis system of psychotherapy for chronic depression: a randomized controlled trial. Psychother Psychosom. 2014;83:263–269.
   PubMed Web of Science ®Google Scholar
• Michalak J, Schultze M, Heidenreich T, et al. A randomized controlled trial on the efficacy of mindfulness-based cognitive therapy and a group version of cognitive behavioral analysis system of psychotherapy for chronically depressed patients. J Consult Clin Psychol. 2015;83:951–963.
   PubMed Web of Science ®Google Scholar
• Schramm E, Kriston L, Zobel I, et al. Effect of disorder-specific vs nonspecific psychotherapy for chronic depression: a randomized clinical trial. JAMA Psychiatry. 2017;74:233–242.
   PubMed Web of Science ®Google Scholar
• Schramm E, Zobel I, Dykierek P, et al. Cognitive behavioral analysis system of psychotherapy versus interpersonal psychotherapy for early-onset chronic depression: a randomized pilot study. J Affect Disord. 2011;129:109–116.
   PubMed Web of Science ®Google Scholar
• Klein DN, Santiago NJ, Vivian D, et al. Cognitive-behavioral analysis system of psychotherapy as a maintenance treatment for chronic depression. J Consult Clin Psychol. 2004;72:681–688.
   PubMed Web of Science ®Google Scholar
• de Maat SM, Dekker J, Schoevers RA, et al. Relative efficacy of psychotherapy and combined therapy in the treatment of depression: A meta-analysis. Eur Psychiatry. 2007;22:1–8.
   PubMed Web of Science ®Google Scholar
• Keller MB, McCullough JP, Klein DN, et al. A comparison of nefazodone, the cognitive behavioral-analysis system of psychotherapy, and their combination for the treatment of chronic depression. N Engl J Med. 2000;342:1462–1470.
   PubMed Web of Science ®Google Scholar
• Schramm E, Zobel I, Schoepf D, et al. Cognitive behavioral analysis system of psychotherapy versus escitalopram in chronic major depression. Psychother Psychosom. 2015;84:227–240.
   PubMed Web of Science ®Google Scholar
• Schatzberg AF, Rush AJ, Arnow BA, et al. Chronic depression: medication (nefazodone) or psychotherapy (CBASP) is effective when the other is not. Arch Gen Psychiatry. 2005;62:513–520.
   PubMed Web of Science ®Google Scholar
• Churchill R, Hunot V, Corney R, et al. A systematic review of controlled trials of the effectiveness and cost-effectiveness of brief psychological treatments for depression. Health Technol Assess. 2001;5:1–173.
   PubMedGoogle Scholar
• Cuijpers P, van Straten A, Andersson G, et al. Psychotherapy for depression in adults: a meta-analysis of comparative outcome studies. J Consult Clin Psychol. 2008;76:909–922.
   PubMed Web of Science ®Google Scholar
• Cuijpers P, Van Straten A, Warmerdam L, et al. Characteristics of effective psychological treatments of depression: a metaregression analysis. Psychother Res. 2008;18:225–236.
   PubMed Web of Science ®Google Scholar
• Ilardi SS, Craighead WE. The role of nonspecific factors in cognitive-behavior therapy for depression. Clin Psychol Sci Pract. 1994;1:138–155.
   Web of Science ®Google Scholar
• Tang TZ, Derubeis RJ, Hollon SD, et al. Sudden gains in cognitive therapy of depression and depression relapse/recurrence. J Consult Clin Psychol. 2007;75:404–408.
   PubMed Web of Science ®Google Scholar
• Cuijpers P, Karyotaki E, Reijnders M, et al. Was Eysenck right after all? A reassessment of the effects of psychotherapy for adult depression. Epidemiol Psychiatr Sci. 2019;28:21–30.
   PubMed Web of Science ®Google Scholar
• Munder T, Flückiger C, Leichsenring F, et al. Is psychotherapy effective? A re-analysis of treatments for depression. Epidemiol Psychiatr Sci. 2018;28:268–274.
   PubMed Web of Science ®Google Scholar
• Imel ZE, Malterer MB, McKay KM, et al. A meta-analysis of psychotherapy and medication in unipolar depression and dysthymia. J Affect Disord. 2008;110:197–206.
   PubMed Web of Science ®Google Scholar
• Levkovitz Y, Tedeschini E, Papakostas GI. Efficacy of antidepressants for dysthymia: a meta-analysis of placebo-controlled randomized trials. J Clin Psychiatry. 2011;72:509–514.
   PubMed Web of Science ®Google Scholar
• Meister R, von Wolff A, Mohr H, et al. Comparative safety of pharmacologic treatments for persistent depressive disorder: a systematic review and network meta-analysis. PLoS One. 2016;11:e0153380.
   PubMed Web of Science ®Google Scholar
• Devanand DP. Dysthymic disorder in the elderly population. Int Psychogeriatrics. 2014;26:39–48.
   PubMed Web of Science ®Google Scholar
• Devanand DP, Pelton GH, Marston K, et al. Sertraline treatment of elderly patients with depression and cognitive impairment. Int J Geriatr Psychiatry. 2003;18:123–130.
   PubMed Web of Science ®Google Scholar
• Hellerstein DJ, Hunnicutt-Ferguson K, Stewart JW, et al. Do social functioning and symptoms improve with continuation antidepressant treatment of persistent depressive disorder? An observational study. J Affect Disord. 2017;210:258–264.
   PubMed Web of Science ®Google Scholar
• Hellerstein DJ, Stewart JW, Chen Y, et al. Desvenlafaxine vs. placebo in the treatment of persistent depressive disorder. J Affect Disord. 2019;245:403–411.
   PubMed Web of Science ®Google Scholar
• Wasserstein RL, Schirm AL, Lazar NA. Moving to a World Beyond “ p < 0.05”. Am Stat. 2019;73:1–19.
   Web of Science ®Google Scholar
• Komossa K, Depping AM, Kissling W, et al. Second-generation antipsychotic drugs for major depressive disorder. In: Cochrane database of systematic reviews, editor Leucht S. John Wiley & Sons, Ltd; 2010, Issue 12.
   Google Scholar
• Lecrubier Y, Boyer P, Turjanski S, et al. Amisulpride versus imipramine and placebo in dysthymia and major depression. Amisulpride study group. J Affect Disord. 1997;43:95–103.
   PubMed Web of Science ®Google Scholar
• Smeraldi E. Amisulpride versus fluoxetine in patients with dysthymia or major depression in partial remission: a double-blind, comparative study. J Affect Disord. 1998;48:47–56.
   PubMed Web of Science ®Google Scholar
• Ravizza L. Amisulpride in medium-term treatment of dysthymia: a six-month, double-blind safety study versus amitriptyline. AMILONG investigators. J Psychopharmacol. 1999;13:248–254.
   PubMed Web of Science ®Google Scholar
• Boyer P, Lecrubier Y, Stalla-Bourdillon A, et al. Amisulpride versus amineptine and placebo for the treatment of dysthymia. Neuropsychobiology. 1999;39:25–32.
   PubMed Web of Science ®Google Scholar
• Amore M, Jori MC, AMISERT Investigators. Faster response on amisulpride 50 mg versus sertraline 50-100 mg in patients with dysthymia or double depression: a randomized, double-blind, parallel group study. Int Clin Psychopharmacol. 2001;16:317–324.
   PubMed Web of Science ®Google Scholar
• Wang SM, Han C, Lee SJ, et al. A review of current evidence for acetyl-l-carnitine in the treatment of depression. J Psychiatr Res. 2014;53:30–37.
   PubMed Web of Science ®Google Scholar
• Bella R, Biondi R, Raffaele R, et al. Effect of acetyl-L-carnitine on geriatric patients suffering from dysthymic disorders. Int J Clin Pharmacol Res. 1990;10:355–360.
   PubMedGoogle Scholar
• Fulgente TOM, Del Re ML, Ferracci F, et al. Laevo-acetylcarnitine (NicetileR) treatment of senile depression. J Soc Clin Trials. 1990;27:155–163.
   Google Scholar
• Zanardi R, Smeraldi E. A double-blind, randomised, controlled clinical trial of acetyl-L-carnitine vs. amisulpride in the treatment of dysthymia. Eur Neuropsychopharmacol. 2006;16:281–287.
   PubMed Web of Science ®Google Scholar
• Bersani G, Meco G, Denaro A, et al. L-Acetylcarnitine in dysthymic disorder in elderly patients: a double-blind, multicenter, controlled randomized study vs. fluoxetine. Eur Neuropsychopharmacol. 2013;23:1219–1225.
   PubMed Web of Science ®Google Scholar
• Fitzgerald PB, Daskalakis ZJ. The effects of repetitive transcranial magnetic stimulation in the treatment of depression. Expert Rev Med Devices. 2011;8:85–95.
   PubMed Web of Science ®Google Scholar
• Rapinesi C, Bersani FS, Kotzalidis GD, et al. Maintenance deep transcranial magnetic stimulation sessions are associated with reduced depressive relapses in patients with unipolar or bipolar depression. Front Neurol. 2015;6.
   PubMed Web of Science ®Google Scholar