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Review

Established and recent developments in the pharmacological management of urolithiasis: an overview of the current treatment armamentarium

, , &
Pages 85-96 | Received 22 Aug 2019, Accepted 24 Oct 2019, Published online: 12 Nov 2019

References

  • Knoll T. Epidemiology, pathogenesis and pathophysiology of urolithiasis. Eur Urol Suppl. 2010;9(12):802–806.
  • Brikowski TH, Lotan Y, Pearle MS. Climate-related increase in the prevalence of urolithiasis in the United States. Proc Natl Acad Sci U S A. 2008;105(28):9841–9846.
  • Chen Z, Prosperi M, Bird VY. Prevalence of kidney stones in the USA: the national health and nutrition evaluation survey. J Clin Urol. 2019;12(4):296–302.
  • Worcester EM, Coe FL. Nephrolithiasis. Prim Care. 2008;35(2):369–vii.
  • Borghi L, Meschi T, Amato F, et al. Urinary volume, water and recurrences in idiopathic calcium nephrolithiasis: a 5 year randomized prospective study. J Urol. 1996;155(3):839–843.
  • Ljunghall S, Danielson BG. A prospective study of renal stone recurrence. B J Urol. 1984;56:122–124.
  • Lotan Y, Cadeddu JA, Roerhborn CG, et al. Cost-effectiveness of medical management strategies for nephrolithiasis. J Urol. 2004;172(6 Pt 1):2275–2281.
  • Park S, Pearle MS. Urolithiasis: update on metabolic evaluation of stone formers. ScientificWorldJournal. 2005;5:902–914.
  • Tiselius HG, Daudon M, Thomas K, et al. Metabolic work-up of patients with urolithiasis: indications and diagnostic algorithm. Eur Urol Focus. 2017;3(1):62–71.
  • Fink HA, Akorno R, Garimella PS, et al. Diet, fluid, or supplements for secondary prevention of nephrolithiasis: a systematic review and meta-analysis of randomized trials. Eur Urol. 2009 Jul;56(1):72–80.
  • Borghi L, Schianchi T, Meschi T, et al. Comparison of two diets for the prevention of recurrent stones in idiopathic hypercalciuria. N Engl J Med. 2002;346(2):77–84.
  • Escribano J, Balaguer A, Roqué I Figuls M, et al. Dietary interventions for preventing complications in idiopathic hypercalciuria. Cochrane Database Syst Rev. 2014 Feb 11;(2):CD006022.
  • Trinchieri A. Diet and renal stone formation. Minerva Med. 2013;104(1):41–54.
  • Coll DM, Varanelli MJ, Smith RC. Relationship of spontaneous passage of ureteral calculi to stone size and location as revealed by unenhanced helical CT. AJR Am J Roentgenol. 2002;178(1):101–103.
  • Miller OF, Kane CJ. Time to stone passage for observed ureteral calculi: a guide for patient education. J Urol. 1999;162(3Pt 1):688–90. discussion 690–1.
  • Campschroer T, Zhu Y, Duijvesz D, et al. Alpha-blockers as medical expulsive therapy for ureteral stones. Cochrane Database Syst Rev. 2014 Apr 2;(4):CD008509.
  • Parsons JK, Hergan LA, Sakamoto K, et al. Efficacy of alpha-blockers for the treatment of ureteral stones. J Urol. 2007;177(3):983–7; discussion 987.
  • Yilmaz E, Batislam E, Basar MM, et al. The comparison and efficacy of 3 different alpha1-adrenergic blockers for distal ureteral stones. J Urol. 2005;173(6):2010–2012.
  • Sun X, He L, Ge W, et al. Efficacy of selective alpha1D-blocker naftopidil as medical expulsive therapy for distal ureteral stones. J Urol. 2009;181(4):1716–1720.
  • Liu XJ, Wen JG, Wan YD, et al. Role of silodosin as medical expulsive therapy in ureteral calculi: a meta-analysis of randomized controlled trials. Urolithiasis. 2018;46(2):211–218.
  • Hollingsworth JM, Rogers MA, Kaufman SR, et al. Medical therapy to facilitate urinary stone passage: a meta-analysis. Lancet. 2006;30;368(9542):1171–1179.
  • Seitz C, Liatsikos E, Porpiglia F, et al. Medical therapy to facilitate the passage of stones: what is the evidence? Eur Urol. 2009;56(3):455–471.
  • Cao D, Yang L, Liu L, et al. A comparison of nifedipine and tamsulosin as medical expulsive therapy for the management of lower ureteral stones without ESWL. Sci Rep. 2014;4:5254.
  • Porpiglia F, Vaccino D, Billia M, et al. Corticosteroids and tamsulosin in the medical expulsive therapy for symptomatic distal ureter stones: single drug or association? Eur Urol. 2006;50(2):339–344.
  • Saita A, Bonaccorsi A, Marchese F, et al. Our experience with nifedipine and prednisolone as expulsive therapy for ureteral stones. Urol Int. 2004;72(Suppl 1):43–45.
  • Gratzke C, Uckert S, Reich O, et al. PDE5 inhibitors. A new option in the treatment of ureteral colic? Urologe A. 2007;46(9):1219–1223.
  • Kumar S, Jayant K, Agrawal S, et al. Comparative efficacy of tamsulosin versus tamsulosin with tadalafil in combination with prednisolone for the medical expulsive therapy of lower ureteric stones: a randomized trial. Korean J Urol. 2014;55(3):196–200.
  • Bai Y, Yang Y, Wang X, et al. Tadalafil facilitates the distal ureteral stone expulsion: a meta-analysis. J Endourol. 2017;31(6):557–563.
  • Türk C, Skolarikos A, Neisius A, et al. Guidelines on urolithiasis. Eur Assoc Urol. 2019. available from: http://uroweb.org/guideline/urolithiasis/.
  • Assimos D, Krambeck A, Miller NL, et al. surgical management of stones: American urological association/endourological society guideline, PART II. J Urol. 2016 Oct;196(4):1161–1169.
  • Fedrigon DC, Jain R, Sivalingam S. Current use of medical expulsive therapy among endourologists. Can Urol Assoc J. 2018;12(9):E384–E390.
  • Asplin JR. Hyperoxaluric calcium nephrolithiasis. Endocrinol Metab Clin North Am. 2002;31(4):927–949.
  • Chaudhary A, Singla SK, Tandon C. In vitro evaluation of terminalia arjuna on calcium phosphate and calcium oxalate crystallization. Indian J Pharm Sci. 2010;72(3):340–345.
  • Penniston KL, Nakada SY. Updates in the metabolic management of calcium stones. Curr Urol Rep. 2018;19(6):41.
  • Craven BL, Passman C, Assimos DG. Hypercalcemic states associated with nephrolithiasis. Rev Urol. 2008;10(3):218–226.
  • Worcester EM, Coe FL. New insights into the pathogenesis of idiopathic hypercalciuria. Semin Nephrol. 2008;28(2):120–132.
  • Brocks P, Dahl C, Wolf H, et al. Do thiazides prevent recurrent idiopathic renal calcium stones? Lancet. 1981;2(8238):124–125.
  • Scholz D, Schwille PO, Sigel A. Double-blind study with thiazides in recurrent calcium lithiasis. J Urol. 1982;128(5):903–907.
  • Robertson WG, Peacock M, Selby PL, et al. A multicentre trial to evaluate three treatments for recurrent idiopathic calcium stone disease—a preliminary report. Urol Res. 1985;12:48.
  • Mortensen JT, Schultz A, Ostergaard AH. Thiazides in the prophylactic treatment of recurrent idiopathic kidney stones. Int Urol Nephrol. 1986;18(3):265–269.
  • Ettinger B, Citron JT, Livermore B, et al. Chlorthalidone reduces calcium oxalate calculous recurrence but magnesium hydroxide does not. J Urol. 1988;139(4):679–684.
  • Ohkawa M, Tokunaga S, Nakashima T, et al. Thiazide treatment for calcium urolithiasis in patients with idiopathic hypercalciuria. Br J Urol. 1992;69(6):571–576.
  • Borghi L, Meschi T, Guerra A, et al. Randomized prospective study of a nonthiazide diuretic, indapamide, in preventing calcium stone recurrences. J Cardiovasc Pharmacol. 1993;22(suppl 6):S78–S86.
  • Wilson DR, Strauss AL, Manuel MA. Comparison of medical treatment for the prevention of recurrent calcium nephrolithiasis. Urol Res. 1984;12:39–40.
  • Fernández-Rodríguez A, Arrabal-Martín M, García-Ruiz MJ, et al. The role of thiazides in the prophylaxis of recurrent calcium lithiasis. Actas Urol Esp. 2006;30(3):305–309.
  • Laerum E, Larsen S. Thiazide prophylaxis of urolithiasis. Acta Med Scand. 1984;215(4):383–389.
  • Ahlstrand C, Sandvall K, Tiselius HG. Prophylactic treatment of calcium stone formers with hydrochlorothiazide and magnesium. Edsbruk, Sweden: Akademitryck; 1996.
  • Vigen R, Weideman RA, Reilly RF. Thiazides diuretics in the treatment of nephrolithiasis: are we using them in an evidence-based fashion? Int Urol Nephrol. 2011;43(3):813–819.
  • Alexander RT, McArthur E, Jandoc R, et al. Thiazide diuretic dose and risk of kidney stones in older adults: a retrospective cohort study. Can J Kidney Health Dis. 2018;5:2054358118787480.
  • Martins MC, Meyers AM, Whalley NA, et al. Indapamide (Natrilix): the agent of choice in the treatment of recurrent renal calculi associated with idiopathic hypercalciuria. Br J Urol. 1996;78(2):176–180.
  • Ceylan K, Topal C, Erkoc R, et al. Effect of indapamide on urinary calcium excretion in patients with and without urinary stone disease. Ann Pharmacother. 2005;39(6):1034–1038. Epub 2005 Apr 19.
  • Bergsland KJ, Worcester EM, Coe FL. Role of proximal tubule in the hypocalciuric response to thiazide of patients with idiopathic hypercalciuria. Am J Physiol Renal Physiol. 2013;305(4):F592–F599.
  • Dhayat NA, Faller N, Bonny O, et al. Efficacy of standard and low dose hydrochlorothiazide in the recurrence prevention of calcium nephrolithiasis (NOSTONE trial): protocol for a randomized double-blind placebo-controlled trial. BMC Nephrol. 2018;19(1):349.
  • Sica DA. Diuretic-related side effects: development and treatment. J Clin Hypertens (Greenwich). 2004;6(9):532–540.
  • Gress TW, Nieto FJ, Shahar E, et al. Hypertension and antihypertensive therapy as risk factors for type 2 diabetes mellitus. Atherosclerosis risk in communities study. N Engl J Med. 2000;342(13):905–912.
  • Wassertheil-Smoller S, Blaufox MD, Oberman A, et al. Effect of antihypertensives on sexual function and quality of life: the TAIM Study. Ann Intern Med. 1991;114(8):613–620.
  • Chang SW, Fine R, Siegel D, et al. The impact of diuretic therapy on reported sexual function. Arch Intern Med. 1991;151(12):2402–2408.
  • Diffey BL, Langtry J. Phototoxic potential of thiazide diuretics in normal subjects. Arch Dermatol. 1989;125(10):1355–1358.
  • Huen SC, Goldfarb DS. Adverse metabolic side effects of thiazides: implications for patients with calcium nephrolithiasis. J Urol. 2007;177(4):1238–1243.
  • Mandel EI, Taylor EN, Curhan GC. Dietary and lifestyle factors and medical conditions associated with urinary citrate excretion. Clin J Am Soc Nephrol. 2013;8(6):901–908.
  • Zuckerman JM, Assimos DG. Hypocitraturia: pathophysiology and medical management. Rev Urol. 2009 Summer;11(3):134–144.
  • Chow K, Dixon J, Gilpin S, et al. Citrate inhibits growth of residual fragments in an in vitro model of calcium oxalate renal stones. Kidney Int. 2004;65(5):1724–1730.
  • Pak CY, Poindexter JR, Adams-Huet B, et al. Predictive value of kidney stone composition in the detection of metabolic abnormalities. Am J Med. 2003;115:26–32.
  • Caudarella R, Vescini F. Urinary citrate and renal stone disease: the preventive role of alkali citrate treatment. Arch Ital Urol Androl. 2009;81(3):182–187.
  • Sheng X, Jung T, Wesson JA, et al. Adhesion at calcium oxalate crystal surfaces and the effect of urinary constituents. Proc Natl Acad Sci U S A. 2005;102(2):267–272.
  • Simpson DP. Citrate excretion: a window on renal metabolism. Am J Physiol. 1983;244(3):F223–F234.
  • Phillips R, Hanchanale VS, Myatt A, et al. Citrate salts for preventing and treating calcium containing kidney stones in adults. Cochrane Database Syst Rev. 2015 Oct 6;(10):CD010057.
  • Barcelo P, Wuhl O, Servitge E, et al. Randomized double-blind study of potassium citrate in idiopathic hypocitraturic calcium nephrolithiasis. J Urol. 1993;150(6):1761–1764.
  • Hofbauer J, Höbarth K, Szabo N, et al. Alkali citrate prophylaxis in idiopathic recurrent calcium oxalate urolithiasis–a prospective randomized study. Br J Urol. 1994;73(4):362–365.
  • Ettinger B, Pak CY, Citron JT, et al. Potassium-magnesium citrate is an effective prophylaxis against recurrent calcium oxalate nephrolithiasis. J Urol. 1997;158(6):2069–2073.
  • Cicerello E, Merlo F, Gambaro G, et al. Effect of alkaline citrate therapy on clearance of residual renal stone fragments after extracorporeal shock wave lithotripsy in sterile calcium and infection nephrolithiasis patients. J Urol. 1994;151(1):5–9.
  • Jiménez Verdejo A, Arrabal Martín M, Miján Ortiz JL, et al. Effect of potassium citrate in the prophylaxis of urinary lithiasis. Arch Esp Urol. 2001;54(9):1036–1046.
  • Soygur T, Akbay A, Kupeli S. Effect of potassium citrate therapy on stone recurrence and residual fragments after shockwave lithotripsy in lower caliceal calcium oxalate urolithiasis: a randomized controlled trial. J Endourol. 2002;16(3):149–152.
  • Lojanapiwat B, Tanthanuch M, Pripathanont C, et al. Alkaline citrate reduces stone recurrence and regrowth after shockwave lithotripsy and percutaneous nephrolithotomy. Int Braz J Urol. 2011;37(5):611–616.
  • Carvalho M, Erbano BO, Kuwaki EY, et al. Effect of potassium citrate supplement on stone recurrence before or after lithotripsy: systematic review and meta-analysis. Urolithiasis. 2017;45(5):449–455.
  • Mattle D, Hess B. Preventive treatment of nephrolithiasis with alkali citrate-a critical review. Urol Res. 2005;33(2):73–79.
  • Parks JH, Worcester EM, Coe FL, et al. Clinical implications of abundant calcium phosphate in routinely analyzed kidney stones. Kidney Int. 2004;66(2):777–785.
  • Mandel N, Mandel I, Fryjoff K, et al. Conversion of calcium oxalate to calcium phosphate with recurrent stone episodes. J Urol. 2003;169(6):2026–2029.
  • Rimer JD, Sakhaee K, Maalouf NM. Citrate therapy for calcium phosphate stones. Curr Opin Nephrol Hypertens. 2019;28(2):130–139.
  • Preminger GM, Sakhaee K, Pak CY. Alkali action on the urinary crystallization of calcium salts: contrasting responses to sodium citrate and potassium citrate. J Urol. 1988;139(2):240–242.
  • Fegan J, Khan R, Poindexter J, et al. Gastrointestinal citrate absorption in nephrolithiasis. J Urol. 1992;147(5):1212–1214.
  • Shenoy C. Hypocitraturia despite potassium citrate tablet supplementation. MedGenMed. 2006;8(3):8.
  • Kang DE, Sur RL, Haleblian GE, et al. Long-term lemonade based dietary manipulation in patients with hypocitraturic nephrolithiasis. J Urol. 2007;177(4):1358–62; discussion 1362; quiz 1591.
  • Penniston KL, Steele TH, Nakada SY. Lemonade therapy increases urinary citrate and urine volumes in patients with recurrent calcium oxalate stone formation. Urology. 2007;70(5):856–860. Epub 2007 Oct 24
  • Nicar MJ, Peterson R, Pak CY. Use of potassium citrate as potassium supplement during thiazide therapy of calcium nephrolithiasis. J Urol. 1984;131(3):430–433.
  • Odvina CV, Preminger GM, Lindberg JS, et al. Long-term combined treatment with thiazide and potassium citrate in nephrolithiasis does not lead to hypokalemia or hypochloremic metabolic alkalosis. Kidney Int. 2003;63(1):240–247.
  • Asplin JR. Hyperoxaluric calcium nephrolithiasis. Endocrinol Metab Clin North Am. 2002;31(4):927–949.
  • Hoppe B, Beck BB, Milliner DS. The primary hyperoxalurias. Kidney Int. 2009;75(12):1264–1271.
  • Cramer SD, Ferree PM, Lin K, et al. The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II. Hum Mol Genet. 1999;8(11):2063–2069.
  • Belostotsky R, Seboun E, Idelson GH, et al. Mutations in DHDPSL are responsible for primary hyperoxaluria type III. Am J Hum Genet. 2010;10;87(3):392–399.
  • Karaolanis G, Lionaki S, Moris D, et al. Secondary hyperoxaluria: a risk factor for kidney stone formation and renal failure in native kidneys and renal grafts. Transplant Rev (Orlando). 2014;28(4):182–187.
  • Bhasin B, Ürekli HM, Atta MG. Primary and secondary hyperoxaluria: understanding the enigma. World J Nephrol. 2015;4(2):235–244.
  • Cochat P, Hulton SA, Acquaviva C, et al. Primary hyperoxaluria type 1: indications for screening and guidance for diagnosis and treatment. Nephrol Dial Transplant. 2012;27:1729–1736.
  • Sikora P, von Unruh GE, Beck B, et al. Oxalate absorption in children with idiopathic calcium oxalate urolithiasis or primary hyperoxaluria. Kidney Int. 2008;73(10):1181–1186.
  • Hoppe B, Niaudet P, Salomon R, et al. A randomised phase I/II trial to evaluate the efficacy and safety of orally administered oxalobacter formigenes to treat primary hyperoxaluria. Pediatr Nephrol. 2017;32(5):781–790.
  • Cochat P, Liutkus A, Fargue S, et al. Primary hyperoxaluria type 1: still challenging! Pediatr Nephrol. 2006;21(8):1075–1081. Epub 2006 Jun 30.
  • Pang R, Linnes MP, O’Connor HM, et al. Controlled metabolic diet reduces calcium oxalate supersaturation but not oxalate excretion after bariatric surgery. Urology. 2012;80(2):250–254.
  • Nordenvall B, Backman L, Larsson L, et al. Effects of calcium, aluminium, magnesium and cholestyramine on hyperoxaluria in patients with jejunoileal bypass. Acta Chir Scand. 1983;149(1):93–98.
  • Lonsdale K. Epitaxy as a growth factor in urinary calculi and gallstones. Nature. 1968;217(5123):56–58.
  • Grover PK, Marshall VR, Ryall RL. Dissolved urate salts out calcium oxalate in undiluted human urine in vitro: implications for calcium oxalate stone genesis. Chem Biol. 2003;10(3):271–278.
  • Ettinger B, Tang A, Citron JT, et al. Randomized trial of allopurinol in the prevention of calcium oxalate calculi. N Engl J Med. 1986;315(22):1386–1389.
  • Goldfarb DS, MacDonald PA, Gunawardhana L, et al. Randomized controlled trial of febuxostat versus allopurinol or placebo in individuals with higher urinary uric acid excretion and calcium stones. Clin J Am Soc Nephrol. 2013;8(11):1960–1967.
  • Arowojolu O, Goldfarb DS. Treatment of calcium nephrolithiasis in the patient with hyperuricosuria. J Nephrol. 2014;27(6):601–605.
  • Dawson CH, Tomson CR. Kidney stone disease: pathophysiology, investigation and medical treatment. Clin Med (Lond). 2012;12(5):467–471.
  • Buckalew VM Jr. Nephrolithiasis in renal tubular acidosis. J Urol. 1989;141(3 Pt 2):731–737.
  • Goldfarb DS. A woman with recurrent calcium phosphate kidney stones. Clin J Am Soc Nephrol. 2012;7(7):1172–1178.
  • Krieger NS, Asplin JR, Frick KK, et al. Effect of potassium citrate on calcium phosphate stones in a model of hypercalciuria. J Am Soc Nephrol. 2015;26(12):3001–3008.
  • Sakhaee K. Epidemiology and clinical pathophysiology of uric acid kidney stones. J Nephrol. 2014;27(3):241–245.
  • Ngo TC, Assimos DG. Uric acid nephrolithiasis: recent progress and future directions. Rev Urol. 2007 Winter;9(1):17–27.
  • Pak CY, Sakhaee K, Peterson RD, et al. Biochemical profile of idiopathic uric acid nephrolithiasis. Kidney Int. 2001;60(2):757–761.
  • Shekarriz B, Stoller ML. Uric acid nephrolithiasis: current concepts and controversies. J Urol. 2002;168(4 Pt 1):1307–1314.
  • Cicerello E, Merlo F, Maccatrozzo L. Urinary alkalization for the treatment of uric acid nephrolithiasis. Arch Ital Urol Androl. 2010;82(3):145–148.
  • Abou-Elela A. Epidemiology, pathophysiology, and management of uric acid urolithiasis: a narrative review. J Adv Res. 2017;8(5):513–527.
  • Sterrett SP, Penniston KL, Wolf JS Jr, et al. Acetazolamide is an effective adjunct for urinary alkalization in patients with uric acid and cystine stone formation recalcitrant to potassium citrate. Urology. 2008;72(2):278–281.
  • Wiederkehr MR, Moe OW. Uric acid nephrolithiasis: a systemic metabolic disorder. Clin Rev Bone Miner Metab. 2011;9(3–4):207–217.
  • Mattoo A, Goldfarb DS. Cystinuria. Semin Nephrol. 2008;28(2):181–191.
  • Andreassen KH, Pedersen KV, Osther SS, et al. How should patients with cystine stone disease be evaluated and treated in the twenty-first century? Urolithiasis. 2016;44(1):65–76.
  • Ng CS, Streem SB. Contemporary management of cystinuria. J Endourol. 1999;13(9):647–651.
  • Joly D, Rieu P, Méjean A, et al. Treatment of cystinuria. Pediatr Nephrol. 1999;13(9):945–950.
  • Fjellstedt E, Denneberg T, Jeppsson JO, et al. A comparison of the effects of potassium citrate and sodium bicarbonate in the alkalinization of urine in homozygous cystinuria. Urol Res. 2001;29(5):295–302.
  • Pak CY, Fuller C, Sakhaee K, et al. Management of cystine nephrolithiasis with alpha-mercaptopropionylglycine. J Urol. 1986;136(5):1003–1008.
  • Thiola [package insert on the internet] mission pharmacal company. San Antonio, TX; 2018 [cited 2018 Jul 1]. Available from: http://www.retrophin.com/pdf/Thiola%20PI.pdf
  • Sloand JA, Izzo JL Jr. Captopril reduces urinary cystine excretion in cystinuria. Arch Intern Med. 1987;147(8):1409–1412.
  • Cohen TD, Streem SB, Hall P. Clinical effect of captopril on the formation and growth of cystine calculi. J Urol. 1995;154(1):164–166.
  • Hu L, Yang Y, Aloysius H, et al. l-cystine diamides as l-cystine crystallization inhibitors for cystinuria. J Med Chem. 2016;59(15):7293–7298.
  • Lee MH, Sahota A, Ward MD, et al. Cystine growth inhibition through molecular mimicry: a new paradigm for the prevention of crystal diseases. Curr Rheumatol Rep. 2015;17(5):33.
  • Wilmer MJ, Willems PH, Verkaart S, et al. Cystine dimethylester model of cystinosis: still reliable? Pediatr Res. 2007;62(2):151–155.
  • Zee T, Bose N, Zee J, et al. α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria. Nat Med. 2017;23(3):288–290.
  • de Boer H, Roelofsen A, Janssens PM. Antidiuretic hormone antagonist to reduce cystine stone formation. Ann Intern Med. 2012;157(6):459–460.
  • Torres VE, Chapman AB, Devuyst O, et al. Tolvaptan in patients with autosomal dominant polycystic kidney disease. N Engl J Med. 2012;20;367(25):2407–2418.
  • Bichler KH, Eipper E, Naber K, et al. Urinary infection stones. Int J Antimicrob Agents. 2002;19(6):488–498.
  • Flannigan R, Choy WH, Chew B, et al. Renal struvite stones–pathogenesis, microbiology, and management strategies. Nat Rev Urol. 2014;11(6):333–341.
  • Jarrar K, Boedeker RH, Weidner W. Struvite stones: long term follow up under metaphylaxis. Ann Urol (Paris). 1996;30(3):112–117.
  • Medical management of kidney stones. American Urological Association. 2014 Mar. [cited 2019 Nov 2]. Available from: https://www.auanet.org/guidelines/kidney-stones-medical-mangement-guideline.
  • Griffith DP, Gleeson MJ, Lee H, et al. Randomized, double-blind trial of lithostat (acetohydroxamic acid) in the palliative treatment of infection-induced urinary calculi. Eur Urol. 1991;20(3):243–247.
  • Williams JJ, Rodman JS, Peterson CM. A randomized double-blind study of acetohydroxamic acid in struvite nephrolithiasis. N Engl J Med. 1984;311(12):760–764.
  • Griffith DP, Khonsari F, Skurnick JH, et al. A randomized trial of acetohydroxamic acid for the treatment and prevention of infection-induced urinary stones in spinal cord injury patients. J Urol. 1988;140(2):318–324.
  • Trinchieri A. Urinary calculi and infection. Urologia. 2014;81(2):93–98.

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