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Review

Pharmacotherapeutic considerations and options for the management of osteoarthritis in women

, , &
Pages 557-566 | Received 10 Jul 2019, Accepted 16 Jan 2020, Published online: 31 Jan 2020

References

  • Zhang Y, Jordan JM. Epidemiology of osteoarthritis. Clin Geriatr Med. 2010;26(3):355–369.
  • Cisternas MG, Murphy L, Sacks JJ, et al. Alternative methods for defining osteoarthritis and the impact on estimating prevalence in a US population-based survey. Arthritis Care Res. 2016. DOI:10.1002/acr.22721
  • Torio CM, Moore BJ National inpatient hospital costs: the most expensive conditions by payer, 2013; 2016. doi:10.1377/hlthaff.2015.1194.3
  • Palazzo C, Nguyen C, Lefevre-Colau MM, et al. Risk factors and burden of osteoarthritis. Ann Phys Rehabil Med. 2016. DOI:10.1016/j.rehab.2016.01.006
  • Moskowitz RW. The burden of osteoarthritis: clinical and quality-of-life issues. Am J Manag Care. 2009;15(8):S223–9.
  • Lohmander LS, Roos EM. Disease modification in OA — will we ever get there? Nat Rev Rheumatol. 2019. DOI:10.1038/s41584-019-0174-1
  • Srikanth VK, Fryer JL, Zhai G, et al. A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis. Osteoarthr Cartil. 2005. DOI:10.1016/j.joca.2005.04.014
  • O’Connor MI. Osteoarthritis of the Hip and Knee: sex and gender differences. Orthop Clin North Am. 2006. DOI:10.1016/j.ocl.2006.09.004
  • Hawker GA, Wright JG, Coyte PC, et al. Differences between men and women in the rate of use of Hip and Knee arthroplasty. N Engl J Med. 2002. DOI:10.1056/nejm200004063421405.
  • Rosemann T, Laux G, Szecsenyi J. Osteoarthritis: quality of life, comorbidities, medication and health service utilization assessed in a large sample of primary care patients. J Orthop Surg Res. 2007;2:12. Published 2007 Jun 30. .
  • Woo J, Lau E, Lee P, et al. Impact of osteoarthritis on quality of life in a Hong Kong Chinese population. J Rheumatol. 2004;31(12):2433–8.
  • Keefe FJ, Lefebvre JC, Egert JR, et al. The relationship of gender to pain, pain behavior, and disability in osteoarthritis patients: the role of catastrophizing. Pain. 2000. DOI:10.1016/S0304-3959(00)00296-7
  • Robinson ME, Gagnon CM, Riley JL, et al. Altering gender role expectations: effects on pain tolerance, pain threshold, and pain ratings. J Pain. 2003. DOI:10.1016/S1526-5900(03)00559-5
  • Madry H, Kon E, Condello V, et al. Early osteoarthritis of the knee. Knee Surg Sports Traumatol Arthrosc. 2016. DOI:10.1007/s00167-016-4068-3.
  • Bay-Jensen AC, Thudium CS, Gualillo O, et al. Biochemical marker discovery, testing and evaluation for facilitating OA drug discovery and development. Drug Discov Today. 2018. DOI:10.1016/j.drudis.2017.10.008
  • Bay-Jensen AC, Thudium CS, Mobasheri A. Development and use of biochemical markers in osteoarthritis: current update. Curr Opin Rheumatol. 2018. DOI:10.1097/BOR.0000000000000467.
  • Sowers MF, Karvonen-Gutierrez CA, Yosef M, et al. Longitudinal changes of serum COMP and urinary CTX-II predict X-ray defined knee osteoarthritis severity and stiffness in women. Osteoarthr Cartil. 2009. DOI:10.1016/j.joca.2009.06.001.
  • Prieto-Alhambra D, Judge A, Javaid MK, et al. Incidence and risk factors for clinically diagnosed knee, hip and hand osteoarthritis: influences of age, gender and osteoarthritis affecting other joints. Ann Rheum Dis. 2014. DOI:10.1136/annrheumdis-2013-203355
  • Debi R, Mor A, Segal O, et al. Differences in gait patterns, pain, function and quality of life between males and females with knee osteoarthritis: A clinical trial. BMC Musculoskelet Disord. 2009;10:127. DOI:10.1186/1471-2474-10-127.
  • Maillefert JF, Gueguen A, Monreal M, et al. Sex differences in hip osteoarthritis: results of a longitudinal study in 508 patients. Ann Rheum Dis. 2003. DOI:10.1136/ard.62.10.931.
  • Dell’Isola A, Allan R, Smith SL, et al. Identification of clinical phenotypes in knee osteoarthritis: a systematic review of the literature. BMC Musculoskelet Disord. 2016;17(1):425. Published 2016 Oct 12. .
  • Deveza LA, Melo L, Yamato TP, et al. Knee osteoarthritis phenotypes and their relevance for outcomes: a systematic review. Osteoarthr Cartil. 2017. DOI:10.1016/j.joca.2017.08.009
  • Van Spil WE, Kubassova O, Boesen M, et al. Osteoarthritis phenotypes and novel therapeutic targets. Biochem Pharmacol. 2019. DOI:10.1016/j.bcp.2019.02.037
  • Berenbaum F. Deep phenotyping of osteoarthritis: A step forward. Ann Rheum Dis. 2019. DOI:10.1136/annrheumdis-2018-213864
  • Felson DT. Identifying different osteoarthritis phenotypes through epidemiology. Osteoarthr Cartil. 2010. DOI:10.1016/j.joca.2010.01.007
  • Herrero-Beaumont G, Roman-Blas JA, Castañeda S, et al. Primary osteoarthritis no longer primary: three subsets with distinct etiological, clinical, and therapeutic characteristics. Semin Arthritis Rheum. 2009. DOI:10.1016/j.semarthrit.2009.03.006.
  • STECHER RM. Heberden’s nodes; the clinical characteristic of osteo-arthritis of the fingers. Ann Rheum Dis. 1948. DOI:10.1136/ard.7.1.1
  • Spector TD, Cicuttini F, Baker J, et al. Genetic influences on osteoarthritis in women: A twin study. Br Med J. 1996. DOI:10.1136/bmj.312.7036.940
  • Loughlin J. Genetic epidemiology of primary osteoerthritis. Curr Opin Rheumatol. 2001. DOI:10.1097/00002281-200103000-00004
  • Tachmazidou I, Hatzikotoulas K, Southam L, et al. Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data. Nat Genet. 2019. DOI:10.1038/s41588-018-0327-1.
  • Van der Kraan PM, Van den Berg WB. Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration? Osteoarthr Cartil. 2012. DOI:10.1016/j.joca.2011.12.00332
  • Rushton MD, Reynard LN, Barter MJ, et al. Characterization of the cartilage DNA methylome in knee and hip osteoarthritis. Arthritis Rheumatol. 2014. DOI:10.1002/art.38713.
  • Hussain SM, Cicuttini FM, Alyousef B, et al. Female hormonal factors and osteoarthritis of the knee, hip and hand: a narrative review. Climacteric. 2018. DOI:10.1080/13697137.2017.1421926
  • Herrero-Beaumont G, Roman-Blas JA, Bruyère O, et al. Clinical settings in knee osteoarthritis: pathophysiology guides treatment. Maturitas. 2017. DOI:10.1016/j.maturitas.2016.11.013.
  • Stevens-Lapsley JE, Kohrt WM. Osteoarthritis in women: effects of estrogen, obesity and physical activity. Women’s Heal. 2010. DOI:10.2217/whe.10.38
  • Liu B, Balkwill A, Cooper C, et al. Reproductive history, hormonal factors and the incidence of hip and knee replacement for osteoarthritis in middle-aged women. Ann Rheum Dis. 2009. DOI:10.1136/ard.2008.095653
  • Jung JH, Bang CH, Song GG, et al. Knee osteoarthritis and menopausal hormone therapy in postmenopausal women: A nationwide cross-sectional study. Menopause. 2019. DOI:10.1097/GME.0000000000001280
  • Roman-Blas JA, Castañeda S, Largo R, et al. Osteoarthritis associated with estrogen deficiency. Arthritis Res Ther. 2009. DOI:10.1186/ar2791
  • Loeser RF. Age-related changes in the musculoskeletal system and the development of osteoarthritis. Clin Geriatr Med. 2010. DOI:10.1016/j.cger.2010.03.002
  • Shane Anderson A, Loeser RF. Why is osteoarthritis an age-related disease? Best Pract Res Clin Rheumatol. 2010. DOI:10.1016/j.berh.2009.08.006
  • Litwic A, Edwards MH, Dennison EM, et al. Epidemiology and burden of osteoarthritis. Br Med Bull. 2013. DOI:10.1093/bmb/lds038
  • Greene MA, Loeser RF. Aging-related inflammation in osteoarthritis. Osteoarthr Cartil. 2015. DOI:10.1016/j.joca.2015.01.008
  • Bruunsgaard H. A high plasma concentration of tnf-α is associated with dementia in centenarians. J Gerontol - Ser A Biol Sci Med Sci. 1999. DOI:10.1093/gerona/54.7.M357
  • Sanchez-Ramirez DC, van der Leeden M, van der Esch M, et al. Elevated C-reactive protein is associated with lower increase in knee muscle strength in patients with knee osteoarthritis: A 2-year follow-up study in the Amsterdam Osteoarthritis (AMS-OA) cohort. Arthritis Res Ther. 2014. DOI:10.1186/ar4580.
  • Castañeda S, Roman-Blas JA, Largo R, et al. Osteoarthritis: A progressive disease with changing phenotypes. Rheumatol (United Kingdom). 2014. DOI:10.1093/rheumatology/ket247
  • Felson DT, Anderson JJ, Naimark A, et al. Obesity and knee osteoarthritis. The Framingham Study. Ann Intern Med. 1988. DOI:10.7326/0003-4819-109-1-18
  • Wills AK, Black S, Cooper R, et al. Life course body mass index and risk of knee osteoarthritis at the age of 53 years: evidence from the 1946 British birth cohort study. Ann Rheum Dis. 2012. DOI:10.1136/ard.2011.154021.
  • Reyes C, Leyland KM, Peat G, et al. Association between overweight and obesity and risk of clinically diagnosed Knee, Hip, and hand osteoarthritis: a population-based cohort study. Arthritis Rheumatol. 2016. DOI:10.1002/art.39707.
  • Wang Y, Simpson JA, Wluka AE, et al. Relationship between body adiposity measures and risk of primary knee and hip replacement for osteoarthritis: A prospective cohort study. Arthritis Res Ther. 2009. DOI:10.1186/ar2636.
  • Driban JB, Eaton CB, Lo GH, et al. Association of Knee injuries with accelerated Knee osteoarthritis progression: data from the osteoarthritis initiative. Arthritis Care Res. 2014. DOI:10.1002/acr.22359
  • Muthuri SG, McWilliams DF, Doherty M, et al. History of knee injuries and knee osteoarthritis: A meta-analysis of observational studies. Osteoarthr Cartil. 2011. DOI:10.1016/j.joca.2011.07.015
  • Felson DT, Zhang Y. An update on the epidemiology of knee and hip osteoarthritis with a view to prevention. Arthritis Rheum. 1998. DOI:10.1002/1529-0131(199808)41:8<1343::AID-ART3>3.0.CO;2-9
  • Van Meer BL, Meuffels DE, Van Eijsden WA, et al. Which determinants predict tibiofemoral and patellofemoral osteoarthritis after anterior cruciate ligament injury? A systematic review. Br J Sports Med. 2015. DOI:10.1136/bjsports-2013-093258
  • Lohmander LS, Englund PM, Dahl LL, et al. The long-term consequence of anterior cruciate ligament and meniscus injuries: osteoarthritis. Am J Sports Med. 2007. DOI:10.1177/0363546507307396
  • Lohmander LS, Östenberg A, Englund M, et al. High prevalence of knee osteoarthritis, pain, and functional limitations in female soccer players twelve years after anterior cruciate ligament injury. Arthritis Rheum. 2004. DOI:10.1002/art.20589
  • Stein V, Li L, Lo G, et al. Pattern of joint damage in persons with knee osteoarthritis and concomitant ACL tears. Rheumatol Int. 2012. DOI:10.1007/s00296-010-1749-y.
  • Prodromos CC, Han Y, Rogowski J, et al. A meta-analysis of the incidence of anterior cruciate ligament tears as a function of gender, sport, and a knee injury-reduction regimen. Arthrosc - J Arthrosc Relat Surg. 2007;23(12):1320–1325.e6.
  • Franklin J, Ingvarsson T, Englund M, et al. Association between occupation and knee and hip replacement due to osteoarthritis: A case-control study. Arthritis Res Ther. 2010. DOI:10.1186/ar3033
  • Bernard TE, Wilder FV, Aluoch M, et al. Job-related osteoarthritis of the knee, foot, hand, and cervical spine. J Occup Environ Med. 2010. DOI:10.1097/JOM.0b013e3181c40e98
  • Edwards RR, Dworkin RH, Turk DC, et al. Patient phenotyping in clinical trials of chronic pain treatments: IMMPACT recommendations. Pain. 2016. DOI:10.1097/j.pain.0000000000000602.
  • Jepsen KJ, Bigelow EMR, Schlecht SH. Women build long bones with less cortical mass relative to body size and bone size compared with men. Clin Orthop Relat Res. 2015;473:2530–2539.
  • Lang TF. The bone-muscle relationship in men and women. J Osteoporos. 2011. DOI:10.4061/2011/702735
  • Hanna FS, Teichtahl AJ, Wluka AE, et al. Women have increased rates of cartilage loss and progression of cartilage defects at the knee than men: A gender study of adults without clinical knee osteoarthritis. Menopause. 2009. DOI:10.1097/gme.0b013e318198e30e.
  • Hame SL, Alexander RA. Knee osteoarthritis in women. Curr Rev Musculoskelet Med. 2013. DOI:10.1007/s12178-013-9164-0
  • Fairweather D, Frisancho-Kiss S, Rose NR. Sex differences in autoimmune disease from a pathological perspective. Am J Pathol. 2008. DOI:10.2353/ajpath.2008.071008
  • Klein SL, Flanagan KL. Sex differences in immune responses. Nat Rev Immunol. 2016. DOI:10.1038/nri.2016.90.
  • Isacson D, Bingefors K. Epidemiology of analgesic use: a gender perspective. Eur J Anaesthesiol. 2002. DOI:10.1097/00003643-200219261-00003
  • Elboim-Gabyzon M, Rozen N, Laufer Y. Gender differences in pain perception and functional ability in subjects with knee osteoarthritis. ISRN Orthop. 2012. DOI:10.5402/2012/413105
  • Karlson EW, Daltroy LH, Liang MH, et al. Gender differences in patient preferences may underlie differential utilization of elective surgery. Am J Med. 1997. DOI:10.1016/S0002-9343(97)00050-8
  • Hawker GA, Wright JG, Coyte PC, et al. Differences between men and women in the rate of use of hip and knee arthroplasty. N Engl J Med. 2000. DOI:10.1056/NEJM200004063421405.
  • Bay-Jensen AC, Thudium CS, Gualillo O, et al. Biochemical marker discovery, testing and evaluation for facilitating OA drug discovery and development. Drug Discov Today. 2018. DOI:10.1016/j.drudis.2017.10.008
  • Bay-Jensen AC, Thudium CS, Mobasheri A. Development and use of biochemical markers in osteoarthritis: current update. Curr Opin Rheumatol. 2018. DOI:10.1097/BOR.0000000000000467
  • Rousseau J-C, Millet M, Crozet M, et al. Association of circulating microRNAs with prevalent and incident osteoarthritis in women: the OFELY study. Osteoarthr Cartil. 2018. DOI:10.1016/j.joca.2018.02.396
  • Bauer DC, Hunter DJ, Abramson SB, et al. Classification of osteoarthritis biomarkers: a proposed approach. Osteoarthr Cartil. 2006. DOI:10.1016/j.joca.2006.04.001.
  • Crofford LJ. Use of NSAIDs in treating patients with arthritis. Arthritis Res Ther. 2013. DOI:10.1186/ar4174
  • Wongrakpanich S, Wongrakpanich A, Melhado K, et al. A comprehensive review of non-steroidal anti-inflammatory drug use in the elderly. Aging Dis. 2018. DOI:10.14336/AD.2017.0306
  • Neutel CI, Maxwell CJ, Appel WC. Differences between males and females in risk of NSAID-related severe gastrointestinal events. Pharmacoepidemiol Drug Saf. 1999. DOI:10.1002/(SICI)1099-1557(199912)8:7<501::AID-PDS454>3.0.CO;2-Y
  • Maniar KH, Jones IA, Gopalakrishna R, et al. Lowering side effects of NSAID usage in osteoarthritis: recent attempts at minimizing dosage. Expert Opin Pharmacother. 2018. DOI:10.1080/14656566.2017.1414802.
  • da Costa BR, Reichenbach S, Keller N, et al. Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis. Lancet. 2017. DOI:10.1016/S0140-6736(17)31744-0.
  • Graham GG, Scott KF. Mechanism of action of paracetamol. Am J Ther. 2005. DOI:10.1097/00045391-200501000-00008
  • Jozwiak-Bebenista M, Nowak JZ. Paracetamol: mechanism of action, applications and safety concern. Acta Pol Pharm - Drug Res. 2014;71(1):11–23.
  • Anderson BJ. Paracetamol (Acetaminophen): mechanisms of action. Paediatr Anaesth. 2008. DOI:10.1111/j.1460-9592.2008.02764.x
  • Graham GG, Davies MJ, Day RO, et al. The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings. Inflammopharmacology. 2013. DOI:10.1007/s10787-013-0172-x
  • Towheed T, Maxwell L, Judd M, et al. Acetaminophen for osteoarthritis. Cochrane Database Syst Rev. 2006. DOI:10.1002/14651858.CD004257.pub2
  • Pincus T, Swearingen C, Cummins P, et al. Preference for nonsteroidal antiinflammatory drugs versus acetaminophen and concomitant use of both types of drugs in patients with osteoarthritis. J Rheumatol. 2000;27(4):1020–7.
  • Leopoldino AO, MacHado GC, Ferreira PH, et al. Paracetamol versus placebo for knee and hip osteoarthritis. Cochrane Database Syst Rev. 2019. DOI:10.1002/14651858.CD013273.
  • Larson AM, Polson J, Fontana RJ, et al. Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study. Hepatology. 2005. DOI:10.1002/hep.20948.
  • Ramachandran A, Jaeschke H. 2017. Acetaminophen. In: Liver pathophysiology: therapies and antioxidants. DOI:10.1016/B978-0-12-804274-8.00006-0.
  • Lancaster EM, Hiatt JR, Zarrinpar A. Acetaminophen hepatotoxicity: an updated review. Arch Toxicol. 2015. DOI:10.1007/s00204-014-1432-2
  • DeMik DE, Bedard NA, Dowdle SB, et al. Are we still prescribing opioids for osteoarthritis? J Arthroplasty. 2017. DOI:10.1016/j.arth.2017.07.030
  • Sommer C, Welsch P, Klose P, et al. [Opioids in chronic neuropathic pain. A systematic review and meta-analysis of efficacy, tolerability and safety in randomized placebo-controlled studies of at least 4 weeks duration]. Schmerz. 2015;29(1):35–46. DOI:10.1007/s00482-014-1455.
  • Krebs EE, Gravely A, Nugent S, et al. Effect of opioid vs nonopioid medications on pain-related function in patients with chronic back pain or hip or knee osteoarthritis pain the SPACE randomized clinical trial. J Am Med Assoc. 2018. DOI:10.1001/jama.2018.0899.
  • Jevsevar DS. Treatment of osteoarthritis of the knee: evidence-based guideline, 2nd edition. J Am Acad Orthop Surg. 2013. DOI:10.5435/JAAOS-21-09-571
  • Ling W, Mooney L, Hillhouse M. Prescription opioid abuse, pain and addiction: clinical issues and implications. Drug Alcohol Rev. 2011. DOI:10.1111/j.1465-3362.2010.00271.x
  • Upadhyay J, Maleki N, Potter J, et al. Alterations in brain structure and functional connectivity in prescription opioid-dependent patients. Brain. 2010. DOI:10.1093/brain/awq138.
  • Rudd RA, Aleshire N, Zibbell JE, et al. Increases in drug and opioid overdose deaths — United States, 2000–2014. MMWR Morb Mortal Wkly Rep. 2015. DOI:10.15585/mmwr.mm6450a3
  • Agarwal P, Sambamoorthi U. healthcare expenditures associated with depression among individuals with osteoarthritis: post-regression linear decomposition approach. J Gen Intern Med. 2015. DOI:10.1007/s11606-015-3393-4
  • Arendt-Nielsen L, Nie H, Laursen MB, et al. Sensitization in patients with painful knee osteoarthritis. Pain. 2010. DOI:10.1016/j.pain.2010.04.003.
  • Bajaj P, Bajaj P, Graven-Nielsen T, et al. Osteoarthritis and its association with muscle hyperalgesia: an experimental controlled study. Pain. 2001. DOI:10.1016/S0304-3959(01)00300-1
  • Havelin J, Imbert I, Cormier J, et al. Central sensitization and neuropathic features of ongoing pain in a rat model of advanced osteoarthritis. J Pain. 2016. DOI:10.1016/j.jpain.2015.12.001
  • Wang ZY, Shi SY, Li SJ, et al. Efficacy and safety of duloxetine on osteoarthritis knee pain: a meta-analysis of randomized controlled trials. Pain Med. 2015. DOI:10.1111/pme.12800.
  • Chappell AS, Ossanna MJ, Liu-Seifert H, et al. Duloxetine, a centrally acting analgesic, in the treatment of patients with osteoarthritis knee pain: A 13-week, randomized, placebo-controlled trial. Pain. 2009. DOI:10.1016/j.pain.2009.06.024.
  • Konno S, Oda N, Ochiai T, et al. Randomized, double-blind, placebo-controlled phase III trial of duloxetine monotherapy in Japanese patients with chronic low back pain. Spine (Phila Pa 1976). 2016. (Phila Pa 1976). DOI:10.1097/BRS.0000000000001707.
  • Sofat N, Harrison A, Russell MD, et al. The effect of pregabalin or duloxetine on arthritis pain: A clinical and mechanistic study in people with hand osteoarthritis. J Pain Res. 2017. DOI:10.2147/JPR.S147640.
  • Chen L, Gong M, Liu G, et al. Efficacy and tolerability of duloxetine in patients with knee osteoarthritis: a meta-analysis of randomised controlled trials. Intern Med J. 2019;49(12):1514–1523.
  • Skinner MH, Kuan HY, Skerjanec A, et al. Effect of age on the pharmacokinetics of duloxetine in women. Br J Clin Pharmacol. 2004. DOI:10.1046/j.1365-2125.2003.01963.x.
  • Lobo ED, Quinlan T, O’Brien L, et al. Population pharmacokinetics of Orally administered duloxetine in patients: implications for dosing recommendation. Clin Pharmacokinet. 2009. DOI:10.2165/00003088-200948030-00005
  • Osani MC, Bannuru RR. Efficacy and safety of duloxetine in osteoarthritis: a systematic review and meta-analysis. Korean J Intern Med. 2019;34(5):966–973. .
  • Ananías J, Irarrázaval S. Is duloxetine an alternative in the treatment of osteoarthritis? Medwave. 2017. DOI:10.5867/medwave.2017.08.7063
  • Oelke M, Roovers JPWR, Michel MC. Safety and tolerability of duloxetine in women with stress urinary incontinence. BJOG An Int J Obstet Gynaecol. 2006. DOI:10.1111/j.1471-0528.2006.00880.x
  • Greist J, McNamara RK, Mallinckrodt CH, et al. Incidence and duration of antidepressant-induced nausea: duloxetine compared with paroxetine and fluoxetine. Clin Ther. 2004. DOI:10.1016/j.clinthera.2004.09.010
  • Goldstein DJ, Lu Y, Detke MJ, et al. Duloxetine vs. placebo in patients with painful diabetic neuropathy. Pain. 2005. DOI:10.1016/j.pain.2005.03.029
  • Wilson S, Argyropoulos S. Antidepressants and sleep: A qualitative review of the literature. Drugs. 2005. DOI:10.2165/00003495-200565070-00003
  • Higgins A, Nash M, Lynch AM. Antidepressant-associated sexual dysfunction: impact, effects, and treatment. Drug Healthc Patient Saf. 2010. DOI:10.2147/DHPS.S7634
  • Clayton A, Kornstein S, Prakash A, et al. Changes in sexual functioning associated with duloxetine, escitalopram, and placebo in the treatment of patients with major depressive disorder. J Sex Med. 2007. DOI:10.1111/j.1743-6109.2007.00520.x
  • Delgado PL, Brannan SK, Mallinckrodt CH, et al. Sexual functioning assessed in 4 double-blind placebo- and paroxetine-controlled trials of duloxetine for major depressive disorder. J Clin Psychiatry. 2005. DOI:10.4088/JCP.v66n0603.
  • Du Souich P. Absorption, distribution and mechanism of action of SYSADOAS. Pharmacol Ther. 2014. DOI:10.1016/j.pharmthera.2014.01.002
  • Dougados M. Symptomatic slow-acting drugs for osteoarthritis: what are the facts? Jt Bone Spine. 2006. DOI:10.1016/j.jbspin.2006.09.008
  • Kongtharvonskul J, Anothaisintawee T, McEvoy M, et al. Efficacy and safety of glucosamine, diacerein, and NSAIDs in osteoarthritis knee: A systematic review and network meta-analysis. Eur J Med Res. 2015. DOI:10.1186/s40001-015-0115-7
  • Hochberg MC, Martel-Pelletier J, Monfort J, et al. Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: A multicentre, randomised, double-blind, non-inferiority trial versus celecoxib. Ann Rheum Dis. 2016. DOI:10.1136/annrheumdis-2014-206792.
  • Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med. 2006. DOI:10.1056/NEJMoa052771.
  • Roman-Blas JA, Castañeda S, Sánchez-Pernaute O, et al. CS/GSCombined therapy study group. combined treatment with chondroitin sulfate and glucosamine sulfate shows no superiority over placebo for reduction of joint pain and functional impairment in patients with knee osteoarthritis: a six-month multicenter, randomized, double-blind, placebo-controlled clinical trial. Arthritis Rheumatol. 2017;69:77–85. Erratum in: Arthritis Rheumatol 2017;69:2080.109. .
  • Castañeda S, Roman-Blas JA, Largo R, et al. Subchondral bone as a key target for osteoarthritis treatment. Biochem Pharmacol. 2012;83:315–323.
  • Vaysbrot EE, Osani MC, Musetti MC, et al. Are bisphosphonates efficacious in knee osteoarthritis? A meta-analysis of randomized controlled trials. Osteoarthr Cartil. 2018. DOI:10.1016/j.joca.2017.11.013
  • Davis AJ, Smith TO, Hing CB, et al. Are bisphosphonates effective in the treatment of osteoarthritis pain? A meta-analysis and systematic review. PLoS One. 2013;8(9):e72714. Published 2013 Sep 4. .
  • Xing RL, Zhao LR, Wang PM. Bisphosphonates therapy for osteoarthritis: a meta-analysis of randomized controlled trials. Springerplus. 2016;5(1):1704. Published2016 Oct 3. .
  • Esenyel M, İçağasıoğlu A, Esenyel CZ. Effects of calcitonin on knee osteoarthritis and quality of life. Rheumatol Int. 2013. DOI:10.1007/s00296-012-2399-z
  • Wen ZH, Tang CC, Chang YC, et al. Calcitonin attenuates cartilage degeneration and nociception in an experimental rat model of osteoarthritis: role of TGF-β in chondrocytes. Sci Rep. 2016. DOI:10.1038/srep28862.
  • Vinardell T, Dejica V, Poole AR, et al. Evidence to suggest that cathepsin K degrades articular cartilage in naturally occurring equine osteoarthritis. Osteoarthr Cartil. 2009. DOI:10.1016/j.joca.2008.07.017
  • Hayami T, Zhuo Y, Wesolowski GA, et al. Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis. Bone. 2012. DOI:10.1016/j.bone.2012.03.025
  • Karsdal MA, Byrjalsen I, Leeming DJ, et al. Tibolone inhibits bone resorption without secondary positive effects on cartilage degradation. BMC Musculoskelet Disord. 2008. DOI:10.1186/1471-2474-9-153
  • Yang PY, Tang CC, Chang YC, et al. Effects of tibolone on osteoarthritis in ovariectomized rats: association with nociceptive pain behaviour. Eur J Pain (United Kingdom). 2014. DOI:10.1002/j.1532-2149.2013.00406.x.
  • Han W, Fan S, Bai X, et al. Strontium ranelate, a promising disease modifying osteoarthritis drug. Expert Opin Investig Drugs. 2017. DOI:10.1080/13543784.2017.1283403
  • Schnitzer TJ, Easton R, Pang S, et al. Effect of tanezumab on joint pain, physical function, and patient global assessment of osteoarthritis among patients with osteoarthritis of the Hip or Knee: a randomized clinical trial. J Am Med Assoc. 2019. DOI:10.1001/jama.2019.8044.
  • Hsu YH, Yang YY, Huwang MH, et al. Anti-IL-20 monoclonal antibody inhibited inflammation and protected against cartilage destruction in murine models of osteoarthritis. PLoS One. 2017. DOI:10.1371/journal.pone.0175802.
  • Atkinson SM, Bleil J, Maier R, et al. Anti-RANKL treatment inhibits erosive joint destruction and lowers inflammation but has no effect on bone formation in the delayed-type hypersensitivity arthritis (DTHA) model. Arthritis Res Ther. 2016. DOI:10.1186/s13075-016-0931-3.
  • Kon E, Filardo G, Drobnic M, et al. Non-surgical management of early knee osteoarthritis. Knee Surg Sports Traumatol Arthrosc. 2012. DOI:10.1007/s00167-011-1713-8.
  • Ayhan E. Intraarticular injections (corticosteroid, hyaluronic acid, platelet rich plasma) for the knee osteoarthritis. World J Orthop. 2014. DOI:10.5312/wjo.v5.i3.351
  • Kompel AJ, Roemer FW, Murakami AM, et al. Intra-articular corticosteroid injections in the Hip and Knee: perhaps not as safe as we thought? Radiology. 2019. DOI:10.1148/radiol.2019190341
  • Zeng C, Lane NE, Hunter DJ, et al. Intra-articular corticosteroids and the risk of knee osteoarthritis progression: results from the Osteoarthritis Initiative. Osteoarthr Cartil. 2019;27(6):855–862.
  • Jones IA, Chen X, Evseenko D, et al. Nomenclature inconsistency and selective outcome reporting hinder understanding of stem cell therapy for the knee. J Bone Jt Surg Am Vol. 2019. doi:10.2106/JBJS.17.01474.
  • Franchi M, Schinko E. Estrogens and bone metabolism. Minerva Ginecol. 1995. DOI:10.1017/cbo9780511545221.008
  • Xiao YP, Tian FM, Dai MW, et al. Are estrogen-related drugs new alternatives for the management of osteoarthritis? Arthritis Res Ther. 2016. DOI:10.1186/s13075-016-1045-7

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