Evaluating brexanolone for the treatment of postpartum depression

References

• Gavin NI, Gaynes BN, Lohr KN, et al. Perinatal depression: a systematic review of prevalence and incidence. Obstet Gynecol. 2005;106(5 Pt 1):1071–1083.
   PubMed Web of Science ®Google Scholar
• Toohey J. Depression during pregnancy and postpartum. Clin Obstet Gynecol. 2012;55(3):788–797.
   PubMed Web of Science ®Google Scholar
• Frank E, Kupfer DJ, Jacob M, et al. Pregnancy-related affective episodes among women with recurrent depression. Am J Psychiatry. 1987;144(3):288–293.
   PubMed Web of Science ®Google Scholar
• Payne JL, Roy PS, Murphy-Eberenz K, et al. Reproductive cycle-associated mood symptoms in women with major depression and bipolar disorder. J Affect Disord. 2007;99(1–3):221–229. .
   PubMed Web of Science ®Google Scholar
• Cox JL, Murray D, Chapman G. A controlled study of the onset, duration and prevalence of postnatal depression. Br J Psychiatry. 1993;163(1):27–31.
   PubMed Web of Science ®Google Scholar
• Lindahl V, Pearson JL, Colpe L. Prevalence of suicidality during pregnancy and the postpartum. Arch Women’s Mental Health. 2005;8(2):77–87.
   PubMed Web of Science ®Google Scholar
• Akman I, Kusçu K, Ozdemir N, et al. Mothers’ postpartum psychological adjustment and infantile colic. Arch Dis Child. 2006;91(5):417–419. .
   PubMed Web of Science ®Google Scholar
• Flynn HA, Davis M, Marcus SM, et al. Rates of maternal depression in pediatric emergency department and relationship to child service utilization. Gen Hosp Psychiatry. 2004;26(4):316–322.
   PubMed Web of Science ®Google Scholar
• McLearn KT, Minkovitz CS, Strobino DM, et al. The timing of maternal depressive symptoms and mothers’ parenting practices with young children: implications for pediatric practice. Pediatrics. 2006;118(1):174.
   PubMed Web of Science ®Google Scholar
• Grace SL, Evindar A, Stewart DE. The effect of postpartum depression on child cognitive development and behavior: a review and critical analysis of the literature. Arch Womens Ment Health. 2003;6(4):263–274.
   PubMedGoogle Scholar
• American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed ed. American Psychiatric Press, Washington, DC; 2000.
   Google Scholar
• American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. American Psychiatric Publishing, Inc., Arlington, VA; 2013.
   Google Scholar
• Vesga-Lopez O, Blanco C, Keyes K, et al. Psychiatric disorders in pregnant and postpartum women in the United States. Arch Gen Psychiatry. 2008;65(7):805–815.
   PubMed Web of Science ®Google Scholar
• Payne JL, Maguire J. Pathophysiological mechanisms implicated in postpartum depression. Front Neuroendocrinol. 2019;52:165–180.
   PubMed Web of Science ®Google Scholar
• Walton N, Maguire J. Allopregnanolone-based treatments for postpartum depression: why/how do they work? Neurobiology of Stress. 2019;11:100198.
   PubMed Web of Science ®Google Scholar
• Molyneaux E, Howard LM, McGeown HR, et al. Antidepressant treatment for postnatal depression. Cochrane Database Syst Rev. 2014;11(9):CD002018.
   Google Scholar
• Nonacs RM, Soares CN, Viguera AC, Pearson K, Poitras JR, Cohen LS. Bupropion SR for the treatment of postpartum depression: a pilot study. Int J Neuropsychopharmacol. 2005;8(3):445.
   PubMed Web of Science ®Google Scholar
• Cohen LS, Viguera AC, Bouffard SM, et al. Venlafaxine in the treatment of postpartum depression. J Clin Psychiatry. 2001;62(8):592–596.
   PubMed Web of Science ®Google Scholar
• Misri S, Swift E, Abizadeh J, et al. Overcoming functional impairment in postpartum depressed or anxious women: a pilot trial of desvenlafaxine with flexible dosing. Ther Adv Psychopharmacol. 2016;6(4):269–276.
   PubMed Web of Science ®Google Scholar
• Rosenthal ES, Claassen J, Wainwright MS, et al. Brexanolone as adjunctive therapy in super-refractory status epilepticus. In Annals of Neurology. 2017;82(3):342-352.
   Google Scholar
• Schule C, Nothdurfter C, Rupprecht R. The role of allopregnanolone in depression and anxiety. Prog Neurobiol. 2014;113:79–87.
   PubMed Web of Science ®Google Scholar
• Zorumski CF, Paul SM, Covey DF, et al. Neurosteroids as novel antidepressants and anxiolytics: GABA-A receptors and beyond. Neurobiology of Stress. 2019;11:100196.
   PubMed Web of Science ®Google Scholar
• Hellgren C, Åkerud H, Skalkidou A, et al. Low serum allopregnanolone is associated with symptoms of depression in late pregnancy. Neuropsychobiology. 2014;69(3):147.
   PubMed Web of Science ®Google Scholar
• Osborne LM, Gispen F, Sanyal A, et al. Lower allopregnanolone during pregnancy predicts postpartum depression: an exploratory study. Psychoneuroendocrinology. 2017;79:116–121.
   PubMed Web of Science ®Google Scholar
• Deligiannidis KM, Sikoglu EM, Shaffer SA, et al. GABAergic neuroactive steroids and resting-state functional connectivity in postpartum depression: a preliminary study. J Psychiatr Res. 2013;47(6):816–828. .
   PubMed Web of Science ®Google Scholar
• Zulresso package insert. 2019. [cited 2020 Dec 15]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211371lbl.pdf
   Google Scholar
• Kanes SJ, Colquhoun H, Doherty J, et al., Open-label, proof-of-concept study of brexanolone in the treatment of severe postpartum depression. Hum Psychopharmacol. 32(2): e2576. 2017.
   Web of Science ®Google Scholar
• Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960;23(1):56–62.
   PubMed Web of Science ®Google Scholar
• Cox JL, Chapman G, Murray D, et al. Validation of the Edinburgh postnatal depression scale (EPDS) in non-postnatal women. J Affect Disord. 1996;39(3):185–189.
   PubMed Web of Science ®Google Scholar
• Spitzer RL, Kroenke K, Williams JBW, et al. A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch Intern Med. 2006;166(10):1092–1097.
   PubMed Web of Science ®Google Scholar
• Kroenke K, Spitzer RL, Williams JB, et al. Validity of a brief depression severity measure. J Gen Intern Med. 2001;16(9):606–613.
   PubMed Web of Science ®Google Scholar
• Guy W. ECDEU assessment manual for psychopharmacology. Rockville, MD: Department of Health, Education, and Wellfare; 1976.
   Google Scholar
• Kanes S, Colquhoun H, Gunduz-Bruce H, et al., Brexanolone (SAGE-547 injection) in post-partum depression: a randomised controlled trial. Lancet. 390(10093): 480–489. 2017.
   PubMed Web of Science ®Google Scholar
• Meltzer-Brody S, Colquhoun H, Riesenberg R, et al., Brexanolone injection in post-partum depression: two multicentre, double-blind, randomised, placebo-controlled, phase 3 trials. Lancet. 392(10152): 1058–1070. 2018.
   PubMed Web of Science ®Google Scholar
• Zheng W, Cai DB, Zheng W, et al. Brexanolone for postpartum depression: a meta-analysis of randomized controlled studies. Psychiatry Res. 2019;279:83–89.
   PubMed Web of Science ®Google Scholar
• Hoffman E, Wald J, Colquhoun H. Evaluation of breast milk concentrations following brexanolone iv administration to healthy lactating women. Am J Obstet Gynecol. 2019;220(1):S554.
   Web of Science ®Google Scholar
• Hoffman E, Wald J, Dray D, et al. Brexanolone injection administration to lactating women: breast milk allopregnanolone levels. Obstet Gynecol. 2019;133(Suppl1):115S.
   Web of Science ®Google Scholar
• Guintivano J, Arad M, Gould TD, et al. Antenatal prediction of postpartum depression with blood DNA methylation biomarkers (vol 19, pg 560, 2013). Mol Psychiatry. 2014;19(5):633.
   Web of Science ®Google Scholar
• Osborne L, Clive M, Kimmel M, et al. Replication of epigenetic postpartum depression biomarkers and variation with hormone levels. Neuropsychopharmacology. 2016;41(6):1648–1658.
   PubMed Web of Science ®Google Scholar
• Payne JL, Osborne LM, Cox O, et al. DNA methylation biomarkers prospectively predict both antenatal and postpartum depression. Psychiatry Res. 2020;285:112711.
   PubMed Web of Science ®Google Scholar