Rethinking the use of hypnotics for treatment of insomnia in the elderly

References

• Campbell SS, Tobler I. Animal sleep: a review of sleep duration across phylogeny. Neurosc & Biobehav Rev. 1984;8(3):269–300.
   PubMed Web of Science ®Google Scholar
• Liu D, Li W, Ma C, et al. A common hub for sleep and motor control in the substantia nigra. Science. 2020;367(6476):440–445. .
   PubMed Web of Science ®Google Scholar
• Saper CB, Scammell TE, Lu J. Hypothalamic regulation of sleep and circadian rhythms. Nature. 2005;437(7063):1257–1263.
   PubMed Web of Science ®Google Scholar
• Fultz NE, Bonmassar G, Setsompop K, et al. Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep. Science. 2019;366(6465):628–631. .
   PubMed Web of Science ®Google Scholar
• Niethard N, Born J. Back to baseline: sleep recalibrates synapses. Nat Neurosc. 2019;22:149–153.
   Google Scholar
• Rechtschaffen A, Kales A. A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects. Washington: US Government Printing Office; 1968.
   Google Scholar
• Hudson AN, Van Dongen HPA, Honn KA. Sleep deprivation, vigilant attention, and brain function: a review. Neuropsychopharmacology. 2020;45(1):21–30.
   PubMed Web of Science ®Google Scholar
• Hertenstein E, Feige B, Gmeiner T, et al. Insomnia as a predictor of mental disorders: a systematic review and meta-analysis. Sleep Med Rev. 2019;43:96–105.
   PubMed Web of Science ®Google Scholar
• Schousboe JT,Kats AM, Stone KT, et al. Multidimensional sleep health and subsequent health-care costs and utilization in older women. Sleep. 2020;43
   Web of Science ®Google Scholar
• Van Cauter E, Leproult R, Plat L. Age-related changes in slow wave sleep and REM sleep and relationship with growth hormone and cortisol levels in healthy men. JAMA. 2000;284(7):861–868.
   PubMed Web of Science ®Google Scholar
• Dijk DJ, Duffy JF, et al. Ageing and the circadian and homeostatic regulation of human sleep during forced desynchrony of rest, melatonin and temperature rhythms. J Physiol. 1999;516(2):611–627.
   PubMed Web of Science ®Google Scholar
• Kunz D, Mahlberg R, Müller C, et al. Melatonin in patients with reduced REM sleep duration: two randomized controlled trials. J Clin Endocrinol Metab. 2004;89(1):128–134.
   PubMed Web of Science ®Google Scholar
• Ohayon MM. Prevalence and correlates of nonrestorative sleep complaints. Arch Intern Med. 2005;165(1):35–41.
   PubMed Web of Science ®Google Scholar
• Postuma RB, Iranzo A, Hu, M, et al. Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study. BRAIN. 2019;0:1–16.
   Google Scholar
• Holth JK, Fritschi SK, Wang C, et al. The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans. Science. 2019;363(6429):880–884.
   PubMed Web of Science ®Google Scholar
• Nedergaard M, Goldman SA. Glymphatic failure as a final common pathway to dementia. Science. 2020;370(6512):50–56.
   PubMed Web of Science ®Google Scholar
• Lim AS, Kowgier YLM, Buchman AS, et al. Sleep Fragmentation and the risk of incident Alzheimer’s disease and cognitive decline in older persons. Sleep. 2013;36(7):1027–1032.
   PubMed Web of Science ®Google Scholar
• Riemann D, Baglione C, Bassetti C, et al. European guideline for the diagnosis and treatment of insomnia. J Sleep Res. 2017;26(6):675–700.
   PubMed Web of Science ®Google Scholar
• Münch M, Nowozin C, Regente J, et al. Light as a countermeasure to light at the wrong time: effects on cognition, sleepiness, sleep, and circadian phase. Neuropsychobiology. 2016;74(4):207–218.
   PubMed Web of Science ®Google Scholar
• Ben Simon E, Rossi A, Harvey AG, et al. Overanxious and underslept. Nature Hum Behav. 2020;4(1):100–110.
   PubMed Web of Science ®Google Scholar
• Reynolds III CF, Kupfer DJ. Sleep research in affective illness: state of the art circa 1987. Sleep. 1987;10(3):199–215.
   PubMed Web of Science ®Google Scholar
• Roehrs T, Roth T. Insomnia as a path to alcoholism: tolerance development and dose escalation. Sleep. 2018;41(8):41.
   Web of Science ®Google Scholar
• Goerke M, Cohrs S, Rodenbeck A, et al. Differential effect of an anticholinergic antidepressant on sleep-dependent memory consolidation. Sleep. 2014;37(5):977–985.
   PubMed Web of Science ®Google Scholar
• Bastien CH, LeBlanc M, Carrier J, et al. Sleep EEG power spectra, insomnia, and chronic use of benzodiazepines. Sleep. 2003;26(3):313–317.
   PubMed Web of Science ®Google Scholar
• Randall S, Roehrs TA, Roth T. Efficacy of eight months of nightly zolpidem: a prospective placebo-controlled study. Sleep. 2012;35(11):1551–1557.
   PubMed Web of Science ®Google Scholar
• Staner L, Ertlé S, Boeijinga P, et al. Next-day residual effects of hypnotics in DSM-IV primary insomnia: a driving simulator study with simultaneous electroencephalogram monitoring. Psychopharmacol. 2005;181(4):790–798.
   PubMed Web of Science ®Google Scholar
• Kunz D. Editorial: circadian rhythms are everywhere: except in neurodegenerative disorders. Curr Alz Res. 2017;14(10):1018–1021.
   PubMed Web of Science ®Google Scholar
• Hoever P, Dorffner G, Beneš H, et al. Orexin receptor antagonism, a new sleep-enabling paradigm: a proof-of-concept clinical trial. Clin Pharmacol Ther. 2012;91(6):975–985.
   PubMed Web of Science ®Google Scholar
• Zammit G, Dauvilliers Y, Pain S, et al. Daridorexant, a new dual orexin receptor antagonist, in elderly subjects with insomnia disorder. Neurology. 2020;94(21):e2222–e32.
   PubMed Web of Science ®Google Scholar
• Kang JE, Lim MM, Bateman RJ, et al. Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle. Science. 2009;326(5955):1005–1007.
   PubMed Web of Science ®Google Scholar
• Seol J, Fujii Y, Park I, et al. Distinct effects of orexin receptor antagonist and GABAA agonist on sleep and physical/cognitive functions after forced awakening. PNAS. 2019;116(48):24353–24358.
   PubMed Web of Science ®Google Scholar
• Neylan TC, Richards A, Metzler TJ, et al. Acute cognitive effects of the hypocretin receptor antagonist almorexant relative to zolpidem and placebo: a randomized clinical trial. Sleep. 2020;43(10):1–11.
   Web of Science ®Google Scholar