References
- Tan JKL, Stein Gold LF, Alexis AF, et al. Current concepts in acne pathogenesis: pathways to inflammation. Semin Cutan Med Surg. 2018 Jun;37(3S):S60–S62.
- Dréno B. What is new in the pathophysiology of acne, an overview. J Eur Acad Dermatol Venereol. 2017 Sep;31(Suppl 5):8–12.
- Zaenglein AL, Pathy AL, Schlosser BJ, et al. Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol. 2016 May;74(5):945–73.e33.
- Rosette C, Agan FJ, Mazzetti MA. Cortexolone 17α-propionate (clascoterone) is a novel androgen receptor antagonist that inhibits production of lipids and inflammatory cytokines from sebocytes in vitro. J Drugs Dermatol. 2019;18(5):412–418.
- Hebert A, Thiboutot D, Stein Gold L, et al., Efficacy and safety of topical clascoterone cream, 1%, for treatment in patients with facial acne: two phase 3 randomized clinical trials. JAMA Dermatol. 2020;156(6): 621–630.
- Eichenfield LF, Leyden JJ. Acne: current concepts of pathogenesis and approach to rational treatment. Pediatrician. 1991;18(3):218–223.
- Schaller M, Plewig G. Structure and function of eccrine, apocrine, and sebaceous glands. In: Bolognia JL, Schaffer JV, Cerroni L, editors. Dermatology. 4th ed. Philadelphia, PA, USA: Elsevier; 2018. p. 580–587.
- Bergfeld WF. The pathophysiology of acne vulgaris in children and adolescents, Part 1. Cutis. 2004;74(2):92–97.
- Webster GF. The pathophysiology of acne. Cutis. 2005;76(2 Suppl):4–7.
- Sardana K, Bansal P, Sharma LK, et al. A study comparing the clinical and hormonal profile of late onset and persistent acne in adult females. Int J Dermatol. 2020;59(4):428–433.
- Lee WJ, Jung HD, Chi SG, et al. Effect of dihydrotestosterone on the upregulation of inflammatory cytokines in cultured sebocytes. Arch Dermatol Res. 2010;302(6):429–433.
- Del Rosso JQ, Kircik LH, Stein Gold L, et al. Androgens, androgen receptors, and the skin: from the laboratory to the clinic with emphasis on clinical and therapeutic implications. J Drugs Dermatol. 2020;19(3):30–35.
- Zouboulis CC Endocrinology and immunology of acne: two sides of the same coin [published online ahead of print, 2020 Aug 10]. Exp Dermatol. 2020;10.1111
- Trivedi MK, Shinkai K, Murase JE. A review of hormone-based therapies to treat adult acne vulgaris in women. Int J Womens Dermatol. 2017;3(1):44–52.
- Brown EJ, Deshmukh P, Antell K. Contraception update: oral contraception. FP Essent. 2017;462:11–19.
- Charny JW, Choi JK, James WD. Spironolactone for the treatment of acne in women, a retrospective study of 110 patients. Int J Womens Dermatol. 2017;3(2):111–115.
- Roberts EE, Nowsheen S, Davis MDP, et al. Treatment of acne with spironolactone: a retrospective review of 395 adult patients at Mayo Clinic, 2007–2017. J Eur Acad Dermatol Venereol. 2020;34(9):2106–2110.
- Sansone G, Reisner RM. Differential rates of conversion of testerone to dihydrotestosterone in acne and in normal human skin- a possible pathogenic factor in acne. J Invest Dermatol. 1971 May;56(5):366–372.
- Mazzetti A, Moro L, Gerloni M, et al. A phase 2b, randomized, double-blind vehicle controlled, dose escalation study evaluating clascoterone 0.1%, 0.5%, and 1% topical cream in subjects with facial acne. J Drugs Dermatol. 2019;18(6):570–575.
- Mazzetti A, Moro L, Gerloni M, et al. Pharmacokinetic profile, safety, and tolerability of clascoterone (Cortexolone 17-alpha propionate, CB-03–01) topical cream, 1% in subjects with acne vulgaris: an open-label phase 2a study. J Drugs Dermatol. 2019;18(6):563–568.
- Winlevi prescribing information, Cassiopea, SpA; 2020.
- Park JH, Bienenfeld A, Orlow SJ, et al. the use of hormonal antiandrogen therapy in female patients with acne: a 10-year retrospective study. Am J Clin Dermatol. 2018 Jun;19(3):449–455.
- Barros B, Thiboutot D. Hormonal therapies for acne. Clin Dermatol. 2017 Mar-Apr;35(2):168–172.
- Trifu V, Tiplica GS, Naumescu E, et al. Cortexolone 17alpha-propionate 1% cream, a new potent antiandrogen for topical treatment of acne vulgaris. A pilot randomized, double-blind comparative study vs. placebo and tretinoin 0.05% cream. Br J Dermatol. 2011;165(1):177–183.
- Kolli SS, Pecone D, Pona A, et al. topical retinoids in acne vulgaris: a systematic review. Am J Clin Dermatol. 2019 Jun;20(3):345–365.
- Schmidt JB, Spona J. The levels of androgen in serum in female acne patients. Endocrinol Exp. 1985 Mar;19(1):17–23.
- Iftikhar U, Choudhry N. Serum levels of androgens in acne & their role in acne severity. Pak J Med Sci. 2019 Jan-Feb;35(1):146–150.