Stemming the tide with ileocecal Crohn’s disease: when is pharmacotherapy enough?

References

• Solberg IC, Vatn MH, Høie O, et al. Clinical course in crohn’s disease: results of a Norwegian population-based ten-year follow-up study. Clin Gastroenterol Hepatol. 2007;5(12):1430–1438. doi: 10.1016/j.cgh.2007.09.002
   PubMed Web of Science ®Google Scholar
• Freeman HJ. Natural history and long-term clinical course of Crohn’s disease. World J Gastroenterol. 2014 Jan;20(1):31–36. doi:10.3748/wjg.v20.i1.31
   PubMed Web of Science ®Google Scholar
• Thia KT, Sandborn WJ, Harmsen WS, et al. Risk factors associated with progression to intestinal complications of Crohn’s disease in a population-based cohort. Gastroenterology. 2010; 139(4):1147–1155. doi: 10.1053/j.gastro.2010.06.070
   PubMed Web of Science ®Google Scholar
• Bernell O, Lapidus A, Hellers G. Risk factors for surgery and postoperative recurrence in Crohn’s disease. Ann Surg. 2000 Jan;231(1):38–45. doi:10.1097/00000658-200001000-00006
   PubMed Web of Science ®Google Scholar
• Kalman TD, Everhov ÅH, Nordenvall C, et al. Decrease in primary but not in secondary abdominal surgery for Crohn’s disease: nationwide cohort study, 1990–2014. Br J Surg. 2020 Sep;107(11):1529–1538.
   PubMed Web of Science ®Google Scholar
• Basilisco G, Campanini M, Cesana B, et al. Risk factors for first operation in crohn’s disease. Am J Gastroenterol. 1989;84(7):749–752. doi: 10.1111/j.1572-0241.1989.tb02646.x
   PubMed Web of Science ®Google Scholar
• Farmer RG, Whelan G, Fazio VW. Long-term follow-up of patients with Crohn’s disease. Relationship between the clinical pattern and prognosis. Gastroenterology. 1985;88(6):1818–1825. doi: 10.1016/0016-5085(85)90006-X
   PubMed Web of Science ®Google Scholar
• Gionchetti P, Dignass A, Danese S, et al. 3rd European evidence-based consensus on the diagnosis and management of Crohn’s disease 2016: part 2: surgical management and special situations. J Crohn’s Colitis. 2017 Feb;11(2):135–149.
   Google Scholar
• Ponsioen CY, de Groof EJ, Eshuis EJ, et al. Laparoscopic ileocaecal resection versus infliximab for terminal ileitis in Crohn’s disease: a randomised controlled, open-label, multicentre trial. Lancet Gastroenterol Hepatol. 2017 Nov;2(11):785–792.
   PubMed Web of Science ®Google Scholar
• Lichtenstein GR, Loftus EV, Isaacs KL, et al. ACG clinical guideline: management of crohn’s disease in adults. Am J Gastroenterol. 2018 Apr 01;113(4):481–517. Am J Gastroenterol. doi: 10.1038/ajg.2018.27
   PubMed Web of Science ®Google Scholar
• Martins R, Carmona C, George B, et al. Management of Crohn’s disease: summary of updated NICE guidance. BMJ 2019;367. BMJ 10.1136/bmj.l5940
   PubMedGoogle Scholar
• Adamina M, Bonovas S, Raine T, et al. ECCO guidelines on therapeutics in crohn’s disease: surgical treatment. J Crohn’s Colitis. 2020 Feb;14(2):155–168.
   Google Scholar
• Kelm M, Germer CT, Schlegel N, et al. The revival of surgery in crohn’s disease—early intestinal resection as a reasonable alternative in localized ileitis. Biomedicines. 2021 Oct 01;9(10): Biomedicines. doi: 10.3390/biomedicines9101317.
   PubMed Web of Science ®Google Scholar
• Broide E, Eindor-Abarbanel A, Naftali T, et al. Early Surgery versus biologic therapy in limited nonstricturing ileocecal Crohn’sdisease—A decision-making analysis. Inflamm Bowel Dis. 2020 Nov;26(11):1648–1657.
   PubMed Web of Science ®Google Scholar
• Stevens TW, Haasnoot ML, D’Haens GR, et al. Laparoscopic ileocaecal resection versus infliximab for terminal ileitis in Crohn’s disease: retrospective long-term follow-up of the LIR!C trial. Lancet Gastroenterol Hepatol. 2020 Oct;5(10):900–907.
   PubMed Web of Science ®Google Scholar
• Agrawal M, Ebert AC, Poulsen G, et al. Early ileocecal resection for Crohn’s disease is associated with improved long-term outcomes compared to anti-tumor necrosis factor therapy: a population-based cohort study. Gastroenterology. 2023. doi:10.1053/J.GASTRO.2023.05.051.
   Google Scholar
• Herfarth H, Gross V, Andus T, et al. Analysis of the therapeutic efficacy of different doses of budesonide in patients with active Crohn’s ileocolitis depending on disease activity and localization. Int J Colorectal Dis. 2004 Mar;19(2):147–152.
   PubMed Web of Science ®Google Scholar
• Gerdin L, Eriksson AS, Olaison G, et al. The Swedish Crohn trial: a prematurely terminated randomized controlled trial of thiopurines or open surgery for primary treatment of ileocaecal Crohn’s disease. J Crohn’s Colitis. 2016 Jan;10(1):50–54.
   Google Scholar
• Vidigal FM, de Souza GS, Chebli LA, et al. Azathioprine is more effective than mesalazine at preventing recurrent bowel obstruction in patients with ileocecal Crohn’s disease. Med Sci Monit. 2014 Nov;20:2165–2170.
   PubMed Web of Science ®Google Scholar
• de Souza GS, Vidigal FM, Chebli LA, et al. Effect of azathioprine or mesalazine therapy on incidence of re-hospitalization in sub-occlusive ileocecal Crohn’s disease patients. Med Sci Monit. 2013 Aug;19(1):716–722.
   PubMedGoogle Scholar
• Husnoo N, Gana, T., Hague, A G., et al. Is early bowel resection better than medical therapy for ileocolonic Crohn’s disease? A systematic review and meta-analysis. Colorectal Disease. 2023;25(6):1090–1101. doi: 10.1111/codi.16502
   PubMed Web of Science ®Google Scholar
• An V, Cohen L, Lawrence M, et al. Early surgery in Crohn’s disease a benefit in selected cases. World J Gastrointest Surg. 2016; 8(7):492. doi: 10.4240/wjgs.v8.i7.492
   PubMedGoogle Scholar
• Torres J, Mehandru S, Colombel JF, et al. Crohn’s disease. Lancet. 2017 29;389(10080. Lancet):1741–1755. Apr. doi: 10.1016/S0140-6736(16)31711-1
   PubMed Web of Science ®Google Scholar
• Agrawal M, Spencer EA, Colombel JF, et al. Approach to the management of recently diagnosed inflammatory bowel disease patients: a user’s guide for adult and pediatric gastroenterologists. Gastroenterology. 2021 Jul 01;161(1. Gastroenterology):47–65. doi: 10.1053/j.gastro.2021.04.063.
   PubMed Web of Science ®Google Scholar
• Berg DR, Colombel JF, Ungaro R. The role of early biologic therapy in inflammatory bowel disease. Inflamm Bowel Dis. 2019 Dec 01;25(12):1896–1905. Inflamm Bowel Dis. doi: 10.1093/ibd/izz059
   PubMed Web of Science ®Google Scholar
• Maruyama BY, Ma C, Panaccione R, et al. Early laparoscopic ileal resection for localized ileocecal crohn’s disease: hard sell or a revolutionary new norm? Inflamm Intest Dis. 2021 Jan;7(1):13–20. doi: 10.1159/000515959
   PubMedGoogle Scholar
• Rungoe C, Langholz E, Andersson M, et al. Changes in medical treatment and surgery rates in inflammatory bowel disease: a nationwide cohort study 1979–2011. Gut. 2014 Oct;63(10):1607–1616.
   PubMed Web of Science ®Google Scholar
• Olivera P, Spinelli A, Gower-Rousseau C, et al. Surgical rates in the era of biological therapy: up, down or unchanged? Curr Opin Gastroenterol. 2017 Jul 01;33(4):246–253. Curr Opin Gastroenterol. doi: 10.1097/MOG.0000000000000361
   PubMed Web of Science ®Google Scholar
• Turner D, Ricciuto A, Lewis A, et al. STRIDE-II: an update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): determining therapeutic goals for treat-to-target strategies in IBD. Gastroenterology. 2021 Apr;160(5):1570–1583.
   PubMed Web of Science ®Google Scholar
• Colombel JF, Panaccione R, Bossuyt P, et al. Effect of tight control management on Crohn’s disease (CALM): a multicentre, randomised, controlled phase 3 trial. Lancet. 2017 Dec;390(10114):2779–2789.
   PubMed Web of Science ®Google Scholar
• Vieujean S, D’Amico F, Netter P, et al. Landscape of new drugs and targets in inflammatory bowel disease. United Eur Gastroenterol J. 2022;10(10):1129–1166. doi: 10.1002/ueg2.12305
   PubMed Web of Science ®Google Scholar
• Vieujean S, Louis E. Precision medicine and drug optimization in adult inflammatory bowel disease patients. Therap Adv Gastroenterol. 2023 Jan;16:175628482311733. doi: 10.1177/17562848231173331
   Web of Science ®Google Scholar
• Grass F, Fletcher JG, Alsughayer A, et al. Development of an objective model to define near-term risk of ileocecal resection in patients with terminal ileal Crohn disease. Inflamm Bowel Dis. 2019 Oct;25(11):1845–1853.
   PubMed Web of Science ®Google Scholar
• Polito JM, Childs B, Mellits ED, et al. Crohn’s disease: influence of age at diagnosis on site and clinical type of disease. Gastroenterology. 1996; 111(3):580–586. doi: 10.1053/gast.1996.v111.pm8780560
   PubMed Web of Science ®Google Scholar
• Vernier-Massouille G, et al. Natural history of pediatric crohn’s disease: a population-based cohort study. Gastroenterology. 2008;135(4):1106–1113. doi: 10.1053/j.gastro.2008.06.079
   PubMed Web of Science ®Google Scholar
• Romberg-Camps MJL, Dagnelie PC, Kester ADM, et al. Influence of phenotype at diagnosis and of other potential prognostic factors on the course of inflammatory bowel disease. Am J Gastroenterol. 2009 Feb;104(2):371–383.
   PubMed Web of Science ®Google Scholar
• Bernell O, Lapidus A, Hellers G. Risk factors for surgery and recurrence in 907 patients with primary ileocaecal Crohn’s disease. Br J Surg. 2000; 87(12):1697–1701. doi: 10.1046/j.1365-2168.2000.01589.x
   PubMed Web of Science ®Google Scholar
• Rosenbaum DG, Conrad MA, Biko DM, et al. Ultrasound and MRI predictors of surgical bowel resection in pediatric Crohn disease. Pediatr Radiol. 2017 Jan;47(1):55–64. doi: 10.1007/s00247-016-3704-x.
   PubMed Web of Science ®Google Scholar
• Cosnes J, Cattan S, Blain A, et al. Long-term evolution of disease behavior of Crohn’s disease. Inflamm Bowel Dis. 2002;8(4):244–250. doi: 10.1097/00054725-200207000-00002
   PubMed Web of Science ®Google Scholar
• Cosnes J, Gower–Rousseau C, Seksik P, et al. Epidemiology and natural history of inflammatory bowel diseases. Gastroenterology. 2011 May;140(6):1785–1794.e4. doi: 10.1053/j.gastro.2011.01.055
   PubMed Web of Science ®Google Scholar
• Louis E, Collard A, Oger AF, et al. Behaviour of Crohn’s disease according to the Vienna classification: changing pattern over the course of the disease. Gut. 2001; 49(6):777–782. doi: 10.1136/GUT.49.6.777
   PubMed Web of Science ®Google Scholar
• Rieder F, Zimmermann EM, Remzi FH, et al. Crohn’s disease complicated by strictures: a systematic review. Gut. 2013 Jul;62(7. Gut):1072–1084. doi:10.1136/gutjnl-2012-304353
   PubMed Web of Science ®Google Scholar
• Bossuyt P, Debeuckelaere C, Ferrante M, et al. Risk stratification for surgery in stricturing ileal Crohn’s disease: the BACARDI risk model. J Crohn’s Colitis. 2018 Jan;12(1):32–38.
   Google Scholar
• Magro F, Rodrigues-Pinto E, Santos-Antunes J, et al. High C-reactive protein in Crohn’s disease patients predicts nonresponse to infliximab treatment. J Crohn’s Colitis. 2014 Feb;8(2):129–136.
   Google Scholar
• Kristensen VA, Cvancarova M, Høivik ML, et al. Serological antibodies and surgery in a population-based inception cohort of Crohn’s disease patients–the IBSEN study. Scand J Gastroenterol. 2020 Apr;55(4):436–441. doi:10.1080/00365521.2020.1745879
   PubMed Web of Science ®Google Scholar
• Lakatos PL, Papp M, Rieder F. Serologic antiglycan antibodies in inflammatory bowel disease. Am J Gastroenterol. 2011 Mar;106(3):406–412. Am J Gastroenterol. doi: 10.1038/ajg.2010.505
   PubMed Web of Science ®Google Scholar
• Xiong Y, Wang GZ, Zhou JQ, et al. Serum antibodies to microbial antigens for Crohn’s disease progression: a meta-analysis. Eur J Gastroenterol Hepatol. 2014;26(7):733–742. doi: 10.1097/MEG.0000000000000102
   PubMed Web of Science ®Google Scholar
• Parker D, Karmazyn B, Steiner SJ. Radiologic predictors of surgery in newly diagnosed pediatric Crohn disease patients. J Pediatr Gastroenterol Nutr. 2016; 63(6):e182–e185. doi: 10.1097/MPG.0000000000001217
   PubMed Web of Science ®Google Scholar
• Lenze F, Wessling J, Bremer J, et al. Detection and differentiation of inflammatory versus fibromatous Crohnʼs disease strictures: prospective comparison of 18F-FDG-PET/CT, MR-enteroclysis, and transabdominal ultrasound versus endoscopic/histologic evaluation. Inflamm Bowel Dis. 2012 Dec;18(12):2252–2260.
   PubMed Web of Science ®Google Scholar
• Dillman JR, Smith EA, Sanchez RJ, et al. Pediatric small bowel Crohn disease: correlation of US and MR enterography. Radiographics. 2015 May;35(3):835–848.
   PubMed Web of Science ®Google Scholar
• Hata J, Haruma K, Yamanaka H, et al. Ultrasonographic evaluation of the bowel wall in inflammatory bowel disease: comparison of in vivo and in vitro studies. Abdom Imaging. 1994 Sep;19(5):395–399.
   PubMedGoogle Scholar
• Maconi G, Carsana L, Fociani P, et al. Small bowel stenosis in Crohn’s disease: clinical, biochemical and ultrasonographic evaluation of histological features. Aliment Pharmacol Ther. 2003 Oct;18(7):749–756.
   PubMed Web of Science ®Google Scholar
• Ahmad TM, Greer ML, Walters TD, et al. Bowel sonography and MR enterography in children. Am J Roentgenol. 2016 Jan;206(1):173–181. doi: 10.2214/AJR.15.14767.
   PubMed Web of Science ®Google Scholar
• Grillot J, D’Engremont C, Parmentier A-L, et al. Sarcopenia and visceral obesity assessed by computed tomography are associated with adverse outcomes in patients with Crohn’s disease. Clin Nutr. 2020 Oct;39(10):3024–3030.
   PubMed Web of Science ®Google Scholar
• Boparai G, Kedia S, Kandasamy D, et al. Combination of sarcopenia and high visceral fat predict poor outcomes in patients with Crohn’s disease. Eur J Clin Nutr. 2021 Oct;75(10):1491–1498.
   PubMed Web of Science ®Google Scholar
• Cravo ML, Velho S, Torres J, et al. Lower skeletal muscle attenuation and high visceral fat index are associated with complicated disease in patients with Crohn’s disease: an exploratory study. Clin Nutr ESPEN. 2017 Oct;21:79–85.
   PubMedGoogle Scholar
• Velho S, Morão, B., Gouveia, C., et al. Body composition and Crohn’s disease behavior: is adiposity the main game changer? Nutrition. 2023 Apr;108:111959.
   PubMed Web of Science ®Google Scholar
• Vincoli G, Candeloro L, Calarco R, et al. P133 Small bowel stricture in Crohn’s disease: the main factor for surgery indication? J Crohn’s Colitis. 2014;8:S117. doi: 10.1016/s1873-9946(14)60255-5
   Google Scholar
• Radlmayr M, Török HP, Martin K, et al. The c-insertion mutation of the NOD2 gene is associated with fistulizing and fibrostenotic phenotypes in Crohn’s disease [2]. Gastroenterology. 2002;122(7):2091–2092. doi: 10.1053/gast.2002.34020
   PubMed Web of Science ®Google Scholar
• Büning C, Genschel J, Bühner S, et al. Mutations in the NOD2/CARD15 gene in Crohn’s disease are associated with ileocecal resection and are a risk factor for reoperation. Aliment Pharmacol Ther. 2004 May;19(10):1073–1078.
   PubMed Web of Science ®Google Scholar
• Ogura Y, Bonen DK, Inohara N, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn’s disease. Nature. 2001 May;411(6837):603–606.
   PubMed Web of Science ®Google Scholar
• Inohara N, Ogura Y, Fontalba A, et al. Host recognition of bacterial muramyl dipeptide mediated through NOD2: implications for Crohn’s disease. J Biol Chem. 2003 Feb;278(8):5509–5512.
   PubMed Web of Science ®Google Scholar
• Glas J, Torok H-P, Tonenchi L, et al. The 14-bp deletion polymorphism in the HLA-G gene displays significant differences between ulcerative colitis and Crohn’s disease and is associated with ileocecal resection in Crohn’s disease. Int Immunol. 2007 May;19(5):621–626.
   PubMed Web of Science ®Google Scholar
• Carosella ED, Moreau P, Le Maoult J, et al. HLA-G molecules: from maternal-fetal tolerance to tissue acceptance. Adv Immunol. 2003;81:199–252. Adv Immunol. doi: 10.1016/S0065-2776(03)81006-4
   PubMed Web of Science ®Google Scholar
• Fish S, Wei Z, Bradfield J, et al. P-217 YI SLC11A1 polymorphism increases the risk of early surgery in pediatric patients with inflammatory bowel disease. Inflamm Bowel Dis. 2013 Dec;19:S111–S112.
   Google Scholar
• Blackwell JM, Searle S, Mohamed H, et al. Divalent cation transport and susceptibility to infectious and autoimmune disease: continuation of the Ity/Lsh/Bcg/Nramp1/Slc11a1 gene story. Immunol Lett. 2003 Jan 22;85(2):197–203. Immunol Lett. doi: 10.1016/S0165-2478(02)00231-6
   PubMed Web of Science ®Google Scholar
• Crawford NPS, Eichenberger MR, Colliver DW, et al. Evaluation of SLC11A1 as an inflammatory bowel disease candidate gene. BMC Med Genet. 2005 Mar;6(1). doi: 10.1186/1471-2350-6-10
   PubMedGoogle Scholar
• Guizzetti L, Zou G, Khanna R, et al. Development of clinical prediction models for surgery and complications in Crohn’s disease. J Crohn’s Colitis. 2018 Jan;12(2):167–177.
   Google Scholar
• Siegel CA, Whitman CB, Spiegel BMR, et al. Development of an index to define overall disease severity in IBD. Gut. 2018 Feb;67(2):244–254.
   PubMed Web of Science ®Google Scholar
• Peyrin-Biroulet L, Loftus EV, Colombel JF, et al. The natural history of adult crohn’s disease in population-based cohorts. Am J Gastroenterol. 2010;105(2):289–297. doi: 10.1038/ajg.2009.579
   PubMed Web of Science ®Google Scholar
• Olaison G, Smedh K, Sjödahl R. Natural course of Crohn’s disease after ileocolic resection: endoscopically visualised ileal ulcers preceeding symptoms. Gut. 1992;33(3):331–335. doi: 10.1136/gut.33.3.331
   PubMed Web of Science ®Google Scholar
• Rutgeerts P, Geboes K, Vantrappen G, et al. Predictability of the postoperative course of Crohn’s disease. Gastroenterology. 1990; 99(4):956–963. doi: 10.1016/0016-5085(90)90613-6
   PubMed Web of Science ®Google Scholar
• Tandon P, Malhi G, Abdali D, et al. Active margins, plexitis, and granulomas increase postoperative crohn’s recurrence: systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2021 Mar;19(3):451–462.
   PubMedGoogle Scholar
• Pascua M, Su C, Lewis JD, et al. Meta-analysis: factors predicting post-operative recurrence with placebo therapy in patients with Crohn’s disease. Aliment Pharmacol Ther. 2008 Sep;28(5):545–556. doi: 10.1111/j.1365-2036.2008.03774.x.
   PubMed Web of Science ®Google Scholar
• Rutgeerts P, Geboes K, Vantrappen G, et al. Natural history of recurrent Crohn's disease at the ileocolonic anastomosis after curative surgery. Gut. 1984;25(6):665–672. doi: 10.1136/gut.25.6.665
   PubMed Web of Science ®Google Scholar
• Connelly TM, Messaris E. Predictors of recurrence of Crohn’s disease after ileocolectomy: a review. World J Gastroenterol. Oct; 20(39):14393–14406. World J Gastroenterol 21, 2014. 10.3748/wjg.v20.i39.14393
   PubMed Web of Science ®Google Scholar
• de Buck van Overstraeten A, Eshuis EJ, Vermeire S, et al. Short- and medium-term outcomes following primary ileocaecal resection for Crohn’s disease in two specialist centres. Br J Surg. 2017 Nov;104(12):1713–1722.
   PubMed Web of Science ®Google Scholar
• Muñoz-Juárez M, Yamamoto T, Wolff BG, et al. Wide-lumen stapled anastomosis vs. conventional end-to-end anastomosis in the treatment of Crohn’s disease. Dis Colon Rectum. 2001;44(1):20–25. doi: 10.1007/bf02234814
   PubMed Web of Science ®Google Scholar
• Valibouze C, Desreumaux P, Zerbib P. Post-surgical recurrence of Crohn’s disease: situational analysis and future prospects. J Visc Surg. Oct. 1, 2021;158(5):401–410. J Visc Surg. doi: 10.1016/j.jviscsurg.2021.03.012
   PubMed Web of Science ®Google Scholar
• Cunningham MF, Docherty NG, Coffey JC, et al. Postsurgical recurrence of ileal crohn’s disease: an update on risk factors and intervention points to a central role for impaired host-microflora homeostasis. World J Surg. 2010 Jul;34(7):1615–1626. doi: 10.1007/s00268-010-0504-6.
   PubMed Web of Science ®Google Scholar
• Yamamoto T. Factors affecting recurrence after surgery for Crohn’s disease. World J Gastroenterol. 2005 Jul 14;11(26):3971–3979. World J Gastroenterol. doi: 10.3748/wjg.v11.i26.3971
   PubMed Web of Science ®Google Scholar
• Yang KM, Yu CS, Lee JL, et al. Risk factors for postoperative recurrence after primary bowel resection in patients with Crohn’s disease. World J Gastroenterol. 2017 Oct;23(38):7016–7024.
   PubMed Web of Science ®Google Scholar
• Ng SC, Arslan Lied G, Arebi N, et al. Clinical and surgical recurrence of Crohn’s disease after ileocolonic resection in a specialist unit. Eur J Gastroenterol Hepatol. 2009 May;21(5):551–557. doi: 10.1097/MEG.0b013e328326a01e
   PubMed Web of Science ®Google Scholar
• Gathungu G, Zhang Y, Tian X, et al. Impaired granulocyte-macrophage colony-stimulating factor bioactivity accelerates surgical recurrence in ileal crohn’s disease. World J Gastroenterol. 2018 Feb;24(5):623–630.
   PubMed Web of Science ®Google Scholar
• Mancabelli L, Milani C, Lugli GA, et al. Identification of universal gut microbial biomarkers of common human intestinal diseases by meta-analysis. FEMS Microbiol Ecol. 2017 Dec;93(12). doi: 10.1093/femsec/fix153
   PubMed Web of Science ®Google Scholar
• Mondot S, et al. Structural robustness of the gut mucosal microbiota is associated with Crohn’s disease remission after surgery. Gut. 2016 Jun;65(6):954–962. doi: 10.1136/gutjnl-2015-309184.
   PubMed Web of Science ®Google Scholar
• Sokol H, Pigneur B, Watterlot L, et al. Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci U S A. 2008 Oct;105(43):16731–16736.
   PubMed Web of Science ®Google Scholar
• Darfeuille-Michaud A, Boudeau J, Bulois P, et al. High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn’s disease. Gastroenterology. 2004;127(2):412–421. doi: 10.1053/j.gastro.2004.04.061
   PubMed Web of Science ®Google Scholar
• MacHiels K, Pozuelo Del Río M, Martinez-De la Torre A, et al. Early postoperative endoscopic recurrence in crohn’s disease is characterised by distinct microbiota recolonisation. J Crohn’s Colitis. 2020 Nov;14(11):1535–1546.
   Google Scholar
• Ryan WR, Allan RN, Yamamoto T, et al. Crohn’s disease patients who quit smoking have a reduced risk of reoperation for recurrence. Am J Surg. 2004;187(2):219–225. doi: 10.1016/j.amjsurg.2003.11.007
   PubMed Web of Science ®Google Scholar
• Aratari A, Papi C, Leandro G, et al. Early versus late surgery for ileo-caecal Crohn’s disease. Aliment Pharmacol Ther. 2007 Nov;26(10):1303–1312. Aliment Pharmacol Ther. doi: 10.1111/j.1365-2036.2007.03515.x
   PubMed Web of Science ®Google Scholar
• Auzolle C, Nancey S, Tran-Minh M-L, et al. Male gender, active smoking and previous intestinal resection are risk factors for post-operative endoscopic recurrence in Crohn’s disease: results from a prospective cohort study. Aliment Pharmacol Ther. 2018 Nov;48(9):924–932.
   PubMed Web of Science ®Google Scholar
• Kuenzig ME, Lee SM, Eksteen B, et al. Smoking influences the need for surgery in patients with the inflammatory bowel diseases: a systematic review and meta-analysis incorporating disease duration. BMC Gastroenterol. 2016 Dec;16(1). doi: 10.1186/s12876-016-0555-8
   PubMedGoogle Scholar
• Poredska K, Kunovsky L, Marek F, et al. The influence of microscopic inflammation at resection margins on early postoperative endoscopic recurrence after ileocaecal resection for crohn’s disease. J Crohn’s Colitis. 2020 Mar;14(3):361–368.
   Google Scholar
• Sokol H, et al. Plexitis as a predictive factor of early postoperative clinical recurrence in Crohn’s disease. Gut. 2009 Sep;58(9):1218–1225. doi: 10.1136/gut.2009.177782.
   PubMed Web of Science ®Google Scholar
• Fortinsky KJ, Kevans D, Qiang J, et al. Rates and predictors of endoscopic and clinical recurrence after primary ileocolic resection for crohn’s disease. Dig Dis Sci. 2017 Jan;62(1):188–196.
   PubMed Web of Science ®Google Scholar
• McLeod RS, Wolff BG, Ross S, et al. Recurrence of Crohn’s disease after ileocolic resection is not affected by anastomotic type: results of a multicenter, randomized, controlled trial. Dis Colon Rectum. 2009 May;52(5):919–927. doi: 10.1007/DCR.0b013e3181a4fa58
   PubMed Web of Science ®Google Scholar
• Iaculli E, Agostini M, Biancone L, et al. C-reactive protein levels in the perioperative period as a predictive marker of endoscopic recurrence after ileo-colonic resection for Crohn’s disease. Cell Death Discov. 2016 Dec;2(1). doi: 10.1038/cddiscovery.2016.32
   PubMedGoogle Scholar
• Holt DQ, Moore GT, Strauss BJG, et al. Visceral adiposity predicts post-operative Crohn’s disease recurrence. Aliment Pharmacol Ther. 2017 May;45(9):1255–1264. doi: 10.1111/apt.14018.
   PubMed Web of Science ®Google Scholar
• Li Y, Zhu W, Gong J, et al. Visceral fat area is associated with a high risk for early postoperative recurrence in crohn’s disease. Color Dis. 2015 Mar;17(3):225–234.
   PubMed Web of Science ®Google Scholar
• Kelm M, Reibetanz J, Kim M, et al. Kono-S anastomosis in crohn’s disease: a retrospective study on postoperative morbidity and disease recurrence in comparison to the conventional side-to-side anastomosis. J Clin Med. 2022 Dec;11(23):6915.
   PubMed Web of Science ®Google Scholar
• Kono T, Ashida T, Ebisawa Y, et al. A new antimesenteric functional end-to-end handsewn anastomosis: surgical prevention of anastomotic Recurrence in Crohn’s disease. Dis Colon Rectum. 2011 May;54(5):586–592.
   PubMed Web of Science ®Google Scholar
• Kono T, Fichera A, Maeda K, et al. Kono-S anastomosis for surgical prophylaxis of anastomotic recurrence in crohn’s disease: an international multicenter study. J Gastrointest Surg. 2016 Apr;20(4):783–790.
   PubMed Web of Science ®Google Scholar
• Luglio G, Rispo A, Imperatore N, et al. Surgical prevention of anastomotic recurrence by excluding mesentery in crohn’s disease: the SuPREMe-CD study - a randomized clinical trial. Ann Surg. 2020 Aug;272(2):210–217.
   PubMed Web of Science ®Google Scholar
• Aaltonen G, Keränen I, Carpelan-Holmström M, et al. Risk factors for anastomotic recurrence after primary ileocaecal resection in Crohn’s disease. Eur J Gastroenterol Hepatol. 2018 Oct;30(10):1143–1147. doi: 10.1097/MEG.0000000000001206.
   PubMed Web of Science ®Google Scholar
• Ryan JM, Rogers AC, O’Toole A, et al. Meta-analysis of histological margin positivity in the prediction of recurrence after crohn’s resection. Dis Colon Rectum. 2019 Jul 01;62(7):882. Dis Colon Rectum. doi: 10.1097/DCR.0000000000001407
   PubMed Web of Science ®Google Scholar
• Yzet C, Riault C, Brazier F, et al. Positive margins and plexitis increase the risk of recurrence after ileocecal resection: a systematic review and meta-analysis. Dig Liver Dis. 2023 Jan. doi: 10.1016/j.dld.2022.12.021
   PubMedGoogle Scholar
• Ferrante M, de Hertogh G, Hlavaty T, et al. The value of myenteric plexitis to predict early postoperative crohn’s disease recurrence. Gastroenterology. 2006;130(6):1595–1606. doi: 10.1053/j.gastro.2006.02.025
   PubMed Web of Science ®Google Scholar
• Decousus S, Boucher A-L, Joubert J, et al. Myenteric plexitis is a risk factor for endoscopic and clinical postoperative recurrence after ileocolonic resection in Crohn’s disease. Dig Liver Dis. 2016 Jul;48(7):753–758.
   PubMedGoogle Scholar
• Misteli H, Koh CE, Wang LM, et al. Myenteric plexitis at the proximal resection margin is a predictive marker for surgical recurrence of ileocaecal Crohn’s disease. Colorectal Dis. 2015 Apr;17(4):304–310. doi: 10.1111/CODI.12896.
   PubMed Web of Science ®Google Scholar
• Simillis C, Purkayastha S, Yamamoto T, et al. A meta-analysis comparing conventional end-to-end anastomosis vs. other anastomotic configurations after resection in Crohn’s disease. Dis Colon Rectum. 2007 Oct;50(10):1674–1687. doi: 10.1007/s10350-007-9011-8.
   PubMed Web of Science ®Google Scholar
• Riault C, Diouf M, Chatelain D, et al. Positive histologic margins is a risk factor of recurrence after ileocaecal resection in Crohn’s disease. Clin Res Hepatol Gastroenterol. 2021 Sep;45(5):101569.
   PubMed Web of Science ®Google Scholar
• Regueiro M, Feagan BG, Zou B, et al. Infliximab reduces endoscopic, but not clinical, recurrence of crohn’s disease after ileocolonic resection. Gastroenterology. 2016 Jun;150(7):1568–1578.
   PubMed Web of Science ®Google Scholar
• De Cruz P, Kamm MA, Hamilton AL, et al. Efficacy of thiopurines and adalimumab in preventing Crohn’s disease recurrence in high-risk patients - a POCER study analysis. Aliment Pharmacol Ther. 2015 Oct;42(7):867–879.
   PubMed Web of Science ®Google Scholar
• Yoshida K, Fukunaga K, Ikeuchi H, et al. Scheduled infliximab monotherapy to prevent recurrence of Crohnʼs disease following ileocolic or ileal resection: a 3-year prospective randomized open trial. Inflamm Bowel Dis. 2012 Sep;18(9):1617–1623.
   PubMed Web of Science ®Google Scholar
• da Baraúna FSB, Kotze PG. Correlation between trough levels of infliximab and postoperative endoscopic recurrence in Crohn’s disease patients submitted to ileocolonic resections: a systematic review. Arq Gastroenterol. 2021; 58(1):107–113. doi: 10.1590/S0004-2803.202100000-18
   PubMedGoogle Scholar
• Fay S, Ungar B, Paul S, et al. The association between drug levels and endoscopic recurrence in postoperative patients with crohnʼs disease treated with tumor necrosis factor inhibitors. Inflamm Bowel Dis. 2017 Nov;23(11):1924–1929.
   PubMed Web of Science ®Google Scholar
• Bressenot A, Chevaux J-B, Williet N, et al. Submucosal plexitis as a predictor of postoperative surgical recurrence in crohnʼs disease. Inflamm Bowel Dis. 2013 Jul;19(8):1654–1661.
   PubMed Web of Science ®Google Scholar
• Buisson A, Chevaux JB, Allen PB, et al. Review article: the natural history of postoperative Crohn’s disease recurrence. Aliment Pharmacol Ther. 2012 Mar;35(6):625–633. Aliment Pharmacol Ther. doi: 10.1111/j.1365-2036.2012.05002.x
   PubMed Web of Science ®Google Scholar
• Reese GE, Nanidis T, Borysiewicz C, et al. The effect of smoking after surgery for Crohn’s disease: a meta-analysis of observational studies. Int J Colorectal Dis. 2008; 23(12):1213–1221. doi: 10.1007/s00384-008-0542-9
   PubMed Web of Science ®Google Scholar
• Yamamoto T, Keighley MRB. The association of cigarette smoking with a high risk of recurrence after ileocolonic resection for ileocecal Crohn’s disease. Surg Today. 1999;29(6):579–580. doi: 10.1007/BF02482360
   PubMed Web of Science ®Google Scholar
• Bolckmans R, Kalman T, Singh S, et al. Does smoking cessation reduce surgical recurrence after primary ileocolic resection for Crohn’s disease? Dis Colon Rectum. 2020;63(2):200–206. doi: 10.1097/DCR.0000000000001547
   PubMed Web of Science ®Google Scholar
• Birrenbach T, Böcker U. Inflammatory bowel disease and smoking. A review of epidemiology, pathophysiology, and therapeutic implications. Inflamm Bowel Dis. 2004 Nov;10(6):848–859. Inflamm Bowel Dis. doi: 10.1097/00054725-200411000-00019
   PubMed Web of Science ®Google Scholar
• Margagnoni G, Aratari A, Mangone M, et al. Natural history of ileo-caecal Crohn’s disease after surgical resection. A long term study. Minerva Gastroenterol Dietol. 2011 Dec Accessed Feb 15, 2023;57(4):335–344. Available: https://pubmed.ncbi.nlm.nih.gov/22105722/
   PubMedGoogle Scholar
• Ikeuchi H, Kusunoki M, Yamamura T. Long-term results of stapled and hand-sewn anastomoses in patients with Crohn’s disease. Dig Surg. 2000;17(5):493–496. doi: 10.1159/000051946
   PubMed Web of Science ®Google Scholar
• Scarpa M, Ruffolo C, Bertin E, et al. Surgical predictors of recurrence of Crohn’s disease after ileocolonic resection. Int J Colorectal Dis. 2007 Sep;22(9):1061–1069.
   PubMed Web of Science ®Google Scholar
• He X, Chen Z, Huang J, et al. Stapled side-to-side anastomosis might be better than handsewn end-to-end anastomosis in ileocolic resection for Crohn’s disease: a meta-analysis. Dig Dis Sci. 2014;59(7):1544–1551. Dig Dis Sci. doi: 10.1007/s10620-014-3039-0
   PubMed Web of Science ®Google Scholar
• Feng JS, Li JY, Yang Z, et al. Stapled side-to-side anastomosis might be benefit in intestinal resection for Crohn’s disease. Medicine (USA). 97(15): Medicine (Baltimore):e0315. Apr. 1, 2018. doi: 10.1097/MD.0000000000010315
   Google Scholar
• Guo Z, Li Y, Zhu W, et al. Comparing outcomes between side-to-side anastomosis and other anastomotic configurations after intestinal resection for patients with Crohn’s disease: a meta-analysis. World J Surg. 2013 Apr;37(4):893–901. World J Surg. doi: 10.1007/s00268-013-1928-6
   PubMed Web of Science ®Google Scholar
• Reynolds IS, Doogan KL, Ryan ÉJ, et al. Surgical strategies to reduce postoperative recurrence of crohn’s disease after ileocolic resection. Front Surg. 2021 Dec;8. doi:10.3389/FSURG.2021.804137.
   Web of Science ®Google Scholar
• Coffey CJ, Kiernan MG, Sahebally SM, et al. Inclusion of the mesentery in ileocolic resection for Crohn’s disease is associated with reduced surgical recurrence. J Crohn’s Colitis. 2018 Nov;12(10):1139–1150.
   Google Scholar
• Zhu Y, Qian W, Huang L, et al. Role of extended mesenteric excision in postoperative recurrence of crohn’s colitis: a single-center study. Clin Transl Gastroenterol. 2021 Oct;12(10):e00407.
   PubMedGoogle Scholar
• Peltrini R, Greco PA, Manfreda A, et al. Kono-S anastomosis after intestinal resection for Crohn’s disease. Updates Surg. 2020 Jun 01;72(2):335–340. Updates Surg. doi: 10.1007/s13304-019-00700-w
   PubMed Web of Science ®Google Scholar
• Alshantti A, Hind D, Hancock L, et al. The role of Kono-S anastomosis and mesenteric resection in reducing recurrence after surgery for Crohn’s disease: a systematic review. Colorectal Dis. 2021 Jan 01;23(1):7–17. Colorectal Dis. doi: 10.1111/codi.15136
   PubMed Web of Science ®Google Scholar
• Ng CH, Chin YH, Lin SY, et al. Kono-S anastomosis for Crohn’s disease: a systemic review, meta-analysis, and meta-regression. Surg Today. Apr. 1, 2021;51(4): 493–501. Surg Today. 10.1007/s00595-020-02130-3.
   PubMed Web of Science ®Google Scholar
• Unger LW, Argeny S, Stift A, et al. Mesenteric granulomas independently predict long-term risk of surgical recurrence in Crohn’s disease. Colorectal Dis. 2020 Feb;22(2):170–177.
   PubMed Web of Science ®Google Scholar
• Li Y, Mohan H, Lan N, et al. Mesenteric excision surgery or conservative limited resection in Crohn’s disease: study protocol for an international, multicenter, randomized controlled trial. Trials. 2020 Feb;21(1). doi: 10.1186/s13063-020-4105-x
   Web of Science ®Google Scholar
• Strömbeck A, Lasson A, Strid H, et al. Fecal microbiota composition is linked to the postoperative disease course in patients with Crohn’s disease. BMC Gastroenterol. 2020 May;20(1):1–10.
   Web of Science ®Google Scholar
• Wasmann KATGM, Van Amesfoort J, Van Montfoort ML, et al. The predictive value of inflammation at ileocecal resection margins for postoperative crohn’s recurrence: a cohort study. Inflamm Bowel Dis. 2020 Nov;26(11):1691–1699. doi: 10.1093/ibd/izz290
   PubMed Web of Science ®Google Scholar
• Bergamaschi R, Pessaux P, Arnaud JP. Comparison of conventional and laparoscopic ileocolic resection for Crohn’s disease. Dis Colon Rectum. 2003 Aug;46(8):1129–1133. doi:10.1007/s10350-004-7292-8
   PubMed Web of Science ®Google Scholar
• Fazio VW, Marchetti F, Church JM, et al. Effect of resection margins on the recurrence of Crohn’s disease in the small bowel: a randomized controlled trial. Ann Surg. 1996;224(4):563–573. doi: 10.1097/00000658-199610000-00014
   PubMed Web of Science ®Google Scholar
• Nygaard K, Fausa O. Crohn’s disease: recurrence after surgical treatment. Scand J Gastroenterol. 1977;12(5):577–584. doi: 10.3109/00365527709181336
   PubMed Web of Science ®Google Scholar
• Krause U, Ejerblad S, Bergman L. A long-term study of the clinical course in 186 patients. Scand J Gastroenterol. 1985; 20(4):516–524. doi: 10.3109/00365528509089690
   PubMed Web of Science ®Google Scholar
• Hammoudi N, Auzolle C, Tran Minh M-L, et al. Postoperative endoscopic recurrence on the neoterminal ileum but not on the anastomosis is mainly driving long-term outcomes in crohn’s disease. Am J Gastroenterol. 2020 Jul;115(7):1084–1093.
   PubMed Web of Science ®Google Scholar
• Simillis C, Jacovides M, Reese GE, et al. Meta-analysis of the role of granulomas in the recurrence of Crohn disease. Dis Colon Rectum. 2010 Feb;53(2):177–185. doi: 10.1007/DCR.0b013e3181b7bfb0.
   PubMed Web of Science ®Google Scholar
• Li Y, Stocchi L, Liu X, et al. Presence of granulomas in mesenteric lymph nodes is associated with postoperative recurrence in crohnʼs disease. Inflamm Bowel Dis. 2015 Jul;21(11):2613–2618.
   PubMed Web of Science ®Google Scholar
• Hammoudi N, Cazals-Hatem D, Auzolle C, et al. Association between microscopic lesions at ileal resection margin and recurrence after surgery in patients with crohn’s disease. Clin Gastroenterol Hepatol. 2020 Jan;18(1):141–149.e2.
   PubMed Web of Science ®Google Scholar
• Ng SC, Lied GA, Kamm MA, et al. Predictive value and clinical significance of myenteric plexitis in Crohn’s disease. Inflamm Bowel Dis. 2009;15(10):1499–1507. doi: 10.1002/ibd.20932
   PubMed Web of Science ®Google Scholar
• Gordon M, Taylor K, Akobeng AK, et al. Azathioprine and 6-mercaptopurine for maintenance of surgically-induced remission in Crohn’s disease. Cochrane Database Syst Rev. 2014 Aug 01;2017(12): Cochrane Database Syst Rev. doi: 10.1002/14651858.CD010233.pub2.
   Google Scholar
• Singh S, Al-Darmaki A, Frolkis AD, et al. Postoperative mortality among patients with inflammatory bowel diseases: a systematic review and meta-analysis of population-based studies. Gastroenterology. 2015 Oct;149(4):928–937.
   PubMed Web of Science ®Google Scholar
• Papamichael K, Archavlis E, Lariou C, et al. Adalimumab for the prevention and/or treatment of post-operative recurrence of Crohn’s disease: a prospective, two-year, single center, pilot study. J Crohn’s Colitis. 2012 Oct;6(9):924–931. doi: 10.1016/j.crohns.2012.02.012.
   Google Scholar
• Yanai H, Kagramanova A, Knyazev O, et al. Endoscopic Postoperative recurrence in crohn’s disease after curative ileocecal resection with early prophylaxis by anti-TNF, Vedolizumab or ustekinumab: a real-world multicentre European Study. J Crohns Colitis. 2022 Dec;16(12):1882–1892.
   PubMed Web of Science ®Google Scholar
• Connelly TM, Juza RM, Sangster W, et al. Volumetric fat ratio and not body mass index is predictive of ileocolectomy outcomes in Crohn’s disease patients. Dig Surg. 2014 Nov;31(3):219–224. doi:10.1159/000365359
   PubMed Web of Science ®Google Scholar
• Sharma A, Deeb AP, Iannuzzi JC, et al. Tobacco smoking and postoperative outcomes after colorectal surgery. Ann Surg. 2013 Aug;258(2):296–300. doi:10.1097/SLA.0b013e3182708cc5
   PubMed Web of Science ®Google Scholar
• Mege D, Bege T, Beyer-Berjot L, et al. Does faecal diversion prevent morbidity after ileocecal resection for Crohn’s disease? Retrospective series of 80 cases. ANZ J Surg. 2017 Sep;87(9):E74–E79.
   PubMed Web of Science ®Google Scholar
• Fumery M, Seksik P, Auzolle C, et al. Postoperative complications after ileocecal resection in crohn’s disease: a prospective study from the REMIND group. Am J Gastroenterol. 2017;112(2):337–345. doi: 10.1038/ajg.2016.541
   PubMed Web of Science ®Google Scholar
• El-Hussuna A, Krag A, Olaison G, et al. The effect of anti-tumor necrosis factor alpha agents on postoperative anastomotic complications in Crohn’s disease: a systematic review. Dis Colon Rectum. 2013 Dec;56(12):1423–1433. doi:10.1097/DCR.0b013e3182a48505
   PubMed Web of Science ®Google Scholar
• El-Hussuna A, Theede K, Olaison G. Increased risk of post-operative complications in patients with Crohn’s disease treated with antitumour necrosis factor α agents – a systematic review. Dan Med J. 2014;61(12). Accessed Feb 17, 2023. [Online]. Available. https://pubmed.ncbi.nlm.nih.gov/25441731/
   PubMed Web of Science ®Google Scholar
• El-Hussuna A, Iesalnieks I, Horesh N, et al. The effect of pre-operative optimization on post-operative outcome in Crohn’s disease resections. Int J Colorectal Dis. 2017 Jan;32(1):49–56. doi: 10.1007/s00384-016-2655-x.
   PubMed Web of Science ®Google Scholar
• El-Hussuna A. Risk factors for unfavourable postoperative outcome in patients with Crohn’s disease undergoing right hemicolectomy or ileocaecal resection. An international audit by ESCP and S-ECCO. Colorectal Dis. 2017 Mar;20(3):219–227. doi: 10.1111/CODI.13889.
   Web of Science ®Google Scholar
• Galata C, Weiss C, Hardt J, et al. Risk factors for early postoperative complications and length of hospital stay in ileocecal resection and right hemicolectomy for Crohn’s disease: a single-center experience. Int J Colorectal Dis. 2018 Jul;33(7):937–945.
   PubMed Web of Science ®Google Scholar
• Yang SS, Yu CS, Yoon YS, et al. Risk factors for complications after bowel surgery in Korean patients with Crohn’s disease. J Korean Surg Soc. 2012 Sep;83(3):141–148. doi:10.4174/jkss.2012.83.3.141
   PubMedGoogle Scholar
• Yamamoto T, Allan RN, Keighley MRB. Risk factors for intra-abdominal sepsis after surgery in Crohn’s disease. Dis Colon Rectum. 2000; 43(8):1141–1145. doi: 10.1007/BF02236563
   PubMed Web of Science ®Google Scholar
• Hennessey DB, Burke JP, Ni-Dhonochu T, et al. Preoperative hypoalbuminemia is an independent risk factor for the development of surgical site infection following gastrointestinal surgery: a multi-institutional study. Ann Surg. 2010 Aug;252(2):325–329. doi: 10.1097/SLA.0b013e3181e9819a.
   PubMed Web of Science ®Google Scholar
• Sungurtekin H, Sungurtekin U, Balci C, et al. The influence of nutritional status on complications after major intraabdominal surgery. J Am Coll Nutr. 2004 Jun;23(3):227–232. doi:10.1080/07315724.2004.10719365
   PubMed Web of Science ®Google Scholar
• Ding Z, Wu XR, Remer EM, et al. Association between high visceral fat area and postoperative complications in patients with Crohn’s disease following primary surgery. Color Dis. 2016 Feb;18(2):163–172.
   PubMed Web of Science ®Google Scholar
• El-Hussuna A, Hadi S, Iesalnieks I. No difference in postoperative outcome after acute surgery whether the patients presented for first time or are known with Crohn’s disease. Int J Surg Open. 2017;6:1–4. doi: 10.1016/j.ijso.2016.11.001
   Google Scholar
• Garofalo E, Lucarini A, Flashman KG, et al. A positive proximal resection margin is associated with anastomotic complications following primary ileocaecal resection for Crohn’s disease. Int J Colorectal Dis. 2019 Sep;34(9):1585–1590. doi: 10.1007/s00384-019-03358-3.
   PubMed Web of Science ®Google Scholar