Future treatment of vascular calcification in chronic kidney disease

References

• Vashistha V, Lee M, Wu YL, et al. Low glomerular filtration rate and risk of myocardial infarction: a systematic review and meta-analysis. Int J Cardiol. 2016;223:401–409. doi: 10.1016/j.ijcard.2016.07.175
   PubMed Web of Science ®Google Scholar
• Lees JS, Welsh CE, Celis-Morales CA, et al. Glomerular filtration rate by differing measures, albuminuria and prediction of cardiovascular disease, mortality and end-stage kidney disease. Nat Med. 2019;25(11):1753–1760. doi: 10.1038/s41591-019-0627-8
   PubMed Web of Science ®Google Scholar
• Matsushita K, Van der Velde M, Astor BC, et al. Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis. Lancet. 2010;375(9731). doi: 10.1016/S0140-6736(10)60674-5
   PubMed Web of Science ®Google Scholar
• Go AS, Chertow GM, Fan D, et al. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med. 2004;351(13):1296–1305. doi: 10.1056/nejmoa041031
   PubMed Web of Science ®Google Scholar
• Nelson AJ, Raggi P, Wolf M, et al. Targeting vascular calcification in chronic kidney disease. JACC. 2020;5(4):398–412. doi: 10.1016/j.jacbts.2020.02.002
   Google Scholar
• Matsushita K, Sang Y, Ballew SH, et al. Subclinical atherosclerosis measures for cardiovascular prediction in CKD. J Am Soc Nephrol. 2015;26(2):439–447. doi: 10.1681/ASN.2014020173
   PubMed Web of Science ®Google Scholar
• Cozzolino M, Mangano M, Stucchi A, et al. Cardiovascular disease in dialysis patients. Nephrol Dialysis Transplantation. 2018;33(suppl_3):iii28–iii34. doi: 10.1093/ndt/gfy174
   PubMedGoogle Scholar
• Shroff R, Long DA, Shanahan C. Mechanistic insights into vascular calcification in CKD. J Am Soc Nephrol. 2013;24(2):179–189. doi: 10.1681/ASN.2011121191
   PubMed Web of Science ®Google Scholar
• Hénaut L, Chillon JM, Kamel S, et al. Updates on the mechanisms and the care of cardiovascular calcification in chronic kidney disease. Semin Nephrol. 2018;38(3):233–250. doi: 10.1016/j.semnephrol.2018.02.004
   PubMed Web of Science ®Google Scholar
• Voelkl J, Lang F, Eckardt KU, et al. Signaling pathways involved in vascular smooth muscle cell calcification during hyperphosphatemia. Cell Mol Life Sci. 2019. doi:10.1007/s00018-019-03054-z.
   PubMed Web of Science ®Google Scholar
• Bover J, Aguilar A, Arana C, et al. Clinical approach to vascular calcification in patients with non-dialysis dependent chronic kidney disease: mineral-bone disorder-related aspects. Front Med. 2021;8. doi: 10.3389/fmed.2021.642718
   Web of Science ®Google Scholar
• Vervloet M, Cozzolino M. Vascular calcification in chronic kidney disease: different bricks in the wall? Kidney Int. 2017;91(4):808–817. doi: 10.1016/j.kint.2016.09.024
   PubMed Web of Science ®Google Scholar
• Vahed SZ, Mostafavi S, Khatibi SMH, et al. vascular calcification: an important understanding in nephrology. VHRM. 2020;16:167–180. doi: 10.2147/VHRM.S242685
   Google Scholar
• Valdivielso JM, Rodriguez-Puyol D, Pascual J, et al. Atherosclerosis in chronic kidney disease: more, less, or just different? Arteriosclerosis Thrombosis Vasc Biol. 2019;39(10):1938–1966. doi: 10.1161/ATVBAHA.119.312705
   PubMed Web of Science ®Google Scholar
• Zanoli L, Lentini P, Briet M, et al. Arterial stiffness in the heart disease of CKD. J Am Soc Nephrol. 2019;30(6):918–928. doi: 10.1681/asn.2019020117
   PubMed Web of Science ®Google Scholar
• Wang AYM, Woo J, Wang M, et al. Association of inflammation and malnutrition with cardiac valve calcification in continuous ambulatory peritoneal dialysis patients. J Am Soc Nephrol. 2001;12(9):1927–1936. doi: 10.1681/asn.v1291927
   PubMed Web of Science ®Google Scholar
• Virmani R, Joner M, Sakakura K. Recent highlights of ATVB: calcification. Arteriosclerosis Thrombosis Vasc Biol. 2014;34(7):1329–1332. doi: 10.1161/ATVBAHA.114.304000
   PubMed Web of Science ®Google Scholar
• Ix JH, De Boer I, Peralta C, et al. Serum phosphorus concentrations and arterial stiffness among individuals with normal kidney function to moderate kidney disease in MESA. Clin J Am Soc Nephrol. 2009;4(3):609–615. doi: 10.2215/CJN.04100808
   PubMed Web of Science ®Google Scholar
• Chen Z, Qureshi A, Ripsweden J, et al. Vertebral bone density associates with coronary artery calcification and is an independent predictor of poor outcome in end-stage renal disease patients. Bone. 2016;92:50–57. doi: 10.1016/j.bone.2016.08.007
   PubMed Web of Science ®Google Scholar
• Chen J, Budoff M, Reilly M, et al. Coronary artery calcification and risk of cardiovascular disease and death among patients with chronic kidney disease. JAMA Cardiol. 2017;2(6):635. doi: 10.1001/jamacardio.2017.0363
   PubMed Web of Science ®Google Scholar
• Hutcheson JD, Goettsch C. Cardiovascular calcification heterogeneity in chronic kidney disease. Circ Res. 2023;132(8):993–1012. doi: 10.1161/CIRCRESAHA.123.321760
   PubMed Web of Science ®Google Scholar
• Pencak P, Czerwienska B, Ficek R, et al. Calcification of coronary arteries and abdominal aorta in relation to traditional and novel risk factors of atherosclerosis in hemodialysis patients. BMC Nephrol. 2013;14(1). doi: 10.1186/1471-2369-14-10
   PubMedGoogle Scholar
• Bernelot Moens SJ, Verweij S, Van Der Valk F, et al. Arterial and cellular inflammation in patients with CKD. J Am Soc Nephrol. 2017;28(4):1278–1285. doi: 10.1681/ASN.2016030317
   PubMed Web of Science ®Google Scholar
• Libby P, Buring J, Badimon L, et al. Atherosclerosis. Nat Rev Dis Primers. 2019;5(1). doi: 10.1038/s41572-019-0106-z
   PubMedGoogle Scholar
• Jinnouchi H, Sato Y, Sakamoto A, et al. Calcium deposition within coronary atherosclerotic lesion: implications for plaque stability. Atherosclerosis. 2020;306:85–95. doi: 10.1016/j.atherosclerosis.2020.05.017
   PubMed Web of Science ®Google Scholar
• Vliegenthart R, Oudkerk M, Hofman A, et al. Coronary calcification improves cardiovascular risk prediction in the elderly. Circulation. 2005;112(4):572–577. doi: 10.1161/CIRCULATIONAHA.104.488916
   PubMed Web of Science ®Google Scholar
• Mori H, Torii S, Kutyna M, et al. Coronary artery calcification and its progression: what does it really mean? JACC Cardiovasc Imaging. 2018;11(1):127–142. doi: 10.1016/j.jcmg.2017.10.012
   PubMed Web of Science ®Google Scholar
• Criqui MH, Denenberg JO, Ix JH, et al. Calcium density of coronary artery plaque and risk of incident cardiovascular events. JAMA. 2014;311(3):271. doi: 10.1001/jama.2013.282535
   PubMed Web of Science ®Google Scholar
• Reiss AB, Miyawaki N, Moon J, et al. CKD, arterial calcification, atherosclerosis and bone health: inter-relationships and controversies. Atherosclerosis. 2018;278:49–59. doi: 10.1016/j.atherosclerosis.2018.08.046
   PubMed Web of Science ®Google Scholar
• Sage AP, Tintut Y, Demer LL. Regulatory mechanisms in vascular calcification. Nat Rev Cardiol. 2010;7(9):528–536. doi: 10.1038/nrcardio.2010.115
   PubMed Web of Science ®Google Scholar
• Shi X, Gao J, Lv Q, et al. Calcification in atherosclerotic plaque vulnerability: friend or foe? Front Physiol. 2020;11: doi: 10.3389/fphys.2020.00056
   Web of Science ®Google Scholar
• Kawtharany L, Bessueille L, Issa H, et al. Inflammation and microcalcification: a never-ending vicious cycle in atherosclerosis? J Vasc Res. 2022;59(3):137–150. doi: 10.1159/000521161
   PubMed Web of Science ®Google Scholar
• Lanzer P, Hannan FM, Lanzer JD, et al. Medial arterial calcification: JACC state-of-the-art review. J Am Coll Cardiol. 2021;78(11):1145–1165. doi: 10.1016/j.jacc.2021.06.049
   PubMed Web of Science ®Google Scholar
• London GM, Guérin AP, Marchais SJ, et al. Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality. Nephrol Dialysis Transplantation. 2003;18(9):1731–1740. doi: 10.1093/ndt/gfg414
   PubMed Web of Science ®Google Scholar
• Niskanen L, Siitonen O, Suhonen M, et al. Medial artery calcification predicts cardiovascular mortality in patients with NIDDM. Diabetes Care. 1994;17(11):1252–1256. doi: 10.2337/diacare.17.11.1252
   PubMed Web of Science ®Google Scholar
• Lehto S, Niskanen L, Suhonen M, et al. Medial artery calcification: a neglected harbinger of cardiovascular complications in non-insulin-dependent diabetes mellitus. Arterioscler Thromb Vasc Biol. 1996;16(8):978–983. doi: 10.1161/01.ATV.16.8.978
   PubMed Web of Science ®Google Scholar
• Shanahan CM. Mechanisms of vascular calcification in CKD—evidence for premature ageing? Nat Rev Nephrol. 2013;9(11):661–670. doi: 10.1038/nrneph.2013.176
   PubMed Web of Science ®Google Scholar
• Losurdo F, Ferraresi R, Ucci A, et al. Association of infrapopliteal medial arterial calcification with lower-limb amputations in high-risk patients: a systematic review and meta-analysis. Vascular Medicine (United Kingdom). 2021;26(2):164–173. doi: 10.1177/1358863X20979738
   PubMed Web of Science ®Google Scholar
• Paoletti E, Bellino D, Cassottana P, et al. Left ventricular hypertrophy in nondiabetic predialysis CKD. Am J Kidney Diseases. 2005;46(2):320–327. doi: 10.1053/j.ajkd.2005.04.031
   PubMed Web of Science ®Google Scholar
• Ritz E. Left ventricular hypertrophy in renal disease: beyond preload and afterload. Kidney Int. 2009;75(8):771–773. doi: 10.1038/ki.2009.35
   PubMed Web of Science ®Google Scholar
• Baber U, Howard VJ, Halperin JL, et al. Association of chronic kidney disease with atrial fibrillation among adults in the United States REasons for geographic and racial differences in stroke (REGARDS) study. Circ Arrhythm Electrophysiol. 2011;4(1):26–32. doi: 10.1161/CIRCEP.110.957100
   PubMed Web of Science ®Google Scholar
• Huang CL, Wu IH, Wu YW, et al. Association of lower extremity arterial calcification with amputation and mortality in patients with symptomatic peripheral artery disease. PLoS One. 2014;9(2):e90201. doi: 10.1371/journal.pone.0090201
   PubMed Web of Science ®Google Scholar
• Roijers JP, Rakké YS, Hopmans CJ, et al. A mortality prediction model for elderly patients with critical limb ischemia. J Vasc Surg. 2020;71(6):2065–2072.e2. doi: 10.1016/j.jvs.2019.08.245
   PubMed Web of Science ®Google Scholar
• Chen W, Melamed ML. Vascular calcification in predialysis CKD: common and deadly. Clin J Am Soc Nephrol. 2015;10(4):551–553. doi: 10.2215/CJN.01940215
   PubMed Web of Science ®Google Scholar
• Ureña-Torres P, D’Marco L, Raggi P, et al. Valvular heart disease and calcification in CKD: more common than appreciated. Nephrol Dialysis Transplantation. 2021;35(12):2046–2053. doi: 10.1093/NDT/GFZ133
   Web of Science ®Google Scholar
• Leopold JA. Cellular mechanisms of aortic valve calcification. Circ Cardiovasc Interv. 2012;5(4):605–614. doi: 10.1161/CIRCINTERVENTIONS.112.971028
   PubMed Web of Science ®Google Scholar
• Di Lullo L, Gorini A, Bellasi A, et al. Fibroblast growth factor 23 and parathyroid hormone predict extent of aortic valve calcifications in patients with mild to moderate chronic kidney disease. Clin Kidney J. 2015;8(6):732–736. doi: 10.1093/ckj/sfv073
   PubMedGoogle Scholar
• Linefsky JP, OBrien KD, Katz R, et al. Association of serum phosphate levels with aortic valve sclerosis and annular calcification. J Am Coll Cardiol. 2011;58(3):291–297. doi: 10.1016/j.jacc.2010.11.073
   PubMed Web of Science ®Google Scholar
• Brandenburg VM, Schuh A, Kramann R. Valvular calcification in chronic kidney disease. Adv Chronic Kidney Dis. 2019;26(6):464–471. doi: 10.1053/j.ackd.2019.10.004
   PubMed Web of Science ®Google Scholar
• Amann K. Media calcification and intima calcification are distinct entities in chronic kidney disease. Clin J Am Soc Nephrol. 2008;3(6):1599–1605. doi: 10.2215/CJN.02120508
   PubMed Web of Science ®Google Scholar
• Adeney KL, Siscovick DS, Ix JH, et al. Association of serum phosphate with vascular and valvular calcification in moderate CKD. J Am Soc Nephrol. 2009;20(2):381–387. doi: 10.1681/ASN.2008040349
   PubMed Web of Science ®Google Scholar
• Cianciolo G, Manna GL, Capelli I, et al. The role of activin: the other side of chronic kidney disease–mineral bone disorder? Nephrol Dialysis Transplantation. 2021;36(6):966–974. doi: 10.1093/ndt/gfaa203
   PubMed Web of Science ®Google Scholar
• Marreiros C, Viegas C, Simes D. Targeting a silent disease: vascular calcification in chronic kidney disease. IJMS. 2022;23(24):16114. doi: 10.3390/ijms232416114
   Google Scholar
• Kanbay M, Copur S, Tanriover C, et al. The pathophysiology and management of vascular calcification in chronic kidney disease patients. Expert Rev Cardiovasc Ther. 2023;21(2):75–85. doi: 10.1080/14779072.2023.2174525
   PubMed Web of Science ®Google Scholar
• Cannata‐Andía JB, Carrillo‐López N, Messina OD, et al. Pathophysiology of vascular calcification and bone loss: linked disorders of ageing? Nutrients. 2021;13(11):3835. doi: 10.3390/nu13113835
   PubMed Web of Science ®Google Scholar
• Evenepoel P, Dejongh S, Verbeke K, et al. The role of gut dysbiosis in the bone–vascular axis in chronic kidney disease. Toxins (Basel). 2020;12(5):285. doi: 10.3390/toxins12050285
   PubMed Web of Science ®Google Scholar
• Moe SM, Drüeke TB. Kidney disease: improving global outcomes (KDIGO) CKD-MBD work group. KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease–mineral and bone disorder (CKD–MBD). Kidney Int. 2009;76(113):S1–S130.
   Google Scholar
• Mok Y, Wang F, Ballew SH, et al. Kidney function, bone-mineral metabolism markers, and calcification of coronary arteries, aorta, and cardiac valves in older adults. Atherosclerosis. 2023;368:35–43. doi: 10.1016/j.atherosclerosis.2023.01.007
   PubMed Web of Science ®Google Scholar
• Cozzolino M, Ciceri P, Galassi A, et al. The key role of phosphate on vascular calcification. Toxins (Basel). 2019;11(4):213. doi: 10.3390/toxins11040213
   PubMed Web of Science ®Google Scholar
• Haarhaus M, Cianciolo G, Barbuto S, et al. Alkaline phosphatase: an old friend as treatment target for cardiovascular and mineral bone disorders in chronic kidney disease. Nutrients. 2022;14(10):2124. doi: 10.3390/nu14102124
   PubMed Web of Science ®Google Scholar
• Ciceri P, Elli F, Cappelletti L, et al. A new in vitro model to delay high phosphate-induced vascular calcification progression. Mol Cell Biochem. 2015;410(1–2):197–206. doi: 10.1007/s11010-015-2552-6
   PubMed Web of Science ®Google Scholar
• Liu L, Liu Y, Zhang Y, et al. High phosphate-induced downregulation of PPARγ contributes to CKD-associated vascular calcification. J Mol Cell Cardiol. 2018;114:264–275. doi: 10.1016/j.yjmcc.2017.11.021
   PubMed Web of Science ®Google Scholar
• Baron R, Rawadi G. Minireview: targeting the Wnt/β-catenin pathway to regulate bone formation in the adult skeleton. Endocrinology. 2007;148(6):2635–2643. doi: 10.1210/en.2007-0270
   PubMed Web of Science ®Google Scholar
• Carrillo-López N, Panizo S, Alonso-Montes C, et al. Direct inhibition of osteoblastic Wnt pathway by fibroblast growth factor 23 contributes to bone loss in chronic kidney disease. Kidney Int. 2016;90(1):77–89. doi: 10.1016/j.kint.2016.01.024
   PubMed Web of Science ®Google Scholar
• Huber BC. Impact of parathyroid hormone on bone marrow-derived stem cell mobilization and migration. World J Stem Cells. 2014;6(5):637. doi: 10.4252/wjsc.v6.i5.637
   PubMedGoogle Scholar
• Cianciolo G, Galassi A, Capelli I, et al. Klotho-FGF23, cardiovascular disease, and vascular calcification: black or white? Curr Vasc Pharmacol. 2017;16(2):143–156. doi: 10.2174/1570161115666170310092202
   Web of Science ®Google Scholar
• Kuro-O M. Ageing-related receptors resolved. Nature. 2018;553(7689):409–410. doi: 10.1038/d41586-017-09032-4
   Web of Science ®Google Scholar
• Kuro-O M, Matsumura Y, Aizawa H, et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature. 1997;390(6655):45–51. doi: 10.1038/36285
   PubMed Web of Science ®Google Scholar
• Shimada T, Kakitani M, Yamazaki Y, et al. Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J Clin Investig. 2004;113(4):561–568. doi: 10.1172/JCI200419081
   PubMed Web of Science ®Google Scholar
• Lindberg K, Olauson H, Amin R, et al. Arterial Klotho expression and FGF23 effects on vascular calcification and function. PLoS One. 2013;8(4):e60658. doi: 10.1371/journal.pone.0060658
   PubMed Web of Science ®Google Scholar
• Mencke R, Hillebrands JL. The role of the anti-ageing protein Klotho in vascular physiology and pathophysiology. Ageing Res Rev. 2017;35:124–146. doi: 10.1016/j.arr.2016.09.001
   PubMed Web of Science ®Google Scholar
• Faul C, Wolf M. Hunt for the culprit of cardiovascular injury in kidney disease: figure 1. Cardiovasc Res. 2015;108(2):209–211. doi: 10.1093/cvr/cvv228
   PubMed Web of Science ®Google Scholar
• Martin A, David V, Darryl Quarles L. Regulation and function of the FGF23/klotho endocrine pathways. Physiol Rev. 2012;92(1):131–155. doi: 10.1152/physrev.00002.2011
   PubMed Web of Science ®Google Scholar
• Faul C, Amaral AP, Oskouei B, et al. FGF23 induces left ventricular hypertrophy. J Clin Investig. 2011;121(11):4393–4408. doi: 10.1172/JCI46122
   PubMed Web of Science ®Google Scholar
• Leifheit-Nestler M, Siemer RG, Flasbart K, et al. Induction of cardiac FGF23/FGFR4 expression is associated with left ventricular hypertrophy in patients with chronic kidney disease. Nephrol Dialysis Transplantation. 2016;31(7):1088–1099. doi: 10.1093/ndt/gfv421
   PubMed Web of Science ®Google Scholar
• Durlacher-Betzer K, Hassan A, Levi R, et al. Interleukin-6 contributes to the increase in fibroblast growth factor 23 expression in acute and chronic kidney disease. Kidney Int. 2018;94(2):315–325. doi: 10.1016/j.kint.2018.02.026
   PubMed Web of Science ®Google Scholar
• Czaya B, Faul C. FGF23 and inflammation—a vicious coalition in CKD. Kidney Int. 2019;96(4):813–815. doi: 10.1016/j.kint.2019.05.018
   PubMed Web of Science ®Google Scholar
• Komaba H, Fukagawa M. The role of FGF23 in CKD—with or without Klotho. Nat Rev Nephrol. 2012;8(8):484–490. doi: 10.1038/nrneph.2012.116
   PubMed Web of Science ®Google Scholar
• Mirza MAI, Larsson A, Melhus H, et al. Serum intact FGF23 associate with left ventricular mass, hypertrophy and geometry in an elderly population. Atherosclerosis. 2009;207(2):546–551. doi: 10.1016/j.atherosclerosis.2009.05.013
   PubMed Web of Science ®Google Scholar
• Jimbo R, Kawakami-Mori F, Mu S, et al. Fibroblast growth factor 23 accelerates phosphate-induced vascular calcification in the absence of Klotho deficiency. Kidney Int. 2014;85(5):1103–1111. doi: 10.1038/ki.2013.332
   PubMed Web of Science ®Google Scholar
• Schoppet M, Hofbauer LC, Brinskelle-Schmal N, et al. Serum level of the phosphaturic factor FGF23 is associated with abdominal aortic calcification in men: the STRAMBO study. J Clin Endocrinol Metab. 2012;97(4):E575–E583. doi: 10.1210/jc.2011-2836
   PubMed Web of Science ®Google Scholar
• Khan AM, Chirinos JA, Litt H, et al. FGF-23 and the progression of coronary arterial calcification in patients new to dialysis. Clin J Am Soc Nephrol. 2012;7(12):2017–2022. doi: 10.2215/CJN.02160212
   PubMed Web of Science ®Google Scholar
• Ozkok A, Kekik C, Karahan GE, et al. FGF-23 associated with the progression of coronary artery calcification in hemodialysis patients. BMC Nephrol. 2013;14(1). doi: 10.1186/1471-2369-14-241
   PubMedGoogle Scholar
• Tamei N, Ogawa T, Ishida H, et al. Serum fibroblast growth factor-23 levels and progression of aortic arch calcification in non-diabetic patients on chronic hemodialysis. J Atheroscler Thromb. 2011;18(3):217–223. doi: 10.5551/jat.5595
   PubMed Web of Science ®Google Scholar
• Viegas CSB, Santos L, Macedo AL, et al. Chronic kidney disease circulating calciprotein particles and extracellular vesicles promote vascular calcification: a role for GRP (Gla-rich protein). Arterioscler Thromb Vasc Biol. 2018;38(3):575–587. doi: 10.1161/ATVBAHA.117.310578
   PubMed Web of Science ®Google Scholar
• Schurgers LJ, Uitto J, Reutelingsperger CP. Vitamin K-dependent carboxylation of matrix Gla-protein: a crucial switch to control ectopic mineralization. Trends Mol Med. 2013;19(4):217–226. doi: 10.1016/j.molmed.2012.12.008
   PubMed Web of Science ®Google Scholar
• Fusaro M, Noale M, Viola V, et al. Vitamin K, vertebral fractures, vascular calcifications, and mortality: VItamin K Italian (VIKI) dialysis study. J Bone Miner Res. 2012;27(11):2271–2278. doi: 10.1002/jbmr.1677
   PubMed Web of Science ®Google Scholar
• Shea MK, Booth SL, Miller ME, et al. Association between circulating vitamin K1 and coronary calcium progression in community-dwelling adults: the multi-ethnic study of atherosclerosis. Am J Clin Nutr. 2013;98(1):197–208. doi: 10.3945/ajcn.112.056101
   PubMed Web of Science ®Google Scholar
• Rattazzi M, Bennett BJ, Bea F, et al. Calcification of advanced atherosclerotic lesions in the innominate arteries of ApoE-deficient mice: potential role of chondrocyte-like cells. Arterioscler Thromb Vasc Biol. 2005;25(7):1420–1425. doi: 10.1161/01.ATV.0000166600.58468.1b
   PubMed Web of Science ®Google Scholar
• Fadini GP, Rattazzi M, Matsumoto T, et al. Emerging role of circulating calcifying cells in the bone-vascular axis. Circulation. 2012;125(22):2772–2781. doi: 10.1161/CIRCULATIONAHA.112.090860
   PubMed Web of Science ®Google Scholar
• Gössl M, Mödder UI, Atkinson EJ, et al. Osteocalcin expression by circulating endothelial progenitor cells in patients with coronary atherosclerosis. J Am Coll Cardiol. 2008;52(16):1314–1325. doi: 10.1016/j.jacc.2008.07.019
   PubMed Web of Science ®Google Scholar
• Fadini GP, Albiero M, Menegazzo L, et al. Procalcific phenotypic drift of circulating progenitor cells in type 2 diabetes with coronary artery disease. Exp Diabetes Res. 2012;2012:1–7. doi: 10.1155/2012/921685
   Google Scholar
• Cianciolo G, Capelli I, Cappuccilli M, et al. Calcifying circulating cells: an uncharted area in the setting of vascular calcification in CKD patients. Clin Kidney J. 2016;9(2):280–286. doi: 10.1093/ckj/sfv145
   PubMed Web of Science ®Google Scholar
• Cianciolo G, Manna GL, Della Bella E, et al. Effect of vitamin D receptor activator therapy on vitamin D receptor and osteocalcin expression in circulating endothelial progenitor cells of hemodialysis patients. Blood Purif. 2013;35(1–3):187–195. doi: 10.1159/000347102
   PubMed Web of Science ®Google Scholar
• Mazzaferro S, Cianciolo G, De Pascalis A, et al. Bone, inflammation and the bone marrow niche in chronic kidney disease: what do we know? Nephrol Dialysis Transplantation. 2018;33(12):2092–2100. doi: 10.1093/ndt/gfy115
   PubMed Web of Science ®Google Scholar
• Fadini GP, Albiero M, Menegazzo L, et al. Widespread increase in myeloid calcifying cells contributes to ectopic vascular calcification in type 2 diabetes. Circ Res. 2011;108(9):1112–1121. doi: 10.1161/CIRCRESAHA.110.234088
   PubMed Web of Science ®Google Scholar
• Menegazzo L, Albiero M, Millioni R, et al. Circulating myeloid calcifying cells have antiangiogenic activity via thrombospondin-1 overexpression. FASEB J. 2013;27(11):4355–4365. doi: 10.1096/fj.12-223719
   PubMed Web of Science ®Google Scholar
• Hou YC, Lu CL, Yuan TH, et al. The epigenetic landscape of vascular calcification: an integrative perspective. Int J Mol Sci. 2020;21(3):980. doi: 10.3390/ijms21030980
   PubMed Web of Science ®Google Scholar
• Wang C, Xu W, An J, et al. Poly(adp-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2. Nat Commun. 2019;10(1). doi: 10.1038/s41467-019-09174-1
   Google Scholar
• Agatston AS, Janowitz WR, Hildner FJ, et al. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol. 1990;15(4):827–832. doi: 10.1016/0735-1097(90)90282-T
   PubMed Web of Science ®Google Scholar
• Yeboah J, McClelland RL, Polonsky TS, et al. Comparison of novel risk markers for improvement in cardiovascular risk assessment in intermediate-risk individuals. JAMA. 2012;308(8):788. doi: 10.1001/jama.2012.9624
   PubMed Web of Science ®Google Scholar
• Wang XR, Zhang JJ, Xu XX, et al. Prevalence of coronary artery calcification and its association with mortality, cardiovascular events in patients with chronic kidney disease: a systematic review and meta-analysis. Ren Fail. 2019;41(1):244–256. doi: 10.1080/0886022X.2019.1595646
   PubMed Web of Science ®Google Scholar
• Ketteler M, Block GA, Evenepoel P, et al. Diagnosis, evaluation, prevention, and treatment of chronic kidney disease–mineral and bone disorder: synopsis of the kidney disease: improving global outcomes 2017 clinical practice guideline update. Ann internal med. 2018;168(6):422. doi: 10.7326/M17-2640
   PubMed Web of Science ®Google Scholar
• Adragão T, Pires A, Birne R, et al. A plain X-ray vascular calcification score is associated with arterial stiffness and mortality in dialysis patients. Nephrol Dialysis Transplantation. 2009;24(3):997–1002. doi: 10.1093/ndt/gfn584
   PubMed Web of Science ®Google Scholar
• Kauppila LI, Polak JF, Cupples LA, et al. New indices to classify location, severity and progression of calcific lesions in the abdominal aorta: a 25-year follow-up study. Atherosclerosis. 1997;132(2):245–250. doi: 10.1016/S0021-9150(97)00106-8
   PubMed Web of Science ®Google Scholar
• Bellasi A, Ferramosca E, Muntner P, et al. Correlation of simple imaging tests and coronary artery calcium measured by computed tomography in hemodialysis patients. Kidney Int. 2006;70(9):1623–1628. doi: 10.1038/sj.ki.5001820
   PubMed Web of Science ®Google Scholar
• Utsunomiya H, Yamamoto H, Urabe Y, et al. Association between heart calcification assessed by echocardiography and future cardiovascular disease mortality and morbidity. IJC Heart And Vessels. 2013;2:15–20. doi: 10.1016/j.ijchv.2013.11.007
   PubMedGoogle Scholar
• Zebboudj AF, Imura M, Boström K. Matrix GLA protein, a regulatory protein for bone morphogenetic protein-2. J Biol Chem. 2002;277(6):4388–4394. doi: 10.1074/jbc.M109683200
   PubMed Web of Science ®Google Scholar
• Raggi P, Bellasi A. Clinical assessment of vascular calcification. Adv Chronic Kidney Dis. 2007;14(1):37–43. doi: 10.1053/j.ackd.2006.10.006
   PubMed Web of Science ®Google Scholar
• Desjardins L, Liabeuf S, Renard C, et al. FGF23 is independently associated with vascular calcification but not bone mineral density in patients at various CKD stages. Osteoporosis Int. 2012;23(7):2017–2025. doi: 10.1007/s00198-011-1838-0
   PubMed Web of Science ®Google Scholar
• Scialla JJ, Xie H, Rahman M, et al. Fibroblast growth factor-23 and cardiovascular events in CKD. J Am Soc Nephrol. 2014;25(2):349–360. doi: 10.1681/ASN.2013050465
   PubMed Web of Science ®Google Scholar
• Turan MN, Kircelli F, Yaprak M, et al. FGF-23 levels are associated with vascular calcification, but not with atherosclerosis, in hemodialysis patients. Int Urol Nephrol. 2016;48(4):609–617. doi: 10.1007/s11255-016-1231-1
   PubMed Web of Science ®Google Scholar
• Hu MC, Shi M, Zhang J, et al. Klotho deficiency causes vascular calcification in chronic kidney disease. J Am Soc Nephrol. 2011;22(1):124–136. doi: 10.1681/ASN.2009121311
   PubMed Web of Science ®Google Scholar
• Komaba H, Fukagawa M. Fetuin–mineral complex: a new potential biomarker for vascular calcification? Kidney Int. 2009;75(9):874–876. doi: 10.1038/ki.2009.52
   PubMed Web of Science ®Google Scholar
• Ketteler M, Bongartz P, Westenfeld R, et al. Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study. Lancet. 2003;361(9360):827–833. doi: 10.1016/S0140-6736(03)12710-9
   PubMed Web of Science ®Google Scholar
• Pasch A. Novel assessments of systemic calcification propensity. Curr Opin Nephrol Hypertens. 2016;25(4):278–284. doi: 10.1097/MNH.0000000000000237
   PubMed Web of Science ®Google Scholar
• Nollet L, Van Gils M, Fischer S, et al. Serum calcification propensity T50 associates with disease severity in patients with Pseudoxanthoma Elasticum. J Clin Med. 2022;11(13):3727. doi: 10.3390/jcm11133727
   PubMed Web of Science ®Google Scholar
• Lomashvili KA, Wang X, Wallin R, et al. Matrix gla protein metabolism in vascular smooth muscle and role in uremic vascular calcification. J Biol Chem. 2011;286(33):28715–28722. doi: 10.1074/jbc.M111.251462
   PubMed Web of Science ®Google Scholar
• Delanaye P, Krzesinski JM, Warling X, et al. Dephosphorylated-uncarboxylated matrix Gla protein concentration is predictive of vitamin K status and is correlated with vascular calcification in a cohort of hemodialysis patients. BMC Nephrol. 2014;15(1). doi: 10.1186/1471-2369-15-145
   Google Scholar
• Munroe PB, Olgunturk RO, Fryns JP, et al. Mutations in the gene encoding the human matrix Gla protein cause keutel syndrome. Nat Genet. 1999;21(1):142–144. doi: 10.1038/5102
   PubMed Web of Science ®Google Scholar
• Leonor Cancela M, Conceição N, Laizé V. Gla-rich protein, a new player in tissue calcification? Adv Nutr. 2012;3(2):174–181. doi: 10.3945/an.111.001685
   PubMed Web of Science ®Google Scholar
• Xu C, Smith ER, Tiong MK, et al. Interventions to attenuate vascular calcification progression in chronic kidney disease: a systematic review of clinical trials. J Am Soc Nephrol. 2022;33(5):1011–1032. doi: 10.1681/ASN.2021101327
   PubMed Web of Science ®Google Scholar
• Floege J. Phosphate binders in chronic kidney disease: an updated narrative review of recent data. J Nephrol. 2020;33(3):497–508. doi: 10.1007/s40620-019-00689-w
   PubMed Web of Science ®Google Scholar
• Gosik R, Danel K. The rising risk of chronic kidney disease (CKD) and how it is dealt with: a review of Current and potential phosphate binders (PB). MRMC. 2021;21(19):3052–3061. doi: 10.2174/1389557521666210616161728
   Google Scholar
• Neradova A, Schumacher SP, Hubeek I, et al. Phosphate binders affect vitamin K concentration by undesired binding, an in vitro study. BMC Nephrol. 2017;18(1). doi: 10.1186/s12882-017-0560-3
   PubMedGoogle Scholar
• Ogata H, Takeshima A, Ito H. An update on phosphate binders for the treatment of hyperphosphatemia in chronic kidney disease patients on dialysis: a review of safety profiles. Expert Opin Drug Saf. 2022;21(7):947–955. doi: 10.1080/14740338.2022.2044472
   PubMed Web of Science ®Google Scholar
• Raggi P, Bommer J, Chertow GM. Valvular calcification in hemodialysis patients randomized to calcium-based phosphorus binders or sevelamer. J Heart Valve Disease. 2004;13(1):134–41.
   PubMed Web of Science ®Google Scholar
• Galassi A, Spiegel DM, Bellasi A, et al. Accelerated vascular calcification and relative hypoparathyroidism in incident haemodialysis diabetic patients receiving calcium binders. Nephrol Dialysis Transplantation. 2006;21(11):3215–3222. doi: 10.1093/ndt/gfl395
   PubMed Web of Science ®Google Scholar
• Qunibi W, Moustafa M, Muenz LR, et al. A 1-year randomized trial of calcium acetate versus sevelamer on progression of coronary artery calcification in hemodialysis patients with comparable lipid control: the calcium acetate renagel evaluation-2 (CARE-2) study. Am J Kidney Diseases. 2008;51(6):952–965. doi: 10.1053/j.ajkd.2008.02.298
   PubMed Web of Science ®Google Scholar
• Barreto DV, Barreto FDC, De Carvalho AB, et al. Phosphate binder impact on bone remodeling and coronary calcification – results from the BRiC study. Nephron Clin Pract. 2008;110(4):c273–c283. doi: 10.1159/000170783
   PubMed Web of Science ®Google Scholar
• Toussaint ND, Pedagogos E, Lioufas NM, et al. A randomized trial on the effect of phosphate reduction on vascular end points in CKD (improve-CKD). J Am Soc Nephrol. 2020;31(11):2653–2666. doi: 10.1681/ASN.2020040411
   PubMed Web of Science ®Google Scholar
• Mozos I, Marginean O. Links between vitamin D deficiency and cardiovascular diseases. Bio Med Res Int. 2015;2015:1–12. doi: 10.1155/2015/109275
   Google Scholar
• Watson KE, Abrolat ML, Malone LL, et al. Active serum vitamin D levels are inversely correlated with coronary calcification. Circulation. 1997;96(6):1755–1760. doi: 10.1161/01.CIR.96.6.1755
   PubMed Web of Science ®Google Scholar
• Levin A, Yan CL. Vitamin D and its analogues: do they protect against cardiovascular disease in patients with kidney disease? Kidney Int. 2005;68(5):1973–1981. doi: 10.1111/j.1523-1755.2005.00651.x
   PubMed Web of Science ®Google Scholar
• Cheng S, Coyne D. Oral paricalcitol for the treatment of secondary hyperparathyroidism in chronic kidney disease. Ther Clin Risk Manag. 2006;2(3):297–301. doi: 10.2147/tcrm.2006.2.3.297
   PubMedGoogle Scholar
• Lau WL, Leaf EM, Hu MC, et al. Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet. Kidney Int. 2012;82(12):1261–1270. doi: 10.1038/ki.2012.322
   PubMed Web of Science ®Google Scholar
• Slatopolsky E, Finch J, Ritter C, et al. A new analog of calcitriol, 19-nor-1,25-(OH)2D2, suppresses parathyroid hormone secretion in uremic rats in the absence of hypercalcemia. Am J Kidney Diseases. 1995;26(5):852–860. doi: 10.1016/0272-6386(95)90455-7
   PubMed Web of Science ®Google Scholar
• Mizobuchi M, Finch JL, Martin DR, et al. Differential effects of vitamin D receptor activators on vascular calcification in uremic rats. Kidney Int. 2007;72(6):709–715. doi: 10.1038/sj.ki.5002406
   PubMed Web of Science ®Google Scholar
• Bellasi A, Reiner M, Pétavy F, et al. Presence of valvular calcification predicts the response to cinacalcet: data from the ADVANCE study. J Heart Valve Dis. 2013;22(3):391–9.
   PubMed Web of Science ®Google Scholar
• Anis KH, Pober D, Rosas SE. Vitamin D analogues and coronary calcification in CKD stages 3 and 4: a randomized controlled trial of calcitriol versus paricalcitol. Kidney Med. 2020;2(4):450–458. doi: 10.1016/j.xkme.2020.05.009
   PubMedGoogle Scholar
• Sundararaman SS, van der Vorst EPC. Calcium-sensing receptor (casr), its impact on inflammation and the consequences on cardiovascular health. Int J Mol Sci. 2021;22(5):2478. doi: 10.3390/ijms22052478
   PubMed Web of Science ®Google Scholar
• Torres PAU, De Broe M. Calcium-sensing receptor, calcimimetics, and cardiovascular calcifications in chronic kidney disease. Kidney Int. 2012;82(1):19–25. doi: 10.1038/ki.2012.69
   PubMed Web of Science ®Google Scholar
• Raggi P, Chertow GM, Torres PU, et al. The ADVANCE study: a randomized study to evaluate the effects of cinacalcet plus low-dose vitamin D on vascular calcification in patients on hemodialysis. Nephrol Dialysis Transplantation. 2011;26(4):1327–1339. doi: 10.1093/ndt/gfq725
   PubMed Web of Science ®Google Scholar
• Koleganova N, Piecha G, Ritz E, et al. A calcimimetic (R-568), but not calcitriol, prevents vascular remodeling in uremia. Kidney Int. 2009;75(1):60–71. doi: 10.1038/ki.2008.490
   PubMed Web of Science ®Google Scholar
• Shoji T, Nakatani S, Kabata D, et al. Comparative effects of etelcalcetide and maxacalcitol on serum calcification propensity in secondary hyperparathyroidism a randomized clinical trial. Clin J Am Soc Nephrol. 2021;16(4):599–612. doi: 10.2215/CJN.16601020
   PubMed Web of Science ®Google Scholar
• Giger EV, Castagner B, Leroux JC. Biomedical applications of bisphosphonates. JControlled Release. 2013;167(2):175–188. doi: 10.1016/j.jconrel.2013.01.032
   PubMed Web of Science ®Google Scholar
• Li Q, Kingman J, Sundberg JP, et al. Etidronate prevents, but does not reverse, ectopic mineralization in a mouse model of pseudoxanthoma elasticum (Abcc6−/−). Oncotarget. 2018;9(56):30721–30730. doi: 10.18632/oncotarget.10738
   PubMedGoogle Scholar
• Hildebrand S, Cunningham J. Is there a role for bisphosphonates in vascular calcification in chronic kidney disease? Bone. 2021;142:115751. doi: 10.1016/j.bone.2020.115751
   PubMed Web of Science ®Google Scholar
• Caffarelli C, Montagnani A, Nuti R, et al. Bisphosphonates, atherosclerosis and vascular calcification: update and systematic review of clinical studies. Clin Interventions Aging. 2017;12:1819–1828. doi: 10.2147/CIA.S138002
   PubMed Web of Science ®Google Scholar
• Singh A, Tandon S, Tandon C. An update on vascular calcification and potential therapeutics. Mol Biol Rep. 2021;48(1):887–896. doi: 10.1007/s11033-020-06086-y
   PubMed Web of Science ®Google Scholar
• Roumeliotis S, Duni A, Vaios V, et al. Vitamin K supplementation for prevention of vascular calcification in chronic kidney disease patients: are we there yet? Nutrients. 2022;14(5):925. doi: 10.3390/nu14050925
   PubMed Web of Science ®Google Scholar
• Cozzolino M, Mangano M, Galassi A, et al. Vitamin K in chronic kidney disease. Nutrients. 2019 Jan 14;11(1): 168. PMID: 30646590; PMCID: PMC6356438.]. 10.3390/nu11010168.
   PubMed Web of Science ®Google Scholar
• Li Y, Xie Z, Xu D. Inhibition of maintenance hemodialysis related vascular calcification by vitamin K in chronic kidney disease. Int J Clin Exp Med. 2017;10(11):15309–15315.
   Web of Science ®Google Scholar
• Lin YL, Hsu BG. Vitamin K and vascular calcification in chronic kidney disease: an update of current evidence. Tzu Chi Med J. 2023;35(1):44. doi: 10.4103/tcmj.tcmj_100_22
   PubMed Web of Science ®Google Scholar
• Wen W, Portales-Castillo I, Seethapathy R, et al. Intravenous sodium thiosulphate for vascular calcification of hemodialysis patients—a systematic review and meta-analysis. Nephrol Dialysis Transplantation. 2023;38(3):733–745. doi: 10.1093/ndt/gfac171
   PubMed Web of Science ®Google Scholar
• Song YH, Wang SY, Lang JH, et al. Therapeutic effect of intravenous sodium thiosulfate for uremic pruritus in hemodialysis patients. Ren Fail. 2020;42(1):987–993. doi: 10.1080/0886022X.2020.1822867
   PubMed Web of Science ®Google Scholar
• Djuric P, Dimkovic N, Schlieper G, et al. Sodium thiosulphate and progression of vascular calcification in end-stage renal disease patients: a double-blind, randomized, placebo-controlled study. Nephrol Dialysis Transplantation. 2020;35(1):162–169. doi: 10.1093/ndt/gfz204
   PubMed Web of Science ®Google Scholar
• Chen NC, Hsu CY, Chen CL. The strategy to prevent and regress the vascular calcification in dialysis patients. Bio Med Res Int. 2017;2017:1–11. doi: 10.1155/2017/9035193
   Google Scholar
• Iseri K, Watanabe M, Yoshikawa H, et al. Effects of denosumab and alendronate on bone Health and vascular function in hemodialysis patients: a randomized, controlled trial. J Bone Mineral Res. 2019;34(6):1014–1024. doi: 10.1002/jbmr.3676
   PubMed Web of Science ®Google Scholar
• Cianciolo G, Tondolo F, Barbuto S, et al. Denosumab-induced hypocalcemia and hyperparathyroidism in de novo kidney transplant recipients. Am J Nephrol. 2021;52(8):611–619. doi: 10.1159/000518363
   PubMed Web of Science ®Google Scholar
• Goettsch C, Strzelecka-Kiliszek A, Bessueille L, et al. TNAP as a therapeutic target for cardiovascular calcification: a discussion of its pleiotropic functions in the body. Cardiovasc Res. 2022;118(1):84–96. doi: 10.1093/cvr/cvaa299
   PubMed Web of Science ®Google Scholar
• Tani T, Fujiwara M, Orimo H, et al. Inhibition of tissue-nonspecific alkaline phosphatase protects against medial arterial calcification and improves survival probability in the CKD-MBD mouse model. J Pathol. 2020;250(1):30–41. doi: 10.1002/path.5346
   PubMed Web of Science ®Google Scholar
• Sinha S, Raggi P, Chertow GM. SNF472: mechanism of action and results from clinical trials. Curr Opin Nephrol Hypertens. 2021;30(4):424–429. doi: 10.1097/MNH.0000000000000726
   PubMed Web of Science ®Google Scholar
• Zabirnyk A, Ferrer MD, Bogdanova M, et al. SNF472, a novel anti-crystallization agent, inhibits induced calcification in an in vitro model of human aortic valve calcification. Vasc Pharmacol. 2019;122-123:106583. doi: 10.1016/j.vph.2019.106583
   PubMed Web of Science ®Google Scholar
• Perelló J, Ferrer MD, Del Mar Pérez M, et al. Mechanism of action of SNF472, a novel calcification inhibitor to treat vascular calcification and calciphylaxis. Br J Pharmacol. 2020;177(19):4400–4415. doi: 10.1111/bph.15163
   PubMed Web of Science ®Google Scholar
• Raggi P, Bellasi A, Bushinsky D, et al. Slowing progression of cardiovascular calcification with SNF472 in patients on hemodialysis: results of a randomized Phase 2b study. Circulation. 2020;141(9):728–739. doi: 10.1161/CIRCULATIONAHA.119.044195
   PubMed Web of Science ®Google Scholar