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Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders Volume 1, 2000 - Issue 3
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Research Article

Role of mitochondria in amyotrophic lateral sclerosis

Russell H Swerdlow Department of Neurology and Center for the Study of Neurodegenerative Diseases, University of Virginia Health System, Charlottesville, VA 22908, USA
,
Janice K Parks Department of Neurology and Center for the Study of Neurodegenerative Diseases, University of Virginia Health System, Charlottesville, VA 22908, USA
,
Gary Pattee Lincoln, Nebraska
&
w davis Parker Jr Department of Neurology and Center for the Study of Neurodegenerative Diseases, University of Virginia Health System, Charlottesville, VA, USA
Pages 185-190 | Published online: 10 Jul 2009

  • Tandan R, Bradley WC. Amyotrophic lateral sclerosis: Part 2. Etiopathogenesis. Ann Neurol 1985; 18: 419-431.
  • Martin LJ. Neuronal death in amyotrophic lateral sclerosis is apoptosis: Possible contribution of a programmed cell death mechanism. J Neuropath Exp Neurol 1999; 58: 459-471.
  • Migheli A, Cristiana A, Piva R, et al. Lack of apoptosis in mice with ALS. Nat Med 1999; 5: 966-967.
  • Majoor-Krakauer D, Oilman R, Johnson WC, Rowland LP. Familial aggregation of amyotrophic lateral sclerosis, dementia, and Parkinson's disease: Evidence of shared genetic susceptibility. Neurology 1994; 44: 1872-1877.
  • Beal MF. Aging, energy, and oxidative stress in neurodegenerative diseases. Ann Neurol 1995; 38: 357-366.
  • Swerdlow RH, Parks JK, Miller SW, et al. Origin and functional consequences of the complex I defect in Parkinson's disease. Ann Neurol 1996; 40: 663-671.
  • Swerdlow RH, Parks JK, Cassarino DS, et al. Cybrids in Alzheimer's disease: A cellular model of the disease? Neurology 1997; 49: 918-925.
  • Gu M, Cooper JM, Taanman JW, Schapira AHV. Mitochondrial DNA transmission of the mitochondrial defect in Parkinson's disease. Ann Neurol 1998; 44: 177-186.
  • Shults CW, Miller SW. Reduced complex I activity in parkinsonian cybrids. Mov Disorders 1998; 13 (Suppl 2): 217.
  • Rosen DR, Siddique T, Patterson D, et al. Mutations in Cu/Zn Superoxide dismutase are associated with familial amyotrophic lateral sclerosis. Nature 1993; 362: 59-62.
  • DaI Canto MC, Curney ME. Development of central nervous system pathology in a murine transgenic model of human amyotrophic lateral sclerosis. Am J Path 1994; 145: 1271-1280.
  • Wong PC, Pardo CA, Borchelt DR, et al. An adverse property of familial ALS-linked SODl mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron 1995; 14: 1105-1116.
  • Kong JM, Xu ZS. Massive mitochondria! degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SODl. J Neuroscience 1998; 18: 3241-3250.
  • Hirano A, Nakano I, Kurland LT, Mulder DW, Holley PW, Saccomanno C. line structural study of neurofibrillaiy changes in a family with amyotrophic lateral sclerosis. J Neuropath Exp Neurol 1984; 43: 471-480.
  • Hirano A, Donnenfeld H, Sasaki S, Nakano I. line structural observations of neurofilamentous changes in amyotrophic lateral sclerosis. J Neuropath Exp Neurol 1994; 43: 461-470.
  • Sasaki S, Iwata M. Dendritic synapses of anterior horn neurons in amyotrophic lateral sclerosis: an ultrastructural study. Acta Neuropathol 1996; 91: 278-283.
  • Sasaki S, Iwata M. Ultrastructural change of synapses of Betz cells in patients with amyotrophic lateral sclerosis. Neurosci Lett 1999; 268: 29-32.
  • Nakano K, Hirayama K, Terao K. Hepatic ultrastructural changes and liver dysfunction in amyotrophic lateral sclerosis. Arch Neurol 1987; 44: 103-106.
  • Hart MN, Cancilla PA, Frommes S, Hirano A. Anterior horn cell degeneration and Bunina-type inclusions associated with dementia. Acta Neuropathol 1977; 38: 225-228.
  • Okamoto K, Hirai S, Amari M, Watanabe M, Sakurai A. Bunina bodies in amyotrophic lateral sclerosis immunostained with rabbit anti-cystatin C serum. Neurosci Lett 1993; 162: 125-128.
  • Curti D, Malaspina A, Facchetti C, et al. Amyotrophic lateral sclerosis: Oxidative energy metabolism and calcium homeostasis in peripheral blood lymphocytes. Neurology 1996; 47: 1060-1064.
  • Kasarkis EJ, Tandon L, Lovell MA, Ehmann WD. Aluminum, calcium, and iron in the spinal cord of patients with sporadic amyotrophic lateral sclerosis using laser microprobe mass spectroscopy: a preliminary study. J Neurol Sci 1995; 130: 203-208.
  • Siklos L, Engelhardt J, Harati Y, et al. Ultrastructural evidence for altered calcium in motor nerve terminals in amyotrophic lateral sclerosis. Ann Neurol 1996; 39: 203-216.
  • Witt MR, Gredal O, Dekermendjian K, linden H Nielsen M. Calcium homeostasis in fibroblasts from patients with amyotrophic lateral sclerosis. J Neurol Sci 1994; 126: 206-212.
  • Hartley DM, Kurth MC, Bjerkness L, Weiss JH, Choi DW. Glutamate receptor-induced 45Ca2+ accumulation in cortical cell culture correlates with subsequent neuronal degeneration. J Neurosci 1993; 13: 1993-2000.
  • Nicotera P, Orrenius S. Calcium and cell death. Ann NY Acad Sci 1992; 648: 17-27.
  • Oshimi Y, Miyaszki S. Fas antigen-mediated DNA fragmentation and apoptotic morphologic changes are regulated by elevated cytosolic Ca2+ level. J Immunol 1995; 154: 599-609.
  • Tong JX, Eichler ME, Rich KM. Intracellular calcium levels influence apoptosis in mature sensory neurons after trophic factor deprivation. Exp Neurol 1996; 138: 45-52.
  • Uitei K, Sato S, Miyake T, Miyata Y. Induction of apoptosis in a drosophila neuronal cell line by calcium ionophore. Neurosci Lett 1996; 203: 191-194.
  • Bowling AC, Schulz JB, Brown RH Jr, Beal MF. Superoxide dismutase activity, oxidative damage, and mitochondria! energy metabolism in familial and sporadic amyotrophic lateral sclerosis. J Neurochem 1993; 61: 2322-2325.
  • Shaw PJ, Ince PC, Falkaus C, Mantle D. Oxidative damage to protein in sporadic motor neuron disease spinal cord. Ann Neurol 1995; 38: 691-695.
  • Yim MB, Kang JH, Yim HS, Kwak HS, Chock PB, Stadtman ER. A gain-of-function of an amyotrophic lateral sclerosis-associated Cu,Zn-superoxide dismutase mutant An enhancement of free radical formation due to a decrease in Km for hydrogen peroxide. Proc Natl Acad Sci USA 1996; 93: 5709-5714.
  • Borchelt DR, Cuarnieri M, Wong PC, et al. Superoxide dismutase 1 subunits with mutations linked to familial amyotrophic lateral sclerosis do not affect wild-type subunit function. J Biol Chem 1995; 270: 3234-3238.
  • Fujita K, Yamauchi M, Shibayama K, et al. Decreased cytochrome c oxidase activity but unchanged Superoxide dismutase and glutathione peroxidase activities in the spinal cords of patients with amyotrophic lateral sclerosis. J Neurosci Res 1996; 45: 276-281.
  • Wiedemann FR, Winkler K, Kuznetsov AV, et al. Impairment of mitochondria! function in skeletal muscle of patients with amyotrophic lateral sclerosis. J Neurol Sci 1998; 156: 65-72.
  • Parker WD, Boyson SJ, Parks JK. Electron transport chain abnormalities in idiopathic Parkinson's disease. Ann Neurol 1989; 26: 719-723.
  • King MP, Attardi C. Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation. Science 1989; 246: 500-503.
  • Desjardins P, Frost E, Morais R. Ethidium bromide-induced loss of mitochondrial DMA from primary chicken embryo fibroblasts. MoI Cell Biol 1985; 5: 1163-1169.
  • Chomyn A, Lai ST, Shakeley R, Bresolin N, Scarlatto C, Attardi C. Platelet-mediated transformation of mtDNA-less human cells: Analysis of phenotypic variability among clones from normal individuals -- and complementation behavior of tRNAlya mutation causing myodonic epilepsy and ragged red fibers. J Hum Genet 1994; 54: 966-974.
  • Miller SW, Trimmer PA, Parker WD Jr., Davis RE. Creation and characterization of mitochondrial DNA depleted cell lines with 'neuronal-like' properties. J Neurochem 1996; 67: 1897-1907.
  • Swerdlow RH, Miller SW, Parks JK, et al. Mitochondria in sporadic amyotrophic lateral sclerosis. Experimental Neurology 1998; 153: 135-142.
  • Hirano A. Cytopathology of amyotrophic lateral sclerosis. In: Rowland LP, ed. Advances in Neurology, VoI 56: Amyotrophic Lateral Sderosis and Other Motor Neuron Diseases. New York: Raven Press 1991: 91-101.
  • Chou SM, Wang HS, Taniguchi A. Role of SOD-1 and nitric oxide/cyclic CMP cascade on neurofilament aggregation in ALS/MND. J Neurol Sci 1996; 139 (Suppl):16-26.
  • Swerdlow RH, Parks JK, Miller SW, et al. Evidence of genetic mitochondrial pathology in sporadic amyotrophic lateral sclerosis. Soc Neurosci Abstr 1996; 22: 2143.
  • Borthwick GM, Johnson MA, Ince PG, Shaw PJ, Turnbull DM. Mitochondria! enzyme activity in amyotrophic lateral sclerosis: Implications for the role of mitochondria in neuronal cell death. Ann Neurol 1999; 46: 787-790.
  • Vielhaber S, Winkler K, lurches E, et al. Visualization of defective mitochondria! function in skeletal muscle fibers of patients with sporadic amyotrophic lateral sclerosis. J Neurol Sci 1999; 169: 133-139.
  • Comi GP, Bordoni A, Salani S, et al. Cytochrome c oxidase subunit I microdeletion in a patient with motor neuron disease. Ann Neurol 1998; 43: 110-116.
  • Croteau DL, Bohr VA. Repair of oxidative damage to nuclear and mitochondrial DNA in mammalian cells. J Biol Chem 1997; 272: 25409-25412.
  • Melov S, Shoffher JH Kaufman A, Wallace DC. Marked increase in the number and variety of mitochondrial DNA rearrangements in aging human skeletal muscle. Nucleic Adds Research 1995; 23: 4122-4126.
  • Newman NJ. Leber's hereditary optic neuropathy. Arch Neurol 1993; 50: 540-548.
  • Johns DR, Lessell S, Miller NR. Molecularly confirmed Leber's hereditary optic neuropathy. Neurology 1991; 41 (Suppl 1): 347.
  • Leone M. Parental sex effect in familial amyotrophic lateral sclerosis. Neurology 1991; 41: 1292-1294.
  • Klivenyi P, Ferrante RJ, Matthews RT, et al. Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis. Nature Medicine 1999; 5: 347-350.

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