Advanced search
Publication Cover
Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders Volume 1, 2000 - Issue 3
Journal homepage
264
Views
229
CrossRef citations to date
0
Altmetric
Research Article

A phase I/II trial of recombinant methionyl human brain derived neurotrophic factor administered by intrathecal infusion to patients with amyotrophic lateral sclerosis

Günter Ochs Department of Neurology, Julius-Maximilians University, Würzburg, Germany
,
Richard D Penn Department of Neurosurgery, Rush Medical Center, Chicago IL, USA
,
Michelle York Department of Neurosurgery, Rush Medical Center, Chicago IL, USA
,
Ralf Giess Department of Neurology, Julius-Maximilians University, Würzburg, Germany
,
Marcus Beck Department of Neurology, Julius-Maximilians University, Würzburg, Germany
,
Jörg Tonn Department of Neurosurgery, Julius-Maximilians University, Würzburg, Germany
,
Jeremy Haigh Amgen Ltd, Cambridge, UK
,
E Malta Amgen Ltd, Cambridge, UK
,
Michael Traub Amgen Ltd, Cambridge, UK
,
Michael Sendtner Department of Neurology, Julius-Maximilians University, Würzburg, Germany
&
Klaus V Toyka Department of Neurology, Julius-Maximilians University, Würzburg, Germany
 show all
Pages 201-206 | Published online: 10 Jul 2009

  • Sendtner M, Holtmann B, Kolbeck R, Thoenen H, Barde YA. Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section. Nature 1992; 360: 757-759.
  • Yan Q, Mathesn C, Lopez OT, Miller JA. The biological responses of axotomized adult motoneurons to brain-derived neurotrophic factor. J Neurosci 1994; 14: 5281-5291.
  • Novikov L, Novikova L, Kellerth JO. Brain-derived neurotrophic factor promotes survival and blocks nitric oxide synthase expression in adult rat spinal motoneurons after ventral root avulsion. Neurosci Lett 1995; 200: 45-48.
  • Koliatsos VE, Price WL, Pardo CA, Price DL Ventral root avulsion: an experimental model of death of adult motor neurons. J Comp Neurol 1994; 342: 35-44.
  • Mitsumoto H, Ikeda K, Klinkosz B, Cedarbaum JH Wong V, Lindsay RM. Arrest of motor neuron disease in wobbler mice cotreated with CNIF and BDNF. Science 1994; 265: 1107-1110.
  • Mitsumoto H, Ikeda K, Holmlund T, et al. The effects of ciliary neurotrophic factor on motor dysfunction in wobbler mouse motor neuron disease. Ann Neurol 1994; 36: 142-148.
  • Bradley WG, The BDNF Study Croup. Subcutaneous administration of recombinant brain-derived neurotrophic factor in patients with ALS (abstract). 6th International Symposium on ALS/MND 1995, Dublin.
  • Bradley WG, The BDNF Trial Croup. A phase I/II study of recombinant brain-derived neurotrophic factor in patients with amyotrophic lateral sclerosis (abstract). Ann Neurol 1995; 38: 971.
  • Dittrich F, Ochs G, Grosse-Wilde A, et al. Pharmacokinetics of intrathecally applied BDNF and effects on spinal motoneurons. Exp Neurol 1996; 141: 225-239.
  • Brooks BR, Antel J, Bradley W. El Escorial World Federation of Neurology Criteria for the diagnosis of amyotrophic lateral sclerosis. Neurol Sci 1994; 124: 96-107.
  • Brooks BR, Sanjak M, Ringel S, et al. The amyotrophic lateral sclerosis functional rating scale: Assessment of activities of daily living in patients with amyotrophic lateral sclerosis. Arch Neurol 1996; 53: 141-147.
  • Munsat TL, Andres PL, Finnison L, Conlon T, Thibodeau L The natural history of motoneuron loss in amyotrophic lateral sclerosis. Neurology 1988; 38: 409-413.
  • Klein R, Nanduri V, Jing S, et al. The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3. Cell 1991; 66: 395-403.
  • Gravel C, Cotz R, Lorrain A, Sendtner M. Adenoviral gene transfer of ciliary neurotrophic factor and brain-derived neurotrophic factor leads to long-term survival of axotomized motor neurons. Nat Med 1997; 3: 765-770.
  • Baumgartner BJ, Shine HD. Targeted transduction of CNS neurons with adenoviral vectors carrying neurotrophic factor genes confers neuroprotection that exceeds the transduced population. J Neurosci 1997; 17: 6504-6511.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.