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Original article

Expression of FKBP12 and ryanodine receptors (RyRs) in the spinal cord of MND patients

, &
Pages 94-99 | Received 06 Feb 2004, Accepted 18 Feb 2005, Published online: 10 Jul 2009

References

  • Krieger C, Jones K, Kim SU, Eisen AA. The role of intracellular free calcium in motor neuron disease. J Neurol Sci. 1994; 124(Suppl 1): 27–32.
  • Shaw PJ, Eggett CJ. Molecular factors underlying selective vulnerability of motor neurons to neurodegeneration in amyotrophic lateral sclerosis. J Neurol. 2000; 247(Suppl 1): 117–27.
  • Wagenknecht T, Grassucci R, Berkowitz J, Wiederrecht GJ, Xin HB, Fleischer S. Cryoelectron microscopy resolves FK506-binding protein sites on the skeletal muscle ryanodine receptor. Biophys J. 1996;70:1709–15.
  • Rose CR, Konnerth A. Stores not just for storage: intracel- lular calcium release and synaptic plasticity. Neuron. 2001;31:519–22.
  • Thorell WE, Leibrock LG, Agrawal SK. Role of RyRs and IP3 receptors after traumatic injury to spinal cord white matter. J Neurotrauma. 2002;19:335–42.
  • Gold BG. Neuroimmunophilin ligands: evaluation of their therapeutic potential for the treatment of neurological disorders. Expert Opin Investig Drugs. 2000;9:2331–42.
  • Snyder SH, Lai MM, Burnett PE. Innmunophilins in the nervous system. Review. Neuron. 1998;21:283–94.
  • Shou W, Aqhdasi B, Armstrong DL, Guo Q, Bao S, Charng MJ, et al. Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12. Nature. 1998;391:489–92.
  • Kihira T, Hironishi M, Utunomiya H, Kondo T. FKBP12 immunoreactivity in the human spinal cord of motor neuron disease patients. Neuropathology. 2002;22:269– 74.
  • Ouyang Y, Deerinck TJ, Walton PD, Airey JA, Sutko JL, Ellisman MH. Distribution of ryanodine receptors in the chicken central nervous system. Brain Res. 1993;620:269–80.
  • Cifuentes F, Gonzalez CE, Fiordelisio T, Guerrero G, Lai FA, Hernandez-Cruz A. A ryanodine fluorescent deriva- tive reveals the presence of high-affinity ryanodine binding sites in the Golgi complex of rat sympathetic neurons, with possible functional roles in intracellular Ca2+signaling. Cellular Signalling. 2001;13:353–62.
  • Bosch LVD, Verhoeven K, Smedt HD, Wuytack F, Missiaen L, Robberecht W. Calcium handling proteins in isolated spinal motor neurons. Life Sci. 1999; 65:1599–1606.
  • Dawson VL, Dawson TM, London ED, Bredt DS, Snyder HS. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc Natl Acad Sci. USA. 1991;88:6368–71.
  • Steiner JP, Hamilton GS, Rose DT, Valentine HL, Hou H, Connolly MA, et al. Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegen- erative animal models. Proc Natl Acad Sci. USA. 1997;94:2019–24.
  • Bavetta S, Hamlyn PJ, Burnstock G, Lieberman AR, Anderson PN. The effects of FK506 on dorsal column axons following spinal cord injury in adult rats: neuro- protection and local regeneration. Exp Neurol. 1999;158:382–93.
  • Lyons WE, Steiner JP, Snyder SH, Dawson TM. Neuronal regeneration enhances the expression of the immunophilin FKBP-12. J Neuroscience. 1995;15:2985–94.
  • Tanaka K, Fukita N, Asanuma M, Ogawa N. Immunophilin ligands prevent H2O2-induced apoptotic cell death by increasing glutathione levels in neuro 2A neuroblastoma cells. Acta Med Okayama. 2000;54:275–80.
  • Kato H, Okikawa T, Otsuka K, Takahashi A, Itoyama Y. Post-ishemic changes in the immunophilin FKBP12 in the rat brain. Mole Brain Res. 2000;84:58–66.

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