The SOD1 transgene in the G93A mouse model of amyotrophic lateral sclerosis lies on distal mouse chromosome 12

Francesca Achilli Department of Neurodegenerative DiseaseCorrespondence[email protected]

Shelagh Boyle Sorbell Department of Motor Science and Movement Disorders, Institute of NeurologyQueen Square, London

Dairin Kieran Chromosome Biology Section, MRC Human Genetics Unit, Crewe Road, Edinburgh

Ruth Chia Department of Biochemistry, School of Life Sciences, University of Sussex, Falmer, Brighton

Majid Hafezparast Department of Histopathology, Queen Mary University of London, The Royal London Hospital, Whitechapel

Joanne E. Martin Molecular Neuropathobiology Laboratory, Cancer Research UK London Research Institute, London

Giampietro Schiavo Department of Neurodegenerative Disease

Linda Greensmith Sorbell Department of Motor Science and Movement Disorders, Institute of NeurologyQueen Square, London

Wendy Bickmore Chromosome Biology Section, MRC Human Genetics Unit, Crewe Road, Edinburgh

Elizabeth M. C. Fisher Department of Biochemistry, School of Life Sciences, University of Sussex, Falmer, Brighton

show all

References

Kunst CB. Complex genetics of amyotrophic lateral sclerosis. Am J Hum Genet. 2004;75:933–47.
PubMed Web of Science ®Google Scholar
Gurney ME, Pu H, Chiu AY, Dal Canto MC, Polchow CY, Alexander DD, et al. Motor neuron degeneration in mice that express a human Cu/Zn superoxide dismutase mutation. Science. 1994;264:1772–5.
PubMed Web of Science ®Google Scholar
Alexander GM, Erwin KL, Byers N, Deitch JS, Augelli BJ, Blankenhorn EP, Heiman-Patterson TD. Effect of transgene copy number on survival in the G93A SOD1 transgenic mouse model of ALS. Brain Res Mol Brain Res. 2004;130:7–15.
PubMedGoogle Scholar
Hafezparast M, Klocke R, Ruhrberg C, Marquardt A, Ahmad-Annuar A, Bowen S, et al. Mutations in dynein link motor neuron degeneration to defects in retrograde transport. Science. 2003;300:808–12.
PubMed Web of Science ®Google Scholar
Kieran D, Hafezparast M, Bohnert S, Dick JRT, Martin J, Schiavo G, et al., A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice. J. Cell. Biol. In press. 2005.
Google Scholar
Elroy-Stein O, Bernstein Y, Groner Y. Overproduction of human Cu/Zn-superoxide dismutase in transfected cells: extenuation of paraquat-mediated cytotoxicity and enhance- ment of lipid peroxidation. EMBO J. 1986;5:615–22.
PubMed Web of Science ®Google Scholar

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

The SOD1 transgene in the G93A mouse model of amyotrophic lateral sclerosis lies on distal mouse chromosome 12

References

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

The SOD1 transgene in the G93A mouse model of amyotrophic lateral sclerosis lies on distal mouse chromosome 12

References

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date