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Review

Managing autonomic dysfunction in Parkinson’s disease: a review of emerging drugs

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Pages 37-47 | Received 21 Oct 2019, Accepted 10 Feb 2020, Published online: 20 Feb 2020

References

  • Pfeiffer RF. Non-motor symptoms in Parkinson’s disease. Parkinsonism Relat Disord. 2016 Jan;22(Suppl 1):S119–22.
  • Kim HS, Cheon SM, Seo JW, et al. Non motor symptoms more closely related to Parkinson’s disease: comparison with normal elderly. J Neurol Sci. 2013 Jan 15;324(1–2):70–73.
  • Witjas T, Kaphan E, Azulay JP, et al. Nonmotor fluctuations in Parkinson’s disease: frequent and disabling. Neurology. 2002 Aug 13;59(3):408–413.
  • Merola A, Romagnolo A, Comi C, et al. Prevalence and burden of dysautonomia in advanced Parkinson’s disease. Mov Disord. 2017;32:796–797.
  • Mendoza-Velásquez JJ, Flores-Vázquez JF, Barrón-Velázquez E, et al. Autonomic dysfunction in a-synucleinopathies. Front Neurol. 2019 Apr;12(10):363.
  • Martinez-Martin P, Rodriguez-Blazquez C, Kurtis MM, et al. The impact of nonmotor symptoms on health-related quality of life of patients with Parkinson’s disease. Mov Disord. 2011;26(3):399–406.
  • Coon EA, Cutsforth-Gregory JK, Benarroch EE. Neuropathology of autonomic dysfunction in synucleinopathies. Mov Disord. 2018 Mar;33(3):349–358.
  • Fasano A, Visanji NP, Liu LWC, et al. Gastrointestinal dysfunction in Parkinson’s disease. Lancet Neurol. 2015;14:625–639.
  • Zhu J, Chang L, Xie J, et al. Arginine vasopressin injected into the dorsal motor nucleus of the vagus inhibits gastric motility in rats. Gastroenterol Res Pract. 2016;2016:4618672.
  • Lebouvier T, Neunlist M, Des Varannes SB, et al. Colonic biopsies to assess the neuropathology of Parkinson’s disease and its relationship with symptoms. PLoS ONE. 2010;5(9):e12728. ArticleID.
  • Liu L. Chronic constipation: current treatment options. Can J Gastroenterol. 2011;25:22B–28B.
  • Bharucha AE, Pemberton JH, Locke GR. American gastroenterological association technical review on constipation. Gastroenterology. 2013 Jan;144(1):218–238.
  • Arya NG, Weissbart SJ. Central control of micturition in women: brain-bladder pathways in continence and urgency urinary incontinence. Clin Anat. 2017 Apr;30(3):373–384.. Epub 2017 Mar 9.
  • Sakakibara R, Tateno F, Kishi M, et al. Pathophysiology of bladder dysfunction in Parkinson’s disease. Neurobiol Dis. 2012 Jun;46(3):565–571.
  • Weiss JP, Blaivas JG, Bliwise DL, et al. The evaluation and treatment of nocturia: a consensus statement. BJU Int. 2011;108(1):6–21.
  • Xue P, Wang T, Zong H, et al. Urodynamic analysis and treatment of male Parkinson’s disease patients with voiding dysfunction. Chin Med J. 2014;127(5):878–881.
  • Dalmose AL, Bjarkam CR, Sorensen JC, et al. Effects of high frequency deep brain stimulation on urine storage and voiding function in conscious minipigs. Neurourol Urodyn. 2004;23(3):265–272.
  • Sakakibara R, Nakazawa K, Uchiyama T, et al. Effects of subthalamic nucleus stimulation on the micturation reflex in cats. Neuroscience. 2003;120(3):871–875.
  • Yamamoto T, Sakakibara R, Hashimoto K, et al. Striatal dopamine level increases in the urinary storage phase in cats: an in vivo microdialysis study. Neuroscience. 2005;135(1):299–303.
  • Shibao CA M.D.1, Kaufmann H. Pharmacotherapy of cardiovascular autonomic dysfunction in Parkinson disease. CNS Drugs. 2017 Nov;31(11):975–989.
  • Velseboer DC, de Haan RJ, Wieling W, et al. Prevalence of orthostatic hypotension in Parkinson’s disease: a systematic review and meta-analysis. Parkinsonism Relat Disord. 2011 Dec;17(10):724–729.
  • Palma JA, Gomez-Esteban JC, Norcliffe-Kaufmann L, et al. Orthostatic hypotension in Parkinson disease: how much you fall or how low you go? Mov Disord. 2015 Apr 15;30(5):639–645.
  • Fanciulli A, Jordan J, Biaggioni I. Consensus statement on the definition of neurogenic supine hypertension in cardiovascular autonomic failure by the American Autonomic Society (AAS) and the European Federation of Autonomic Societies (EFAS). Endorsed by the European Academy of Neurology (EAN) and the European Society of Hypertension (ESH). Clin Auton Res. 2018;28(4):355–362.
  • Gibbons CH, Schmidt P, Biaggioni I, et al. The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic orthostatic hypotension and associated supine hypertension. J Neurol. 2017;264:1567–1582.
  • Fanciulli A, Göbel G, Ndayisaba JP, et al. Supine hypertension in Parkinson’s disease and multiple system atrophy. Clin Auton Res. 2016 Apr;26(2):97–105.
  • Palma JA, Kaufmann H. Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies. Mov Disord. 2018 Mar;33(3):372–390.
  • Kalf JG, de Swart BJ, Bloem BR, et al. Prevalence of oropharyngeal dysphagia in Parkinson’s disease: a meta-analysis. Parkinsonism Relat Disord. 2012 May;18(4):311–315.
  • Pfeiffer RF. Gastrointestinal dysfunction in Parkinson’s disease. Parkinsonism Relat Disord. 2011 Jan;17(1):10–15. AstarloaR, Mena MA, Sánchez V et al. Clinical and fiber on Parkinson disease. Clin Neuropharmacol. 1992 Oct;15(5):375–80.
  • Astarloa R, Mena MA, Sánchez V, et al. Clinical and pharmacokinetic effects of a diet rich in insoluble fiber on Parkinson disease. Clin Neuropharmacol. 1992 Oct;15(5):375–380.
  • Ashraf W, Pfeiffer RF, Park F, et al. Constipation in Parkinson’s disease: objective assessment and response to psyllium. Mov Disord. 1997 Nov;12(6):946–951.
  • Cassani E, Privitera G, Pezzoli G, et al. Use of probiotics for the treatment of constipation in Parkinson’s disease patients. Minerva Gastroenterol Dietol. 2011 Jun;57(2):117–121.
  • Zangaglia R, Martignoni E, Glorioso M, et al. Macrogol for the treatment of constipation in Parkinson’s disease. A randomized placebo-controlled study. Mov Disord. 2007 Jul 15;22(9):1239–1244.
  • Eichhorn TE, Oertel WH. Macrogol 3350/electrolyte improves constipation in Parkinson’s disease and multiple system atrophy. Mov Disord. 2001 Nov;16(6):1176–1177.
  • Jost WH, Schimrigk K. Long-term results with cisapride in Parkinson’s disease. Mov Disord. 1997 May;12(3):423–425.
  • Camilleri M, Deiteren A. Prucalopride for constipation. Expert Opin Pharmacother. 2010;11:451–461.
  • Navailles S, Di Giovanni G, De Deurwaerdère P. The 5-HT4 agonist prucalopride stimulates L-DOPA-induced dopamine release in restricted brain regions of the hemiparkinsonian rat in vivo. CNS Neurosci Ther. 2015;21(9):745–747.
  • Pinyopornpanish K, Soontornpun A, Kijdamrongthum P, et al. The effect of prucalopride on gastric emptying in Parkinson’s disease patients, a pilot randomized, open-label study. Dig Sys. 2017;1(1):1–6.
  • Freitas ME, Alqaraawi A, Lang AE, et al. Linaclotide and prucalopride for management of constipation in patients with parkinsonism. Mov Disord Clin Pract. 2018;5(2):218–220.
  • Johanson JF, Morton D, Geenen J, et al. Multicenter, 4-week, double-blind, randomized, placebo-controlled trial of lubiprostone, a locally-acting type-2 chloride channel activator, in patients with chronic constipation. Am J Gastroenterol. 2008;103:170–177.
  • Barish CF, Drossman D, Johanson JF, et al. Efficacy and safety of lubiprostone in patients with chronic constipation. Dig Dis Sci. 2010;55:1090–1097.
  • Thayalasekeran S, Ali H, Tsai HH. Novel therapies for constipation. World J Gastroenterol. 2013;19(45):8247–8251.
  • Ondo WG, Kenney C, Sullivan K, et al. Placebo-controlled trial of lubiprostone for constipation associated with Parkinson disease. Neurology. 2012 May 22;78(21):1650–1654.
  • Bassotti G, Usai-Satta P, Bellini M. Linaclotide for the treatment of chronic constipation. Expert Opin Pharmacother. 2018 Aug;19(11):1261–1266.
  • Bryant AP, Busby RW, Bartolini WP, et al. Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract. Life Sci. 2010 May 8;86(19–20):760–765.
  • Ahsan MK, Tchernychev B, Kessler MM, et al. Linaclotide activates guanylate cyclase-C/cGMP/protein kinase-II-dependent trafficking of CFTR in the intestine. Physiol Rep. 2017 Jun;5(11):e13299.
  • Chiu CM, Wang CP, Sung WH, et al. Functional magnetic stimulation in constipation associated with Parkinson’s disease. J Rehabil Med. 2009 Nov;41(13):1085–1089.
  • Krogh K, Chiarioni G, Whitehead W. Management of chronic constipation in adults. United European Gastroenterol J. 2017;5(4):465–472.
  • Albanese A, Brisinda G, Bentivoglio AR, et al. Treatment of outlet obstruction constipation in Parkinson’s disease with botulinum neurotoxin A. Am J Gastroenterol. 2003 Jun;98(6):1439–1440.
  • Cadeddu F, Bentivoglio AR, Brandara F, et al. Outlet type constipation in Parkinson’s disease: results of botulinum toxin treatment. Ailment Pharmacol Ther. 2005 Nov 15;22(10):997–1003.
  • Edwards LL, Quigley EM, Harned RK, et al. Defecatory function in Parkinson’s disease: response to apomorphine. Ann Neurol. 1993;33:490–493.
  • Griffiths DJ, McCracken PN, Harrison GM, et al. Relationship of fluid intake to voluntary micturition and urinary incontinence in geriatric patients. Neurourol Urodyn. 1993;12(1):1–7.
  • Batla A, Phé V, De Min L, et al. Nocturia in Parkinson’s disease: why does it occur and how to manage? Mov Disord Clin Pract. 2016 Jun 7;3(5):443–451.
  • Panicker JN, Fowler CJ, Kessler TM. Lower urinary tract dysfunction in the neurological patient: clinical assessment and management. Lancet Neurol. 2015 Jul;14(7):720–732.
  • Yamada S, Ito Y, Nishijima S. Basic and clinical aspects of antimuscarinic agents used to treat overactive bladder. Pharmacol Ther. 2018 Sep;189:130–148.
  • Batla A, Tayim N, Pakzad M, et al. Treatment options for urogenital dysfunction in Parkinson’s disease. Curr Treat Options Neurol. 2016 Oct;18(10):45.
  • Hajebrahimi S, Chapple CR, Pashazadeh F, et al. Management of neurogenic bladder in patients with Parkinson’s disease: a systematic review. Neurourology and Urodynamics. 2019;38:31–62.
  • Giannantoni A, Rossi A, Mearini E, et al. Botulinum toxin A for overactive bladder and detrusor muscle overactivity in patients with Parkinson’s disease and multiple system atrophy. J Urol. 2009;182:1453–1457.
  • Vurture G, Peyronnet B, Feigin A. Outcomes of intradetrusor onabotulinum toxin A injection in patients with Parkinson’s disease. Neurourol Urodyn. 2018 Nov;37(8):2669–2677.
  • Gaziev G, Topazio L, Iacovelli V. Percutaneous Tibial Nerve Stimulation (PTNS) efficacy in the treatment of lower urinary tract dysfunctions: a systematic review. BMC Urol. 2013 Nov;25(13):61.
  • Kabay S, Kabay CS, Cetiner M. The clinical and urodynamic results of percutaneous posterior tibial nerve stimulation on neurogenic detrusor overactivity in patients with Parkinson’s disease. Urology. 2016 Jan;87:76–81.
  • Schneier MP, Gross T, Bachmann LM, et al. Tibial nerve stimulation for treating neurogenic lower urinary tract dysfunction: a systematic review. Eur Urol. 2015 Nov;68(5):859–867.
  • Peyronnet B, Vurture G, Palma JA, et al. Mirabegron in patients with Parkinson disease and overactive bladder symptoms: a retrospective cohort. Parkinsonism Relat Disord. 2018 Dec;57:22–26.
  • Warren K, Burden H, Abrams P. Mirabegron in overactive bladder patients: efficacy review and update on drug safety. Ther Adv Drug Saf. 2016 Oct;7(5):204–216.
  • Isaacson SH, Skettini J. Neurogenic orthostatic hypotension in Parkinson’s disease: evaluation, management, and emerging role of droxidopa. Vasc Health Risk Manag. 2014 Apr 3;10:169–176.
  • Hauser RA, Biaggioni LI, Hewitt A, et al. Integrated analysis of droxidopa for the treatment of neurogenic orthostatic hypotension in patients with Parkinson disease. Mov Disord Clin Pract. 2018 Nov 8;5(6):627–634.
  • Schreglmann SR, Büchele F, Sommerauer M, et al. Pyridostigmine bromide versus fludrocortisone in the treatment of orthostatic hypotension in Parkinson’s disease - a randomized controlled trial. Eur J Neurol. 2017 Apr;24(4):545–551.
  • Senard JM, Brefel-Courbon C, Rascol O, et al. Orthostatic hypotension in patients with Parkinson’s disease: pathophysiology and management. Drugs Aging. 2001;18(7):495–505.
  • Perez-Lloret S, Rey MV, Pavy-Le Traon A, et al. Emerging drugs for autonomic dysfunction in Parkinson’s disease. Expert Opin Emerg Drugs. 2013 Mar;18(1):39–53.
  • Palma JA, Norcliffe-Kaufmann L, Martinez J, et al. Supine plasma NE predicts the pressor response to droxidopa in neurogenic orthostatic hypotension. Neurology. 2018 Oct 16;91(16):e1539–e1544.
  • Jordan J, Biaggioni I. Diagnosis and treatment of supine hypertension in autonomic failure patients with orthostatic hypotension. J Clin Hypertens. 2002;4(2):139–145.
  • Mobley DF, Khera M, Baum N. Recent advances in the treatment of erectile dysfunction. Postgrad Med J. 2017;93:679–685.
  • Randrup E, Baum N, Feibus A. Erectile dysfunction and cardiovascular disease. Postgrad Med. 2015;127:166–172.
  • Gul M, Serefoglu EC. An update on the drug safety of treating erectile dysfunction. Expert Opin Drug Saf. 2019 Oct;18(10):965–975.
  • Cai T, Palumbo F, Liguori G, et al. The intra-meatal application of alprostadil cream (Vitaros®) improves drug efficacy and patient’s satisfaction: results from a randomized, two-administration route, cross-over clinical trial. Int J Impot Res. 2019 Mar;31(2):119–125.
  • Allahdadi KJ, Tostes RC, Webb RC. Female sexual dysfunction: therapeutic options and experimental challenges. Cardiovasc Hematol Agents Med Chem. 2009 Oct;7(4):260–269. AshrafW, Pfeiffer RF, Park F et al. Constipation in Parkinson’s disease: objective assessment and response to psyllium. Mov Disord. 1997 Nov;12(6):946–51.
  • Hyson HC, Johnson AM, Jog MS. Sublingual atropine for sialorrhea secondary to parkinsonism: a pilot study. Mov Disord. 2002 Nov;17(6):1318–1320.
  • Arbouw MEL, Movig KLL, Koopmann M. Glycopyrrolate for sialorrhea in Parkinson disease - a randomized, double-blind, crossover trial. Neurology. 2010;74:1203–1207.
  • Srivanitchapoom P, Pandey S, Hallett M. Drooling in Parkinson’s disease: a review. Parkinsonism Relat Disord. 2014 Nov;20(11):1109–1118.
  • Rodríguez-Blázquez C, Forjaz MJ, Lizán L. Estimating the direct and indirect costs associated with Parkinson’s disease. Expert Rev Pharmacoecon Outcomes Res. 2015;15(6):889–911.
  • Reese JP, Dams J, Winter Y. Pharmacoeconomic considerations of treating patients with advanced Parkinson’s disease. Expert Opin Pharmacother. 2012 May;13(7):939–958.
  • Arnold AC, Jessica NG, Lei L, et al. Autonomic dysfunction in cardiology – pathophysiology, investigation, and management. Can J Cardiol. 2017 Dec;33(12):1524–1534.
  • Brundin P, Dave KD, Kordowera JH. Therapeutic approaches to target alpha-synuclein pathology. Exp Neurol. 2017 Dec;298(Pt B):225–235.
  • Miller AJ, Arnold AC. The renin-angiotensin system in cardiovascular autonomic control: recent developments and clinical implications. Clin Auton Res. 2019 Apr;29(2):231–243.
  • Poirier A, Aubé B, Côté M, et al. Gastrointestinal dysfunctions in Parkinson’s disease: symptoms and treatments. Parkinsons Dis. 2016;2016:6762528.
  • Fox SH, Brotchie JM, Lang AE. Non-dopaminergic treatments in development for Parkinson’s disease. Lancet Neurol. 2008;7(10):927–938.
  • Smith JA, Beattie DT, Marquess D, et al. The in vitro pharmacological profile of TD-5108, a selective 5-HT(4) receptor agonist with high intrinsic activity. Naunyn Schmiedebergs Arch Pharmacol. 2008;378:125–137.
  • Beattie DT, Armstrong SR, Shaw JP, et al. The in vivo gastrointestinal activity of TD-5108, a selective 5-HT(4) receptor agonist with high intrinsic activity. Naunyn Schmiedebergs Arch Pharmacol. 2008;378:139–147.
  • Dennis D, Palme M, Irwin I, et al. ATI-7505 is a novel, selective 5HT(4) receptor agonist that causes gastrointestinal prokinetic activity in dogs. Gastroenterol. 2004;126:641.
  • Tack J, Camilleri M, Chang L, et al. Systematic review: cardiovascular safety profile of 5-HT(4) agonists developed for gastrointestinal disorders. Aliment Pharmacol Ther. 2012;35:745–767.
  • Shin A, Camilleri M, Kolar G, et al. Systematic review with meta-analysis: highly selective 5-HT4 agonists (prucalopride, velusetrag or naronapride) in chronic constipation. Aliment Pharmacol Ther. 2014 Feb;39(3):239–253.
  • ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). [Cited 2000 Feb 29] - . Identifier: NCT02838797, RQ-00000010 for Gastroparesis and Constipation in Parkinson’s Disease (RQ-10); 2016 July [Verified Dec 2018]; [about 4 screens]. [cited 2019 Oct]. Available from: http://clinicaltrials.gov/ct/show/NCT02838797
  • Parkinson Study Group. A randomized trial of relamorelin for constipation in Parkinson’s disease (MOVE-PD): trial results and lessons learned. Parkinsonism Relat Disord. 2017 Apr;37:101–105.
  • Mosinska P, Zatorski H, Storr M, et al. Future treatment of constipation-associated disorders: role of relamorelin and other ghrelin receptor agonists. J Neurogastroenterol Motil. 2017;23(2):171–179.
  • Rao SSC. Plecanatide: a new guanylate cyclase agonist for the treatment of chronic idiopathic constipation. Therap Adv Gastroenterol. 2018;11:1756284818777945.
  • Perni MC, Galvagnion A, Maltsev G, et al. A natural product inhibits the initiation of alpha-synuclein aggregation and suppresses its toxicity. Proc Natl Acad Sci U S A. 2017;114(6):pp. E1009-E1017.
  • Hauser RA, Sutherland D, Madrid JA, et al. Targeting neurons in the gastrointestinal tract to treat Parkinson’s disease. Clinical Parkinsonism & Related Disorders. 2019;1:2–7.
  • ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine(US). [Cited 2000 Feb 29 - . Identifier: NCT03781791, Orally Administered ENT-01 for Parkinson’s Disease-Related Constipation (KARMET); 2018 Dec [Verified Jul 2019]; [about 4 screens]. [cited 2019 Dec]. Available from: http://clinicaltrials.gov/ct/show/NCT03781791
  • Wong BS, Camilleri M. Elobixibat for the treatment of constipation. Expert Opin Investig Drugs. 2013;22:277–284.
  • Mitcheson HD, Samanta S, Muldowney K. Vibegron (RVT-901/MK-4618/KRP-114V) administered once daily as monotherapy or concomitantly with tolterodine in patients with an overactive bladder: a multicenter, phase IIb, randomized, double-blind, controlled trial. Eur Urol. 2019 Feb;75(2):274–282.
  • Keam SJ. Vibegron: first global approval. Drugs. 2018 Nov;78(17):1835–1839.
  • Pinyopornpanish K, Soontornpun A, Kijdamrongthum P, et al. The effect of prucalopride on gastric emptying in Parkinson’s disease patients, a pilot randomized, open-label study. Dig Sys. 2017;1(1):1–6.

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