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Editorial

Long non-coding RNA CCAT2 as a therapeutic target in colorectal cancer

, &
Pages 973-976 | Received 16 Aug 2018, Accepted 24 Oct 2018, Published online: 30 Oct 2018

References

  • Ling H, Vincent K, Pichler M, et al. Junk DNA and the long non-coding RNA twist in cancer genetics. Oncogene. 2015;34:5003–5011.
  • Mercer TR, Dinger ME, Mattick JS. Long non-coding RNAs: insights into functions. Nat Rev Genet. 2009;10:155.
  • Rigoutsos I, Lee SK, Nam SY, et al. N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration. Genome Biol. 2017;18:98.
  • Shah MY, Ferrajoli A, Sood AK, et al. microRNA therapeutics in cancer - an emerging concept. EBioMedicine. 2016;12:34–42.
  • Slaby O, Laga R, Sedlacek O. Therapeutic targeting of non-coding RNAs in cancer. Biochem J. 2017;474:4219–4251.
  • Ling H, Spizzo R, Atlasi Y, et al. CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer. Genome Res. 2013;23:1446–1461.
  • Shen P, Pichler M, Chen M, et al. To Wnt or lose: the missing non-coding linc in colorectal cancer. Int J Mol Sci. 2017;18:2003.
  • Redis RS, Vela LE, Lu W, et al. Allele-specific reprogramming of cancer metabolism by the long non-coding RNA CCAT2. Mol Cell. 2016;61:640.
  • Cai Y, He J, Zhang D. Long noncoding RNA CCAT2 promotes breast tumor growth by regulating the Wnt signaling pathway. Onco Targets Ther. 2015;8:2657–2664.
  • Cai Y, He J, Zhang D. Suppression of long non-coding RNA CCAT2 improves tamoxifen-resistant breast cancer cells’ response to tamoxifen. Molekuliarnaia biologiia. 2016;50:821–827.
  • Li J, Zhuang C, Liu Y, et al. shRNA targeting long non-coding RNA CCAT2 controlled by tetracycline-inducible system inhibits progression of bladder cancer cells. Oncotarget. 2016;7:28989–28997.
  • Huang JL, Liao Y, Qiu MX, et al. Long non-coding RNA CCAT2 promotes cell proliferation and invasion through regulating Wnt/beta-catenin signaling pathway in clear cell renal cell carcinoma. Tumour Biol. 2017;39:1010428317711314.
  • Guo H, Hu G, Yang Q, et al. Knockdown of long non-coding RNA CCAT2 suppressed proliferation and migration of glioma cells. Oncotarget. 2016;7:81806–81814.
  • Xu Y, Wang B, Zhang F, et al. Long non-coding RNA CCAT2 is associated with poor prognosis in hepatocellular carcinoma and promotes tumor metastasis by regulating Snail2-mediated epithelial–mesenchymal transition. Onco Targets Ther. 2017;10:1191–1198.
  • Zheng J, Zhao S, He X, et al. The up-regulation of long non-coding RNA CCAT2 indicates a poor prognosis for prostate cancer and promotes metastasis by affecting epithelial-mesenchymal transition. Biochem Biophys Res Commun. 2016;480:508–514.

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