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Expert Opinion on Therapeutic Targets Volume 24, 2020 - Issue 2
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Editorial

ONECUT2 is a novel target for treatment of castration-resistant prostate cancer

Tejashree JoglekarDepartment of Anatomy and Cell Biology, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA;The George Washington University Cancer Center, The George Washington University School of Medicine and Health Sciences, Washington, DC, USAView further author information
,
Jianqing LinThe George Washington University Cancer Center, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA;Division of Hematology/Oncology, Department of Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, USACorrespondence[email protected]
View further author information
&
Maho ShibataDepartment of Anatomy and Cell Biology, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA;The George Washington University Cancer Center, The George Washington University School of Medicine and Health Sciences, Washington, DC, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-7056-3939View further author information
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Pages 89-90 | Received 13 Aug 2019, Accepted 25 Jan 2020, Published online: 03 Feb 2020

References

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  • Zou M, Toivanen R, Mitrofanova A, et al. Transdifferentiation as a mechanism of treatment resistance in a mouse model of castration-resistant prostate cancer. Cancer Discov. 2017 Jul;7(7):736–749.
  • Lapuk AV, Wu C, Wyatt AW, et al. From sequence to molecular pathology, and a mechanism driving the neuroendocrine phenotype in prostate cancer. J Pathol. 2012 Jul;227(3):286–297.
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  • Aparicio AM, Harzstark AL, Corn PG, et al. Platinum-based chemotherapy for variant castrate-resistant prostate cancer. Clin Cancer Res. 2013 Jul 1;19(13):3621–3630.
  • Ma Q, Wu K, Li H, et al. ONECUT2 overexpression promotes RAS-driven lung adenocarcinoma progression. Sci Rep. 2019 Dec 27;9(1):20021.
  • Li Q, Deng Q, Chao HP, et al. Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses. Nat Commun. 2018 Sep 6;9(1):3600.

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