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Review

Oral vinorelbine-based concomitant chemoradiotherapy in unresectable stage III non-small cell lung cancer: a systematic review

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Pages 1159-1165 | Received 10 Jul 2018, Accepted 29 Aug 2018, Published online: 17 Sep 2018

References

  • World Health Organization, Cancer Fact Sheet No. 297, (2017). [cited 2018 Feb 1]. Available from: http://www.who.int/mediacentre/factsheets/fs297/en/).
  • Yang P, Allen MS, Aubry MC, et al. Clinical features of 5,628 primary lung cancer patients: experience at Mayo Clinic from 1997 to 2003. Chest. 2005;128:452–462.
  • Goya T, Asamura H, Yoshimura H, et al. Prognosis of 6644 resected non-small cell lung cancers in Japan: a Japanese lung cancer registry study. Lung Cancer. 2005;50:227–234.
  • Eberhardt WE, De Ruysscher D, Weder W, et al. 2nd ESMO Consensus conference in lung cancer: locally advanced stage III non-small-cell lung cancer. Ann Oncol. 2015;26:1573–1588.
  • O’Rourke N, Roque IFM, Farre Bernado N, et al. Concurrent chemoradiotherapy in non-small cell lung cancer. Cochrane Database Syst Rev. 2010;6:CD002140.
  • Auperin A, Le Pechoux C, Rolland E, et al. Meta-analysis of concomitant versus sequential radiochemotherapy in locally advanced non-small-cell lung cancer. J Clin Oncol. 2010;28:2181–2190.
  • Ahn JS, Ahn YC, Kim JH, et al. Multinational randomized Phase III trial with or without consolidation chemotherapy using docetaxel and cisplatin after concurrent chemoradiation in inoperable Stage III non-small-cell lung cancer: KCSG-LU05-04. J Clin Oncol. 2015;33:2660–2666.
  • Antonia SJ, Villegas A, Daniel D, et al. Durvalumab after chemoradiotherapy in Stage III non-small-cell lung cancer. N Engl J Med. 2017;377:1919–1929.
  • [cited 2018 May 25]. Available from: https://www.astrazeneca.com/media-centre/press-releases/2018/imfinzi-significantly-improves-overall-survival-in-the-phase-iii-pacific-trial-for-unresectable-stage-iii-non-small-cell-lung-cancer-25052018.html
  • Barletta G, Genova C, Rijavec E, et al. Oral vinorelbine in the treatment of non-small-cell lung cancer. Expert Opin Pharmacother. 2014;15:1585–1599.
  • Zatloukal P, Petruzelka L, Zemanova M, et al. Concurrent versus sequential chemoradiotherapy with cisplatin and vinorelbine in locally advanced non-small cell lung cancer: a randomized study. Lung Cancer. 2004;46:87–98.
  • Hirose T, Mizutani Y, Ohmori T, et al. The combination of cisplatin and vinorelbine with concurrent thoracic radiation therapy for locally advanced stage IIIA or IIIB non-small-cell lung cancer. Cancer Chemother Pharmacol. 2006;58:361–367.
  • Sekine I, Nokihara H, Sumi M, et al. Docetaxel consolidation therapy following cisplatin, vinorelbine, and concurrent thoracic radiotherapy in patients with unresectable stage III non-small cell lung cancer. J Thorac Oncol. 2006;1:810–815.
  • Leong SS, Fong KW, Lim WT, et al. A phase II trial of induction gemcitabine and vinorelbine followed by concurrent vinorelbine and radiotherapy in locally advanced non-small cell lung cancer. Lung Cancer. 2010;67:325–329.
  • Lin Q, Liu Y, Wang N, et al. A modified Phase I trial of radiation dose escalation in 3D conformal radiation therapy with concurrent vinorelbine and carboplatin chemotherapy for non-small-cell lung cancer. J Radiat Res. 2013;54:126–134.
  • Fournel P, Vergnenegre A, Robinet G, et al. Induction or consolidation chemotherapy for unresectable stage III non-small-cell lung cancer patients treated with concurrent chemoradiation: a randomised phase II trial GFPC – IFCT 02-01. Eur J Cancer. 2016;52:181–187.
  • Zhao Q, Wang Z, Huang W, et al. Phase III study of cisplatin with pemtrexed or vinorelbine plus concurrent late course accelerated hyperfractionated radiotherapy in patients with unresectable stage III non-small cell lung cancer. Oncotarget. 2016;7:8422–8431.
  • Hughes BG, Ahern E, Lehman M, et al. Concurrent chemoradiation with cisplatin and vinorelbine followed by consolidation with oral vinorelbine in locally advanced non-small cell lung cancer (NSCLC): the phase II CONCAVE study. Asia Pac J Clin Oncol. 2017;13:137–144.
  • Genestreti G, Grossi F, Genova C, et al. Third- and further-line therapy in advanced non-small-cell lung cancer patients: an overview. Future Oncol. 2014;10:2081–2096.
  • Gebbia V, Puozzo C. Oral versus intravenous vinorelbine: clinical safety profile. Expert Opin Drug Saf. 2005;4:915–928.
  • Beckmann G, Fietkau R, Huber RM, et al. Oral vinorelbine and cisplatin with concomitant radiotherapy in stage III non-small cell lung cancer (NSCLC): a feasibility study. Onkologie. 2006;29:137–142.
  • Perri F, Lazzari G, Della Vittoria Scarpati G, et al. Oral vinorelbine: a feasible and safe partner for radiotherapy in the treatment of locally advanced non-small cell lung cancer. Onco Targets Ther. 2016;9:2359–2364.
  • Krzakowski M, Provencio M, Utracka-Hutka B, et al. Oral vinorelbine and cisplatin as induction chemotherapy and concomitant chemo-radiotherapy in stage III non-small cell lung cancer: final results of an international phase II trial. J Thorac Oncol. 2008;3:994–1002.
  • Descourt R, Vergnenegre A, Barlesi F, et al. Oral vinorelbine and cisplatin with concurrent radiotherapy after induction chemotherapy with cisplatin and docetaxel for patients with locally advanced non-small cell lung cancer: the GFPC 05-03 study. J Thorac Oncol. 2011;6:351–357.
  • Strom HH, Bremnes RM, Sundstrom SH, et al. Concurrent palliative chemoradiation leads to survival and quality of life benefits in poor prognosis stage III non-small-cell lung cancer: a randomised trial by the Norwegian Lung Cancer Study Group. Br J Cancer. 2013;109:1467–1475.
  • Strom HH, Bremnes RM, Sundstrom SH, et al. How do elderly poor prognosis patients tolerate palliative concurrent chemoradiotherapy for locally advanced non-small-cell lung cancer Stage III? A subset analysis from a clinical Phase III trial. Clin Lung Cancer. 2015;16:183–192.
  • Strom HH, Bremnes RM, Sundstrom SH, et al. Poor prognosis patients with inoperable locally advanced NSCLC and large tumors benefit from palliative chemoradiotherapy: a subset analysis from a randomized clinical phase III trial. J Thorac Oncol. 2014;9:825–833.
  • Juan O, Sanchez-Hernandez A, Vazquez S, et al. Full-dose cisplatin and oral vinorelbine concomitant with radiotherapy in unresectable stage III non-small cell lung cancer: a multi-center phase II study. Anticancer Res. 2014;34:1959–1966.
  • Lerouge D, Riviere A, Dansin E, et al. A phase II study of cisplatin with intravenous and oral vinorelbine as induction chemotherapy followed by concomitant chemoradiotherapy with oral vinorelbine and cisplatin for locally advanced non-small cell lung cancer. BMC Cancer. 2014;14:231.
  • Singhal N, Mislang A, Karapetis CS, et al. Oral vinorelbine and cisplatin with concomitant radiotherapy in stage III non-small-cell lung cancer: an open-label phase II multicentre trial (COVeRT study). Anticancer Drugs. 2015;26:1083–1088.
  • Flentje M, Huber RM, Engel-Riedel W, et al. GILT – a randomised phase III study of oral vinorelbine and cisplatin with concomitant radiotherapy followed by either consolidation therapy with oral vinorelbine and cisplatin or best supportive care alone in stage III non-small cell lung cancer. Strahlenther Onkol. 2016;192:216–222.
  • Costa Rivas M, Huidobro Vence G, Firvida Perez JL, et al. Concurrent chemoradiation for locally advanced stage III non-small cell lung cancer with cisplatin, vinorelbine, and thoracic radiotherapy: a phase II study from the Galician Lung Cancer Group. Clin Transl Oncol. 2018 April 25 doi: 10.1007/s12094-018-1880.
  • Locher C, Pourel N, Le Caer H, et al. Impact of a comprehensive geriatric assessment to manage elderly patients with locally advanced non-small–cell lung cancers: an open phase II study using concurrent cisplatin–oral vinorelbine and radiotherapy (GFPC 08-06). Lung Cancer. 2018;121:25–29.
  • Isla D, Majem M, Guirado M, et al. NORA trial (GECP 15/02): first efficacy results of the Spanish Lung Cancer Group (SLCG) phase II trial of concurrent chemo-radiotherapy (CT-RT) with cisplatin (P) plus metronomic oral vinorelbine (mOV) for unresectable locally advanced non-small cell lung cancer (LA-NSCLC). J Clin Oncol. 2018;36:8537.
  • Chiu W-H, Chen HH-W, Su W-C. Oral vinorelbine: a better choice for concurrent chemoradiotherapy in stage III non-small cell lung cancer. J Solid Tumors. 2012;2:4.
  • Scotti V, Saieva C, Di Cataldo V, et al. Vinorelbine-based chemo-radiotherapy in non-small cell lung cancer. Tumori. 2012;98:464–470.
  • Schwarzenberger P, Fariss A, Linares L, et al. Dose escalation of once weekly oral vinorelbine concurrent with weekly split dose hypofractionated chest radiation for palliation of advanced non-small cell lung cancer: a phase I/II study. Am J Med Sci. 2011;341:454–459.
  • Hansen O, Knap MM, Khalil A, et al. A randomized phase II trial of concurrent chemoradiation with two doses of radiotherapy, 60Gy and 66Gy, concomitant with a fixed dose of oral vinorelbine in locally advanced NSCLC. Radiother Oncol. 2017;123:276–281.
  • Bezjak A, Temin S, Franklin G, et al. Definitive and adjuvant radiotherapy in locally advanced non-small-cell lung cancer: American Society of Clinical Oncology Clinical Practice Guideline Endorsement of the American Society for Radiation Oncology evidence-based clinical practice guideline. J Clin Oncol. 2015;33:2100–2105.
  • Vokes EE, Herndon JE 2nd, Crawford J, et al. Randomized phase II study of cisplatin with gemcitabine or paclitaxel or vinorelbine as induction chemotherapy followed by concomitant chemoradiotherapy for stage IIIB non-small-cell lung cancer: cancer and leukemia group B study 9431. J Clin Oncol. 2002;20:4191–4198.
  • Gnoni A, Silvestris N, Licchetta A, et al. Metronomic chemotherapy from rationale to clinical studies: a dream or reality? Crit Rev Oncol Hematol. 2015;95:46–61.
  • Pallis AG, Chandrinos V, Pavlakou G, et al. A multicenter phase I trial of metronomic oral vinorelbine plus cisplatin in patients with NSCLC. Cancer Chemother Pharmacol. 2011;67:1239–1245.
  • Briasoulis E, Aravantinos G, Kouvatseas G, et al. Dose selection trial of metronomic oral vinorelbine monotherapy in patients with metastatic cancer; a hellenic cooperative oncologyl group clinical translational study. Bmc Cancer. 2013;13:263.
  • Camerini A, Puccetti C, Donati S, et al. Metronomic oral vinorelbine as first-line treatment in elderly patients with advanced non-small cell lung cancer: results of a phase II trial (MOVE trial). BMC Cancer. 2015;15:359.
  • Katsaounis P, Kotsakis A, Agelaki S, et al. Cisplatin in combination with metronomic vinorelbine as front-line treatment in advanced non-small cell lung cancer: a multicenter phase II study of the Hellenic Oncology Research Group (HORG). Cancer Chemother Pharmacol. 2015;75:821–827.
  • Briasoulis E, Aravantinos G, Kouvatseas G, et al. Dose selection trial of metronomic oral vinorelbine monotherapy in patients with metastatic cancer: a Hellenic Cooperative Oncology Group clinical translational study. BMC Cancer. 2013;13:263.
  • Kontopodis E, Hatzidaki D, Varthalitis I, et al. A phase II study of metronomic oral vinorelbine administered in the second line and beyond in non-small cell lung cancer (NSCLC): a phase II study of the Hellenic Oncology Research Group. J Chemother. 2013;25:49–55.
  • Cazzaniga ME, Camerini A, Addeo R, et al. Metronomic oral vinorelbine in advanced breast cancer and non-small-cell lung cancer: current status and future development. Future Oncol. 2016;12:373–387.
  • Pasini F, Barile C, Caruso D, et al. Oral metronomic vinorelbine (OMV) in elderly or pretreated patients with advanced non small cell lung cancer: outcome and pharmacokinetics in the real world. Invest New Drugs. 2018;28(Jun). [ Epub ahead of print]. doi:10.1007/s10637-018-0631-8
  • Biziota E, Mavroeidis L, Hatzimichael E, et al. Metronomic chemotherapy: a potent macerator of cancer by inducing angiogenesis suppression and antitumor immune activation. Cancer Lett. 2017;400:243–251.
  • Orlandi P, Di Desidero T, Salvia G, et al. Metronomic vinorelbine is directly active on non small cell lung cancer cells and sensitizes the EGFRL858R/T790M cells to reversible EGFR tyrosine kinase inhibitors. Biochem Pharmacol. 2018;152:327–337.
  • Altinoz MA, Ozpinar A, Alturfan EE, et al. Vinorelbine’s anti-tumor actions may depend on the mitotic apoptosis, autophagy and inflammation: hypotheses with implications for chemo-immunotherapy of advanced cancers and pediatric gliomas. J Chemother. 2018;20:1–10.

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