Increased cancer incidence in Holocaust survivors and the implications for survivors of other extreme events

References

• Olsen J, Overvad K. The concept of multifactorial etiology of cancer. Pharmacol Toxicol. 1993;72(Suppl 1):33–38.
   PubMedGoogle Scholar
• Rothman KJ. Modern epidemiology. Boston: Little, Brown and company; 1986.
   Google Scholar
• Doll R, Peto R. The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. JNCI. 1981;66:1191–1308.
   PubMed Web of Science ®Google Scholar
• Islami F, Goding Sauer A, Miller KD, et al. Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States. CA Cancer J Clin. 2018;68:31‐54.
   PubMed Web of Science ®Google Scholar
• Barker DJ, Osmond C, Golding J, et al. Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. BMJ. 1989;298(6673):564–567.
   PubMed Web of Science ®Google Scholar
• Barker DJ, Martyn CN. The maternal and fetal origins of cardiovascular disease. J Epidemiol Community Health. 1992;46(1):8–11.
   PubMed Web of Science ®Google Scholar
• Barker DJ, Gluckman PD, Godfrey KM, et al. Fetal nutrition and cardiovascular disease in adult life. Lancet. 1993;341(8850):938–941.
   PubMed Web of Science ®Google Scholar
• Gillman MW, Barker D, Bier D, et al. Meeting report on the 3rd international congress on developmental origins of health and disease (DOHaD). Pediatr Res. 2007;61(5 Pt 1):625–629.
   PubMed Web of Science ®Google Scholar
• Wadhwa PT, Buss C, Entringer S, et al. Developmental origins of health and disease: brief history of the approach and current focus on epigenetic mechanisms. Semin Reprod Med. 2009;27(5):358–368.
   PubMed Web of Science ®Google Scholar
• Heindel JJ, Vandenberg LN. Developmental origins of health and disease: a paradigm for understanding disease etiology and prevention. Curr Opin Pediatr. 2015;27(2):248–253.
   PubMed Web of Science ®Google Scholar
• Heindel JJ, Skalla LA, Joubert BR, et al. Review of developmental origins of health and disease publications in environmental epidemiology. Repr Toxicol. 2017;68:34–48.
   PubMed Web of Science ®Google Scholar
• Hursting SD, Lavigne JA, Berrigan D, et al. Calorie restriction, aging, and cancer prevention: mechanisms of action and applicability to humans. Ann Rev Med. 2003;54:131–152.
   PubMed Web of Science ®Google Scholar
• Mellemkjaer L, Papadopoulos FC, Pukkala E, et al. Cancer incidence among patients with Anorexia Nervosa from Sweden, Denmark and Finland. PLoS One. 2015;10(5):e0128018.
   PubMed Web of Science ®Google Scholar
• Nilsen TI, Vatten LJ. Adult height and risk of breast cancer: a possible effect of early nutrition. Br J Cancer. 2001;85:959–961.
   PubMed Web of Science ®Google Scholar
• Tretli S, Gaard M. Lifestyle changes during adolescence and risk of breast cancer: an ecologic study of the effect of World War II in Norway. Cancer Causes Control. 1996;7:507–512.
   PubMed Web of Science ®Google Scholar
• Svensson E, Grotmol T, Hoff G, et al. Trends in colorectal cancer incidence in Norway by gender and anatomic site: an age-period-cohort analysis. Eur J Cancer Prev. 2002;11:489–495.
   PubMed Web of Science ®Google Scholar
• Svensson E, Møller B, Tretli S, et al. Early life events and later risk of colorectal cancer: age-period-cohort modelling in the Nordic countries and Estonia. Cancer Causes Control. 2005;16(3):215–223.
   PubMed Web of Science ®Google Scholar
• Robsahm TE, Tretli S. Breast cancer incidence in food – vs non-food producing areas in Norway: possible beneficial effects of World War II. Br J Cancer. 2002;86:362–366.
   PubMed Web of Science ®Google Scholar
• Dirx MJ. van den brandt PA, Goldbohm RA, et al. Energy restriction in childhood and adolescence and risk of prostate cancer: results from the Netherlands Cohort Study. Am J Epidemiol. 2001;154:530–537.
   PubMed Web of Science ®Google Scholar
• Dirx MJ. van den brandt PA, Goldbohm RA, et al. Diet adolescence risk breast cancer: Results Netherlands Cohort Study cancer causes control. 1999;10:189–199.
   PubMedGoogle Scholar
• Dirx MJ, van den Brandt PA, Goldbohm RA, et al. Energy restriction early in life and colon carcinoma risk: results of The Netherlands Cohort Study after 7.3 years of follow-up. Cancer. 2003;97:46–55.
   PubMed Web of Science ®Google Scholar
• Elias SG, Peeters PHM, Grobbee DE, et al. Breast cancer risk after caloric restriction during the 1944–1945 Dutch famine. J Natl Cancer Inst. 2004;96:539–545.
   PubMed Web of Science ®Google Scholar
• Elias SG, Keinan-Boker L, Peeters PH, et al. Long term consequences of the 1944-1945 Dutch famine on the insulin-like growth factor axis. Int J Cancer. 2004;108(4):628–630.
   PubMed Web of Science ®Google Scholar
• Simons CC, van Den Brandt PA, Stehouwer CD, et al. Body size, physical activity, early-life energy restriction, and associations with methylated insulin-like growth factor-binding protein genes in colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2014;23(9):1852–1862.
   PubMed Web of Science ®Google Scholar
• Fentiman IS, Allen DS, Ellison GTH. The impact of the occupation of Guernsey 1944-1945 on breast cancer risk factors and incidence. Int J Clin Pract. 2007;61:937–943.
   PubMed Web of Science ®Google Scholar
• Koupil I, Plavinskaja S, Parfenova N, et al. Cancer mortality in women and men who survived the siege of Leningrad (1941-1944). Int J Cancer. 2009;124:1416–1421.
   PubMed Web of Science ®Google Scholar
• He D, Fang Y, Gunter MJ, et al. Incidence of breast cancer in Chinese women exposed to the 1959-1961 great Chinese famine. BMC Cancer. 2017;17(1):824.
   PubMedGoogle Scholar
• Shasha SM. Morbidity in the concentration camps of the Third Reich. Harefuah. 2004;143(4): 272–276. 318 [Hebrew].
   PubMedGoogle Scholar
• Keinan-Boker L, Vin-Raviv N, Liphshitz I, et al. Cancer incidence in Israeli Jewish survivors of World War II. J Natl Cancer Inst. 2009;101(21):1489–1500.
   PubMedGoogle Scholar
• Keinan-Boker L, Goldbourt U. Cancer incidence in Holocaust male survivors – an Israeli cohort study. Int J Cancer. 2016;139(11):2426–2435.
   PubMed Web of Science ®Google Scholar
• Sadetzki S, Chetrit A, Freedman LS, et al. Cancer risk among Holocaust survivors in Israel – a nationwide study. Cancer. 2017;123(17):3335–3345.
   PubMed Web of Science ®Google Scholar
• Vin-Raviv N, Barchana M, Linn S, et al. Severe caloric restriction in young women during World War II and subsequent breast cancer risk. Int J Clin Pract. 2012;66(10):948–958.
   PubMed Web of Science ®Google Scholar
• Vin-Raviv N, Dekel R, Barchana M, et al. II-related post-traumatic stress disorder and breast cancer risk among Israeli women: a case-control study. Int Psychogeriatr. 2014;26(3):499–508.
   PubMed Web of Science ®Google Scholar
• Ben David R, Biderman A, Sherf M, et al. Elevated cancer risk in Holocaust survivors residing in Israel: a retrospective cohort study. Eur J Cancer. 2018;95:85–92.
   PubMed Web of Science ®Google Scholar
• Berkovich E, Keinan-Boker L, Shasha SM. Long-term health effects in adults born during the Holocaust. Isr Med Assoc J. 2014;16(4):203–207.
   PubMed Web of Science ®Google Scholar
• Keinan-Boker L, Shasha-Lavsky H, Eilat-Zanani S, et al. Chronic health conditions in Jewish Holocaust survivors born during World War II. Isr Med Assoc J. 2015;17(4):206–212.
   PubMed Web of Science ®Google Scholar
• Yehuda R, Daskalakis NP, Lehrner A, et al. Influences of maternal and paternal PTSD on epigenetic regulation of the glucocorticoid receptor gene in Holocaust survivor offspring. Am J Psychiatry. 2014;171(8):872–880.
   PubMed Web of Science ®Google Scholar
• Yehuda R, Daskalakis NP, Bierer LM, et al. Holocaust exposure induced intergenerational effects on FKBP5 methylation. Biol Psychiatry. 2016;80(5):372–380.
   PubMed Web of Science ®Google Scholar
• Ogino S, Nishihara R, VanderWeele TJ, et al. The role of molecular pathological epidemiology in the study of neoplastic and non-neoplastic diseases in the Era of precision medicine. Epidemiology. 2016;27(4):602–611.
   PubMed Web of Science ®Google Scholar