Risk factors for the development of local recurrence in extremity soft-tissue sarcoma

References

• Stiller CA, Trama A, Serraino D, et al. Descriptive epidemiology of sarcomas in Europe: report from the RARECARE project. Eur J Cancer. 2013;49:684–695.
   Google Scholar
• Antonescu CR. WHO, Classification of Tumours Editorial Board. Soft tissue and bone tumours. Lyon: International Agency for Research on Cancer; 2020.
   Google Scholar
• Ballinger ML, Goode DL, Ray-Coquard I, et al. Monogenic and polygenic determinants of sarcoma risk: an international genetic study. Lancet Oncol. 2016;17(9):1261–1271.
   PubMed Web of Science ®Google Scholar
• Shin SJ, Dodd-Eaton EB, Peng G, et al. Penetrance of Different Cancer Types in Families with Li-Fraumeni Syndrome: a Validation Study Using Multicenter Cohorts. Cancer Res. 2020;80(2):354–360.
   PubMed Web of Science ®Google Scholar
• Jones RM, Melton PE, Pinese M, et al. Identification of novel sarcoma risk genes using a two-stage genome wide DNA sequencing strategy in cancer cluster families and population case and control cohorts. BMC Med Genet. 2019;20(1):69.
   PubMedGoogle Scholar
• Chistiakov DA, Voronova NV, Chistiakov PA. Genetic variations in DNA repair genes, radiosensitivity to cancer and susceptibility to acute tissue reactions in radiotherapy-treated cancer patients. Acta Oncol. 2008;47(5):809–824.
   PubMed Web of Science ®Google Scholar
• Riad S, Biau D, Holt GE, et al. The clinical and functional outcome for patients with radiation-induced soft tissue sarcoma. Cancer. 2012;118(10):2682–2692.
   PubMed Web of Science ®Google Scholar
• Kim PJ, Mufti A, Sachdeva M, et al. Stewart-Treves syndrome and other cutaneous malignancies in the context of chronic lymphedema: a systematic review. Int J Dermatol. 2021; Epub ahead of print. DOI:https://doi.org/10.1111/ijd.15736.
   Google Scholar
• Guram S, Covelli AM, O’Neill AC, et al. Multidisciplinary intervention in radiation-associated angiosarcoma of the breast: patterns of recurrence and response to treatment. Ann Surg Oncol. 2021 doi:https://doi.org/10.1245/s10434-021-10477-1.
   Google Scholar
• Fiore M, Miceli R, Mussi C, et al. Dermatofibrosarcoma protuberans treated at a single institution: a surgical disease with a high cure rate. J Clin Oncol. 2005;23(30):7669–7675.
   PubMed Web of Science ®Google Scholar
• Huis In ’T Veld EA, van Coevorden F, Grünhagen DJ, et al. Outcome after surgical treatment of dermatofibrosarcoma protuberans: is clinical follow-up always indicated? Cancer. 2019;125(5):735–741.
   PubMed Web of Science ®Google Scholar
• Harati K, Lange K, Goertz O, et al. A single-institutional review of 68 patients with dermatofibrosarcoma protuberans: wide re-excision after inadequate previous surgery results in a high rate of local control. World J Surg Oncol. 2017;15(1):5.
   PubMedGoogle Scholar
• Huis In ‘T Veld EA, Grünhagen DJ, van Coevorden F, et al. Adequate surgical margins for dermatofibrosarcoma protuberans - A multi-centre analysis. Eur J Surg Oncol. 2021;47:436–442.
   PubMed Web of Science ®Google Scholar
• Snow HDE, Strauss DC, Smith M, et al. Conservative re-excision is a safe and simple alternative to radical resection in revision surgery for dermatofibrosarcoma protuberans. Ann Surg Oncol. 2019;27:919–923.
   PubMed Web of Science ®Google Scholar
• Woo K-J, Bang SI, Mun G-H, et al. Long-term outcomes of surgical treatment for dermatofibrosarcoma protuberans according to width of gross resection margin. J Plast Reconstr Aesthet Surg. 2016;69(3):395–401.
   PubMed Web of Science ®Google Scholar
• NCCN clinical practice guidelines in oncology. ; 2021.
   Google Scholar
• Sanfilippo R, Miceli R, Grosso F, et al. Myxofibrosarcoma: prognostic factors and survival in a series of patients treated at a single institution. Ann Surg Oncol. 2011;18(3):720–725.
   PubMed Web of Science ®Google Scholar
• Yoo HJ, Hong SH, Kang Y, et al. MR imaging of myxofibrosarcoma and undifferentiated sarcoma with emphasis on tail sign; diagnostic and prognostic value. Eur Radiol. 2014;24(8):1749–1757.
   PubMed Web of Science ®Google Scholar
• Boughzala-Bennadji R, Stoeckle E, Le Péchoux C, et al. Localized myxofibrosarcomas: roles of surgical margins and adjuvant radiation therapy. Int J Radiat Oncol Biol Phys. 2018;102(2):399–406.
   PubMed Web of Science ®Google Scholar
• Bonvalot S, Levy A, Terrier P, et al. Primary Extremity Soft Tissue Sarcomas: does Local Control Impact Survival? Ann Surg Oncol. 2017;24(1):194–201.
   PubMed Web of Science ®Google Scholar
• Gronchi A, Lo Vullo S, Colombo C, et al. Extremity soft tissue sarcoma in a series of patients treated at a single institution: local control directly impacts survival. Ann Surg. 2010;251(3):506–511.
   PubMed Web of Science ®Google Scholar
• Gronchi A, Verderio P, De Paoli A, et al. Quality of surgery and neoadjuvant combined therapy in the ISG-GEIS trial on soft tissue sarcomas of limbs and trunk wall. Ann Oncol. 2013;24(3):817–823.
   PubMed Web of Science ®Google Scholar
• Stacchiotti S, Frezza AM, Blay J-Y, et al. Ultra-rare sarcomas: a consensus paper from the Connective Tissue Oncology Society community of experts on the incidence threshold and the list of entities. Cancer. 2021;127(16):2934–2942.
   PubMed Web of Science ®Google Scholar
• Chbani L, Guillou L, Terrier P, et al. Epithelioid sarcoma: a clinicopathologic and immunohistochemical analysis of 106 cases from the French sarcoma group. Am J Clin Pathol. 2009;131(2):222–227.
   PubMed Web of Science ®Google Scholar
• Frezza AM, Sbaraglia M, Lo Vullo S, et al. The natural history of epithelioid sarcoma. A retrospective multicentre case-series within the Italian Sarcoma Group. Eur J Surg Oncol. 2020;46(7):1320–1326.
   PubMed Web of Science ®Google Scholar
• Levy A, Le Pechoux C, Terrier P, et al. Epithelioid sarcoma: need for a multimodal approach to maximize the chances of curative conservative treatment. Ann Surg Oncol. 2014;21(1):269–276.
   PubMed Web of Science ®Google Scholar
• Pradhan A, Grimer RJ, Abudu A, et al. Epithelioid sarcomas: how important is loco-regional control? Eur J Surg Oncol. 2017;43(9):1746–52.
   PubMed Web of Science ®Google Scholar
• Outani H, Imura Y, Tanaka T, et al. Clinical outcomes of patients with epithelioid sarcomas: impact and management of nodal metastasis. Int J Clin Oncol. 2018;23(1):181–188.
   PubMed Web of Science ®Google Scholar
• Czarnecka AM, Sobczuk P, Kostrzanowski M, et al. Epithelioid sarcoma—from genetics to clinical practice. Cancers (Basel). 2020;12(8):2112.
   Web of Science ®Google Scholar
• Sambri A, Bianchi G, Cevolani L, et al. Can radical margins improve prognosis in primary and localized epithelioid sarcoma of the extremities? J Surg Oncol. 2018;117(6):1204–1210.
   PubMed Web of Science ®Google Scholar
• Martin-Tellez KS, van Houdt WJ, van Coevorden F, et al. Isolated limb perfusion for soft tissue sarcoma: current practices and future directions. A survey of experts and a review of literature. Cancer Treat Rev. 2020;88:102058.
   PubMed Web of Science ®Google Scholar
• Gounder M, Schöffski P, Jones RL, et al. Tazemetostat in advanced epithelioid sarcoma with loss of INI1/SMARCB1: an international, open-label, phase 2 basket study. Lancet Oncol. 2020;21(11):1423–1432.
   PubMed Web of Science ®Google Scholar
• Frezza AM, Jones RL, Lo Vullo S, et al. Anthracycline, gemcitabine, and pazopanib in epithelioid sarcoma: a multi-institutional case series. JAMA Oncol. 2018;4(9):e180219.
   PubMed Web of Science ®Google Scholar
• Jones RL, Constantinidou A, Olmos D, et al. Role of palliative chemotherapy in advanced epithelioid sarcoma. Am J Clin Oncol. 2012;35(4):351–357.
   PubMed Web of Science ®Google Scholar
• Rosenberg SA, Tepper J, Glatstein E, et al. The treatment of soft tissue sarcomas of the extremities: prospective randomized evaluations of (1) limb-sparing surgery plus radiation therapy compared with amputation and (2) the role of adjuvant chemotherapy. Ann Surg. 1982;196:305–315.
   PubMed Web of Science ®Google Scholar
• Gronchi A, Miceli R, Fiore M, et al. Extremity soft tissue sarcoma: adding to the prognostic meaning of local failure. Ann Surg Oncol. 2007;14(5):1583–1590.
   PubMed Web of Science ®Google Scholar
• Ferrone ML, Raut CP. Modern surgical therapy: limb salvage and the role of amputation for extremity soft-tissue sarcomas. Surg Oncol Clin N Am. 2012;21(2):201–213.
   PubMed Web of Science ®Google Scholar
• Sambri A, Caldari E, Fiore M, et al. Margin assessment in soft tissue sarcomas: review of the literature. Cancers (Basel). 2021;13(7):1687.
   PubMed Web of Science ®Google Scholar
• Enneking WF, Spanier SS, Goodman MA. A system for the surgical staging of musculoskeletal sarcoma. Clin Orthop Relat Res. 1980;153:106–120.
   PubMed Web of Science ®Google Scholar
• Gerrand CH, Wunder JS, Kandel RA, et al. Classification of positive margins after resection of soft-tissue sarcoma of the limb predicts the risk of local recurrence. J Bone Joint Surg Br. 2001;83:7.
   Google Scholar
• AJCC manual for staging of cancer. 3rd ed. Philadelphia: JB Lippincott; 1988.
   Google Scholar
• Wittekind C, Compton CC, Greene FL, et al. TNM residual tumor classification revisited. Cancer. 2002;94(9):2511–2516.
   PubMed Web of Science ®Google Scholar
• Gundle KR, Kafchinski L, Gupta S, et al. Analysis of margin classification systems for assessing the risk of local recurrence after soft tissue sarcoma resection. J Clin Oncol. 2018;36:704–709.
   PubMed Web of Science ®Google Scholar
• Kainhofer V, Smolle MA, Szkandera J, et al. The width of resection margins influences local recurrence in soft tissue sarcoma patients. Eur J Surg Oncol. 2016;42(6):899–906.
   PubMed Web of Science ®Google Scholar
• Trovik CS, Skjeldal S, Bauer H, et al. Reliability of margin assessment after surgery for extremity soft tissue sarcoma: the SSG experience. Sarcoma. 2012;2012:290698.
   PubMedGoogle Scholar
• Khanfir K, Alzieu L, Terrier P, et al. Does adjuvant radiation therapy increase locoregional control after optimal resection of soft-tissue sarcoma of the extremities? Eur J Cancer. 2003;39(13) 1872–1880 doi:1016/s0959-8049(03)00426-x.).
   PubMed Web of Science ®Google Scholar
• O’Donnell PW, Griffin AM, Eward WC, et al. The effect of the setting of a positive surgical margin in soft tissue sarcoma. Cancer. 2014;120(18):2866–2875.
   PubMedGoogle Scholar
• Zagars GK, Ballo MT, Pisters PW, et al. Prognostic factors for patients with localized soft-tissue sarcoma treated with conservation surgery and radiation therapy: an analysis of 1225 patients. Cancer. 2003;97(10):2530–2543.
   PubMed Web of Science ®Google Scholar
• Coindre JM, Terrier P, Bui NB, et al. Prognostic factors in adult patients with locally controlled soft tissue sarcoma. A study of 546 patients from the French Federation of Cancer Centers Sarcoma Group. J Clin Oncol. 1996;14(3):869–877.
   PubMed Web of Science ®Google Scholar
• Trovik CS, Bauer HC, Alvegard TA, et al. Surgical margins, local recurrence and metastasis in soft tissue sarcomas: 559 surgically treated patients from the Scandinavian Sarcoma Group Register. Eur J Cancer. 2000;36(6):710–716.
   PubMed Web of Science ®Google Scholar
• Gronchi A, Casali PG, Mariani L, et al. Status of surgical margins and prognosis in adult soft tissue sarcomas of the extremities: a series of patients treated at a single institution. J Clin Oncol. 2005;23(1):96–104.
   PubMed Web of Science ®Google Scholar
• Weitz J, Antonescu CR, Brennan MF. Localized extremity soft tissue sarcoma: improved knowledge with unchanged survival over time. J Clin Oncol. 2003;21(14):2719–2725.
   PubMed Web of Science ®Google Scholar
• Stoeckle E, Gardet H, Coindre J-M, et al. Prospective evaluation of quality of surgery in soft tissue sarcoma. Eur J Surg Oncol. 2006;32(10):1242–1248.
   PubMed Web of Science ®Google Scholar
• Bilgeri A, Klein A, Lindner LH, et al. The effect of resection margin on local recurrence and survival in high grade soft tissue sarcoma of the extremities: how far is far enough? Cancers (Basel). 2020;12(9):2560.
   Web of Science ®Google Scholar
• Grimer R, Parry M, James S. Inadvertent excision of malignant soft tissue tumours. EFORT Open Rev. 2019;4(6):321–329.
   PubMed Web of Science ®Google Scholar
• Fiore M, Casali PG, Miceli R, et al. Prognostic effect of re-excision in adult soft tissue sarcoma of the extremity. Ann Surg Oncol. 2006;13(1):110–117.
   PubMed Web of Science ®Google Scholar
• Smolle MA, Tunn PU, Goldenitsch E, et al. The prognostic impact of unplanned excisions in a cohort of 728 soft tissue sarcoma patients: a multicentre study. Ann Surg Oncol. 2017;24(6):1596–1605.
   PubMed Web of Science ®Google Scholar
• Traub F, Griffin AM, Wunder JS, et al. Influence of unplanned excisions on the outcomes of patients with stage III extremity soft-tissue sarcoma. Cancer. 2018;124(19):3868–3875.
   PubMed Web of Science ®Google Scholar
• Qureshi YA, Huddy JR, Miller JD, et al. Unplanned excision of soft tissue sarcoma results in increased rates of local recurrence despite full further oncological treatment. Ann Surg Oncol. 2012;19(3):871–877.
   PubMed Web of Science ®Google Scholar
• Bone and soft tissue sarcoma - recognition and referral | health topics A to Z | CKS | NICE [Internet]. Available at: https://cks.nice.org.uk/topics/bone-soft-tissue-sarcoma-recognition-referral/
   Google Scholar
• Dangoor A, Seddon B, Gerrand C, et al. UK guidelines for the management of soft tissue sarcomas. Clin Sarcoma Res. 2016;6(1):20.
   PubMedGoogle Scholar
• Improving outcomes for people with sarcoma | guidance | NICE [Internet]. NICE. Available at https://www.nice.org.uk/guidance/csg9
   Google Scholar
• Danieli M, Barretta F, Fiore M, et al. Unplanned excision of extremity and trunk wall soft tissue sarcoma: to re-resect or not to re-resect? Ann Surg Oncol. 2021;28(8):4706–4717.
   PubMed Web of Science ®Google Scholar
• Bianchi G, Sambri A, Cammelli S, et al. Impact of residual disease after “unplanned excision” of primary localized adult soft tissue sarcoma of the extremities: evaluation of 452 cases at a single institution. Musculoskelet Surg. 2017;101(3):243–248.
   PubMedGoogle Scholar
• Zaidi MY, Ethun CG, Liu Y, et al. The impact of unplanned excisions of truncal/extremity soft tissue sarcomas: a multi-institutional propensity score analysis from the US Sarcoma Collaborative. J Surg Oncol. 2019;120(3):332–339.
   PubMed Web of Science ®Google Scholar
• Arai E, Nishida Y, Tsukushi S, et al. Clinical and treatment outcomes of planned and unplanned excisions of soft tissue sarcomas. Clin Orthop Relat Res. 2010;468(11):3028–3034.
   PubMed Web of Science ®Google Scholar
• Charoenlap C, Imanishi J, Tanaka T, et al. Outcomes of unplanned sarcoma excision: impact of residual disease. Cancer Med. 2016;5(6):980–988.
   PubMed Web of Science ®Google Scholar
• Decanter G, Stoeckle E, Honore C, et al. Watch and wait approach for re-excision after unplanned yet macroscopically complete excision of extremity and superficial truncal soft tissue sarcoma is safe and does not affect metastatic risk or amputation rate. Ann Surg Oncol. 2019;26(11):3526–3534.
   PubMed Web of Science ®Google Scholar
• Koulaxouzidis G, Schwarzkopf E, Bannasch H, et al. Is revisional surgery mandatory when an unexpected sarcoma diagnosis is made following primary surgery? World J Surg Onc. 2015;13(1):306.
   PubMedGoogle Scholar
• Liang Y, Guo T-H, Xu B-S, et al. The impact of unplanned excision on the outcomes of patients with soft tissue sarcoma of the trunk and extremity: a propensity score matching analysis. Front Oncol. 2021;10:617590.
   PubMed Web of Science ®Google Scholar
• Nakamura T, Kawai A, Sudo A. Analysis of the patients with soft tissue sarcoma who received additional excision after unplanned excision: report from the Bone and Soft Tissue Tumor Registry in Japan. Jap J Clin Oncol. 2017;47:1055–1059.
   Google Scholar
• American Joint Committee on Cancer. AJCC cancer staging manual. 8th ed. Springer Chicago; 2017.
   Google Scholar
• Kattan MW, Leung DH, Brennan MF. Postoperative nomogram for 12-year sarcoma-specific death. J Clin Oncol. 2002;20(3):791–796.
   PubMed Web of Science ®Google Scholar
• Mariani L, Miceli R, Kattan MW, et al. Validation and adaptation of a nomogram for predicting the survival of patients with extremity soft tissue sarcoma using a three-grade system. Cancer. 2005;103(2):402–408.
   PubMed Web of Science ®Google Scholar
• Callegaro D, Miceli R, Bonvalot S, et al. Development and external validation of two nomograms to predict overall survival and occurrence of distant metastases in adults after surgical resection of localised soft-tissue sarcomas of the extremities: a retrospective analysis. Lancet Oncol. 2016;17(5):671–680.
   PubMed Web of Science ®Google Scholar
• Callegaro D, Miceli R, Bonvalot S, et al. Development and external validation of a dynamic prognostic nomogram for primary extremity soft tissue sarcoma survivors. EClinicalMedicine. 2019;17:100215.
   PubMedGoogle Scholar
• Cahlon O, Brennan MF, Jia X, et al. A postoperative nomogram for local recurrence risk in extremity soft tissue sarcomas after limb-sparing surgery without adjuvant radiation. Ann Surg. 2012;255(2):343–347.
   PubMed Web of Science ®Google Scholar
• Ardoino I, Miceli R, Berselli M, et al. Histology-specific nomogram for primary retroperitoneal soft tissue sarcoma. Cancer. 2010;116(10):2429–2436.
   PubMed Web of Science ®Google Scholar
• Anaya DA, Lahat G, Wang X, et al. Postoperative nomogram for survival of patients with retroperitoneal sarcoma treated with curative intent. Ann Oncol. 2010;21(2):397–402.29.
   PubMed Web of Science ®Google Scholar
• Raut CP, Callegaro D, Miceli R, et al. Predicting survival in patients undergoing resection for locally recurrent retroperitoneal sarcoma: a study and novel nomogram from TARPSWG. Clin Cancer Res. 2019;25(8):2664–2671.
   PubMed Web of Science ®Google Scholar
• Dalal KM, Kattan MW, Antonescu CR, et al. Subtype specific prognostic nomogram for patients with primary liposarcoma of the retroperitoneum, extremity, or trunk. Ann Surg. 2006;244(3):381–391.
   PubMed Web of Science ®Google Scholar
• Canter RJ, Qin LX, Maki RG, et al. A synovial sarcoma-specific preoperative nomogram supports a survival benefit to ifosfamide based chemotherapy and improves risk stratification for patients. Clin Cancer Res. 2008;14(24):8191–8197.
   PubMed Web of Science ®Google Scholar
• Zivanovic O, Jacks LM, Iasonos A, et al. A nomogram to predict postresection 5-year overall survival for patients with uterine leiomyosarcoma. Cancer. 2012;118(3):660–669.
   PubMed Web of Science ®Google Scholar
• Sarculator. Available at: https://www.sarculator.com/
   Google Scholar
• van Praag VM, Rueten-Budde AJ, Jeys LM, et al. A prediction model for treatment decisions in high-grade extremity soft-tissue sarcomas: personalised sarcoma care (PERSARC). Eur J Cancer. 2017;83:313–323.
   PubMed Web of Science ®Google Scholar
• Rueten-Budde AJ, van Praag VM, van de Sande MAJ, et al. Dynamic prediction of overall survival for patients with high-grade extremity soft tissue sarcoma. Surg Oncol. 2018;27(4):695–701.
   PubMed Web of Science ®Google Scholar
• Haas RLM, Delaney TF, O’Sullivan B, et al. Radiotherapy for management of extremity soft tissue sarcomas: why, when, and where? Int J Radiat Oncol Biol Phys. 2012;84(3):572–580.
   PubMed Web of Science ®Google Scholar
• Casali PG, Abecassis N, Aro HT. ESMO guidelines committee and EURACAN. Soft tissue and visceral sarcomas: ESMO-EURACAN clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2018;29:iv268–iv269.
   PubMed Web of Science ®Google Scholar
• Fiore M, Ford S, Callegaro D, et al. Adequate Local control in high-risk soft tissue sarcoma of the extremity treated with surgery alone at a reference centre: should radiotherapy still be a standard? Ann Surg Oncol. 2018;25(6):1536–1543.
   PubMed Web of Science ®Google Scholar
• O’Sullivan B, Davis AM, Turcotte R, et al. Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: a randomised trial. Lancet. 2002;359(9325):2235–2241.
   PubMed Web of Science ®Google Scholar
• Al Yami A, Grifn AM, Ferguson PC, et al. Positive surgical margins in soft tissue sarcoma treated with preoperative radiation: is a postoperative boost necessary? Int J Radiat Oncol Biol Phys. 2010;77:1191–1197.
   PubMed Web of Science ®Google Scholar
• Alamanda VK, Song Y, Shinohara E, et al. Postoperative radiation boost does not improve local recurrence rates in extremity soft tissue sarcomas. J Med Imaging Radiat Oncol. 2014;58(5):633–640.
   PubMed Web of Science ®Google Scholar
• Callegaro D, Miceli R, Bonvalot S, et al. Impact of perioperative chemotherapy and radiotherapy in patients with primary extremity soft tissue sarcoma: retrospective analysis across major histological subtypes and major reference centres. Eur J Cancer. 2018;105:19–27.
   PubMed Web of Science ®Google Scholar
• Sarcoma Meta-analysis Collaboration. Adjuvant chemotherapy for localised resectable soft-tissue sarcoma of adults: meta-analysis of individual data. Sarcoma Metaanalysis Collaboration. Lancet. 1997;350(9092):1647–1654.
   PubMedGoogle Scholar
• Sarcoma Meta-analysis Collaboration (SMAC). Adjuvant chemotherapy for localised resectable soft tissue sarcoma in adults. Sarcoma Meta-analysis Collaboration (SMAC). Cochrane Database Syst Rev. 2000;CD001419.
   Google Scholar
• Pervaiz N, Colterjohn N, Farrokhyar F, et al. A systematic meta-analysis of randomized controlled trials of adjuvant chemotherapy for localized resectable soft-tissue sarcoma. Cancer. 2008;113(3):573–581.
   PubMed Web of Science ®Google Scholar
• Pasquali S, Pizzamiglio S, Touati N, et al. The impact of chemotherapy on survival of patients with extremity and trunk wall soft tissue sarcoma: revisiting the results of the EORTC-STBSG 62931 randomised trial. Eur J Cancer. 2019;109:51–60.
   PubMed Web of Science ®Google Scholar
• Woll PJ, Reichardt P, Le Cesne A, et al. Adjuvant chemotherapy with doxorubicin, ifosfamide, and lenograstim for resected soft-tissue sarcoma (EORTC 62931): a multicentre randomised controlled trial. Lancet Oncol. 2012;13(10):1045–1054.
   PubMed Web of Science ®Google Scholar
• Le Cesne A, Ouali M, Leahy MG, et al. Doxorubicin-based adjuvant chemotherapy in soft tissue sarcoma: pooled analysis of two STBSG-EORTC phase III clinical trials. Ann Oncol. 2014;25(12):2425–2432.
   PubMed Web of Science ®Google Scholar
• Sachpekidis C, Karampinis I, Jakob J, et al. Neoadjuvant pazopanib treatment in high-risk soft tissue sarcoma: a quantitative dynamic 18F-FDG PET/CT study of the German Interdisciplinary Sarcoma Group. Cancers (Basel). 2019;11(6):790.
   Web of Science ®Google Scholar
• Haas RL, Gelderblom H, Sleijfer S, et al. A phase I study on the combination of neoadjuvant radiotherapy plus pazopanib in patients with locally advanced soft tissue sarcoma of the extremities. Acta Oncol. 2015;54:1195–1201.
   PubMed Web of Science ®Google Scholar
• Lewin J, Khamly KK, Young RJ, et al. A phase Ib/II translational study of sunitinib with neoadjuvant radiotherapy in soft-tissue sarcoma. Br J Cancer. 2014;111(12):2254–2261.
   PubMed Web of Science ®Google Scholar
• Hindi N, Carrasco García I, Sánchez-Camacho A, et al. Trabectedin plus radiotherapy for advanced soft-tissue sarcoma: experience in forty patients treated at a sarcoma reference center. Cancers (Basel). 2020;12(12):3740.
   PubMed Web of Science ®Google Scholar
• Eggermont AM, Schraffordt Koops H, Klausner JM, et al. Isolated limb perfusion with tumor necrosis factor and melphalan for limb salvage in 186 patients with locally advanced soft tissue extremity sarcomas. The cumulative multicenter European experience. Ann Surg. 1996;224(6):756–765.
   PubMed Web of Science ®Google Scholar
• Neuwirth MG, Song Y, Sinnamon AJ, et al. Isolated limb perfusion and infusion for extremity soft tissue sarcoma: a contemporary systematic review and meta-analysis. Ann Surg Oncol. 2017;24(13):3803–3810.
   PubMed Web of Science ®Google Scholar
• Hoven-Gondrie ML, Bastiaannet E, van Ginkel RJ, et al. TNF dose reduction and shortening of duration of isolated limb perfusion for locally advanced soft tissue sarcoma of the extremities is safe and effective in terms of long-term patient outcome. J Surg Oncol. 2011;103(7):648–655.
   PubMed Web of Science ®Google Scholar
• Deroose JP, Eggermont AM, van Geel AN, et al. Long-term results of tumor necrosis factor alpha- and melphalan-based isolated limb perfusion in locally advanced extremity soft tissue sarcomas. J Clin Oncol. 2011;29:4036–4044.
   PubMed Web of Science ®Google Scholar
• Jakob J, Smith HG, Wilkinson MJ, et al. Regional chemotherapy by isolated limb perfusion prior to surgery compared with surgery and post-operative radiotherapy for primary, locally advanced extremity sarcoma: a comparison of matched cohorts. Clin Sarcoma Res. 2018;8(1):12.
   PubMedGoogle Scholar
• Smith HG, Cartwright J, Wilkinson MJ, et al. Isolated limb perfusion with melphalan and tumour necrosis factor α for in-transit melanoma and soft tissue sarcoma. Ann Surg Oncol. 2015;22(Suppl S3):356–361.
   Google Scholar
• Smith HG, Wilkinson MJ, Smith MJF, et al. The effect of age on outcomes after isolated limb perfusion for advanced extremity malignancies. Eur J Cancer. 2018;100:46–54.
   PubMed Web of Science ®Google Scholar
• Smith HG, Mansfield D, Roulstone V, et al. PD-1 blockade following isolated limb perfusion with vaccinia virus prevents local and distant relapse of soft-tissue sarcoma. AJ Clin Cancer Res. 2019;25(11):3443–3454.
   PubMed Web of Science ®Google Scholar