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Expert Review of Molecular Diagnostics Volume 17, 2017 - Issue 2
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Letter to the Editor

Convergent lines of evidence support the role of uric acid levels as a potential biomarker in bipolar disorder

Rodrigo Machado-VieiraExperimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USAView further author information
,
Haitham SalemDepartment of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USAView further author information
,
Benicio N FreyDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada;Mood Disorders Program and Women’s Health Concerns Clinic, St. Joseph’s Healthcare, Hamilton, ON, CanadaView further author information
,
Izabela G BarbosaInterdisciplinary Laboratory of Medical Investigation, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, BrazilView further author information
&
Antonio L TeixeiraDepartment of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA;Interdisciplinary Laboratory of Medical Investigation, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, BrazilCorrespondence[email protected]
View further author information
Pages 107-108 | Received 07 Dec 2016, Accepted 07 Dec 2016, Published online: 20 Dec 2016

References

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  • Teixeira AL, Salem H, Frey BN, et al. Update on bipolar disorderbiomarker candidates. Expert Rev Mol Diagn. 2016;16:1209–1220. DOI:10.1080/14737159.2016.1248413
  • Machado-Vieira R. Purinergic system in the treatment of bipolar disorder: uric acid levels as a screening test in mania. J Clin Psychopharmacol. 2012 Oct;32(5):735–736. DOI:10.1097/JCP.0b013e318268391d
  • Ortiz R, Ulrich H, Zarate CA Jr, et al. Purinergic system dysfunction in mood disorders: a key target for developing improved therapeutics. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Mar 3;57: 117–131. DOI:10.1016/j.pnpbp.2014.10.016
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  • Bartoli F, Crocamo C, Dakanalis A, et al. Purinergic system dysfunctions in subjects with bipolar disorder: a comparative cross-sectional study. Compr Psychiatry. 2016 Sep 30;73: 1–6. DOI:10.1016/j.comppsych.2016.09.011
  • Karve AV, Jagtiani SS, Chitnis KA. Evaluation of effect of allopurinol and febuxostat in behavioral model of depression in mice. Indian J Pharmacol. 2013;45:244–247.
  • Jahangard L, Soroush S, Haghighi M, et al. In a double-blind, randomized and placebo-controlled trial, adjuvant allopurinol improved symptoms of mania in in-patients suffering from bipolar disorder. Eur Neuropsychopharmacol. 2014;24:1210–1221.
  • Chung KH, Huang CC, Lin HC. Increased risk of gout among patients with bipolar disorder: a nationwide population-based study. Psychiatry Res. 2010;180:147–150.

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