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Expert Review of Molecular Diagnostics Volume 18, 2018 - Issue 1
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Editorial

Circulating tumor DNA as a biomarker to guide therapy in post-operative locally advanced rectal cancer: the best option?

Jeanne TieDivision of Systems Biology and Personalised Medicine, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia;Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia;Department of Medical Oncology, Western Health, Melbourne, Australia;Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, AustraliaCorrespondence[email protected]
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,
Christine SemiraDivision of Systems Biology and Personalised Medicine, Walter and Eliza Hall Institute of Medical Research, Melbourne, AustraliaView further author information
&
Peter GibbsDivision of Systems Biology and Personalised Medicine, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia;Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia;Department of Medical Oncology, Western Health, Melbourne, Australia;Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, AustraliaView further author information
Pages 1-3 | Received 30 Aug 2017, Accepted 27 Sep 2017, Published online: 06 Oct 2017

References

  • Bettegowda C, Sausen M, Leary RJ, et al. Detection of circulating tumor DNA in early- and late-stage human malignancies. Sci Transl Med. 2014;6(224):224ra24. PubMed PMID: 24553385.
  • Tie J, Kinde I, Wang Y, et al. Circulating tumor DNA as an early marker of therapeutic response in patients with metastatic colorectal cancer. Ann Oncol. 2015;26(8):1715–1722. PubMed PMID: 25851626; PubMed Central PMCID: PMCPMC4511218.
  • Diehl F, Schmidt K, Choti MA, et al. Circulating mutant DNA to assess tumor dynamics. Nat Med. 2008;14(9):985–990. Epub 2008/08/02. nm.1789 [pii] . PubMed PMID: 18670422.
  • Newman AM, Bratman SV, To J, et al. An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage. Nat Med. 2014;20(5):548–554. PubMed PMID: 24705333; PubMed Central PMCID: PMCPMC4016134.
  • Garcia-Murillas I, Schiavon G, Weigelt B, et al. Mutation tracking in circulating tumor DNA predicts relapse in early breast cancer. Sci Transl Med. 2015;7(302):302ra133. PubMed PMID: 26311728.
  • Sausen M, Phallen J, Adleff V, et al. Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients. Nat Commun. 2015;6:7686. PubMed PMID: 26154128; PubMed Central PMCID: PMCPMC4634573.
  • Kinde I, Wu J, Papadopoulos N, et al. Detection and quantification of rare mutations with massively parallel sequencing. Proc Natl Acad Sci U S A. 2011;108(23):9530–9535. Epub 2011/05/19. PubMed PMID: 21586637; PubMed Central PMCID: PMC3111315.
  • Petersen SH, Harling H, Kirkeby LT, et al., Postoperative adjuvant chemotherapy in rectal cancer operated for cure. Cochrane Database Syst Rev. 2012(3):CD004078. PubMed PMID: 22419291.
  • Hong TS, Ryan DP. Adjuvant chemotherapy for locally advanced rectal cancer: is it a given? J Clin Oncol. 2015;33(17):1878–1880. PubMed PMID: 25940719.
  • Breugom AJ, Swets M, Bosset JF, et al. Adjuvant chemotherapy after preoperative (chemo)radiotherapy and surgery for patients with rectal cancer: a systematic review and meta-analysis of individual patient data. Lancet Oncol. 2015;16(2):200–207. PubMed PMID: 25589192.
  • Hong YS, Nam BH, Kim KP, et al. Oxaliplatin, fluorouracil, and leucovorin versus fluorouracil and leucovorin as adjuvant chemotherapy for locally advanced rectal cancer after preoperative chemoradiotherapy (ADORE): an open-label, multicentre, phase 2, randomised controlled trial. Lancet Oncol. 2014;15(11):1245–1253. PubMed PMID: 25201358.
  • Rodel C, Graeven U, Fietkau R, et al. Oxaliplatin added to fluorouracil-based preoperative chemoradiotherapy and postoperative chemotherapy of locally advanced rectal cancer (the German CAO/ARO/AIO-04 study): final results of the multicentre, open-label, randomised, phase 3 trial. Lancet Oncol. 2015;16(8):979–989. PubMed PMID: 26189067.
  • Allegra CJ, Yothers G, O’Connell MJ, et al. Neoadjuvant 5-FU or capecitabine plus radiation with or without oxaliplatin in rectal cancer patients: a phase III randomized clinical trial. J Natl Cancer Inst. 2015;107(11). PubMed PMID: 26374429; PubMed Central PMCID: PMCPMC4849360.
  • Maas M, Nelemans PJ, Valentini V, et al. Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data. Lancet Oncol. 2010;11(9):835–844. PubMed PMID: 20692872.
  • Tie J, Wang Y, Tomasetti C, et al. Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer. Sci Transl Med. 2016;8(346):346ra92. PubMed PMID: 27384348; PubMed Central PMCID: PMCPMC5346159.
  • Tie J, Cohen J, Wang Y, et al. The potential of circulating tumor DNA (ctDNA) to guide adjuvant chemotherapy decision making in locally advanced rectal cancer (LARC). J Clin Oncol. 2017 May;35(15_suppl):3521.

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