Clinical, genetic, and brain imaging predictors of risk for bipolar disorder in high-risk individuals

References

• Goodwin FKJ, Kay Redfield J. Manic-depressive illness: bipolar disorders and recurrent depression. USA: OUP; 2007.
   Google Scholar
• Nierenberg AA. Current perspectives on the diagnosis and treatment of major depressive disorder. Am J Manag Care. 2001 Sep;7(11 Suppl):S353–66.
   PubMed Web of Science ®Google Scholar
• Manchia M, Lampus S, Chillotti C, et al. Age at onset in Sardinian bipolar I patients: evidence for three subgroups. Bipolar Disord. 2008 May;10(3):443–446.
   PubMed Web of Science ®Google Scholar
• Bauer M, Glenn T, Alda M, et al. Influence of birth cohort on age of onset cluster analysis in bipolar I disorder. Eur Psychiatry. 2015 Jan;30(1):99–105.
   PubMed Web of Science ®Google Scholar
• Malhi GS, Morris G, Hamilton A, et al. Is “early intervention” in bipolar disorder what it claims to be? Bipolar Disord. 2017 Dec;19(8):627–636.
   PubMed Web of Science ®Google Scholar
• Bauer M, Beaulieu S, Dunner DL, et al. Rapid cycling bipolar disorder–diagnostic concepts. Bipolar Disord. 2008 Feb;10(1p2):153–162.
   PubMedGoogle Scholar
• Treuer T, Tohen M. Predicting the course and outcome of bipolar disorder: a review. Eur Psychiatry. 2010 Oct;25(6):328–333.
   PubMed Web of Science ®Google Scholar
• McGorry PD, Nelson B, Amminger GP, et al. Intervention in individuals at ultra-high risk for psychosis: a review and future directions. J Clin Psychiatry. 2009 Sep;70(9):1206–1212.
   PubMed Web of Science ®Google Scholar
• Yung AR, McGorry PD. The prodromal phase of first-episode psychosis: past and current conceptualizations. Schizophr Bull. 1996;22(2):353–370.
   PubMed Web of Science ®Google Scholar
• Correll CU. Clinical psychopharmacology of pediatric mood stabilizer and antipsychotic treatment, part 1: challenges and developments. J Clin Psychiatry. 2007 Aug;68(8):1301–1302.
   PubMed Web of Science ®Google Scholar
• Hauser M, Pfennig A, Ozgurdal S, et al. Early recognition of bipolar disorder. Eur Psychiatry. 2007 Mar;22(2):92–98.
   PubMed Web of Science ®Google Scholar
• Birmaher B, Gill MK, Axelson DA, et al. Longitudinal trajectories and associated baseline predictors in youths with bipolar spectrum disorders. Am J Psychiatry. 2014 Sep;171(9):990–999.
   PubMed Web of Science ®Google Scholar
• Duffy A. Toward a comprehensive clinical staging model for bipolar disorder: integrating the evidence. Can J Psychiatry. 2014 Dec;59(12):659–666.
   PubMed Web of Science ®Google Scholar
• Jimenez E, Sole B, Arias B, et al. Impact of childhood trauma on cognitive profile in bipolar disorder. Bipolar Disord. 2017 Aug;19(5):363–374.
   PubMed Web of Science ®Google Scholar
• Ratheesh A, Cotton SM, Betts JK, et al. Prospective progression from high-prevalence disorders to bipolar disorder: exploring characteristics of pre-illness stages. J Affect Disord. 2015 Sep;1(183):45–48.
   Google Scholar
• Craddock N, Sklar P. Genetics of bipolar disorder. Lancet. 2013 May 11;381(9878):1654–1662.
   PubMed Web of Science ®Google Scholar
• Fusar-Poli P, Borgwardt S, Bechdolf A, et al. The psychosis high-risk state: a comprehensive state-of-the-art review. JAMA Psychiatry. 2013 Jan;70(1):107–120.
   PubMed Web of Science ®Google Scholar
• Duffy A, Alda M, Hajek T, et al. Early course of bipolar disorder in high-risk offspring: prospective study. Br J Psychiatry. 2009 Nov;195(5):457–458.
   PubMed Web of Science ®Google Scholar
• Henquet C, Krabbendam L, de Graaf R, et al. Cannabis use and expression of mania in the general population. J Affect Disord. 2006 Oct;95(1–3):103–110.
   PubMed Web of Science ®Google Scholar
• Strober M, Carlson G. Bipolar illness in adolescents with major depression: clinical, genetic, and psychopharmacologic predictors in a three- to four-year prospective follow-up investigation. Arch Gen Psychiatry. 1982 May;39(5):549–555.
   PubMedGoogle Scholar
• Fiedorowicz JG, Endicott J, Leon AC, et al. Subthreshold hypomanic symptoms in progression from unipolar major depression to bipolar disorder. Am J Psychiatry. 2011 Jan;168(1):40–48.
   PubMed Web of Science ®Google Scholar
• Gilman SE, Dupuy JM, Perlis RH. Risks for the transition from major depressive disorder to bipolar disorder in the national epidemiologic survey on alcohol and related conditions. J Clin Psychiatry. 2012 Jun;73(6):829–836.
   PubMed Web of Science ®Google Scholar
• Holma KM, Melartin TK, Holma IA, et al. Predictors for switch from unipolar major depressive disorder to bipolar disorder type I or II: a 5-year prospective study. J Clin Psychiatry. 2008 Aug;69(8):1267–1275.
   PubMed Web of Science ®Google Scholar
• Pancheri C, Verdolini N, Pacchiarotti I, et al. A systematic review on sleep alterations anticipating the onset of bipolar disorder. Eur Psychiatry. 2019;58:45–53.
   PubMed Web of Science ®Google Scholar
• Kaplan KA, Harvey AG. Behavioral treatment of insomnia in bipolar disorder. Am J Psychiatry. 2013 Jul;170(7):716–720.
   PubMed Web of Science ®Google Scholar
• Narayan AJ, Allen TA, Cullen KR, et al. Disturbances in reality testing as markers of risk in offspring of parents with bipolar disorder: a systematic review from a developmental psychopathology perspective. Bipolar Disord. 2013 Nov;15(7):723–740.
   PubMed Web of Science ®Google Scholar
• Klimes-Dougan B, Desjardins CD, James MG, et al. The development of thought problems: a longitudinal family risk study of offspring of bipolar, unipolar, and well parents. Dev Psychopathol. 2013 Nov;25(4pt1):1079–1091.
   PubMedGoogle Scholar
• Duffy A, Grof P, Kutcher S, et al. Measures of attention and hyperactivity symptoms in a high-risk sample of children of bipolar parents. J Affect Disord. 2001 Dec;67(1–3):159–165.
   PubMed Web of Science ®Google Scholar
• MacQueen GM, Grof P, Alda M, et al. A pilot study of visual backward masking performance among affected versus unaffected offspring of parents with bipolar disorder. Bipolar Disord. 2004 Oct;6(5):374–378.
   PubMed Web of Science ®Google Scholar
• Duffy A, Horrocks J, Doucette S, et al. The developmental trajectory of bipolar disorder. Br J Psychiatry. 2014 Feb;204(2):122–128.
   PubMed Web of Science ®Google Scholar
• Raouna A, Osam CS, MacBeth A. Clinical staging model in offspring of parents with bipolar disorder: a systematic review. Bipolar Disord. 2018 Jun;20(4):313–333.
   PubMed Web of Science ®Google Scholar
• Malhi GS, Outhred T, Hamilton A, et al. Early intervention in bipolar disorder is not what it claims to be! Bipolar Disord. 2018 Jun 21;20:414–416.
   Google Scholar
• Duffy A, Grof P. Commentary on McGorry et al.’s debate on: “is ‘early intervention’ in bipolar disorder what it claims to be?”. Bipolar Disord. 2018 Sep;20(6):556–557.
   PubMed Web of Science ®Google Scholar
• Fusar-Poli P, Solmi M, Brondino N, et al. Transdiagnostic psychiatry: a systematic review. World Psychiatry. 2019 Jun;18(2):192–207.
   PubMed Web of Science ®Google Scholar
• Duffy A, Malhi GS, Grof P. Do the trajectories of bipolar disorder and schizophrenia follow a universal staging model? Can J Psychiatry. 2017 Feb;62(2):115–122.
   PubMed Web of Science ®Google Scholar
• Kowianski P, Lietzau G, Czuba E, et al. BDNF: A key factor with multipotent impact on brain signaling and synaptic plasticity. Cell Mol Neurobiol. 2018 Apr;38(3):579–593.
   PubMed Web of Science ®Google Scholar
• Vinberg M, Trajkovska V, Bennike B, et al. The BDNF Val66Met polymorphism: relation to familiar risk of affective disorder, BDNF levels and salivary cortisol. Psychoneuroendocrinology. 2009 Oct;34(9):1380–1389.
   PubMed Web of Science ®Google Scholar
• Mesman E, Hillegers MH, Ambree O, et al. Monocyte activation, brain-derived neurotrophic factor (BDNF), and S100B in bipolar offspring: a follow-up study from adolescence into adulthood. Bipolar Disord. 2015 Feb;17(1):39–49.
   PubMed Web of Science ®Google Scholar
• Duffy A, Horrocks J, Doucette S, et al. Immunological and neurotrophic markers of risk status and illness development in high-risk youth: understanding the neurobiological underpinnings of bipolar disorder. Int J Bipolar Disord. 2014 Dec;2(1):29.
   PubMedGoogle Scholar
• Park MH, Sanders E, Howe M, et al. Association of anxiety symptoms in offspring of bipolar parents with serotonin transporter-linked polymorphic region (5-HTTLPR) genotype. J Child Adolesc Psychopharmacol. 2015 Aug;25(6):458–466.
   PubMed Web of Science ®Google Scholar
• Gasso P, Sanchez-Gistau V, Mas S, et al. Association of CACNA1C and SYNE1 in offspring of patients with psychiatric disorders. Psychiatry Res. 2016 Nov 30;245:427–435.
   PubMed Web of Science ®Google Scholar
• Fries GR, Quevedo J, Zeni CP, et al. Integrated transcriptome and methylome analysis in youth at high risk for bipolar disorder: a preliminary analysis. Transl Psychiatry. 2017 Mar 14;7(3):e1059.
   PubMedGoogle Scholar
• Fries GR, Carvalho AF, Quevedo J. The miRNome of bipolar disorder. J Affect Disord. 2018 Jun;233:110–116.
   PubMed Web of Science ®Google Scholar
• Pisanu C, Heilbronner U, Squassina A. The role of pharmacogenomics in bipolar disorder: moving towards precision medicine. Mol Diagn Ther. 2018 Aug;22(4):409–420.
   PubMed Web of Science ®Google Scholar
• Walker RM, Rybka J, Anderson SM, et al. Preliminary investigation of miRNA expression in individuals at high familial risk of bipolar disorder. J Psychiatr Res. 2015 Mar;62:48–55.
   PubMed Web of Science ®Google Scholar
• Whalley HC, Papmeyer M, Romaniuk L, et al. Effect of variation in diacylglycerol kinase eta (DGKH) gene on brain function in a cohort at familial risk of bipolar disorder. Neuropsychopharmacology. 2012 Mar;37(4):919–928.
   PubMed Web of Science ®Google Scholar
• Manchia M, Squassina A, Congiu D, et al. Interacting genes in lithium prophylaxis: preliminary results of an exploratory analysis on the role of DGKH and NR1D1 gene polymorphisms in 199 Sardinian bipolar patients. Neurosci Lett. 2009 Dec 25;467(2):67–71.
   PubMed Web of Science ®Google Scholar
• Severino G, Squassina A, Costa M, et al. Pharmacogenomics of bipolar disorder. Pharmacogenomics. 2013 Apr;14(6):655–674.
   PubMed Web of Science ®Google Scholar
• Weber H, Kittel-Schneider S, Gessner A, et al. Cross-disorder analysis of bipolar risk genes: further evidence of DGKH as a risk gene for bipolar disorder, but also unipolar depression and adult ADHD. Neuropsychopharmacology. 2011 Sep;36(10):2076–2085.
   PubMed Web of Science ®Google Scholar
• Squassina A, Manchia M, Congiu D, et al. The diacylglycerol kinase eta gene and bipolar disorder: A replication study in a sardinian sample. Mol Psychiatry. 2009 Apr;14(4):350–351.
   Google Scholar
• Delvecchio G, Dima D, Frangou S. The effect of ANK3 bipolar-risk polymorphisms on the working memory circuitry differs between loci and according to risk-status for bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2015 Apr;168B(3:188–196.
   Google Scholar
• Squassina A, Pisanu C, Corbett N, et al. Telomere length in bipolar disorder and lithium response. Eur Neuropsychopharmacol. 2017 Jun;27(6):560–567.
   PubMed Web of Science ®Google Scholar
• Maurya PK, Rizzo LB, Xavier G, et al. Shorter leukocyte telomere length in patients at ultra high risk for psychosis. Eur Neuropsychopharmacol. 2017 May;27(5):538–542.
   PubMed Web of Science ®Google Scholar
• Vinberg M, Ottesen NM, Meluken I, et al. Remitted affective disorders and high familial risk of affective disorders associate with aberrant intestinal microbiota. Acta Psychiatr Scand. 2019 Feb;139(2):174–184.
   PubMed Web of Science ®Google Scholar
• Clark SR, Baune BT, Schubert KO, et al. Prediction of transition from ultra-high risk to first-episode psychosis using a probabilistic model combining history, clinical assessment and fatty-acid biomarkers. Transl Psychiatry. 2016 Sep 20;6(9):e897.
   PubMedGoogle Scholar
• McNamara RK, Jandacek R, Tso P, et al. Adolescents with or at ultra-high risk for bipolar disorder exhibit erythrocyte docosahexaenoic acid and eicosapentaenoic acid deficits: a candidate prodromal risk biomarker. Early Interv Psychiatry. 2016 Jun;10(3):203–211.
   PubMed Web of Science ®Google Scholar
• Snijders G, Schiweck C, Mesman E, et al. A dynamic course of T cell defects in individuals at risk for mood disorders. Brain Behav Immun. 2016;58:11–17.
   PubMed Web of Science ®Google Scholar
• Jones SH, Tai S, Evershed K, et al. Early detection of bipolar disorder: a pilot familial high-risk study of parents with bipolar disorder and their adolescent children. Bipolar Disord. 2006 8;Aug(4):362–372.
   Google Scholar
• Ritter PS, Marx C, Lewtschenko N, et al. The characteristics of sleep in patients with manifest bipolar disorder, subjects at high risk of developing the disease and healthy controls. J Neural Transm (Vienna). 2012 Oct;119(10):1173–1184.
   PubMed Web of Science ®Google Scholar
• Bellivier F, Geoffroy PA, Etain B, et al. Sleep- and circadian rhythm-associated pathways as therapeutic targets in bipolar disorder. Expert Opin Ther Targets. 2015 Jun;19(6):747–763.
   PubMed Web of Science ®Google Scholar
• Geoffroy PA, Etain B, Lajnef M, et al. Circadian genes and lithium response in bipolar disorders: associations with PPARGC1A (PGC-1alpha) and RORA. Genes Brain Behav. 2016 Sep;15(7):660–668.
   PubMed Web of Science ®Google Scholar
• Pisanu C, Congiu D, Melis C, et al. Involvement of core clock genes in lithium response. World J Biol Psychiatry. 2018 Dec;19(8):645–646.
   PubMed Web of Science ®Google Scholar
• Costa M, Squassina A, Piras IS, et al. Preliminary transcriptome analysis in lymphoblasts from cluster headache and bipolar disorder patients implicates dysregulation of circadian and serotonergic genes. J Mol Neurosci. 2015 Jul;56(3):688–695.
   PubMed Web of Science ®Google Scholar
• Fries GR, Colpo GD, Monroy-Jaramillo N, et al. Distinct lithium-induced gene expression effects in lymphoblastoid cell lines from patients with bipolar disorder. Eur Neuropsychopharmacol. 2017 Nov;27(11):1110–1119.
   PubMed Web of Science ®Google Scholar
• McCarthy MJ, Wei H, Nievergelt CM, et al. Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorder. Neuropsychopharmacology. 2019 Feb;44(3):620–628.
   PubMed Web of Science ®Google Scholar
• Oliveira T, Marinho V, Carvalho V, et al. Genetic polymorphisms associated with circadian rhythm dysregulation provide new perspectives on bipolar disorder. Bipolar Disord. 2018 Sep;20(6):515–522.
   PubMed Web of Science ®Google Scholar
• Papadima EM, Niola P, Melis C, et al. Evidence towards RNA binding motif (RNP1, RRM) protein 3 (RBM3) as a potential biomarker of lithium response in bipolar disorder patients. J Mol Neurosci. 2017 Aug;62(3–4):304–308.
   PubMed Web of Science ®Google Scholar
• Teixeira AL, Salem H, Frey BN, et al. Update on bipolar disorder biomarker candidates. Expert Rev Mol Diagn. 2016 Nov;16(11):1209–1220.
   PubMed Web of Science ®Google Scholar
• Ghaziuddin N, Shamseddeen W, Bertram H, et al. Salivary melatonin onset in youth at familial risk for bipolar disorder. Psychiatry Res. 2019;274:49–57.
   PubMed Web of Science ®Google Scholar
• Hosman HCM, Claire M, Engels L. The value of model programmes in mental health promotion and mental disorder prevention. J Public Mental Health. 1999;1(2):4–16.
   Google Scholar
• Vieta E, Salagre E, Grande I, et al. Early intervention in bipolar disorder. Am J Psychiatry. 2018 May 1;175(5):411–426.
   PubMed Web of Science ®Google Scholar
• Phillips ML, Kupfer DJ. Bipolar disorder diagnosis: challenges and future directions. Lancet. 2013 May 11;381(9878):1663–1671.
   PubMed Web of Science ®Google Scholar
• Hajek T, Bauer M, Simhandl C, et al. Neuroprotective effect of lithium on hippocampal volumes in bipolar disorder independent of long-term treatment response. Psychol Med. 2014 Feb;44(3):507–517.
   PubMed Web of Science ®Google Scholar
• Sagar R, Pattanayak RD. Potential biomarkers for bipolar disorder: where do we stand? Indian J Med Res. 2017 Jan;145(1):7–16.
   PubMed Web of Science ®Google Scholar